Carbonic anhydrase (CA) is a seemingly ubiquitous enzyme of profound physiological importance, which plays essential roles in respiration, acid-base homeostasis, bone resorption, calcification, photosynthesis, several biosynthetic pathways and a variety of processes involving ion, gas and fluid tran...

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Weitere Verfasser:	Chegwidden, W. Richard (HerausgeberIn), Carter, Nicholas D. (HerausgeberIn), Edwards, Yvonne H. (HerausgeberIn)
Format:	Elektronisch E-Book
Sprache:	English
Veröffentlicht:	Basel Birkhäuser Basel 2000
Schriftenreihe:	Experientia Supplementum 90
Schlagworte:	Biochemistry, general Human Physiology Plant Physiology Biochemistry Human physiology Plant physiology
Online-Zugang:	UBR01 Volltext
Zusammenfassung:	Carbonic anhydrase (CA) is a seemingly ubiquitous enzyme of profound physiological importance, which plays essential roles in respiration, acid-base homeostasis, bone resorption, calcification, photosynthesis, several biosynthetic pathways and a variety of processes involving ion, gas and fluid transfer. This enzyme, which is present in at least three gene families (a, ß, ?), has found favour as a model for the study of evolution of gene families and for site-directed mutagenesis in structure/function relationships, for protein folding and for transgenic and gene target studies. Since the early use of CA inhibitors as diuretics and in treating congestive heart failure, the enzyme has been target of considerable clinical attention. Much of this is now focused on endeavours to produce a new generation of such drugs for the effective treatment of glaucoma and other potential applications. Recent data, suggesting links between CA and various disease processes, including cancer, have stimulated further..
Beschreibung:	1 Online-Ressource (XVIII, 619 p)
ISBN:	9783034884464
DOI:	10.1007/978-3-0348-8446-4