Nongenotoxic Carcinogenesis:
"What is a nongenotoxic carcinogen?" This question recurred through out the Ernst Schering Research Foundation Workshop on nongeno toxic carcinogenesis, underlining the complexity of the topic. The clarity of the view that all carcinogens act by mutating DNA, origin ally advocated by Br...
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| Weitere Verfasser: | , |
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| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Berlin, Heidelberg
Springer Berlin Heidelberg
1994
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| Schriftenreihe: | Ernst Schering Foundation Symposium Proceedings
10 |
| Schlagworte: | |
| Online-Zugang: | UBR01 Volltext |
| Zusammenfassung: | "What is a nongenotoxic carcinogen?" This question recurred through out the Ernst Schering Research Foundation Workshop on nongeno toxic carcinogenesis, underlining the complexity of the topic. The clarity of the view that all carcinogens act by mutating DNA, origin ally advocated by Bruce Ames nearly 20 years ago, has been clouded by the increasing numbers of compounds which are not genotoxic but which nevertheless can cause cancer. There is an urgent need to in crease our understanding of these compounds so that their risks can be evaluated realistically and decisions made from a position of knowl edge and strength, rather than in fear of the unknown. A nongenotoxic carcinogen can be defined as a compound which causes cancer, but which does not cause damage to DNA as its primary biological activity. This negative definition covers a range of carci nogens acting through a variety of mechanisms. Such chemicals often produce tumours only in a single organ species, and there are a few common locations which are affected most often. For example, in male rats, certain carcinogens bind to az globulin to form a complex which 11 accumulates in the kidney tubular cells, which is followed by necrosis and compensatory cell proliferation leading the neoplasia. Other com mon mechanisms include hormonal imbalance resulting in thyroid tu mours or peroxisome proliferation resulting in liver cancer. These and other examples are studied in some detail in the papers of this book |
| Beschreibung: | 1 Online-Ressource (XII, 240 p. 17 illus) |
| ISBN: | 9783662030226 |
| DOI: | 10.1007/978-3-662-03022-6 |
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| 520 | |a "What is a nongenotoxic carcinogen?" This question recurred through out the Ernst Schering Research Foundation Workshop on nongeno toxic carcinogenesis, underlining the complexity of the topic. The clarity of the view that all carcinogens act by mutating DNA, origin ally advocated by Bruce Ames nearly 20 years ago, has been clouded by the increasing numbers of compounds which are not genotoxic but which nevertheless can cause cancer. There is an urgent need to in crease our understanding of these compounds so that their risks can be evaluated realistically and decisions made from a position of knowl edge and strength, rather than in fear of the unknown. A nongenotoxic carcinogen can be defined as a compound which causes cancer, but which does not cause damage to DNA as its primary biological activity. This negative definition covers a range of carci nogens acting through a variety of mechanisms. Such chemicals often produce tumours only in a single organ species, and there are a few common locations which are affected most often. For example, in male rats, certain carcinogens bind to az globulin to form a complex which 11 accumulates in the kidney tubular cells, which is followed by necrosis and compensatory cell proliferation leading the neoplasia. Other com mon mechanisms include hormonal imbalance resulting in thyroid tu mours or peroxisome proliferation resulting in liver cancer. These and other examples are studied in some detail in the papers of this book | ||
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Datensatz im Suchindex
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| author2 | Cockburn, Andrew Smith, Lewis |
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| dewey-hundreds | 600 - Technology (Applied sciences) |
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| id | DE-604.BV046147292 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-10T08:36:32Z |
| institution | BVB |
| isbn | 9783662030226 |
| language | English |
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| spelling | Nongenotoxic Carcinogenesis edited by Andrew Cockburn, Lewis Smith Berlin, Heidelberg Springer Berlin Heidelberg 1994 1 Online-Ressource (XII, 240 p. 17 illus) txt rdacontent c rdamedia cr rdacarrier Ernst Schering Foundation Symposium Proceedings 10 "What is a nongenotoxic carcinogen?" This question recurred through out the Ernst Schering Research Foundation Workshop on nongeno toxic carcinogenesis, underlining the complexity of the topic. The clarity of the view that all carcinogens act by mutating DNA, origin ally advocated by Bruce Ames nearly 20 years ago, has been clouded by the increasing numbers of compounds which are not genotoxic but which nevertheless can cause cancer. There is an urgent need to in crease our understanding of these compounds so that their risks can be evaluated realistically and decisions made from a position of knowl edge and strength, rather than in fear of the unknown. A nongenotoxic carcinogen can be defined as a compound which causes cancer, but which does not cause damage to DNA as its primary biological activity. This negative definition covers a range of carci nogens acting through a variety of mechanisms. Such chemicals often produce tumours only in a single organ species, and there are a few common locations which are affected most often. For example, in male rats, certain carcinogens bind to az globulin to form a complex which 11 accumulates in the kidney tubular cells, which is followed by necrosis and compensatory cell proliferation leading the neoplasia. Other com mon mechanisms include hormonal imbalance resulting in thyroid tu mours or peroxisome proliferation resulting in liver cancer. These and other examples are studied in some detail in the papers of this book Oncology Pharmacology/Toxicology Biochemistry, general Oncology Toxicology Biochemistry Chemikalie (DE-588)4009833-3 gnd rswk-swf Mutagenität (DE-588)4120777-4 gnd rswk-swf Carcinogen (DE-588)4032909-4 gnd rswk-swf Ausschluss (DE-588)4200579-6 gnd rswk-swf Carcinogenese (DE-588)4069853-1 gnd rswk-swf (DE-588)1071861417 Konferenzschrift gnd-content (DE-588)4143413-4 Aufsatzsammlung gnd-content Carcinogen (DE-588)4032909-4 s Mutagenität (DE-588)4120777-4 s Ausschluss (DE-588)4200579-6 s DE-604 Carcinogenese (DE-588)4069853-1 s Chemikalie (DE-588)4009833-3 s Cockburn, Andrew edt Smith, Lewis edt Erscheint auch als Druck-Ausgabe 9783662030240 Erscheint auch als Druck-Ausgabe 9783662030233 Erscheint auch als Druck-Ausgabe 9783540583424 https://doi.org/10.1007/978-3-662-03022-6 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Nongenotoxic Carcinogenesis Oncology Pharmacology/Toxicology Biochemistry, general Oncology Toxicology Biochemistry Chemikalie (DE-588)4009833-3 gnd Mutagenität (DE-588)4120777-4 gnd Carcinogen (DE-588)4032909-4 gnd Ausschluss (DE-588)4200579-6 gnd Carcinogenese (DE-588)4069853-1 gnd |
| subject_GND | (DE-588)4009833-3 (DE-588)4120777-4 (DE-588)4032909-4 (DE-588)4200579-6 (DE-588)4069853-1 (DE-588)1071861417 (DE-588)4143413-4 |
| title | Nongenotoxic Carcinogenesis |
| title_auth | Nongenotoxic Carcinogenesis |
| title_exact_search | Nongenotoxic Carcinogenesis |
| title_full | Nongenotoxic Carcinogenesis edited by Andrew Cockburn, Lewis Smith |
| title_fullStr | Nongenotoxic Carcinogenesis edited by Andrew Cockburn, Lewis Smith |
| title_full_unstemmed | Nongenotoxic Carcinogenesis edited by Andrew Cockburn, Lewis Smith |
| title_short | Nongenotoxic Carcinogenesis |
| title_sort | nongenotoxic carcinogenesis |
| topic | Oncology Pharmacology/Toxicology Biochemistry, general Oncology Toxicology Biochemistry Chemikalie (DE-588)4009833-3 gnd Mutagenität (DE-588)4120777-4 gnd Carcinogen (DE-588)4032909-4 gnd Ausschluss (DE-588)4200579-6 gnd Carcinogenese (DE-588)4069853-1 gnd |
| topic_facet | Oncology Pharmacology/Toxicology Biochemistry, general Oncology Toxicology Biochemistry Chemikalie Mutagenität Carcinogen Ausschluss Carcinogenese Konferenzschrift Aufsatzsammlung |
| url | https://doi.org/10.1007/978-3-662-03022-6 |
| work_keys_str_mv | AT cockburnandrew nongenotoxiccarcinogenesis AT smithlewis nongenotoxiccarcinogenesis |