Signal Transduction and the Coordination of B Lymphocyte Development and Function I: Transduction of BCR Signals from the Cell Membrane to the Nucleus
Proper development and differentiation of B lymphocytes is es sential to ensure that an organism has the ability to mount an effective humoral immune response against foreign antigens. The immune system must maintain a balance between the deletion of harmful self-reactive B cells and the generation...
Gespeichert in:
| Weitere Verfasser: | , |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Berlin, Heidelberg
Springer Berlin Heidelberg
2000
|
| Schriftenreihe: | Current Topics in Microbiology and Immunology
245/1 |
| Schlagworte: | |
| Online-Zugang: | UBR01 Volltext |
| Zusammenfassung: | Proper development and differentiation of B lymphocytes is es sential to ensure that an organism has the ability to mount an effective humoral immune response against foreign antigens. The immune system must maintain a balance between the deletion of harmful self-reactive B cells and the generation of a diverse rep ertoire of B cells that has the ability to recognize an almost un limited array of foreign antigens. The need to delete self-reactive cells is tempered by the need to avoid the generation of large functional holes in the repertoire of foreign antigen-specific B cells that patrol the periphery. To accomplish this, the immune system must reach a compromise by eliminating only the most dangerous autoreactive clones, while allowing less harmful au toreactive B cells to exist in the periphery where they may com plement the organism's ability to mount a rapid response against invading micro-organisms. Those autoreactive cells that do enter the peripheral pool are subject to a number of conditional re straints that effectively attenuate their ability to respond to self antigens. Deleterious alterations in the homeostasis between tolerance induction and recruitment of B cells into the functional repertoire may lead to increased susceptibility to autoimmune disease or infection, respectively. Therefore, delineation of the molecular processes that maintain immunological homeostasis in the B cell compartment is critical |
| Beschreibung: | 1 Online-Ressource (XV, 267 p) |
| ISBN: | 9783642570667 |
| DOI: | 10.1007/978-3-642-57066-7 |
Internformat
MARC
| LEADER | 00000nmm a2200000zcb4500 | ||
|---|---|---|---|
| 001 | BV046148206 | ||
| 003 | DE-604 | ||
| 005 | 00000000000000.0 | ||
| 007 | cr|uuu---uuuuu | ||
| 008 | 190906s2000 |||| o||u| ||||||eng d | ||
| 020 | |a 9783642570667 |9 978-3-642-57066-7 | ||
| 024 | 7 | |a 10.1007/978-3-642-57066-7 |2 doi | |
| 035 | |a (ZDB-2-SBL)978-3-642-57066-7 | ||
| 035 | |a (OCoLC)1119009396 | ||
| 035 | |a (DE-599)BVBBV046148206 | ||
| 040 | |a DE-604 |b ger |e aacr | ||
| 041 | 0 | |a eng | |
| 049 | |a DE-355 | ||
| 082 | 0 | |a 616.079 |2 23 | |
| 084 | |a WE 5320 |0 (DE-625)148305: |2 rvk | ||
| 084 | |a WF 9880 |0 (DE-625)148476: |2 rvk | ||
| 245 | 1 | 0 | |a Signal Transduction and the Coordination of B Lymphocyte Development and Function I |b Transduction of BCR Signals from the Cell Membrane to the Nucleus |c edited by Louis B. Justement, Katherine A. Siminovitch |
| 264 | 1 | |a Berlin, Heidelberg |b Springer Berlin Heidelberg |c 2000 | |
| 300 | |a 1 Online-Ressource (XV, 267 p) | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b c |2 rdamedia | ||
| 338 | |b cr |2 rdacarrier | ||
| 490 | 0 | |a Current Topics in Microbiology and Immunology |v 245/1 | |
| 520 | |a Proper development and differentiation of B lymphocytes is es sential to ensure that an organism has the ability to mount an effective humoral immune response against foreign antigens. The immune system must maintain a balance between the deletion of harmful self-reactive B cells and the generation of a diverse rep ertoire of B cells that has the ability to recognize an almost un limited array of foreign antigens. The need to delete self-reactive cells is tempered by the need to avoid the generation of large functional holes in the repertoire of foreign antigen-specific B cells that patrol the periphery. To accomplish this, the immune system must reach a compromise by eliminating only the most dangerous autoreactive clones, while allowing less harmful au toreactive B cells to exist in the periphery where they may com plement the organism's ability to mount a rapid response against invading micro-organisms. Those autoreactive cells that do enter the peripheral pool are subject to a number of conditional re straints that effectively attenuate their ability to respond to self antigens. Deleterious alterations in the homeostasis between tolerance induction and recruitment of B cells into the functional repertoire may lead to increased susceptibility to autoimmune disease or infection, respectively. Therefore, delineation of the molecular processes that maintain immunological homeostasis in the B cell compartment is critical | ||
| 650 | 4 | |a Immunology | |
| 650 | 4 | |a Cell Biology | |
| 650 | 4 | |a Molecular Medicine | |
| 650 | 4 | |a Immunology | |
| 650 | 4 | |a Cytology | |
| 650 | 4 | |a Medicine | |
| 700 | 1 | |a Justement, Louis B. |4 edt | |
| 700 | 1 | |a Siminovitch, Katherine A. |4 edt | |
| 776 | 0 | 8 | |i Erscheint auch als |n Druck-Ausgabe |z 9783642630170 |
| 776 | 0 | 8 | |i Erscheint auch als |n Druck-Ausgabe |z 9783540660026 |
| 776 | 0 | 8 | |i Erscheint auch als |n Druck-Ausgabe |z 9783642570674 |
| 856 | 4 | 0 | |u https://doi.org/10.1007/978-3-642-57066-7 |x Verlag |z URL des Erstveröffentlichers |3 Volltext |
| 912 | |a ZDB-2-SBL | ||
| 940 | 1 | |q ZDB-2-SBL_2000/2004 | |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-031528383 | ||
| 966 | e | |u https://doi.org/10.1007/978-3-642-57066-7 |l UBR01 |p ZDB-2-SBL |q ZDB-2-SBL_2000/2004 |x Verlag |3 Volltext | |
Datensatz im Suchindex
| _version_ | 1804180488176271360 |
|---|---|
| any_adam_object | |
| author2 | Justement, Louis B. Siminovitch, Katherine A. |
| author2_role | edt edt |
| author2_variant | l b j lb lbj k a s ka kas |
| author_facet | Justement, Louis B. Siminovitch, Katherine A. |
| building | Verbundindex |
| bvnumber | BV046148206 |
| classification_rvk | WE 5320 WF 9880 |
| collection | ZDB-2-SBL |
| ctrlnum | (ZDB-2-SBL)978-3-642-57066-7 (OCoLC)1119009396 (DE-599)BVBBV046148206 |
| dewey-full | 616.079 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
| dewey-raw | 616.079 |
| dewey-search | 616.079 |
| dewey-sort | 3616.079 |
| dewey-tens | 610 - Medicine and health |
| discipline | Biologie Medizin |
| doi_str_mv | 10.1007/978-3-642-57066-7 |
| format | Electronic eBook |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>03350nmm a2200505zcb4500</leader><controlfield tag="001">BV046148206</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">00000000000000.0</controlfield><controlfield tag="007">cr|uuu---uuuuu</controlfield><controlfield tag="008">190906s2000 |||| o||u| ||||||eng d</controlfield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9783642570667</subfield><subfield code="9">978-3-642-57066-7</subfield></datafield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/978-3-642-57066-7</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ZDB-2-SBL)978-3-642-57066-7</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)1119009396</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV046148206</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">aacr</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-355</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">616.079</subfield><subfield code="2">23</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">WE 5320</subfield><subfield code="0">(DE-625)148305:</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">WF 9880</subfield><subfield code="0">(DE-625)148476:</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Signal Transduction and the Coordination of B Lymphocyte Development and Function I</subfield><subfield code="b">Transduction of BCR Signals from the Cell Membrane to the Nucleus</subfield><subfield code="c">edited by Louis B. Justement, Katherine A. Siminovitch</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Berlin, Heidelberg</subfield><subfield code="b">Springer Berlin Heidelberg</subfield><subfield code="c">2000</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">1 Online-Ressource (XV, 267 p)</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="490" ind1="0" ind2=" "><subfield code="a">Current Topics in Microbiology and Immunology</subfield><subfield code="v">245/1</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Proper development and differentiation of B lymphocytes is es sential to ensure that an organism has the ability to mount an effective humoral immune response against foreign antigens. The immune system must maintain a balance between the deletion of harmful self-reactive B cells and the generation of a diverse rep ertoire of B cells that has the ability to recognize an almost un limited array of foreign antigens. The need to delete self-reactive cells is tempered by the need to avoid the generation of large functional holes in the repertoire of foreign antigen-specific B cells that patrol the periphery. To accomplish this, the immune system must reach a compromise by eliminating only the most dangerous autoreactive clones, while allowing less harmful au toreactive B cells to exist in the periphery where they may com plement the organism's ability to mount a rapid response against invading micro-organisms. Those autoreactive cells that do enter the peripheral pool are subject to a number of conditional re straints that effectively attenuate their ability to respond to self antigens. Deleterious alterations in the homeostasis between tolerance induction and recruitment of B cells into the functional repertoire may lead to increased susceptibility to autoimmune disease or infection, respectively. Therefore, delineation of the molecular processes that maintain immunological homeostasis in the B cell compartment is critical</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Immunology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Cell Biology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Molecular Medicine</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Immunology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Cytology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Medicine</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Justement, Louis B.</subfield><subfield code="4">edt</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Siminovitch, Katherine A.</subfield><subfield code="4">edt</subfield></datafield><datafield tag="776" ind1="0" ind2="8"><subfield code="i">Erscheint auch als</subfield><subfield code="n">Druck-Ausgabe</subfield><subfield code="z">9783642630170</subfield></datafield><datafield tag="776" ind1="0" ind2="8"><subfield code="i">Erscheint auch als</subfield><subfield code="n">Druck-Ausgabe</subfield><subfield code="z">9783540660026</subfield></datafield><datafield tag="776" ind1="0" ind2="8"><subfield code="i">Erscheint auch als</subfield><subfield code="n">Druck-Ausgabe</subfield><subfield code="z">9783642570674</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1007/978-3-642-57066-7</subfield><subfield code="x">Verlag</subfield><subfield code="z">URL des Erstveröffentlichers</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-2-SBL</subfield></datafield><datafield tag="940" ind1="1" ind2=" "><subfield code="q">ZDB-2-SBL_2000/2004</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-031528383</subfield></datafield><datafield tag="966" ind1="e" ind2=" "><subfield code="u">https://doi.org/10.1007/978-3-642-57066-7</subfield><subfield code="l">UBR01</subfield><subfield code="p">ZDB-2-SBL</subfield><subfield code="q">ZDB-2-SBL_2000/2004</subfield><subfield code="x">Verlag</subfield><subfield code="3">Volltext</subfield></datafield></record></collection> |
| id | DE-604.BV046148206 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-10T08:36:33Z |
| institution | BVB |
| isbn | 9783642570667 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-031528383 |
| oclc_num | 1119009396 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR |
| owner_facet | DE-355 DE-BY-UBR |
| physical | 1 Online-Ressource (XV, 267 p) |
| psigel | ZDB-2-SBL ZDB-2-SBL_2000/2004 ZDB-2-SBL ZDB-2-SBL_2000/2004 |
| publishDate | 2000 |
| publishDateSearch | 2000 |
| publishDateSort | 2000 |
| publisher | Springer Berlin Heidelberg |
| record_format | marc |
| series2 | Current Topics in Microbiology and Immunology |
| spelling | Signal Transduction and the Coordination of B Lymphocyte Development and Function I Transduction of BCR Signals from the Cell Membrane to the Nucleus edited by Louis B. Justement, Katherine A. Siminovitch Berlin, Heidelberg Springer Berlin Heidelberg 2000 1 Online-Ressource (XV, 267 p) txt rdacontent c rdamedia cr rdacarrier Current Topics in Microbiology and Immunology 245/1 Proper development and differentiation of B lymphocytes is es sential to ensure that an organism has the ability to mount an effective humoral immune response against foreign antigens. The immune system must maintain a balance between the deletion of harmful self-reactive B cells and the generation of a diverse rep ertoire of B cells that has the ability to recognize an almost un limited array of foreign antigens. The need to delete self-reactive cells is tempered by the need to avoid the generation of large functional holes in the repertoire of foreign antigen-specific B cells that patrol the periphery. To accomplish this, the immune system must reach a compromise by eliminating only the most dangerous autoreactive clones, while allowing less harmful au toreactive B cells to exist in the periphery where they may com plement the organism's ability to mount a rapid response against invading micro-organisms. Those autoreactive cells that do enter the peripheral pool are subject to a number of conditional re straints that effectively attenuate their ability to respond to self antigens. Deleterious alterations in the homeostasis between tolerance induction and recruitment of B cells into the functional repertoire may lead to increased susceptibility to autoimmune disease or infection, respectively. Therefore, delineation of the molecular processes that maintain immunological homeostasis in the B cell compartment is critical Immunology Cell Biology Molecular Medicine Cytology Medicine Justement, Louis B. edt Siminovitch, Katherine A. edt Erscheint auch als Druck-Ausgabe 9783642630170 Erscheint auch als Druck-Ausgabe 9783540660026 Erscheint auch als Druck-Ausgabe 9783642570674 https://doi.org/10.1007/978-3-642-57066-7 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Signal Transduction and the Coordination of B Lymphocyte Development and Function I Transduction of BCR Signals from the Cell Membrane to the Nucleus Immunology Cell Biology Molecular Medicine Cytology Medicine |
| title | Signal Transduction and the Coordination of B Lymphocyte Development and Function I Transduction of BCR Signals from the Cell Membrane to the Nucleus |
| title_auth | Signal Transduction and the Coordination of B Lymphocyte Development and Function I Transduction of BCR Signals from the Cell Membrane to the Nucleus |
| title_exact_search | Signal Transduction and the Coordination of B Lymphocyte Development and Function I Transduction of BCR Signals from the Cell Membrane to the Nucleus |
| title_full | Signal Transduction and the Coordination of B Lymphocyte Development and Function I Transduction of BCR Signals from the Cell Membrane to the Nucleus edited by Louis B. Justement, Katherine A. Siminovitch |
| title_fullStr | Signal Transduction and the Coordination of B Lymphocyte Development and Function I Transduction of BCR Signals from the Cell Membrane to the Nucleus edited by Louis B. Justement, Katherine A. Siminovitch |
| title_full_unstemmed | Signal Transduction and the Coordination of B Lymphocyte Development and Function I Transduction of BCR Signals from the Cell Membrane to the Nucleus edited by Louis B. Justement, Katherine A. Siminovitch |
| title_short | Signal Transduction and the Coordination of B Lymphocyte Development and Function I |
| title_sort | signal transduction and the coordination of b lymphocyte development and function i transduction of bcr signals from the cell membrane to the nucleus |
| title_sub | Transduction of BCR Signals from the Cell Membrane to the Nucleus |
| topic | Immunology Cell Biology Molecular Medicine Cytology Medicine |
| topic_facet | Immunology Cell Biology Molecular Medicine Cytology Medicine |
| url | https://doi.org/10.1007/978-3-642-57066-7 |
| work_keys_str_mv | AT justementlouisb signaltransductionandthecoordinationofblymphocytedevelopmentandfunctionitransductionofbcrsignalsfromthecellmembranetothenucleus AT siminovitchkatherinea signaltransductionandthecoordinationofblymphocytedevelopmentandfunctionitransductionofbcrsignalsfromthecellmembranetothenucleus |