Biochemistry and Genetics of RecQ-Helicases:
Biochemistry And Genetics of RecQ-Helicases provides a background into the role of helicases in general and RecQ helicases specifically in DNA repair. Helicases- enzymes which break down hydrogen bonds between nucleic acid strands in a nucleoside triphosphate-dependent manner-are ubiquitous in biolo...
Gespeichert in:
| 1. Verfasser: | |
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| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Boston, MA
Springer US
2001
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| Schlagworte: | |
| Online-Zugang: | UBR01 Volltext |
| Zusammenfassung: | Biochemistry And Genetics of RecQ-Helicases provides a background into the role of helicases in general and RecQ helicases specifically in DNA repair. Helicases- enzymes which break down hydrogen bonds between nucleic acid strands in a nucleoside triphosphate-dependent manner-are ubiquitous in biology, participating in processes as diverse as replication, repair, recombination, transcription, and translation. The RecQ-family helicases are a group of helicases which have important roles in the maintenance of genomic stability in many organisms. In humans, mutations in three RecQ-family helicases lead to disease. This book thoroughly examines these helicases. Mutations in the BLM gene lead to Bloom syndrome, a disorder characterized by a susceptibility to many types of cancer. Mutations in the WRN gene cause Werner syndrome, a disease which in some respects resembles premature aging. Finally, mutations in a newly characterized RecQ-family member, RECQ4, may lead to the very rare recessive disorder Rothmund-Thomson syndrome, a condition characterized by developmental abnormalities and some aging-like manifestations. This book is intended for any researchers invested in these particular disorders, or with a general interest in DNA. |
| Beschreibung: | 1 Online-Ressource (XVI, 92 p) |
| ISBN: | 9781461514053 |
| DOI: | 10.1007/978-1-4615-1405-3 |
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| 520 | |a Biochemistry And Genetics of RecQ-Helicases provides a background into the role of helicases in general and RecQ helicases specifically in DNA repair. Helicases- enzymes which break down hydrogen bonds between nucleic acid strands in a nucleoside triphosphate-dependent manner-are ubiquitous in biology, participating in processes as diverse as replication, repair, recombination, transcription, and translation. The RecQ-family helicases are a group of helicases which have important roles in the maintenance of genomic stability in many organisms. In humans, mutations in three RecQ-family helicases lead to disease. This book thoroughly examines these helicases. Mutations in the BLM gene lead to Bloom syndrome, a disorder characterized by a susceptibility to many types of cancer. Mutations in the WRN gene cause Werner syndrome, a disease which in some respects resembles premature aging. Finally, mutations in a newly characterized RecQ-family member, RECQ4, may lead to the very rare recessive disorder Rothmund-Thomson syndrome, a condition characterized by developmental abnormalities and some aging-like manifestations. This book is intended for any researchers invested in these particular disorders, or with a general interest in DNA. | ||
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Datensatz im Suchindex
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| author | Lombard, David B. |
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| dewey-full | 611.01816 599.935 |
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| dewey-ones | 611 - Human anatomy, cytology, histology 599 - Mammalia |
| dewey-raw | 611.01816 599.935 |
| dewey-search | 611.01816 599.935 |
| dewey-sort | 3611.01816 |
| dewey-tens | 610 - Medicine and health 590 - Animals |
| discipline | Biologie Medizin |
| doi_str_mv | 10.1007/978-1-4615-1405-3 |
| format | Electronic eBook |
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| id | DE-604.BV046149225 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-10T08:36:35Z |
| institution | BVB |
| isbn | 9781461514053 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-031529402 |
| oclc_num | 1119033713 |
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| physical | 1 Online-Ressource (XVI, 92 p) |
| psigel | ZDB-2-SBL ZDB-2-SBL_2000/2004 ZDB-2-SBL ZDB-2-SBL_2000/2004 |
| publishDate | 2001 |
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| publisher | Springer US |
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| spelling | Lombard, David B. Verfasser aut Biochemistry and Genetics of RecQ-Helicases by David B. Lombard Boston, MA Springer US 2001 1 Online-Ressource (XVI, 92 p) txt rdacontent c rdamedia cr rdacarrier Biochemistry And Genetics of RecQ-Helicases provides a background into the role of helicases in general and RecQ helicases specifically in DNA repair. Helicases- enzymes which break down hydrogen bonds between nucleic acid strands in a nucleoside triphosphate-dependent manner-are ubiquitous in biology, participating in processes as diverse as replication, repair, recombination, transcription, and translation. The RecQ-family helicases are a group of helicases which have important roles in the maintenance of genomic stability in many organisms. In humans, mutations in three RecQ-family helicases lead to disease. This book thoroughly examines these helicases. Mutations in the BLM gene lead to Bloom syndrome, a disorder characterized by a susceptibility to many types of cancer. Mutations in the WRN gene cause Werner syndrome, a disease which in some respects resembles premature aging. Finally, mutations in a newly characterized RecQ-family member, RECQ4, may lead to the very rare recessive disorder Rothmund-Thomson syndrome, a condition characterized by developmental abnormalities and some aging-like manifestations. This book is intended for any researchers invested in these particular disorders, or with a general interest in DNA. Human Genetics Evolutionary Biology Zoology Animal Anatomy / Morphology / Histology Life Sciences, general Human genetics Evolution (Biology) Morphology (Animals) Life sciences Erscheint auch als Druck-Ausgabe 9780792379843 Erscheint auch als Druck-Ausgabe 9781461355373 Erscheint auch als Druck-Ausgabe 9781461514060 https://doi.org/10.1007/978-1-4615-1405-3 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Lombard, David B. Biochemistry and Genetics of RecQ-Helicases Human Genetics Evolutionary Biology Zoology Animal Anatomy / Morphology / Histology Life Sciences, general Human genetics Evolution (Biology) Morphology (Animals) Life sciences |
| title | Biochemistry and Genetics of RecQ-Helicases |
| title_auth | Biochemistry and Genetics of RecQ-Helicases |
| title_exact_search | Biochemistry and Genetics of RecQ-Helicases |
| title_full | Biochemistry and Genetics of RecQ-Helicases by David B. Lombard |
| title_fullStr | Biochemistry and Genetics of RecQ-Helicases by David B. Lombard |
| title_full_unstemmed | Biochemistry and Genetics of RecQ-Helicases by David B. Lombard |
| title_short | Biochemistry and Genetics of RecQ-Helicases |
| title_sort | biochemistry and genetics of recq helicases |
| topic | Human Genetics Evolutionary Biology Zoology Animal Anatomy / Morphology / Histology Life Sciences, general Human genetics Evolution (Biology) Morphology (Animals) Life sciences |
| topic_facet | Human Genetics Evolutionary Biology Zoology Animal Anatomy / Morphology / Histology Life Sciences, general Human genetics Evolution (Biology) Morphology (Animals) Life sciences |
| url | https://doi.org/10.1007/978-1-4615-1405-3 |
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