Pathogenesis of Neurodegenerative Disorders:
Recent scientific advances have dramatically expanded our understanding of the molecular, genetic, and environmental factors that either cause or contribute to a wide variety of age-related neurodegenerative disorders. In Pathogenesis of Neurodegenerative Disorders, leading experts detail the cellul...
Gespeichert in:
| Weitere Verfasser: | |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Totowa, NJ
Humana Press
2001
|
| Schriftenreihe: | Contemporary Neuroscience
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| Schlagworte: | |
| Online-Zugang: | DE-355 Volltext |
| Zusammenfassung: | Recent scientific advances have dramatically expanded our understanding of the molecular, genetic, and environmental factors that either cause or contribute to a wide variety of age-related neurodegenerative disorders. In Pathogenesis of Neurodegenerative Disorders, leading experts detail the cellular and molecular cascades that cause selective degeneration of neuronal populations, and illuminate those factors that are critical to the facilitation or suppression of these neuropathologic processes. Working from studies of human patients, as well as from cell culture and animal models, the authors demonstrate a heretofore unrecognized convergence of the causative pathogenetic mechanisms for many clinically distinct neurological disorders. At center stage are the biochemical and molecular cascades that will ultimately lead to neuronal death-cascades involving oxyradical production, aberrant regulation of cellular ion homeostasis, activation of specific proteases, and activation of a stereotyped sequence of events involving mitochondrial dysfunction. Individual chapters examine how these mechanisms-along with genetic and environmental factors-operate in Alzheimer's and Parkinson's diseases, Down's syndrome, amyotropic lateral sclerosis, ischemic stroke, spinal cord injury, and Duchenne muscular dystrophy. Pioneering and richly insightful, Pathogenesis of Neurodegenerative Disorders offers a critical and integrative summary of the cutting-edge research findings that illuminate the common genetic, cellular, and molecular bases of many neurological disorders today that promise powerful new preventive and treatment approaches in future |
| Beschreibung: | 1 Online-Ressource (X, 294 p. 27 illus) |
| ISBN: | 9781592591060 |
| DOI: | 10.1007/978-1-59259-106-0 |
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Datensatz im Suchindex
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| illustrated | Not Illustrated |
| indexdate | 2024-12-06T19:01:16Z |
| institution | BVB |
| isbn | 9781592591060 |
| language | English |
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| spelling | Pathogenesis of Neurodegenerative Disorders edited by Mark P. Mattson Totowa, NJ Humana Press 2001 1 Online-Ressource (X, 294 p. 27 illus) txt rdacontent c rdamedia cr rdacarrier Contemporary Neuroscience Recent scientific advances have dramatically expanded our understanding of the molecular, genetic, and environmental factors that either cause or contribute to a wide variety of age-related neurodegenerative disorders. In Pathogenesis of Neurodegenerative Disorders, leading experts detail the cellular and molecular cascades that cause selective degeneration of neuronal populations, and illuminate those factors that are critical to the facilitation or suppression of these neuropathologic processes. Working from studies of human patients, as well as from cell culture and animal models, the authors demonstrate a heretofore unrecognized convergence of the causative pathogenetic mechanisms for many clinically distinct neurological disorders. At center stage are the biochemical and molecular cascades that will ultimately lead to neuronal death-cascades involving oxyradical production, aberrant regulation of cellular ion homeostasis, activation of specific proteases, and activation of a stereotyped sequence of events involving mitochondrial dysfunction. Individual chapters examine how these mechanisms-along with genetic and environmental factors-operate in Alzheimer's and Parkinson's diseases, Down's syndrome, amyotropic lateral sclerosis, ischemic stroke, spinal cord injury, and Duchenne muscular dystrophy. Pioneering and richly insightful, Pathogenesis of Neurodegenerative Disorders offers a critical and integrative summary of the cutting-edge research findings that illuminate the common genetic, cellular, and molecular bases of many neurological disorders today that promise powerful new preventive and treatment approaches in future Neurosciences Pathogenese (DE-588)4115512-9 gnd rswk-swf Nervendegeneration (DE-588)4300182-8 gnd rswk-swf Nervendegeneration (DE-588)4300182-8 s Pathogenese (DE-588)4115512-9 s 1\p DE-604 Mattson, Mark P. edt Erscheint auch als Druck-Ausgabe 9781617372155 Erscheint auch als Druck-Ausgabe 9781468496444 Erscheint auch als Druck-Ausgabe 9780896038387 https://doi.org/10.1007/978-1-59259-106-0 Verlag URL des Erstveröffentlichers Volltext 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Pathogenesis of Neurodegenerative Disorders Neurosciences Pathogenese (DE-588)4115512-9 gnd Nervendegeneration (DE-588)4300182-8 gnd |
| subject_GND | (DE-588)4115512-9 (DE-588)4300182-8 |
| title | Pathogenesis of Neurodegenerative Disorders |
| title_auth | Pathogenesis of Neurodegenerative Disorders |
| title_exact_search | Pathogenesis of Neurodegenerative Disorders |
| title_full | Pathogenesis of Neurodegenerative Disorders edited by Mark P. Mattson |
| title_fullStr | Pathogenesis of Neurodegenerative Disorders edited by Mark P. Mattson |
| title_full_unstemmed | Pathogenesis of Neurodegenerative Disorders edited by Mark P. Mattson |
| title_short | Pathogenesis of Neurodegenerative Disorders |
| title_sort | pathogenesis of neurodegenerative disorders |
| topic | Neurosciences Pathogenese (DE-588)4115512-9 gnd Nervendegeneration (DE-588)4300182-8 gnd |
| topic_facet | Neurosciences Pathogenese Nervendegeneration |
| url | https://doi.org/10.1007/978-1-59259-106-0 |
| work_keys_str_mv | AT mattsonmarkp pathogenesisofneurodegenerativedisorders |