Proteins crossing membranes: a scientist's memoir
In an intriguing series of experiments carried out many years ago, a common scientific belief, feted by no less than three Nobel prizes, was brought into question. The observations were about proteins--the molecules that the genetic code specifies and that are in one way or another central to all of...
Gespeichert in:
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| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Boca Raton
CRC Press, Taylor & Francis Group
[2019]
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| Schlagworte: | |
| Online-Zugang: | Volltext |
| Zusammenfassung: | In an intriguing series of experiments carried out many years ago, a common scientific belief, feted by no less than three Nobel prizes, was brought into question. The observations were about proteins--the molecules that the genetic code specifies and that are in one way or another central to all of life's activities. The experiments however were not about what proteins do, but how they are moved, in particular how they are moved from where they are made to where they act. The results of these studies conflicted with the standard view of how this happens, and thus became controversial. The standard view, the vesicle theory of protein secretion, envisions proteins being carried within and out of cells en masse in membrane-bound sacs or vesicles. The controversial experiments demonstrated that to the contrary individual protein molecules cross the relevant membranes as a result of their own motion. This was thought to be impossible at the time. Proteins Crossing Membranes is a personal narrative that tells the story of the controversy. Among other things, the author illustrates that scientists, like the rest of us, can rigidly hold onto their beliefs despite evidence that they are misguided. Key Features Reviews the data in support and critical of the vesicle theory of protein secretion Explores the ways scientists respond to evidence that challenges a favored theory Documents the author's personal experiences in this conflict-laden situation |
| Beschreibung: | OCLC-licensed vendor bibliographic record |
| Beschreibung: | 1 online resource |
| ISBN: | 9780429020810 0429020813 9780429667909 0429667906 9780429662461 0429662467 9780429665189 0429665180 |
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| index_date | 2024-07-03T14:08:06Z |
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| isbn | 9780429020810 0429020813 9780429667909 0429667906 9780429662461 0429662467 9780429665189 0429665180 |
| language | English |
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| spelling | Rothman, S. S. Verfasser aut Proteins crossing membranes a scientist's memoir Stephen Rothman Boca Raton CRC Press, Taylor & Francis Group [2019] 1 online resource txt rdacontent c rdamedia cr rdacarrier OCLC-licensed vendor bibliographic record In an intriguing series of experiments carried out many years ago, a common scientific belief, feted by no less than three Nobel prizes, was brought into question. The observations were about proteins--the molecules that the genetic code specifies and that are in one way or another central to all of life's activities. The experiments however were not about what proteins do, but how they are moved, in particular how they are moved from where they are made to where they act. The results of these studies conflicted with the standard view of how this happens, and thus became controversial. The standard view, the vesicle theory of protein secretion, envisions proteins being carried within and out of cells en masse in membrane-bound sacs or vesicles. The controversial experiments demonstrated that to the contrary individual protein molecules cross the relevant membranes as a result of their own motion. This was thought to be impossible at the time. Proteins Crossing Membranes is a personal narrative that tells the story of the controversy. Among other things, the author illustrates that scientists, like the rest of us, can rigidly hold onto their beliefs despite evidence that they are misguided. Key Features Reviews the data in support and critical of the vesicle theory of protein secretion Explores the ways scientists respond to evidence that challenges a favored theory Documents the author's personal experiences in this conflict-laden situation SCIENCE / Life Sciences / Biochemistry bisacsh SCIENCE / Life Sciences / Cytology bisacsh SCIENCE / Life Sciences / Biology / Microbiology bisacsh SCIENCE / Life Sciences / Biology / Molecular Biology bisacsh Membrane proteins / Metabolism Biology / Research https://www.taylorfrancis.com/books/9780429020810 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Rothman, S. S. Proteins crossing membranes a scientist's memoir SCIENCE / Life Sciences / Biochemistry bisacsh SCIENCE / Life Sciences / Cytology bisacsh SCIENCE / Life Sciences / Biology / Microbiology bisacsh SCIENCE / Life Sciences / Biology / Molecular Biology bisacsh Membrane proteins / Metabolism Biology / Research |
| title | Proteins crossing membranes a scientist's memoir |
| title_auth | Proteins crossing membranes a scientist's memoir |
| title_exact_search | Proteins crossing membranes a scientist's memoir |
| title_exact_search_txtP | Proteins crossing membranes a scientist's memoir |
| title_full | Proteins crossing membranes a scientist's memoir Stephen Rothman |
| title_fullStr | Proteins crossing membranes a scientist's memoir Stephen Rothman |
| title_full_unstemmed | Proteins crossing membranes a scientist's memoir Stephen Rothman |
| title_short | Proteins crossing membranes |
| title_sort | proteins crossing membranes a scientist s memoir |
| title_sub | a scientist's memoir |
| topic | SCIENCE / Life Sciences / Biochemistry bisacsh SCIENCE / Life Sciences / Cytology bisacsh SCIENCE / Life Sciences / Biology / Microbiology bisacsh SCIENCE / Life Sciences / Biology / Molecular Biology bisacsh Membrane proteins / Metabolism Biology / Research |
| topic_facet | SCIENCE / Life Sciences / Biochemistry SCIENCE / Life Sciences / Cytology SCIENCE / Life Sciences / Biology / Microbiology SCIENCE / Life Sciences / Biology / Molecular Biology Membrane proteins / Metabolism Biology / Research |
| url | https://www.taylorfrancis.com/books/9780429020810 |
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