Nuclear Factor кB: Regulation and Role in Disease
Seventeen years after its initial description, nuclear factor-KB (NF-KB) endures as one of the most studied transcription factors. NF-KB has attracted widespread interest based on the variety of stimuli that activate it, the diverse genes and bio logical responses that it controls, the striking evo...
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| Format: | Elektronisch E-Book |
| Sprache: | English |
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Dordrecht
Springer Netherlands
2003
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| Online-Zugang: | UBR01 Volltext |
| Zusammenfassung: | Seventeen years after its initial description, nuclear factor-KB (NF-KB) endures as one of the most studied transcription factors. NF-KB has attracted widespread interest based on the variety of stimuli that activate it, the diverse genes and bio logical responses that it controls, the striking evolutionary conservation of struc ture and function among species, and its involvement in a variety of human diseases. The biochemical basis by which several stimuli converge to activate NF-KB has been largely elucidated during recent years. While first discovered as a key regulatory factor of the immune system, NF-KB is now recognized as an important player in the functioning of many organs and cell types. The ongoing examination of NF-KB signaling has revealed its ever expanding role in immune and inflammatory responses, but also in cancer and development. For this reason, numerous efforts are underway to develop safe inhibitors of NF-KB to be used in the treatment of both chronic and acute disease situations. The present book is the first to review and synthesize our knowledge of this interesting transcription factor. As such, the choice of subjects to review was daunting. To set the stage, an introductory chapter on activators and target genes, as well as the role they play in several responses, has been included |
| Beschreibung: | 1 Online-Ressource (XI, 426 p) |
| ISBN: | 9789401001632 |
| DOI: | 10.1007/978-94-010-0163-2 |
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| 520 | |a Seventeen years after its initial description, nuclear factor-KB (NF-KB) endures as one of the most studied transcription factors. NF-KB has attracted widespread interest based on the variety of stimuli that activate it, the diverse genes and bio logical responses that it controls, the striking evolutionary conservation of struc ture and function among species, and its involvement in a variety of human diseases. The biochemical basis by which several stimuli converge to activate NF-KB has been largely elucidated during recent years. While first discovered as a key regulatory factor of the immune system, NF-KB is now recognized as an important player in the functioning of many organs and cell types. The ongoing examination of NF-KB signaling has revealed its ever expanding role in immune and inflammatory responses, but also in cancer and development. For this reason, numerous efforts are underway to develop safe inhibitors of NF-KB to be used in the treatment of both chronic and acute disease situations. The present book is the first to review and synthesize our knowledge of this interesting transcription factor. As such, the choice of subjects to review was daunting. To set the stage, an introductory chapter on activators and target genes, as well as the role they play in several responses, has been included | ||
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| illustrated | Not Illustrated |
| indexdate | 2024-07-10T08:36:33Z |
| institution | BVB |
| isbn | 9789401001632 |
| language | English |
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| spelling | Nuclear Factor кB Regulation and Role in Disease edited by Rudi Beyaert Dordrecht Springer Netherlands 2003 1 Online-Ressource (XI, 426 p) txt rdacontent c rdamedia cr rdacarrier Seventeen years after its initial description, nuclear factor-KB (NF-KB) endures as one of the most studied transcription factors. NF-KB has attracted widespread interest based on the variety of stimuli that activate it, the diverse genes and bio logical responses that it controls, the striking evolutionary conservation of struc ture and function among species, and its involvement in a variety of human diseases. The biochemical basis by which several stimuli converge to activate NF-KB has been largely elucidated during recent years. While first discovered as a key regulatory factor of the immune system, NF-KB is now recognized as an important player in the functioning of many organs and cell types. The ongoing examination of NF-KB signaling has revealed its ever expanding role in immune and inflammatory responses, but also in cancer and development. For this reason, numerous efforts are underway to develop safe inhibitors of NF-KB to be used in the treatment of both chronic and acute disease situations. The present book is the first to review and synthesize our knowledge of this interesting transcription factor. As such, the choice of subjects to review was daunting. To set the stage, an introductory chapter on activators and target genes, as well as the role they play in several responses, has been included Immunology Animal Anatomy / Morphology / Histology Animal Biochemistry Pharmacy Cancer Research Morphology (Animals) Biochemistry Oncology Nuklearfaktor Kappa B (DE-588)4348985-0 gnd rswk-swf Nuklearfaktor Kappa B (DE-588)4348985-0 s DE-604 Beyaert, Rudi edt Erscheint auch als Druck-Ausgabe 9789401039833 Erscheint auch als Druck-Ausgabe 9781402014345 Erscheint auch als Druck-Ausgabe 9789401001649 https://doi.org/10.1007/978-94-010-0163-2 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Nuclear Factor кB Regulation and Role in Disease Immunology Animal Anatomy / Morphology / Histology Animal Biochemistry Pharmacy Cancer Research Morphology (Animals) Biochemistry Oncology Nuklearfaktor Kappa B (DE-588)4348985-0 gnd |
| subject_GND | (DE-588)4348985-0 |
| title | Nuclear Factor кB Regulation and Role in Disease |
| title_auth | Nuclear Factor кB Regulation and Role in Disease |
| title_exact_search | Nuclear Factor кB Regulation and Role in Disease |
| title_full | Nuclear Factor кB Regulation and Role in Disease edited by Rudi Beyaert |
| title_fullStr | Nuclear Factor кB Regulation and Role in Disease edited by Rudi Beyaert |
| title_full_unstemmed | Nuclear Factor кB Regulation and Role in Disease edited by Rudi Beyaert |
| title_short | Nuclear Factor кB |
| title_sort | nuclear factor кb regulation and role in disease |
| title_sub | Regulation and Role in Disease |
| topic | Immunology Animal Anatomy / Morphology / Histology Animal Biochemistry Pharmacy Cancer Research Morphology (Animals) Biochemistry Oncology Nuklearfaktor Kappa B (DE-588)4348985-0 gnd |
| topic_facet | Immunology Animal Anatomy / Morphology / Histology Animal Biochemistry Pharmacy Cancer Research Morphology (Animals) Biochemistry Oncology Nuklearfaktor Kappa B |
| url | https://doi.org/10.1007/978-94-010-0163-2 |
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