Handbook of in vivo chemistry in mice: from lab to living system
Gespeichert in:
| Weitere Verfasser: | , |
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| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Weinheim
Wiley-VCH
[2020]
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | xiii, 546 Seiten Illustrationen, Diagramme |
| ISBN: | 9783527344321 3527344322 |
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| 245 | 1 | 0 | |a Handbook of in vivo chemistry in mice |b from lab to living system |c edited by Katsunori Tanaka, Kenward Vong |
| 264 | 1 | |a Weinheim |b Wiley-VCH |c [2020] | |
| 300 | |a xiii, 546 Seiten |b Illustrationen, Diagramme | ||
| 336 | |b txt |2 rdacontent | ||
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| 653 | |a Bildgebende Verfahren i. d. Biomedizin | ||
| 653 | |a Biomedical Engineering | ||
| 653 | |a Biomedical Imaging | ||
| 653 | |a Biomedizintechnik | ||
| 653 | |a Biowissenschaften | ||
| 653 | |a Chemie | ||
| 653 | |a Chemistry | ||
| 653 | |a Life Sciences | ||
| 653 | |a Mausmodell | ||
| 653 | |a Molecular Biology | ||
| 653 | |a Molekularbiologie | ||
| 653 | |a Pharmaceutical & Medicinal Chemistry | ||
| 653 | |a Pharmazeutische u. Medizinische Chemie | ||
| 653 | |a Versuchstiere | ||
| 653 | |a BE70: Bildgebende Verfahren i. d. Biomedizin | ||
| 653 | |a CH60: Pharmazeutische u. Medizinische Chemie | ||
| 653 | |a LS31: Molekularbiologie | ||
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| 700 | 1 | |a Tanaka, Katsunori |0 (DE-588)1206563974 |4 edt | |
| 700 | 1 | |a Vong, Kenward |4 edt | |
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Datensatz im Suchindex
| _version_ | 1804180791988584448 |
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| adam_text | CONTENTS
1 SUMMARY OF CURRENTLY AVAILABLE MOUSE MODELS 1
AMI
ITO,
NAMIKO ITO, KIMIE
NIIMI,
TAKASHIARAI, AND EIKI TAKAHASHI
1.1 INTRODUCTION 1
1.2 ORIGIN AND HISTORY OF LABORATORY MICE 2
1.3 LABORATORY MOUSE STRAINS 3
1.3.1 WILD-DERIVED MICE 3
1.3.2 INBRED MICE 4
1.3.3 HYBRID MICE 4
1.3.4 OUTBRED STOCKS 8
1.3.5 CLOSED COLONY 8
1.3.6 CONGENIC MICE 8
1.4 MUTANT MICE 9
1.4.1 SPONTANEOUS 9
1.4.2 TRANSGENESIS 9
1.4.3 TARGETED MUTAGENESIS 11
1.4.4 INDUCIBLE MUTAGENESIS 13
1.4.5 CRE-LOXP SYSTEM 13
1.4.6 CRISPR/CAS9 SYSTEM IS
1.5 RESOURCES OF LABORATORY STRAINS 16
1.6 GERM-FREE MICE 16
1.7 GNOTOBIOTIC MICE 18
1.8 SPECIFIC PATHOGEN-FREE MICE 18
1.9 IMMUNOCOMPETENT AND IMMUNODEFICIENT MICE 18
1.10 MOUSE HEALTH MONITORING 19
1.11 PRODUCTION AND MAINTENANCE OF MOUSE COLONY 19
1.11.1 PRODUCTION PLANNING 19
1.11.2 BREEDING SYSTEMS AND MATING SCHEMES 19
1.12 MATING 21
1.13 GESTATION PERIOD 21
1.14 PARTURITION 21
1.15 PARENTAL BEHAVIOR AND REARING PUPS 21
1.16 GROWTH OF PUPS 22
1.17 REPRODUCTIVE LIFESPAN 23
1.18 RECORD KEEPING AND
COLONY ORGANIZATION
23
BIBLIOGRAFISCHE INFORMATIONEN
HTTP://D-NB.INFO/1191204294
VI I CONTENTS
1.19 ANIMAL IDENTIFICATION 24
1.20 ANIMAL MODELS IN PRECLINICAL RESEARCH 24
REFERENCES 29
2
2.1
2.2
2
.
2.1
2
.
2.2
2.3
2.3.1
2.3.2
2.3.3
2.3.4
2.4
2.4.1
2.4.2
2.5
2.6
2
.
6.1
2
.
6
.
1.1
2
.
6
.
1.2
2
.
6.2
2
.
6
.
2.1
2
.
6
.
2.2
2
.
6
.
2.3
2.6.2.4
2.6.2.5
2
.
6
.
2.6
2.6.2.7
2
.
6
.
2.8
2
.
6
.
2.9
2
.
6
.
2.10
GENERAL NOTES OF CHEMICAL ADMINISTRATION TO LIVE ANIMALS 33
AMI ITO, NAMIKO ITO, TAKASHI ARAI, EIKI TAKAHASHI, AND KIMIE NIIMI
INTRODUCTION 33
RESTRAINT 34
ONE-HANDED RESTRAINT 34
TWO-HANDED RESTRAINT 34
SUBSTANCES 34
SUBSTANCE CHARACTERISTICS 34
VEHICLE CHARACTERISTICS 35
FREQUENCY AND VOLUME OF ADMINISTRATION 36
NEEDLE SIZE 37
ANESTHESIA 37
INHALED AGENTS 38
INJECTABLE AGENTS 38
EUTHANASIA 40
ADMINISTRATION 41
ENTERAL ADMINISTRATION 42
ORAL ADMINISTRATION 42
INTRAGASTRIC ADMINISTRATION 42
PARENTERAL ADMINISTRATION 42
SUBCUTANEOUS ADMINISTRATION 44
INTRAPERITONEAL ADMINISTRATION 44
INTRAVENOUS ADMINISTRATION 46
INTRAMUSCULAR ADMINISTRATION 46
INTRANASAL ADMINISTRATION 46
INTRADERMAL ADMINISTRATION 46
EPICUTANEOUS ADMINISTRATION 46
INTRATRACHEAL ADMINISTRATION 51
INHALATIONAL ADMINISTRATION 51
RETRO-ORBITAL ADMINISTRATION 52
REFERENCES 53
3 OPTICAL-BASED DETECTION IN LIVE ANIMALS
55
MIKAKO OGAWA AND HIDEO TAKAKURA
3.1 INTRODUCTION 55
3.1.1 BASICS OF LUMINESCENCE 55
3.1.2 APPROPRIATE WAVELENGTHS FOR LIVE ANIMAL IMAGING 56
3.1.3 ADVANTAGES AND DISADVANTAGES OF IN VIVO OPTICAL IMAGING 58
3.2 FLUORESCENCE IMAGING IN LIVE ANIMALS 58
3.2.1 FLUORESCENT MOLECULES FOR LIVE ANIMAL IMAGING 58
3.2.2 HOW TO DETECT FLUORESCENCE IN LIVE ANIMALS? 61
3.2.3 ACTIVATABLE PROBES 62
3.2.4 MICROSCOPE 68
3.2,5
APPLICATION OF
FLUORESCENCE
IMAGING TO DRUG DEVELOPMENT
68
3.3 LUMINESCENCE IMAGING IN LIVE ANIMALS
69
3.3.1 LUMINESCENCE SYSTEMS FOR LIVE ANIMAL IMAGING 70
3.3.1.1 FIREFLY/BEETLE LUCIFERIN-LUCIFERASE SYSTEM 70
3.3.1.2 COELENTERAZINE-DEPENDENT LUCIFERASE SYSTEM 76
3.3.1.3 CHEMILUMINESCENCE SYSTEM 82
3.3.2 HOW TO DETECT LUMINESCENCE IN LIVE ANIMALS? 84
3.3.3 LUCIFERASE-BASED BIOLUMINESCENCE PROBES FOR IN VIVO IMAGING 84
3.4 SUMMARY 87
REFERENCES 87
4
ULTRASOUND IMAGING IN LIVE ANIMALS 103
FRANCESCO FAITA
4.1 INTRODUCTION
103
4.2 HIGH-FREQUENCY ULTRASOUND IMAGING 105
4.3 ULTRASOUND CONTRAST AGENTS 109
4.4 PHOTOACOUSTIC IMAGING 112
4.5 PRECLINICAL APPLICATIONS
115
4.5.1 CARDIOVASCULAR 115
4.5.2 ONCOLOGY
120
4.5.3 DEVELOPMENTAL BIOLOGY 121
REFERENCES 123
5 POSITRON EMISSION TOMOGRAPHY (PET) IMAGING IN LIVE
ANIMALS
127
XIAOWEI MA
AND ZHEN CHENG
5.1 INTRODUCTION 127
5.2 BRIEF
HISTORY OF
PET
128
5.3 PRINCIPLES OF PET 129
5.4 SMALL-ANIMAL PET SCANNERS 133
5.5 PET IMAGING TRACERS 134
5.5.1 METABOLIC PROBE 134
5.5.2 SPECIFIC RECEPTOR TARGETING PROBE 135
5.5.3 GENE EXPRESSION 136
5.5.4 SPECIFIC ENZYME SUBSTRATE 137
5.5.5 MICROENVIRONMENT PROBE 137
5.5.6 BIOLOGICAL PROCESSES 138
5.5.7 PERFUSION PROBES 140
5.5.8 NANOPARTICLES 140
5.6 PET IN ANIMAL IMAGING 141
5.6.1 PET IN ONCOLOGY MODEL 141
5.6.1.1 CANCER DIAGNOSIS 142
5.6.1.2 PERSONAL TREATMENT SCREENING 142
5.6.1.3 THERAPEUTIC EFFECT MONITORING 143
5.6.1.4 RADIOTHERAPY PLANNING 144
5.6.1.5 DRUG DISCOVERY 144
5.6.2 PET IN CARDIOLOGY MODEL 145
VIII CONTENTS
5.6.3 PET IN NEUROLOGY MODEL
146
5.6.4 PET IMAGING IN OTHER DISEASE MODELS
147
5.7 PET IMAGE ANALYSIS
147
5.8 OUTLOOK FOR THE FUTURE
148
REFERENCE
149
6 SINGLE-PHOTON EMISSION COMPUTED TOMOGRAPHIC IMAGING IN
LIVE ANIMALS
151
YUSUKE VAGI, HIDEKAZU KAWASHIMA, KENJIARIMITSU, KOKI HASEGAWA, AND
HIROYUKI KIMURA
6.1 INTRODUCTION
151
6.2 SPECT DEVICES USED IN SMALL ANIMALS
152
6.2.1 INNOVATIVE PRECLINICAL FULL-BODY SPECT IMAGER FOR RATS AND MICE:
Y-CUBE
155
6.2.2 INNOVATIVE PRECLINICAL FULL-BODY PET IMAGER FOR RATS AND MICE:
P-CUBE
156
6.2.3 INNOVATIVE
PRECLINICAL FULL-BODY CT IMAGER
FOR
RATS AND MICE:
X-CUBE
156
6.2.4 ANIMAL MONITORING: ITS IMPORTANCE AND OVERVIEW OF MOLECUBES S
INTEGRATED SOLUTION TO ADVANCE PHYSIOLOGICAL MONITORING
157
6.2.5 SELECTED APPLICATIONS ACQUIRED ON THE CUBES
157
6.2.5.1 SPECT IMAGING WITH Y-CUBE
158
6.2.5.2 PET IMAGING WITH P-CUBE
158
6.2.5.3 CT IMAGING WITH X-CUBE
161
6.3 CHARACTERISTICS OF SPECT RADIONUCLIDES AND SPECT IMAGING
PROBES
162
6.3.1 CHARACTERISTICS OF SPECT RADIONUCLIDES
162
6.3.2 CHARACTERISTICS OF SPECT IMAGING PROBES
162
6.4 RADIOLABELING
163
6.4.1 CHARACTERISTIC OF RADIOLABELING
164
6.4.2 RADIOLABELING WITH TECHNETIUM-99M
164
6.4.3 RADIOIABELING WITH IODINE-123 AND IODINE-131
171
6.4.4 RADIOACTIVE IODINE LABELING FOR SMALL MOLECULAR COMPOUNDS
171
6.4.5 AROMATIC ELECTROPHILIC SUBSTITUTION REACTION
171
6.5
IN VIVO
IMAGING OF DISEASE MODELS
172
6.5.1 IMAGING OF CENTRAL NERVOUS SYSTEM DISEASE
173
6.5.1.1 ALZHEIMER S DISEASE
173
6.5.1.2 PARKINSON S DISEASE
174
6.5.1.3 CEREBRAL ISCHEMIA
176
6.5.2 IMAGING OF CARDIOVASCULAR DISEASE
177
6.5.2.1 ATHEROSCLEROTIC PLAQUE
177
6.5.2.2 MYOCARDIAL ISCHEMIA
177
6.5.2.3 IMAGING OF CANCER
178
6.6 CONCLUSIONS
179
REFERENCES
180
7 RADIOTHERAPEUTIC APPLICATIONS
185
KOKI HASEGAWA, HIDEKAZU KAWASHIMA, YUSUKE YAGI, AND
HIROYUKI KIMURA
7.1 INTRODUCTION 185
7.2 RADIONUCLIDE THERAPY IN TUMOR-BEARING MICE 186
7.2.1 RADIOTHERAPY WITH P-EMITTING NUCLIDES 186
7.2.2 RADIOTHERAPY USING OE-EMITTING NUCLIDES 188
7.3 RADIOLABELING STRATEGY 191
7.3.1 LABELED TARGET COMPOUNDS 191
7.3.2 211 AT-LABELED COMPOUNDS 192
7.3.3 CHELATING AGENTS FOR ^Y,177LU, 225AC, 213BI 193
7.3.4 PEPTIDES FOR RADIONUCLIDE THERAPY 195
7.3.4.1 OCTREOTATE (TATE) AND [TYR3] -OCTREOTIDE (TOC) 195
7.3.42 NEOBOMBL
196
7.3.4.3 PENTIXATHER 196
7.3.44 PSMA-617 196
7.3.45 MINIGASTRIN 196
7.3.5 ANTIBODIES FOR RADIONUCLIDE THERAPY 197
7.3.5.1 LINTUZUMAB 197
73.5.2 RITUXIMAB 197
7.3.53 TRASTUZUMAB 197
7.3.6 EXAMPLES OF RADIOTHERAPEUTIC AGENTS AND TARGET DISEASES 197
7.4 RADIOTHERANOSTICS 200
7.4.1 RADIOTHERANOSTICS PROBE 200
7.4.2 OUR APPROACH TO RADIOTHERANOSTIC PROBE DEVELOPMENT 202
7.4.3 EXPECTATIONS AND CHALLENGES IN RADIOTHERANOSTICS 202
7.4.4 BORON NEUTRON CAPTURE THERAPY
(BNCT)
203
7.4.5 CURRENT STATUS OF BNCT DRUGS 204
7.45.1 4-BORONO-L-PHENYLALANINE (BPA) 204
74.5.2 SODIUM BOROCAPTATE (BSH) 204
7.5 CONCLUSION 205
REFERENCES 205
8 METABOLIC GLYCAN ENGINEERING IN LIVE ANIMALS: USING
BIO-ORTHOGONAL CHEMISTRY TO ALTER CELL SURFACE GLYCANS
209
DANIELLE H. DUBE AND DANIEL A. WILLIAMS
8.1 INTRODUCTION 209
8.2 OVERVIEW OF METABOLIC GLYCAN ENGINEERING 210
8.2.1 ORIGIN OF METABOLIC GLYCAN ENGINEERING 210
8.2.2 EXPANSION OF THE METHODOLOGY TO INCLUDE UNNATURAL FUNCTIONAL
GROUPS AND BIO-ORTHOGONAL ELABORATION 213
8.3 BIO-ORTHOGONAL CHEMISTRIES THAT ALTER CELL SURFACE GLYCANS 216
8.3.1 BIO-ORTHOGONAL CHEMISTRIES AMENABLE TO DEPLOYMENT IN LIVE
ANIMALS 216
8.3.2 BIO-ORTHOGONAL CHEMISTRIES AMENABLE TO DEPLOYMENT ON CELLS 221
8.4 PERMISSIVE CARBOHYDRATE BIOSYNTHETIC PATHWAYS 223
CONTENTS
8.41 DEPLOYMENT OF UNNATURAL MONOSACCHARIDES IN MAMMALIAN CELLS 223
8.4.2 UNNATURAL SUGARS THAT LABEL GLYCANS ON BACTERIAL CELLS 225
8.5 CELL- AND TISSUE-SPECIFIC DELIVERY OF UNNATURAL SUGARS 226
8.5.1 HARNESS INHERENT DIFFERENCES IN CARBOHYDRATE BIOSYNTHESIS 227
8.5.2 METABOLICALLY LABEL CELLS EX VIVO BEFORE INTRODUCING THEM IN
VIVO 227
8.5.3 LABEL TISSUES OR ORGANS IN VIVO BEFORE ANALYZING THEM EX VIVO 229
8.5.4 EMPLOY TISSUE-SPECIFIC ENZYMES TO RELEASE MONOSACCHARIDE
SUBSTRATES 229
8.5.5 DELIVER MONOSACCHARIDE SUBSTRATES VIA LIPOSOMES 231
8.5.6 USE TISSUE-SPECIFIC TRANSPORTERS TO INDUCE MONOSACCHARIDE
UPTAKE 234
8.6 APPLICATIONS OF METABOLIC GLYCAN LABELING IN MICE 234
8.6.1 IMAGING GLYCANS IN MICE 234
8.6.2 COVALENT DELIVERY OF THERAPEUTICS IN MICE 236
8.7 BEYOND MICE: METABOLIC GLYCAN ENGINEERING IN DIVERSE ANIMALS 237
8.7.1 ZEBRA FISH 237
8.7.2 WORMS 239
8.7.3 PLANTS 240
8.8 CONCLUSIONS AND FUTURE OUTLOOK 240
8.8.1 METABOLIC GLYCAN ENGINEERING OFFERS A TEST BED FOR BIO-ORTHOGONAL
CHEMISTRIES 240
8.8.2 NEW BIO-ORTHOGONAL REACTIONS COULD TRANSFORM THE FIELD 241
8.8.3 BASIC QUESTIONS ABOUT GLYCANS WITHIN LIVING SYSTEMS REMAIN
UNANSWERED 241
ACKNOWLEDGMENTS 241
REFERENCES 241
9
IN VIVO
BIOCONJUGATION USING BIO-ORTHOGONAL CHEMISTRY
249
MAKSIM ROYZEN, NATHAN YEE, AND JOSE M. MEJIA ONETO
9.1 INTRODUCTION 249
9.1.1 IEDDA CHEMISTRY BETWEEN RAS-CYCLOOCTENE AND TETRAZINE 249
9.1.2 SYNTHESIS OF NEW TETRAZINES AND CHARACTERIZATION OF THEIR
REACTIVITY 251
9.1.3 SECOND GENERATION OF IEDDA REAGENTS 251
9.1.4 BOND-CLEAVING BIO-ORTHOGONAL CLICK-TO-RELEASE CHEMISTRY 251
9.2 IN VIVO APPLICATIONS OF IEDDA CHEMISTRY 251
9.2.1 PRETARGETING APPROACH FOR CELL IMAGING 252
9.2.2 PRETARGETING APPROACH FOR IN VIVO IMAGING 256
9.2.3 APPLICATION OF THE PRETARGETING STRATEGY FOR IN VIVO RADIO
IMAGING 259
9.2.4 IN VIVO DRUG ACTIVATION USING BOND-CLEAVING BIO-ORTHOGONAL
CHEMISTRY 260
9.2.5 RELOADABLE MATERIALS ALLOW LOCAL PRODRUG ACTIVATION 265
9.2.6 RELOADABLE MATERIALS ALLOW LOCAL PRODRUG ACTIVATION USING IEDDA
CHEMISTRY 266
9.2.7 CONTROLLED ACTIVATION OF SIRNA USING IEDDA CHEMISTRY 272
9.3 FUTURE OUTLOOK 274
REFERENCES 277
10
IN
VIVO
TARGETING OF ENDOGENOUS PROTEINS WITH REACTIVE SMALL
MOLECULES
281
NAOYA SHINDO AND AKIO OJIDA
10.1 INTRODUCTION 281
10.2 LIGAND-DIRECTED CHEMICAL LIGATION 282
10.2.1 LIGAND-DIRECTED TOSYL CHEMISTRY 282
10.2.2 LIGAND-DIRECTED ACYL IMIDAZOLE CHEMISTRY 284
10.2.3 OTHER CHEMICAL REACTIONS FOR ENDOGENOUS PROTEIN LABELING 287
10.3 LABELING CHEMISTRY OF TARGETED COVALENT INHIBITORS 287
10.3.1 MICHAEL ACCEPTORS 290
10.3.2 HALOACETAMIDES 293
10.3.3 ACTIVATED ESTERS, AMIDES, CARBAMATES, AND UREAS 295
10.3.4 SULFUR(VI) FLUORIDES 297
10.3.5 OTHER WARHEADS AND REACTIONS 300
10.4 CONCLUSION 301
REFERENCES 302
11 IN VIVO
METAL CATALYSIS IN LIVING BIOLOGICAL SYSTEMS
309
KENWARD VONG AND KATSUNORI TANAKA
11.1 INTRODUCTION 309
11.2 METAL COMPLEX CATALYSTS 310
11.2.1 PROTEIN DECAGING 310
11.2.2 PROTEIN BIOCONJUGATION 311
11.2.3 SMALL MOLECULE - BOND FORMATION 319
11.2.4 SMALL MOLECULE - BOND CLEAVAGE 324
11.3 ARTIFICIAL METALLOENZYMES 332
11.3.1 ARMS UTILIZING NATURALLY OCCURRING METALS 332
11.3.2 ARMS UTILIZING ABIOTIC TRANSITION METALS 335
11.4 CONCLUDING REMARKS 340
REFERENCES 343
12 CHEMICAL CATALYST-MEDIATED SELECTIVE PHOTO-OXYGENATION OF
PATHOGENIC AMYLOIDS
355
YOUHEI SOHMA AND MOTOMU KANAI
12.1 INTRODUCTION 355
12.2 CATALYTIC PHOTO-OXYGENATION OF AP USING A FLAVIN-PEPTIDE
CONJUGATE 357
12.3 ON-OFF SWITCHABLE PHOTO-OXYGENATION CATALYSTS THAT SENSE HIGHER
ORDER AMYLOID STRUCTURES 358
12.4 NEAR-INFRARED PHOTOACTIVATABLE OXYGENATION CATALYSTS: APPLICATION
AMYLOID DISEASE MODEL MICE 363
12.5 CLOSING REMARKS 367
REFERENCES 368
XII CONTENTS
13 NANOMEDICINE THERAPIES
373
PATRICIA FIGUEIREDO, FLAVIA FONTANA, AND HELDER A. SANTOS
13.1 INTRODUCTION 373
13.2 ENGINEERING NANOPARTICLES FOR THERAPEUTIC APPLICATIONS 375
13.2.1 PHYSICOCHEMICAL PROPERTIES OF NPS 375
13.2.2 SURFACE FUNCTIONALIZATION 379
13.2.3 STIMULI-RESPONSIVE NANOMATERIALS 381
13.2.4 ROUTE OF ADMINISTRATION 384
13.3 NANOMEDICINE PLATFORMS 384
13.3.1 LIPIDIC NANOPLATFORMS 384
13.3.2 POLYMER-BASED NANOPLATFORMS 389
13.3.3 INORGANIC NANOPLATFORMS 391
13.3.4 BIOMIMETIC CELL-DERIVED NANOPIATFORMS 393
13.4 CONCLUSIONS 394
REFERENCES 395
14 PHOTOACTIVATABLE TARGETING METHODS 40I
XIANGZHAO AI, MING HU, AND BENGANG XING
14.1 INTRODUCTION 401
14.2 UV LIGHT-RESPONSIVE THERANOSTICS 403
14.2.1 UV LIGHT-TRIGGERED PHOTOCAGED STRATEGY 403
14.2.2 UV LIGHT-MEDIATED PHOTOISOMERIZATION STRATEGY 405
14.3 VISIBLE LIGHT-RESPONSIVE THERANOSTICS 408
14.4 NEAR-INFRARED (NIR) LIGHT-RESPONSIVE THERANOSTICS
410
14.4.1 NIR LIGHT-MEDIATED DRUG DELIVERY APPROACH 411
14.4.2 NIR LIGHT-MEDIATED PHOTODYNAMIC THERAPY (PDT) APPROACH 415
14.4.3 NIR LIGHT-MEDIATED PHOTOTHERMAL THERAPY (PTT) APPROACH 419
14.5 CONCLUSION AND PROSPECTS 421
ACKNOWLEDGMENT 423
REFERENCES 423
15 PHOTOACTIVATABLE DRUG RELEASE METHODS FROM LIPOSOMES
433
HAILEY /. KILIAN, DYEGO MIRANDA, AND JONATHAN F LOVELL
15.1 INTRODUCTION 433
15.1.1 LIGHT-SENSITIVE LIPOSOMES 434
15.2 MECHANISMS OF LIGHT-TRIGGERED RELEASE FROM LIPOSOMES 435
15.2.1 LIGHT-INDUCED OXIDATION 435
15.2.2 PHOTOCROSSLINKING 436
15.2.3 PHOTOISOMERIZATION 438
15.2.4 PHOTOCLEAVAGE 440
15.2.5 PHOTOTHERMAL RELEASE 442
REFERENCES 444
16 PEPTIDE TARGETING METHODS
451
RUEI-MIN LU, CHIEN-HSUN WU, AJAY V. PATIL, AND HAN-CHUNG WU
16.1 INTRODUCTION 451
16.2 IDENTIFICATION OF TARGETING PEPTIDES 452
CONTENTS XIII
16.2.1 NATURAL LIGANDS AND BIOMIMETICS 452
16.2.2 PHAGE DISPLAY PEPTIDE LIBRARY SCREENING 454
16.2.3 SYNTHETIC PEPTIDE LIBRARY SCREENING 458
16.3 THERAPEUTIC APPLICATIONS OF TARGETING PEPTIDES 460
16.3.1 THERAPEUTIC PEPTIDES 460
16.3.1.1 NATURALLY OCCURRING PEPTIDES 464
16.3.1.2 PEPTIDE CONJUGATES 464
16.3.2 DRUG DELIVERY 465
16.3.2.1 PEPTIDE-DRUG CONJUGATES 465
16.3.2.2 PEPTIDE-TARGETED NANOPARTICLES 467
16.4 MOLECULAR IMAGING MEDIATED BY TARGETING PEPTIDES 469
16.4.1 OPTICAL IMAGING 470
16.4.1.1 TARGETING PEPTIDES FOR TUMOR IMAGING 471
16.4.1.2 INTEGRIN AVP3 - RGD TRIPEPTIDE TARGETING PROBES: 471
16.4.1.3 NEAR-INFRARED IMAGING 472
16.4.2 POSITRON EMISSION TOMOGRAPHY 472
16.4.3 MAGNETIC RESONANCE IMAGING 473
16.5 SUMMARY AND FUTURE PERSPECTIVES 474
REFERENCES 475
17 GLYCAN-MEDIATED TARGETING METHODS
489
KENWARD VONG, KATSUNORI TANAKA, AND KOICHI FUKASE
17.1 INTRODUCTION 489
17.2 LIVER AND LIVER-BASED DISEASE TARGETING 491
17.2.1 PARENCHYMAL CELL TARGETING 492
17.2.2 NONPARENCHYMAL CELL TARGETING 498
17.3 IMMUNE SYSTEM TARGETING 501
17.3.1 ALVEOLAR MACROPHAGE TARGETING 503
17.3.2 PERITONEAL MACROPHAGE TARGETING 503
17.3.3 DENDRITIC CELL TARGETING 504
17.3.4 BRAIN MACROPHAGE TARGETING 504
17.4 BACTERIAL CELL TARGETING 505
17.5 CANCER TARGETING 506
17.5.1 NATURAL MONOSACCHARIDE-BASED METHODS 506
17.5.2 SYNTHETIC SUGARS 508
17.5.3 COMPLEX GLYCAN SCAFFOLD 511
17.6 CONCLUDING REMARKS 514
REFERENCES 514
INDEX 531
|
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| building | Verbundindex |
| bvnumber | BV046314028 |
| classification_rvk | XG 4700 WC 6570 |
| ctrlnum | (OCoLC)1110715209 (DE-599)DNB1191204294 |
| discipline | Biologie Medizin |
| format | Book |
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| id | DE-604.BV046314028 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T08:41:23Z |
| institution | BVB |
| isbn | 9783527344321 3527344322 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-031691128 |
| oclc_num | 1110715209 |
| open_access_boolean | |
| owner | DE-11 DE-19 DE-BY-UBM |
| owner_facet | DE-11 DE-19 DE-BY-UBM |
| physical | xiii, 546 Seiten Illustrationen, Diagramme |
| publishDate | 2020 |
| publishDateSearch | 2020 |
| publishDateSort | 2020 |
| publisher | Wiley-VCH |
| record_format | marc |
| spelling | Handbook of in vivo chemistry in mice from lab to living system edited by Katsunori Tanaka, Kenward Vong Weinheim Wiley-VCH [2020] xiii, 546 Seiten Illustrationen, Diagramme txt rdacontent n rdamedia nc rdacarrier Maus (DE-588)4169148-9 gnd rswk-swf Hardback Bildgebende Verfahren i. d. Biomedizin Biomedical Engineering Biomedical Imaging Biomedizintechnik Biowissenschaften Chemie Chemistry Life Sciences Mausmodell Molecular Biology Molekularbiologie Pharmaceutical & Medicinal Chemistry Pharmazeutische u. Medizinische Chemie Versuchstiere BE70: Bildgebende Verfahren i. d. Biomedizin CH60: Pharmazeutische u. Medizinische Chemie LS31: Molekularbiologie Maus (DE-588)4169148-9 s DE-604 Tanaka, Katsunori (DE-588)1206563974 edt Vong, Kenward edt Erscheint auch als Online-Ausgabe, PDF 978-3-527-34437-6 Erscheint auch als Online-Ausgabe, EPUB 978-3-527-34441-3 Erscheint auch als Online-Ausgabe, oBook 978-3-527-34440-6 DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=031691128&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Handbook of in vivo chemistry in mice from lab to living system Maus (DE-588)4169148-9 gnd |
| subject_GND | (DE-588)4169148-9 |
| title | Handbook of in vivo chemistry in mice from lab to living system |
| title_auth | Handbook of in vivo chemistry in mice from lab to living system |
| title_exact_search | Handbook of in vivo chemistry in mice from lab to living system |
| title_full | Handbook of in vivo chemistry in mice from lab to living system edited by Katsunori Tanaka, Kenward Vong |
| title_fullStr | Handbook of in vivo chemistry in mice from lab to living system edited by Katsunori Tanaka, Kenward Vong |
| title_full_unstemmed | Handbook of in vivo chemistry in mice from lab to living system edited by Katsunori Tanaka, Kenward Vong |
| title_short | Handbook of in vivo chemistry in mice |
| title_sort | handbook of in vivo chemistry in mice from lab to living system |
| title_sub | from lab to living system |
| topic | Maus (DE-588)4169148-9 gnd |
| topic_facet | Maus |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=031691128&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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