Methotrexate:
Although surprising, it seems fitting that a drug developed at the dawn of the era of rational drug design and therapeutics, methotrexate, should remain in common use for the therapy of so many different kinds of illnesses. Moreover, methotrexate has completely revolutionized the way in which medici...
Gespeichert in:
| Weitere Verfasser: | , |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Basel
Birkhäuser Basel
2000
|
| Schriftenreihe: | Milestones in Drug Therapy
|
| Schlagworte: | |
| Online-Zugang: | UBR01 Volltext |
| Zusammenfassung: | Although surprising, it seems fitting that a drug developed at the dawn of the era of rational drug design and therapeutics, methotrexate, should remain in common use for the therapy of so many different kinds of illnesses. Moreover, methotrexate has completely revolutionized the way in which medicine is practiced in a number of speciality areas. First developed to treat malignancies, methotrexate is now commonly used to treat gynecological problems, inflammatory arthritis, skin disease and probably other ailments as well. This work is designed to give a broad overview of the history of methotrexate's development, its prior use and its current therapeutic uses. As discussed in Chapter I, aminopterin and methotrexate were designed to inhibit mammalian folate metabolism but the concept of folic acid antag onism was soon applied to the development of antibacterial and anti parasitic agents. Trimethoprim and sulfa drugs were among the first antibiotics developed and they also remain quite useful today for the treat ment of a variety of infections |
| Beschreibung: | 1 Online-Ressource (IX, 139 p) |
| ISBN: | 9783034884525 |
| DOI: | 10.1007/978-3-0348-8452-5 |
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| discipline | Medizin |
| doi_str_mv | 10.1007/978-3-0348-8452-5 |
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| spelling | Methotrexate edited by Bruce N. Cronstein, Joseph R. Bertino Basel Birkhäuser Basel 2000 1 Online-Ressource (IX, 139 p) txt rdacontent c rdamedia cr rdacarrier Milestones in Drug Therapy Although surprising, it seems fitting that a drug developed at the dawn of the era of rational drug design and therapeutics, methotrexate, should remain in common use for the therapy of so many different kinds of illnesses. Moreover, methotrexate has completely revolutionized the way in which medicine is practiced in a number of speciality areas. First developed to treat malignancies, methotrexate is now commonly used to treat gynecological problems, inflammatory arthritis, skin disease and probably other ailments as well. This work is designed to give a broad overview of the history of methotrexate's development, its prior use and its current therapeutic uses. As discussed in Chapter I, aminopterin and methotrexate were designed to inhibit mammalian folate metabolism but the concept of folic acid antag onism was soon applied to the development of antibacterial and anti parasitic agents. Trimethoprim and sulfa drugs were among the first antibiotics developed and they also remain quite useful today for the treat ment of a variety of infections Medicine/Public Health, general Medicine Methotrexat (DE-588)4038985-6 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Methotrexat (DE-588)4038985-6 s DE-604 Cronstein, Bruce N. edt Bertino, Joseph R. edt Erscheint auch als Druck-Ausgabe 9783764359591 Erscheint auch als Druck-Ausgabe 9783034895736 Erscheint auch als Druck-Ausgabe 9783034884532 https://doi.org/10.1007/978-3-0348-8452-5 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Methotrexate Medicine/Public Health, general Medicine Methotrexat (DE-588)4038985-6 gnd |
| subject_GND | (DE-588)4038985-6 (DE-588)4143413-4 |
| title | Methotrexate |
| title_auth | Methotrexate |
| title_exact_search | Methotrexate |
| title_full | Methotrexate edited by Bruce N. Cronstein, Joseph R. Bertino |
| title_fullStr | Methotrexate edited by Bruce N. Cronstein, Joseph R. Bertino |
| title_full_unstemmed | Methotrexate edited by Bruce N. Cronstein, Joseph R. Bertino |
| title_short | Methotrexate |
| title_sort | methotrexate |
| topic | Medicine/Public Health, general Medicine Methotrexat (DE-588)4038985-6 gnd |
| topic_facet | Medicine/Public Health, general Medicine Methotrexat Aufsatzsammlung |
| url | https://doi.org/10.1007/978-3-0348-8452-5 |
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