Techniques in Prion Research:
Prion diseases, also known as Transmissible Spongiform Encephalopathies (TSEs), exist in both humans (Creutzfeldt-Jakob disease (CJD)) and animals (scrapie, bovine spongiform encephalopathy (BSE), chronic wasting disease) and have the unique property of being infectious, sporadic or genetic in origi...
Gespeichert in:
| Weitere Verfasser: | , |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Basel
Birkhäuser Basel
2004
|
| Schriftenreihe: | Methods and Tools in Biosciences and Medicine
|
| Schlagworte: | |
| Online-Zugang: | UBR01 Volltext |
| Zusammenfassung: | Prion diseases, also known as Transmissible Spongiform Encephalopathies (TSEs), exist in both humans (Creutzfeldt-Jakob disease (CJD)) and animals (scrapie, bovine spongiform encephalopathy (BSE), chronic wasting disease) and have the unique property of being infectious, sporadic or genetic in origin. Although the precise nature of the infectious agent responsible for TSEs is not definitely identified, it is now clearly demonstrated that a protein named PrP (for Prion Protein) plays a critical role in the transmission and pathogenesis of TSEs. This book provides the general description as well as the details of the techniques currently used for the study of prion diseases. Taking into account the pivotal role played by PrP it is not surprising that many Chapters of this book deal with the purification, the detection and the characterization of the different forms of this protein. In addition, in vitro, cellular and animal models specifically adapted to the study of TSEs, as well as bio-safety procedures are described. Each Chapter is written by scientists involved for many years in their respective domain of prion biology who give the best of their knowledge in this technical document. This volume is a very useful tool for any laboratory which recently decided to contribute to the study of TSEs as well as for teams already engaged in this field for many years but interested in extending their technical capacity toward new methods. Features: Purification of PrPC and the Pathological Isoform of Prion Protein (PrPsc or PrP-res) Animal Models of TSEs Cell Culture Models of TSEs PrPsc Immunohistochemistry Western Immunoblotting Techniques Antibody Production and ELISA TSE Strain Typing in Mice Biosafety and Decontamination Procedures Cell-free Conversion of Prion Proteins Cytotoxicity of PrP Peptides Cyclic Amplification of Prion Protein Misfolding< Of interest to: Researchers and clinicians in the fields of cell biology, biomedicine, neuroscience/neuropathology, veterinary medicine and biochemistry |
| Beschreibung: | 1 Online-Ressource (X, 221 p) |
| ISBN: | 9783034879491 |
| DOI: | 10.1007/978-3-0348-7949-1 |
Internformat
MARC
| LEADER | 00000nmm a2200000zc 4500 | ||
|---|---|---|---|
| 001 | BV046148736 | ||
| 003 | DE-604 | ||
| 005 | 00000000000000.0 | ||
| 007 | cr|uuu---uuuuu | ||
| 008 | 190906s2004 |||| o||u| ||||||eng d | ||
| 020 | |a 9783034879491 |9 978-3-0348-7949-1 | ||
| 024 | 7 | |a 10.1007/978-3-0348-7949-1 |2 doi | |
| 035 | |a (ZDB-2-SBL)978-3-0348-7949-1 | ||
| 035 | |a (OCoLC)1119114576 | ||
| 035 | |a (DE-599)BVBBV046148736 | ||
| 040 | |a DE-604 |b ger |e aacr | ||
| 041 | 0 | |a eng | |
| 049 | |a DE-355 | ||
| 082 | 0 | |a 610 |2 23 | |
| 245 | 1 | 0 | |a Techniques in Prion Research |c edited by Sylvain Lehmann, Jacques Grassi |
| 264 | 1 | |a Basel |b Birkhäuser Basel |c 2004 | |
| 300 | |a 1 Online-Ressource (X, 221 p) | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b c |2 rdamedia | ||
| 338 | |b cr |2 rdacarrier | ||
| 490 | 0 | |a Methods and Tools in Biosciences and Medicine | |
| 520 | |a Prion diseases, also known as Transmissible Spongiform Encephalopathies (TSEs), exist in both humans (Creutzfeldt-Jakob disease (CJD)) and animals (scrapie, bovine spongiform encephalopathy (BSE), chronic wasting disease) and have the unique property of being infectious, sporadic or genetic in origin. Although the precise nature of the infectious agent responsible for TSEs is not definitely identified, it is now clearly demonstrated that a protein named PrP (for Prion Protein) plays a critical role in the transmission and pathogenesis of TSEs. This book provides the general description as well as the details of the techniques currently used for the study of prion diseases. Taking into account the pivotal role played by PrP it is not surprising that many Chapters of this book deal with the purification, the detection and the characterization of the different forms of this protein. | ||
| 520 | |a In addition, in vitro, cellular and animal models specifically adapted to the study of TSEs, as well as bio-safety procedures are described. Each Chapter is written by scientists involved for many years in their respective domain of prion biology who give the best of their knowledge in this technical document. This volume is a very useful tool for any laboratory which recently decided to contribute to the study of TSEs as well as for teams already engaged in this field for many years but interested in extending their technical capacity toward new methods. | ||
| 520 | |a Features: Purification of PrPC and the Pathological Isoform of Prion Protein (PrPsc or PrP-res) Animal Models of TSEs Cell Culture Models of TSEs PrPsc Immunohistochemistry Western Immunoblotting Techniques Antibody Production and ELISA TSE Strain Typing in Mice Biosafety and Decontamination Procedures Cell-free Conversion of Prion Proteins Cytotoxicity of PrP Peptides Cyclic Amplification of Prion Protein Misfolding< Of interest to: Researchers and clinicians in the fields of cell biology, biomedicine, neuroscience/neuropathology, veterinary medicine and biochemistry | ||
| 650 | 4 | |a Biomedicine general | |
| 650 | 4 | |a Immunology | |
| 650 | 4 | |a Neurosciences | |
| 650 | 4 | |a Infectious Diseases | |
| 650 | 4 | |a Cell Biology | |
| 650 | 4 | |a Neurobiology | |
| 650 | 4 | |a Medicine | |
| 650 | 4 | |a Immunology | |
| 650 | 4 | |a Neurosciences | |
| 650 | 4 | |a Emerging infectious diseases | |
| 650 | 4 | |a Cytology | |
| 650 | 4 | |a Neurobiology | |
| 650 | 0 | 7 | |a Prion |0 (DE-588)4353535-5 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Forschungsmethode |0 (DE-588)4155046-8 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a BSE |0 (DE-588)4345150-0 |2 gnd |9 rswk-swf |
| 655 | 7 | |0 (DE-588)4143413-4 |a Aufsatzsammlung |2 gnd-content | |
| 689 | 0 | 0 | |a BSE |0 (DE-588)4345150-0 |D s |
| 689 | 0 | 1 | |a Forschungsmethode |0 (DE-588)4155046-8 |D s |
| 689 | 0 | |5 DE-604 | |
| 689 | 1 | 0 | |a Prion |0 (DE-588)4353535-5 |D s |
| 689 | 1 | 1 | |a Forschungsmethode |0 (DE-588)4155046-8 |D s |
| 689 | 1 | |5 DE-604 | |
| 700 | 1 | |a Lehmann, Sylvain |4 edt | |
| 700 | 1 | |a Grassi, Jacques |4 edt | |
| 776 | 0 | 8 | |i Erscheint auch als |n Druck-Ausgabe |z 9783764324155 |
| 776 | 0 | 8 | |i Erscheint auch als |n Druck-Ausgabe |z 9783764322243 |
| 776 | 0 | 8 | |i Erscheint auch als |n Druck-Ausgabe |z 9783034879507 |
| 856 | 4 | 0 | |u https://doi.org/10.1007/978-3-0348-7949-1 |x Verlag |z URL des Erstveröffentlichers |3 Volltext |
| 912 | |a ZDB-2-SBL | ||
| 940 | 1 | |q ZDB-2-SBL_2000/2004 | |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-031528913 | ||
| 966 | e | |u https://doi.org/10.1007/978-3-0348-7949-1 |l UBR01 |p ZDB-2-SBL |q ZDB-2-SBL_2000/2004 |x Verlag |3 Volltext | |
Datensatz im Suchindex
| _version_ | 1804180489370599424 |
|---|---|
| any_adam_object | |
| author2 | Lehmann, Sylvain Grassi, Jacques |
| author2_role | edt edt |
| author2_variant | s l sl j g jg |
| author_facet | Lehmann, Sylvain Grassi, Jacques |
| building | Verbundindex |
| bvnumber | BV046148736 |
| collection | ZDB-2-SBL |
| ctrlnum | (ZDB-2-SBL)978-3-0348-7949-1 (OCoLC)1119114576 (DE-599)BVBBV046148736 |
| dewey-full | 610 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 610 - Medicine and health |
| dewey-raw | 610 |
| dewey-search | 610 |
| dewey-sort | 3610 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| doi_str_mv | 10.1007/978-3-0348-7949-1 |
| format | Electronic eBook |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>04368nmm a2200697zc 4500</leader><controlfield tag="001">BV046148736</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">00000000000000.0</controlfield><controlfield tag="007">cr|uuu---uuuuu</controlfield><controlfield tag="008">190906s2004 |||| o||u| ||||||eng d</controlfield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9783034879491</subfield><subfield code="9">978-3-0348-7949-1</subfield></datafield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/978-3-0348-7949-1</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ZDB-2-SBL)978-3-0348-7949-1</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)1119114576</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV046148736</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">aacr</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-355</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">610</subfield><subfield code="2">23</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Techniques in Prion Research</subfield><subfield code="c">edited by Sylvain Lehmann, Jacques Grassi</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Basel</subfield><subfield code="b">Birkhäuser Basel</subfield><subfield code="c">2004</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">1 Online-Ressource (X, 221 p)</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="490" ind1="0" ind2=" "><subfield code="a">Methods and Tools in Biosciences and Medicine</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Prion diseases, also known as Transmissible Spongiform Encephalopathies (TSEs), exist in both humans (Creutzfeldt-Jakob disease (CJD)) and animals (scrapie, bovine spongiform encephalopathy (BSE), chronic wasting disease) and have the unique property of being infectious, sporadic or genetic in origin. Although the precise nature of the infectious agent responsible for TSEs is not definitely identified, it is now clearly demonstrated that a protein named PrP (for Prion Protein) plays a critical role in the transmission and pathogenesis of TSEs. This book provides the general description as well as the details of the techniques currently used for the study of prion diseases. Taking into account the pivotal role played by PrP it is not surprising that many Chapters of this book deal with the purification, the detection and the characterization of the different forms of this protein. </subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">In addition, in vitro, cellular and animal models specifically adapted to the study of TSEs, as well as bio-safety procedures are described. Each Chapter is written by scientists involved for many years in their respective domain of prion biology who give the best of their knowledge in this technical document. This volume is a very useful tool for any laboratory which recently decided to contribute to the study of TSEs as well as for teams already engaged in this field for many years but interested in extending their technical capacity toward new methods. </subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Features: Purification of PrPC and the Pathological Isoform of Prion Protein (PrPsc or PrP-res) Animal Models of TSEs Cell Culture Models of TSEs PrPsc Immunohistochemistry Western Immunoblotting Techniques Antibody Production and ELISA TSE Strain Typing in Mice Biosafety and Decontamination Procedures Cell-free Conversion of Prion Proteins Cytotoxicity of PrP Peptides Cyclic Amplification of Prion Protein Misfolding< Of interest to: Researchers and clinicians in the fields of cell biology, biomedicine, neuroscience/neuropathology, veterinary medicine and biochemistry</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Biomedicine general</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Immunology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Neurosciences</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Infectious Diseases</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Cell Biology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Neurobiology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Medicine</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Immunology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Neurosciences</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Emerging infectious diseases</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Cytology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Neurobiology</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Prion</subfield><subfield code="0">(DE-588)4353535-5</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Forschungsmethode</subfield><subfield code="0">(DE-588)4155046-8</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">BSE</subfield><subfield code="0">(DE-588)4345150-0</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="655" ind1=" " ind2="7"><subfield code="0">(DE-588)4143413-4</subfield><subfield code="a">Aufsatzsammlung</subfield><subfield code="2">gnd-content</subfield></datafield><datafield tag="689" ind1="0" ind2="0"><subfield code="a">BSE</subfield><subfield code="0">(DE-588)4345150-0</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2="1"><subfield code="a">Forschungsmethode</subfield><subfield code="0">(DE-588)4155046-8</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="689" ind1="1" ind2="0"><subfield code="a">Prion</subfield><subfield code="0">(DE-588)4353535-5</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="1" ind2="1"><subfield code="a">Forschungsmethode</subfield><subfield code="0">(DE-588)4155046-8</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="1" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Lehmann, Sylvain</subfield><subfield code="4">edt</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Grassi, Jacques</subfield><subfield code="4">edt</subfield></datafield><datafield tag="776" ind1="0" ind2="8"><subfield code="i">Erscheint auch als</subfield><subfield code="n">Druck-Ausgabe</subfield><subfield code="z">9783764324155</subfield></datafield><datafield tag="776" ind1="0" ind2="8"><subfield code="i">Erscheint auch als</subfield><subfield code="n">Druck-Ausgabe</subfield><subfield code="z">9783764322243</subfield></datafield><datafield tag="776" ind1="0" ind2="8"><subfield code="i">Erscheint auch als</subfield><subfield code="n">Druck-Ausgabe</subfield><subfield code="z">9783034879507</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1007/978-3-0348-7949-1</subfield><subfield code="x">Verlag</subfield><subfield code="z">URL des Erstveröffentlichers</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-2-SBL</subfield></datafield><datafield tag="940" ind1="1" ind2=" "><subfield code="q">ZDB-2-SBL_2000/2004</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-031528913</subfield></datafield><datafield tag="966" ind1="e" ind2=" "><subfield code="u">https://doi.org/10.1007/978-3-0348-7949-1</subfield><subfield code="l">UBR01</subfield><subfield code="p">ZDB-2-SBL</subfield><subfield code="q">ZDB-2-SBL_2000/2004</subfield><subfield code="x">Verlag</subfield><subfield code="3">Volltext</subfield></datafield></record></collection> |
| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV046148736 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-10T08:36:34Z |
| institution | BVB |
| isbn | 9783034879491 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-031528913 |
| oclc_num | 1119114576 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR |
| owner_facet | DE-355 DE-BY-UBR |
| physical | 1 Online-Ressource (X, 221 p) |
| psigel | ZDB-2-SBL ZDB-2-SBL_2000/2004 ZDB-2-SBL ZDB-2-SBL_2000/2004 |
| publishDate | 2004 |
| publishDateSearch | 2004 |
| publishDateSort | 2004 |
| publisher | Birkhäuser Basel |
| record_format | marc |
| series2 | Methods and Tools in Biosciences and Medicine |
| spelling | Techniques in Prion Research edited by Sylvain Lehmann, Jacques Grassi Basel Birkhäuser Basel 2004 1 Online-Ressource (X, 221 p) txt rdacontent c rdamedia cr rdacarrier Methods and Tools in Biosciences and Medicine Prion diseases, also known as Transmissible Spongiform Encephalopathies (TSEs), exist in both humans (Creutzfeldt-Jakob disease (CJD)) and animals (scrapie, bovine spongiform encephalopathy (BSE), chronic wasting disease) and have the unique property of being infectious, sporadic or genetic in origin. Although the precise nature of the infectious agent responsible for TSEs is not definitely identified, it is now clearly demonstrated that a protein named PrP (for Prion Protein) plays a critical role in the transmission and pathogenesis of TSEs. This book provides the general description as well as the details of the techniques currently used for the study of prion diseases. Taking into account the pivotal role played by PrP it is not surprising that many Chapters of this book deal with the purification, the detection and the characterization of the different forms of this protein. In addition, in vitro, cellular and animal models specifically adapted to the study of TSEs, as well as bio-safety procedures are described. Each Chapter is written by scientists involved for many years in their respective domain of prion biology who give the best of their knowledge in this technical document. This volume is a very useful tool for any laboratory which recently decided to contribute to the study of TSEs as well as for teams already engaged in this field for many years but interested in extending their technical capacity toward new methods. Features: Purification of PrPC and the Pathological Isoform of Prion Protein (PrPsc or PrP-res) Animal Models of TSEs Cell Culture Models of TSEs PrPsc Immunohistochemistry Western Immunoblotting Techniques Antibody Production and ELISA TSE Strain Typing in Mice Biosafety and Decontamination Procedures Cell-free Conversion of Prion Proteins Cytotoxicity of PrP Peptides Cyclic Amplification of Prion Protein Misfolding< Of interest to: Researchers and clinicians in the fields of cell biology, biomedicine, neuroscience/neuropathology, veterinary medicine and biochemistry Biomedicine general Immunology Neurosciences Infectious Diseases Cell Biology Neurobiology Medicine Emerging infectious diseases Cytology Prion (DE-588)4353535-5 gnd rswk-swf Forschungsmethode (DE-588)4155046-8 gnd rswk-swf BSE (DE-588)4345150-0 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content BSE (DE-588)4345150-0 s Forschungsmethode (DE-588)4155046-8 s DE-604 Prion (DE-588)4353535-5 s Lehmann, Sylvain edt Grassi, Jacques edt Erscheint auch als Druck-Ausgabe 9783764324155 Erscheint auch als Druck-Ausgabe 9783764322243 Erscheint auch als Druck-Ausgabe 9783034879507 https://doi.org/10.1007/978-3-0348-7949-1 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Techniques in Prion Research Biomedicine general Immunology Neurosciences Infectious Diseases Cell Biology Neurobiology Medicine Emerging infectious diseases Cytology Prion (DE-588)4353535-5 gnd Forschungsmethode (DE-588)4155046-8 gnd BSE (DE-588)4345150-0 gnd |
| subject_GND | (DE-588)4353535-5 (DE-588)4155046-8 (DE-588)4345150-0 (DE-588)4143413-4 |
| title | Techniques in Prion Research |
| title_auth | Techniques in Prion Research |
| title_exact_search | Techniques in Prion Research |
| title_full | Techniques in Prion Research edited by Sylvain Lehmann, Jacques Grassi |
| title_fullStr | Techniques in Prion Research edited by Sylvain Lehmann, Jacques Grassi |
| title_full_unstemmed | Techniques in Prion Research edited by Sylvain Lehmann, Jacques Grassi |
| title_short | Techniques in Prion Research |
| title_sort | techniques in prion research |
| topic | Biomedicine general Immunology Neurosciences Infectious Diseases Cell Biology Neurobiology Medicine Emerging infectious diseases Cytology Prion (DE-588)4353535-5 gnd Forschungsmethode (DE-588)4155046-8 gnd BSE (DE-588)4345150-0 gnd |
| topic_facet | Biomedicine general Immunology Neurosciences Infectious Diseases Cell Biology Neurobiology Medicine Emerging infectious diseases Cytology Prion Forschungsmethode BSE Aufsatzsammlung |
| url | https://doi.org/10.1007/978-3-0348-7949-1 |
| work_keys_str_mv | AT lehmannsylvain techniquesinprionresearch AT grassijacques techniquesinprionresearch |