The Macrophage as Therapeutic Target:
During the past decade, the rapid growth of molecular and cellular knowledge of macrophages, as a specialized host defense and homeostatic system, has begun to offer attractive targets for therapeutic intervention. Macrophages play a central role in a wide range of disease processes, from geneticall...
Gespeichert in:
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| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Berlin, Heidelberg
Springer Berlin Heidelberg
2003
|
| Schriftenreihe: | Handbook of Experimental Pharmacology
158 |
| Schlagworte: | |
| Online-Zugang: | UBR01 Volltext |
| Zusammenfassung: | During the past decade, the rapid growth of molecular and cellular knowledge of macrophages, as a specialized host defense and homeostatic system, has begun to offer attractive targets for therapeutic intervention. Macrophages play a central role in a wide range of disease processes, from genetically determined lysosomal storage diseases, to acute sepsis, chronic inflammation and repair, tissue injury and cell death. Under- or overactivity of macrophage clearance, immune effector functions and responses to metabolic abnormalities contribute to common disorders such as autoimmunity, atherosclerosis, Alzheimer’s disease and major infections including AIDS and Tuberculosis. Whilst the goals of therapeutic intervention based on improved understanding of macrophage functions and their contribution to pathogenesis may seem self evident, there are considerable difficulties in producing useful new agents. The present volume covers a range of subjects and provides opportunities for a more focused macrophage-targeted approach. The individual chapters review selected topics briefly, to place cellular processes and molecular targets in perspective. Overall, the volume should provide a broad sample of the state of the art. Useful reviews and references in the literature are cited within individual chapters |
| Beschreibung: | 1 Online-Ressource (X, 496 p) |
| ISBN: | 9783642557422 |
| DOI: | 10.1007/978-3-642-55742-2 |
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| 520 | |a During the past decade, the rapid growth of molecular and cellular knowledge of macrophages, as a specialized host defense and homeostatic system, has begun to offer attractive targets for therapeutic intervention. Macrophages play a central role in a wide range of disease processes, from genetically determined lysosomal storage diseases, to acute sepsis, chronic inflammation and repair, tissue injury and cell death. Under- or overactivity of macrophage clearance, immune effector functions and responses to metabolic abnormalities contribute to common disorders such as autoimmunity, atherosclerosis, Alzheimer’s disease and major infections including AIDS and Tuberculosis. Whilst the goals of therapeutic intervention based on improved understanding of macrophage functions and their contribution to pathogenesis may seem self evident, there are considerable difficulties in producing useful new agents. The present volume covers a range of subjects and provides opportunities for a more focused macrophage-targeted approach. The individual chapters review selected topics briefly, to place cellular processes and molecular targets in perspective. Overall, the volume should provide a broad sample of the state of the art. Useful reviews and references in the literature are cited within individual chapters | ||
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| spelling | The Macrophage as Therapeutic Target edited by Siamon Gordon with contributions by numerous experts Berlin, Heidelberg Springer Berlin Heidelberg 2003 1 Online-Ressource (X, 496 p) txt rdacontent c rdamedia cr rdacarrier Handbook of Experimental Pharmacology 158 During the past decade, the rapid growth of molecular and cellular knowledge of macrophages, as a specialized host defense and homeostatic system, has begun to offer attractive targets for therapeutic intervention. Macrophages play a central role in a wide range of disease processes, from genetically determined lysosomal storage diseases, to acute sepsis, chronic inflammation and repair, tissue injury and cell death. Under- or overactivity of macrophage clearance, immune effector functions and responses to metabolic abnormalities contribute to common disorders such as autoimmunity, atherosclerosis, Alzheimer’s disease and major infections including AIDS and Tuberculosis. Whilst the goals of therapeutic intervention based on improved understanding of macrophage functions and their contribution to pathogenesis may seem self evident, there are considerable difficulties in producing useful new agents. The present volume covers a range of subjects and provides opportunities for a more focused macrophage-targeted approach. The individual chapters review selected topics briefly, to place cellular processes and molecular targets in perspective. Overall, the volume should provide a broad sample of the state of the art. Useful reviews and references in the literature are cited within individual chapters Immunology Pharmacology/Toxicology Virology Toxicology Medical virology Makrophage (DE-588)4193041-1 gnd rswk-swf Pharmakologie (DE-588)4045687-0 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Makrophage (DE-588)4193041-1 s Pharmakologie (DE-588)4045687-0 s DE-604 Gordon, Siamon edt Erscheint auch als Druck-Ausgabe 9783540442509 Erscheint auch als Druck-Ausgabe 9783642629198 Erscheint auch als Druck-Ausgabe 9783642557439 https://doi.org/10.1007/978-3-642-55742-2 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | The Macrophage as Therapeutic Target Immunology Pharmacology/Toxicology Virology Toxicology Medical virology Makrophage (DE-588)4193041-1 gnd Pharmakologie (DE-588)4045687-0 gnd |
| subject_GND | (DE-588)4193041-1 (DE-588)4045687-0 (DE-588)4143413-4 |
| title | The Macrophage as Therapeutic Target |
| title_alt | with contributions by numerous experts |
| title_auth | The Macrophage as Therapeutic Target |
| title_exact_search | The Macrophage as Therapeutic Target |
| title_full | The Macrophage as Therapeutic Target edited by Siamon Gordon |
| title_fullStr | The Macrophage as Therapeutic Target edited by Siamon Gordon |
| title_full_unstemmed | The Macrophage as Therapeutic Target edited by Siamon Gordon |
| title_short | The Macrophage as Therapeutic Target |
| title_sort | the macrophage as therapeutic target |
| topic | Immunology Pharmacology/Toxicology Virology Toxicology Medical virology Makrophage (DE-588)4193041-1 gnd Pharmakologie (DE-588)4045687-0 gnd |
| topic_facet | Immunology Pharmacology/Toxicology Virology Toxicology Medical virology Makrophage Pharmakologie Aufsatzsammlung |
| url | https://doi.org/10.1007/978-3-642-55742-2 |
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