Sildenafil:
This drug is a landmark discovery, which consequently has become the definitive therapy for the treatment of erectile dysfunction (ED). Following the major breakthrough in the field of nitric oxide (NO)-physiology and pharmacology leading to sildenafil being marketed, the most current information is...
Gespeichert in:
| Weitere Verfasser: | |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Basel
Birkhäuser Basel
2004
|
| Schriftenreihe: | Milestones in Drug Therapy
|
| Schlagworte: | |
| Online-Zugang: | UBR01 URL des Erstveröffentlichers |
| Zusammenfassung: | This drug is a landmark discovery, which consequently has become the definitive therapy for the treatment of erectile dysfunction (ED). Following the major breakthrough in the field of nitric oxide (NO)-physiology and pharmacology leading to sildenafil being marketed, the most current information is presented in this reference book, including ongoing research from several disparate groups about NO as endothelium-derived relaxing factor (EDRF) and also as a neurotransmitter for nerves innervating erectile tissue in mammals. The development of sildenafil as an oral phosphodiesterase-5 (PDE5) inhibitor drug for the treatment of ED resulted in one of the first products, which made its way successfully from basic NO research to routine clinical therapy. This volume addresses all fields of sildenafil application in both men and women. In a highly competitive research environment with a critical medical need for drug improvements the reader will learn more about clinical resistance to sildenafil treatment and the modalities to overcome the failure rates. The individual chapters cover clinical use, pharmacokinetics, pharmacodynamics, biochemistry, and cultural aspects. They are written by leading experts in their respective fields. Therefore, readers – whether professionals in the pharmaceutical industry, physicians treating ED, biochemists, chemists or pharmacologists – will find a detailed and up-to-date knowledge base about current research activities and an excellent overview for further research on this compound class and its cultural impact |
| Beschreibung: | 1 Online-Ressource (IX, 202 p) |
| ISBN: | 9783034879453 |
| DOI: | 10.1007/978-3-0348-7945-3 |
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| spelling | Sildenafil edited by Udo Dunzendorfer Basel Birkhäuser Basel 2004 1 Online-Ressource (IX, 202 p) txt rdacontent c rdamedia cr rdacarrier Milestones in Drug Therapy This drug is a landmark discovery, which consequently has become the definitive therapy for the treatment of erectile dysfunction (ED). Following the major breakthrough in the field of nitric oxide (NO)-physiology and pharmacology leading to sildenafil being marketed, the most current information is presented in this reference book, including ongoing research from several disparate groups about NO as endothelium-derived relaxing factor (EDRF) and also as a neurotransmitter for nerves innervating erectile tissue in mammals. The development of sildenafil as an oral phosphodiesterase-5 (PDE5) inhibitor drug for the treatment of ED resulted in one of the first products, which made its way successfully from basic NO research to routine clinical therapy. This volume addresses all fields of sildenafil application in both men and women. In a highly competitive research environment with a critical medical need for drug improvements the reader will learn more about clinical resistance to sildenafil treatment and the modalities to overcome the failure rates. The individual chapters cover clinical use, pharmacokinetics, pharmacodynamics, biochemistry, and cultural aspects. They are written by leading experts in their respective fields. Therefore, readers – whether professionals in the pharmaceutical industry, physicians treating ED, biochemists, chemists or pharmacologists – will find a detailed and up-to-date knowledge base about current research activities and an excellent overview for further research on this compound class and its cultural impact Pharmacology/Toxicology Human Physiology Urology Cell Biology Toxicology Human physiology Cytology Sildenafil (DE-588)4508843-3 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Sildenafil (DE-588)4508843-3 s DE-604 Dunzendorfer, Udo edt Erscheint auch als Druck-Ausgabe 9783034896313 Erscheint auch als Druck-Ausgabe 9783764362553 Erscheint auch als Druck-Ausgabe 9783034879460 https://doi.org/10.1007/978-3-0348-7945-3 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Sildenafil Pharmacology/Toxicology Human Physiology Urology Cell Biology Toxicology Human physiology Cytology Sildenafil (DE-588)4508843-3 gnd |
| subject_GND | (DE-588)4508843-3 (DE-588)4143413-4 |
| title | Sildenafil |
| title_auth | Sildenafil |
| title_exact_search | Sildenafil |
| title_full | Sildenafil edited by Udo Dunzendorfer |
| title_fullStr | Sildenafil edited by Udo Dunzendorfer |
| title_full_unstemmed | Sildenafil edited by Udo Dunzendorfer |
| title_short | Sildenafil |
| title_sort | sildenafil |
| topic | Pharmacology/Toxicology Human Physiology Urology Cell Biology Toxicology Human physiology Cytology Sildenafil (DE-588)4508843-3 gnd |
| topic_facet | Pharmacology/Toxicology Human Physiology Urology Cell Biology Toxicology Human physiology Cytology Sildenafil Aufsatzsammlung |
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