Role of membrane expressed and soluble CD83 molecules in Foxp3+ Treg function in the context of inflammatory bowel diseases: = Die Rolle von Membran-exprimierten und löslichen CD83 Molekülen bezüglich der Funktion von Foxp3+ Tregs im Zusammenhang mit chronisch-entzündlichen Darmerkrankungen
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | German |
| Veröffentlicht: |
Erlangen ; Nürnberg
[2019]
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Inhaltsverzeichnis |
| Beschreibung: | 146 Seiten Illustrationen, Diagramme |
Internformat
MARC
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| 035 | |a (OCoLC)1141150639 | ||
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| 100 | 1 | |a König, Christina |e Verfasser |0 (DE-588)1206662190 |4 aut | |
| 245 | 1 | 0 | |a Role of membrane expressed and soluble CD83 molecules in Foxp3+ Treg function in the context of inflammatory bowel diseases |b = Die Rolle von Membran-exprimierten und löslichen CD83 Molekülen bezüglich der Funktion von Foxp3+ Tregs im Zusammenhang mit chronisch-entzündlichen Darmerkrankungen |c vorgelegt von Christina König |
| 246 | 1 | 1 | |a Die Rolle von Membran-exprimierten und löslichen CD83 Molekülen bezüglich der Funktion von Foxp3+ Tregs im Zusammenhang mit chronisch-entzündlichen Darmerkrankungen |
| 264 | 1 | |a Erlangen ; Nürnberg |c [2019] | |
| 300 | |a 146 Seiten |b Illustrationen, Diagramme | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 502 | |b Dissertation |c Friedrich-Alexander-Universität Erlangen-Nürnberg |d 2019 | ||
| 650 | 0 | 7 | |a Chronische Darmentzündung |0 (DE-588)4273697-3 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Antigen CD83 |0 (DE-588)4767577-9 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Regulatorischer T-Lymphozyt |0 (DE-588)1032038217 |2 gnd |9 rswk-swf |
| 655 | 7 | |0 (DE-588)4113937-9 |a Hochschulschrift |2 gnd-content | |
| 689 | 0 | 0 | |a Chronische Darmentzündung |0 (DE-588)4273697-3 |D s |
| 689 | 0 | 1 | |a Antigen CD83 |0 (DE-588)4767577-9 |D s |
| 689 | 0 | 2 | |a Regulatorischer T-Lymphozyt |0 (DE-588)1032038217 |D s |
| 689 | 0 | |5 DE-604 | |
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| 999 | |a oai:aleph.bib-bvb.de:BVB01-031840816 | ||
Datensatz im Suchindex
| _version_ | 1804180978279645184 |
|---|---|
| adam_text | TABLE
OF
CONTENTS
ABSTRACT
........................................................................................................................................................
1
ZUSAMMENFASSUNG
.....................................................................................................................................
3
1
INTRODUCTION
..........................................................................................................................................
6
1.1
INSIGHTS
INTO
THE
IMMUNE
SYSTEM
................................................................................................
6
1.1.1
OVERVIEW
OF
THE
INNATE
AND
ADAPTIVE
IMMUNE
SYSTEM
.................................................. 6
1.1.2
ROLE
AND
FUNCTION
OF
THE
INTESTINAL
IMMUNE
SYSTEM
FOR
THE
HOMEOSTASIS
IN
THE
BODY.
.................................................................................................................................
7
1.1.3
DEVELOPMENT
OF
T
CELLS
IN
THE
THYMUS
AND
DIFFERENTIATION
OF
THE
CD4
+
T
CELL
SUBSETS
IN
THE
PERIPHERY
..................................................................................................................
9
1.2
DEVELOPMENT,
CHARACTERIZATION
AND
FUNCTION
OF
REGULATORY
T
CELLS
......................................
18
1.2.1
SPECIFIC
FUNCTION
OF
REGULATORY
T
CELLS
IN
THE
INTESTINAL
/
MUCOSAL
IMMUNE
SYSTEM
.22
1.3
AUTOIMMUNITY
-
INFLAMMATORY
BOWEL
DISEASES
........................................................................
23
1.3.1
DYSREGULATED
IMMUNE
TOLERANCE
AGAINST
SELF-ANTIGENS
AND
THE
MICROBIOME
LEADS
TO
AUTOIMMUNE
DISORDERS
SUCH
AS
IBD
.............................................................................
23
1.3.2
THE
MURINE
TRANSFER
COLITIS
MODEL
RESEMBLES
PATHOLOGY
OF
CROHN
*
S
DISEASE
..........
24
1.3.3
THE
MURINE
DSS-INDUCED
COLITIS
MODEL
USED
TO
STUDY
EARLY
REPAIR
PROCESSES
OF
THE
INTESTINAL
INTEGRITY
.............................................................................................................
26
1.4
THE
IMMUNE
MODULATORY
CD83
MOLECULE
................................................................................
27
1.4.1
RELEVANT
MILESTONES
OF
THE
CD83
MOLECULE
................................................................
27
1.4.2
INTRA
-
THYMIC
FUNCTIONS
OF
THE
MEMBRANE-BOUND
CD83
MOLECULE
...........................
28
1.4.3
MEMBRANE-BOUND
CD83
MODULATES
T
CELL
ACTIVATION
PROCESSES
..............................
29
1.4.4
FUNCTIONAL
RELEVANCE
OF
CD83
ON
ACTIVATED
REGULATORY
T
CELLS
.................................
30
1.4.5
SOLUBLE
CD83
-
IN
VIVO
IMMUNE
MODULATION
IN
AUTOIMMUNE
MODELS
.......................
31
1.5
SPECIFIC
AIMS
OF
THIS
THESIS
........................................................................................................
33
1.5.1
DETERMINE
WHETHER
DELETION
OF
CD83
MODULATES
THE
FUNCTION
OF
FOXP3
+
REGULATORY
T
CELLS
IN
THE
CONTEXT
OF
IBD
...............................................................................................33
1.5.2
EVALUATION
OF
SCD83
APPLICATION
AS
A
STRATEGY
FOR
IBD
THERAPY
................................. 34
2
MATERIAL
AND
METHODS
......................................................................................................................35
2.1
MATERIAL
.......................................................................................................................................35
2.1.1
MOUSE
STRAINS
....................................................................................................................35
2.1.2
LABORATORY
EQUIPMENT
.....................................................................................................
35
2.1.3
CONSUMABLE
SUPPLIES
......................................................................................................
36
2.1.4
CHEMICALS
.........................................................................................................................
37
2.1.5
FREQUENTLY
USED
BUFFERS,
SOLUTIONS
AND
CELL
FLUIDS
........................................................
38
2.1.6
DNA
OLIGONUCLEOTIDES
FOR
POLYMERASE
CHAIN
REACTIONS
................................................
41
2.1.7
ANTIBODIES
.........................................................................................................................
43
2.1.8
CYTOKINES,
PROTEINS
AND
ENZYMES
...................................................................................
44
2.1.9
KITS
.....................................................................................................................................
45
2.1.10
SOFTWARE
......................................................................................................................
46
2.2
METHODS
...................................................................................................................................
47
2.2.1
USED
MOUSE
STRAINS
.........................................................................................................
47
2.2.2
MOUSE
GENOTYPING
...........................................................................................................
47
2.2.3
PREPARATION
OF
MONONUCLEAR
CELL
SUSPENSIONS
............................................................
49
2.2.4
IN
VIVO
MOUSE
MODELS
......................................................................................................50
2.2.4.1
ANALYSIS
OF
CD83
AFOXP3
TREG
FUNCTION
IN
VIVO
USING
THE
MURINE
ADOPTIVE
TRANSFER
COLITIS
MODEL
....................................................................................................................
50
2.2.4
2
IN
VIVO
APPLICATION
OF
SCD83
AS
POTENTIAL
IMMUNE
MODULATING
MOLECULE
IN
IBD
USING
THE
DSS-INDUCED
COLITIS
MODEL
.............................................................
54
2.2.5
HIGH
RESOLUTION
MOUSE
COLONOSCOPY
AND
EVALUATION
OF
COLITIS
PARAMETERS
..............
57
2.2.6
HISTOLOGY
...........................................................................................................................
57
2.2.6.1
GENERATION
OF
COLON
TISSUE
SAMPLES
FOR
HISTOLOGICAL
ANALYSES
.................................
57
2.2.6
2
HISTOLOGICAL
STAINING
FOR
HEMATOXYLIN
AND
EOSIN
.....................................................
58
2.2.6
3
EVALUATION
OF
THE
H&E
STAINING
................................................................................
58
2.2.7
GENE
EXPRESSION
ANALYSES
.............................................................................................
59
2.2.7.1
RNA
ISOLATION
FROM
TISSUE
AND
CELLS
.............................................................................
59
2.2.7.2
CDNA
SYNTHESIS
.............................................................................................................
59
2.2.7.3
QUANTITATIVE
POLYMERASE
CHAIN
REACTION
(QPCR)
ANALYSES
.......................................
60
2.2.8
BIOMOLECULAR
METHODS
FOR
PROTEIN
ANALYSES
.................................................................
60
2.2.8.1
PREPARATION
OF
CELL-
AND
TISSUE
LYSATES
FOR
PROTEIN
DETECTION
BY
WESTERN
BLOT
.......
60
2.2.8.2
DETERMINATION
OF
PROTEIN
CONCENTRATIONS
USING
BICINCHONINIC
ACID
(BCA)
.............
61
2.2.8
3
SDS-POLYACRYLAMIDE
GEL
ELECTROPHORESIS
(PAGE)
................................................
61
2.2.8.4
PROTEIN
DETECTION
BY
WESTERN
BLOT
...............................................................................
63
2.2.9
FLOW
CYTOMETRY
ANALYSIS
.................................................................................................
64
2.2.10
ANALYSES
OF
CYTOKINE
PROFILES
USING
CYTOMETRIC
BEAD
ARRAYS
..................................
66
2.2.11
STATISTICAL
DATA
ANALYSES
.............................................................................................
67
3
RESULTS
...............................................................................................................................................
68
3.1
CHAPTER
ONE:
DELETION
OF
CD83
MODULATES
THE
FUNCTIONAL
PROPERTIES
OF
FOXP3
+
TREGS
IN
THE
CONTEXT
OF
IBD
...............................................................................................................
68
3.1.1
LOESS
OF
CD83
ON
FOXP3
+
TREGS
LEADS
TO
AN
AGGRAVATED
INTESTINAL
INFLAMMATORY
RESPONSE
AFTER
THE
TRANSFER
OF
CD4
+
T
CELLS
FROM
CD83
AFOXP3
INTO
RAGT
7
MICE
IN
VIVO
68
3.1.2
TRANSFER
OF
CD83
AFOXP3
CD4
+
CD25
T
EFF
CELLS
INTO
RAGT
7
MICE
PROMPTS
AN
AGGRAVATED
COURSE
OF
COLITIS
IN
VIVO
76
3.1.3
IMPAIRED
DIFFERENTIATION
OF
NAIVE
CD83
AFOXP3
CD4
+
T
CELLS
INTO
FOXP3
+
PTREGS
IN
VIVO
81
3.1.4
CD83
AFOXP3
TREGS
EXHIBIT
AN
ALTERED
ACTIVATION
STATUS
LEADING
TO
PHENOTYPIC
CHANGES
84
3.2
CHAPTER
TWO:
IN
VIVO
EVALUATION
OF
SCD83
AS
POTENTIALLY
THERAPEUTIC
MOLECULE
FOR
THE
TREATMENT
OF
IBD
94
3.2.1
TREATMENT
WITH
SCD83
UNDER
HOMEOSTATIC
CONDITIONS
HAS
NO
MAJOR
INFLUENCE
ON
THE
DISTRIBUTION
OF
THE
DIFFERENT
T
CELL
SUBSETS
94
3.2.2
TREATMENT
WITH
SCD83
LEADS
TO
AMELIORATED
COLITIS
SYMPTOMS
IN
DSS
CHALLENGED
MICE
..................................................................
97
4
DISCUSSION
109
4.1
CHAPTER
ONE:
DELETION
OF
CD83
MODULATES
THE
FUNCTIONAL
PROPERTIES
OF
FOXP3
+
TREGS
IN
THE
CONTEXT
OF
IBD
109
4.1.1
CD83
DEFICIENCY
ON
FOXP3
+
TREGS
LEADS
TO
AGGRAVATED
INTESTINAL
INFLAMMATION
IN
VIVO
109
4.1.2
THE
TRANSFER
OF
CD4
+
CD25
T
E
TF
CELLS
FROM
CD83
AFOXP3
ANIMALS
TO
RAGT
7
RECIPIENT
MICE
PROMPTS
AN
AGGRAVATED
COLITIS
PATHOLOGY
IN
VIVO
111
4.1.3
NAIVE
CD4
+
CD25
CD44
L0W
T
CELLS
OF
CD83
AFOXP3
ANIMALS
HAVE
AN
IMPAIRED
CAPACITY
TO
DIFFERENTIATE
INTO
PTREGS
IN
VIVO
113
4.1.4
CD83
AFOXP3
TREGS
EXHIBIT
AN
ALTERED
ACTIVATION
STATUS
WHICH
LEADS
TO
THEIR
PHENOTYPE
114
4.1.5
RESUME
AND
PROSPECTS
OF
CHAPTER
ONE:
DELETION
OF
CD83
MODULATES
THE
FUNCTIONAL
PROPERTIES
OF
FOXP3
+
TREGS
IN
THE
CONTEXT
OF
IBD
118
4.2
CHAPTER
TWO:
IN
VIVO
EVALUATION
OF
SCD83
AS
POTENTIALLY
THERAPEUTIC
MOLECULE
IN
THE
TREATMENT
OF
IBD
119
4.2.1
SCD83
HAS
NO
MAJOR
INFLUENCE
ON
THE
CELLULAR
COMPOSITION
OF
THE
INTESTINAL
IMMUNE
SYSTEM
UNDER
HOMEOSTATIC
CONDITIONS
119
4.2.2
SCD83
AMELIORATES
COLITIS
PATHOLOGY
IN
DSS
CHALLENGED
ANIMALS
DURING
RECOVERY
120
4.2.3
SCD83
HAS
A
BENEFICIAL
EFFECT
ON
WOUND
HEALING
PROCESSES
UPON
INTESTINAL
INJURY
121
4.2.4
RESUME
AND
CLINICALLY
RELEVANT
PROSPECTS
OF
CHAPTER
TWO:
IN
VIVO
EVALUATION
OF
SCD83
AS
POTENTIALLY
THERAPEUTIC
MOLECULE
IN
THE
TREATMENT
OF
IBD
.........................
124
5
REFERENCE
LIST
...............................................................................................................................
126
6
ABBREVIATIONS
..................................................................................................................................
136
7
LIST
OF
FIGURES
.................................................................................................................................
139
8
LISTOFTABLES
..................................................................................................................................142
9
ACKNOWLEDGEMENT
.........................................................................................................................
143
10
PUBLICATIONS
AND
PRESENTATIONS
.....................................................................................................
145
|
| any_adam_object | 1 |
| author | König, Christina |
| author_GND | (DE-588)1206662190 |
| author_facet | König, Christina |
| author_role | aut |
| author_sort | König, Christina |
| author_variant | c k ck |
| building | Verbundindex |
| bvnumber | BV046428538 |
| ctrlnum | (OCoLC)1141150639 (DE-599)DNB1204263493 |
| discipline | Biologie Medizin |
| format | Thesis Book |
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| genre | (DE-588)4113937-9 Hochschulschrift gnd-content |
| genre_facet | Hochschulschrift |
| id | DE-604.BV046428538 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T08:44:21Z |
| institution | BVB |
| language | German |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-031840816 |
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| open_access_boolean | |
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| physical | 146 Seiten Illustrationen, Diagramme |
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| publishDateSort | 2019 |
| record_format | marc |
| spelling | König, Christina Verfasser (DE-588)1206662190 aut Role of membrane expressed and soluble CD83 molecules in Foxp3+ Treg function in the context of inflammatory bowel diseases = Die Rolle von Membran-exprimierten und löslichen CD83 Molekülen bezüglich der Funktion von Foxp3+ Tregs im Zusammenhang mit chronisch-entzündlichen Darmerkrankungen vorgelegt von Christina König Die Rolle von Membran-exprimierten und löslichen CD83 Molekülen bezüglich der Funktion von Foxp3+ Tregs im Zusammenhang mit chronisch-entzündlichen Darmerkrankungen Erlangen ; Nürnberg [2019] 146 Seiten Illustrationen, Diagramme txt rdacontent n rdamedia nc rdacarrier Dissertation Friedrich-Alexander-Universität Erlangen-Nürnberg 2019 Chronische Darmentzündung (DE-588)4273697-3 gnd rswk-swf Antigen CD83 (DE-588)4767577-9 gnd rswk-swf Regulatorischer T-Lymphozyt (DE-588)1032038217 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Chronische Darmentzündung (DE-588)4273697-3 s Antigen CD83 (DE-588)4767577-9 s Regulatorischer T-Lymphozyt (DE-588)1032038217 s DE-604 B:DE-101 application/pdf https://d-nb.info/1204263493/04 Inhaltsverzeichnis DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=031840816&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | König, Christina Role of membrane expressed and soluble CD83 molecules in Foxp3+ Treg function in the context of inflammatory bowel diseases = Die Rolle von Membran-exprimierten und löslichen CD83 Molekülen bezüglich der Funktion von Foxp3+ Tregs im Zusammenhang mit chronisch-entzündlichen Darmerkrankungen Chronische Darmentzündung (DE-588)4273697-3 gnd Antigen CD83 (DE-588)4767577-9 gnd Regulatorischer T-Lymphozyt (DE-588)1032038217 gnd |
| subject_GND | (DE-588)4273697-3 (DE-588)4767577-9 (DE-588)1032038217 (DE-588)4113937-9 |
| title | Role of membrane expressed and soluble CD83 molecules in Foxp3+ Treg function in the context of inflammatory bowel diseases = Die Rolle von Membran-exprimierten und löslichen CD83 Molekülen bezüglich der Funktion von Foxp3+ Tregs im Zusammenhang mit chronisch-entzündlichen Darmerkrankungen |
| title_alt | Die Rolle von Membran-exprimierten und löslichen CD83 Molekülen bezüglich der Funktion von Foxp3+ Tregs im Zusammenhang mit chronisch-entzündlichen Darmerkrankungen |
| title_auth | Role of membrane expressed and soluble CD83 molecules in Foxp3+ Treg function in the context of inflammatory bowel diseases = Die Rolle von Membran-exprimierten und löslichen CD83 Molekülen bezüglich der Funktion von Foxp3+ Tregs im Zusammenhang mit chronisch-entzündlichen Darmerkrankungen |
| title_exact_search | Role of membrane expressed and soluble CD83 molecules in Foxp3+ Treg function in the context of inflammatory bowel diseases = Die Rolle von Membran-exprimierten und löslichen CD83 Molekülen bezüglich der Funktion von Foxp3+ Tregs im Zusammenhang mit chronisch-entzündlichen Darmerkrankungen |
| title_full | Role of membrane expressed and soluble CD83 molecules in Foxp3+ Treg function in the context of inflammatory bowel diseases = Die Rolle von Membran-exprimierten und löslichen CD83 Molekülen bezüglich der Funktion von Foxp3+ Tregs im Zusammenhang mit chronisch-entzündlichen Darmerkrankungen vorgelegt von Christina König |
| title_fullStr | Role of membrane expressed and soluble CD83 molecules in Foxp3+ Treg function in the context of inflammatory bowel diseases = Die Rolle von Membran-exprimierten und löslichen CD83 Molekülen bezüglich der Funktion von Foxp3+ Tregs im Zusammenhang mit chronisch-entzündlichen Darmerkrankungen vorgelegt von Christina König |
| title_full_unstemmed | Role of membrane expressed and soluble CD83 molecules in Foxp3+ Treg function in the context of inflammatory bowel diseases = Die Rolle von Membran-exprimierten und löslichen CD83 Molekülen bezüglich der Funktion von Foxp3+ Tregs im Zusammenhang mit chronisch-entzündlichen Darmerkrankungen vorgelegt von Christina König |
| title_short | Role of membrane expressed and soluble CD83 molecules in Foxp3+ Treg function in the context of inflammatory bowel diseases |
| title_sort | role of membrane expressed and soluble cd83 molecules in foxp3 treg function in the context of inflammatory bowel diseases die rolle von membran exprimierten und loslichen cd83 molekulen bezuglich der funktion von foxp3 tregs im zusammenhang mit chronisch entzundlichen darmerkrankungen |
| title_sub | = Die Rolle von Membran-exprimierten und löslichen CD83 Molekülen bezüglich der Funktion von Foxp3+ Tregs im Zusammenhang mit chronisch-entzündlichen Darmerkrankungen |
| topic | Chronische Darmentzündung (DE-588)4273697-3 gnd Antigen CD83 (DE-588)4767577-9 gnd Regulatorischer T-Lymphozyt (DE-588)1032038217 gnd |
| topic_facet | Chronische Darmentzündung Antigen CD83 Regulatorischer T-Lymphozyt Hochschulschrift |
| url | https://d-nb.info/1204263493/04 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=031840816&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT konigchristina roleofmembraneexpressedandsolublecd83moleculesinfoxp3tregfunctioninthecontextofinflammatoryboweldiseasesdierollevonmembranexprimiertenundloslichencd83molekulenbezuglichderfunktionvonfoxp3tregsimzusammenhangmitchronischentzundlichendarmerkrankungen AT konigchristina dierollevonmembranexprimiertenundloslichencd83molekulenbezuglichderfunktionvonfoxp3tregsimzusammenhangmitchronischentzundlichendarmerkrankungen |
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Inhaltsverzeichnis