Characterization of Loop Diuretics and Bumetanide Derivatives with Selective Effect on the Neuronal Cation Chloride Cotransporter NKCC1:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
Gießen
DVG
2019
|
| Ausgabe: | 1. Auflage |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | VI, 53 Seiten |
| ISBN: | 9783863455118 |
Internformat
MARC
| LEADER | 00000nam a2200000 c 4500 | ||
|---|---|---|---|
| 001 | BV046337246 | ||
| 003 | DE-604 | ||
| 005 | 00000000000000.0 | ||
| 007 | t | ||
| 008 | 200116s2019 gw m||| 00||| eng d | ||
| 020 | |a 9783863455118 |9 978-3-86345-511-8 | ||
| 035 | |a (OCoLC)1137847283 | ||
| 035 | |a (DE-599)KXP1685891322 | ||
| 040 | |a DE-604 |b ger |e rda | ||
| 041 | 0 | |a eng | |
| 044 | |a gw |c XA-DE | ||
| 049 | |a DE-188 | ||
| 100 | 1 | |a Hampel, Philip |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Characterization of Loop Diuretics and Bumetanide Derivatives with Selective Effect on the Neuronal Cation Chloride Cotransporter NKCC1 |c by Philip Hampel |
| 246 | 1 | 3 | |a Charakterisierung von Schleifendiuretika und Bumetanid-Derivaten mit selektivem Effekt auf den neuronalen Kation-Chlorid-Cotransporter NKCC1 |
| 250 | |a 1. Auflage | ||
| 264 | 1 | |a Gießen |b DVG |c 2019 | |
| 300 | |a VI, 53 Seiten | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 502 | |b Dissertation |c Tierärztliche Hochschule Hannover |d 2019 | ||
| 546 | |a Zusammenfassungen in deutscher und englischer Sprache | ||
| 650 | 7 | |a cell membranes |2 cabt | |
| 650 | 7 | |a cell structure |2 cabt | |
| 650 | 7 | |a signal transduction |2 cabt | |
| 650 | 7 | |a chlorids |2 cabt | |
| 650 | 7 | |a epilepsy |2 cabt | |
| 650 | 7 | |a drugs |2 cabt | |
| 650 | 7 | |a diuretics |2 cabt | |
| 650 | 0 | 7 | |a Dissertation |0 (DE-588)4012494-0 |2 gnd |9 rswk-swf |
| 655 | 7 | |0 (DE-588)4113937-9 |a Hochschulschrift |2 gnd-content | |
| 689 | 0 | 0 | |a Dissertation |0 (DE-588)4012494-0 |D s |
| 689 | 0 | |5 DE-604 | |
| 710 | 2 | |a Tierärztliche Hochschule Hannover |0 (DE-588)2002227-X |4 dgg | |
| 856 | 4 | 2 | |m HEBIS Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=031713965&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-031713965 | ||
Datensatz im Suchindex
| _version_ | 1804180832603078656 |
|---|---|
| adam_text | Table of Contents
1 Introduction 1
1 1 Epilepsy 1
1 2 Neonatal Seizures 3
1 3 Therapy of Epilepsy and Neonatal Seizures 4
1 4 Na+-Ka*-CT Cotransporter NKCC1 5
1 5 Bumetanide and Loop Diuretics 7
1 6 Animal Models 8
1 7 Bumetanide as an Experimental Therapy 9
171 Predinical Studies 9
172 Clinical Studies 10
1 8 Repurposing 12
1 9 Derivatives 13
191 Prodrug Strategy 13
192 New Chemical Entity Strategy 14
2 Azosemide Is More Potent Than Bumetanide and Various Other
Loop Diuretics to inhibit the Sodium-Potassium-Chloride-
Cotransporter Human Variants hNKCCIA and hNKCClB 16
3 Bumepamine, a Brain-Permeant Benzylamine Derivative of
Bumetanide, Does not Inhibit NKCC1 But Is More Potent to
Enhance Phenobarbital s Anti-Seizure Efficacy 18
4 Corrigendum to Bumepamine, a Brain-Permeant Benzylamine
Derivative of Bumetanide, Does Not Inhibit NKCC1 but Is More
Potent to Enhance Phenobarbital s Anti-Seizure Efficacy 20
5 Discussion 21
5 1 Diuretics 21
511 General Findings 21
512 NKCC1 Inhibitors of Interest for CNS Diseases 22
I
513 Pharmacological Differentiation Between the Two NKCC1 Splice Variants 25
514 Pharmacological Differences Between NKCC1 and NKCC2 26
5 2 Bumepamine 28
521 Hypotheses to the Mechanism of Action 31
522 Proposals for the Future 31
5 3 Overall 32
6 Summary 33
7 Zusammenfassung 35
8 References 37
9 Publication Record 50
Publications in Peer-Reviewed Journals 50
Oral Presentations 50
Posters 51
10 Acknowledgements 52
|
| any_adam_object | 1 |
| author | Hampel, Philip |
| author_facet | Hampel, Philip |
| author_role | aut |
| author_sort | Hampel, Philip |
| author_variant | p h ph |
| building | Verbundindex |
| bvnumber | BV046337246 |
| ctrlnum | (OCoLC)1137847283 (DE-599)KXP1685891322 |
| edition | 1. Auflage |
| format | Thesis Book |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01901nam a2200469 c 4500</leader><controlfield tag="001">BV046337246</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">00000000000000.0</controlfield><controlfield tag="007">t</controlfield><controlfield tag="008">200116s2019 gw m||| 00||| eng d</controlfield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9783863455118</subfield><subfield code="9">978-3-86345-511-8</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)1137847283</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)KXP1685891322</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rda</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="044" ind1=" " ind2=" "><subfield code="a">gw</subfield><subfield code="c">XA-DE</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-188</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Hampel, Philip</subfield><subfield code="e">Verfasser</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Characterization of Loop Diuretics and Bumetanide Derivatives with Selective Effect on the Neuronal Cation Chloride Cotransporter NKCC1</subfield><subfield code="c">by Philip Hampel</subfield></datafield><datafield tag="246" ind1="1" ind2="3"><subfield code="a">Charakterisierung von Schleifendiuretika und Bumetanid-Derivaten mit selektivem Effekt auf den neuronalen Kation-Chlorid-Cotransporter NKCC1</subfield></datafield><datafield tag="250" ind1=" " ind2=" "><subfield code="a">1. Auflage</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Gießen</subfield><subfield code="b">DVG</subfield><subfield code="c">2019</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">VI, 53 Seiten</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="502" ind1=" " ind2=" "><subfield code="b">Dissertation</subfield><subfield code="c">Tierärztliche Hochschule Hannover</subfield><subfield code="d">2019</subfield></datafield><datafield tag="546" ind1=" " ind2=" "><subfield code="a">Zusammenfassungen in deutscher und englischer Sprache</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">cell membranes</subfield><subfield code="2">cabt</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">cell structure</subfield><subfield code="2">cabt</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">signal transduction</subfield><subfield code="2">cabt</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">chlorids</subfield><subfield code="2">cabt</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">epilepsy</subfield><subfield code="2">cabt</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">drugs</subfield><subfield code="2">cabt</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">diuretics</subfield><subfield code="2">cabt</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Dissertation</subfield><subfield code="0">(DE-588)4012494-0</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="655" ind1=" " ind2="7"><subfield code="0">(DE-588)4113937-9</subfield><subfield code="a">Hochschulschrift</subfield><subfield code="2">gnd-content</subfield></datafield><datafield tag="689" ind1="0" ind2="0"><subfield code="a">Dissertation</subfield><subfield code="0">(DE-588)4012494-0</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="710" ind1="2" ind2=" "><subfield code="a">Tierärztliche Hochschule Hannover</subfield><subfield code="0">(DE-588)2002227-X</subfield><subfield code="4">dgg</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">HEBIS Datenaustausch</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=031713965&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-031713965</subfield></datafield></record></collection> |
| genre | (DE-588)4113937-9 Hochschulschrift gnd-content |
| genre_facet | Hochschulschrift |
| id | DE-604.BV046337246 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-10T08:42:02Z |
| institution | BVB |
| institution_GND | (DE-588)2002227-X |
| isbn | 9783863455118 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-031713965 |
| oclc_num | 1137847283 |
| open_access_boolean | |
| owner | DE-188 |
| owner_facet | DE-188 |
| physical | VI, 53 Seiten |
| publishDate | 2019 |
| publishDateSearch | 2019 |
| publishDateSort | 2019 |
| publisher | DVG |
| record_format | marc |
| spelling | Hampel, Philip Verfasser aut Characterization of Loop Diuretics and Bumetanide Derivatives with Selective Effect on the Neuronal Cation Chloride Cotransporter NKCC1 by Philip Hampel Charakterisierung von Schleifendiuretika und Bumetanid-Derivaten mit selektivem Effekt auf den neuronalen Kation-Chlorid-Cotransporter NKCC1 1. Auflage Gießen DVG 2019 VI, 53 Seiten txt rdacontent n rdamedia nc rdacarrier Dissertation Tierärztliche Hochschule Hannover 2019 Zusammenfassungen in deutscher und englischer Sprache cell membranes cabt cell structure cabt signal transduction cabt chlorids cabt epilepsy cabt drugs cabt diuretics cabt Dissertation (DE-588)4012494-0 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Dissertation (DE-588)4012494-0 s DE-604 Tierärztliche Hochschule Hannover (DE-588)2002227-X dgg HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=031713965&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Hampel, Philip Characterization of Loop Diuretics and Bumetanide Derivatives with Selective Effect on the Neuronal Cation Chloride Cotransporter NKCC1 cell membranes cabt cell structure cabt signal transduction cabt chlorids cabt epilepsy cabt drugs cabt diuretics cabt Dissertation (DE-588)4012494-0 gnd |
| subject_GND | (DE-588)4012494-0 (DE-588)4113937-9 |
| title | Characterization of Loop Diuretics and Bumetanide Derivatives with Selective Effect on the Neuronal Cation Chloride Cotransporter NKCC1 |
| title_alt | Charakterisierung von Schleifendiuretika und Bumetanid-Derivaten mit selektivem Effekt auf den neuronalen Kation-Chlorid-Cotransporter NKCC1 |
| title_auth | Characterization of Loop Diuretics and Bumetanide Derivatives with Selective Effect on the Neuronal Cation Chloride Cotransporter NKCC1 |
| title_exact_search | Characterization of Loop Diuretics and Bumetanide Derivatives with Selective Effect on the Neuronal Cation Chloride Cotransporter NKCC1 |
| title_full | Characterization of Loop Diuretics and Bumetanide Derivatives with Selective Effect on the Neuronal Cation Chloride Cotransporter NKCC1 by Philip Hampel |
| title_fullStr | Characterization of Loop Diuretics and Bumetanide Derivatives with Selective Effect on the Neuronal Cation Chloride Cotransporter NKCC1 by Philip Hampel |
| title_full_unstemmed | Characterization of Loop Diuretics and Bumetanide Derivatives with Selective Effect on the Neuronal Cation Chloride Cotransporter NKCC1 by Philip Hampel |
| title_short | Characterization of Loop Diuretics and Bumetanide Derivatives with Selective Effect on the Neuronal Cation Chloride Cotransporter NKCC1 |
| title_sort | characterization of loop diuretics and bumetanide derivatives with selective effect on the neuronal cation chloride cotransporter nkcc1 |
| topic | cell membranes cabt cell structure cabt signal transduction cabt chlorids cabt epilepsy cabt drugs cabt diuretics cabt Dissertation (DE-588)4012494-0 gnd |
| topic_facet | cell membranes cell structure signal transduction chlorids epilepsy drugs diuretics Dissertation Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=031713965&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT hampelphilip characterizationofloopdiureticsandbumetanidederivativeswithselectiveeffectontheneuronalcationchloridecotransporternkcc1 AT tierarztlichehochschulehannover characterizationofloopdiureticsandbumetanidederivativeswithselectiveeffectontheneuronalcationchloridecotransporternkcc1 AT hampelphilip charakterisierungvonschleifendiuretikaundbumetanidderivatenmitselektivemeffektaufdenneuronalenkationchloridcotransporternkcc1 AT tierarztlichehochschulehannover charakterisierungvonschleifendiuretikaundbumetanidderivatenmitselektivemeffektaufdenneuronalenkationchloridcotransporternkcc1 |