Male-Mediated Developmental Toxicity:
The cause of many of the adverse reproductive outcomes and developmental diseases among offspring is not well understood. Most of the epidemiologic and experimental animal research has focused on the relationship between maternal exposures including medications, tobacco smoke, alcohol, infections, a...
Gespeichert in:
Weitere Verfasser: | , |
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Format: | Elektronisch E-Book |
Sprache: | English |
Veröffentlicht: |
Boston, MA
Springer US
1994
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Schriftenreihe: | Reproductive Biology
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Schlagworte: | |
Online-Zugang: | UBR01 Volltext |
Zusammenfassung: | The cause of many of the adverse reproductive outcomes and developmental diseases among offspring is not well understood. Most of the epidemiologic and experimental animal research has focused on the relationship between maternal exposures including medications, tobacco smoke, alcohol, infections, and occupation and the occurrence of spontaneous abortion, low birth weight, and birth defects. The potential role of paternal exposures has not been investigated as extensively despite long-standing animal research that demonstrates the induction of mutations in the male germ cell after exposure to certain agents and subsequent reproductive failure or early pregnancy loss. Given this relative lack of interest, acquisition of epidemiologic data and the development of a definitive model or mechanism for potential male-mediated effects has been hindered. However, recent laboratory and epidemiologic investigations have suggested that paternal exposures may be more important than previously suspected. This topic has been termed by some as "male-mediated developmental toxicity. " This is meant to refer to the effects of exposures and other factors relating to the male parent that result in toxicity to the conceptus and abnormal development. The developmental endpoints of interest can include fetal loss, congenital abnormalities, growth retardation, cancer, and neurobehavioral effects. These effects may operate through a variety of mechanisms including gene mutation, chromosomal aberrations, seminal fluid transfer of toxicants and epigenetic events |
Beschreibung: | 1 Online-Ressource (XII, 406 p) |
ISBN: | 9781461518778 |
DOI: | 10.1007/978-1-4615-1877-8 |
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520 | |a The cause of many of the adverse reproductive outcomes and developmental diseases among offspring is not well understood. Most of the epidemiologic and experimental animal research has focused on the relationship between maternal exposures including medications, tobacco smoke, alcohol, infections, and occupation and the occurrence of spontaneous abortion, low birth weight, and birth defects. The potential role of paternal exposures has not been investigated as extensively despite long-standing animal research that demonstrates the induction of mutations in the male germ cell after exposure to certain agents and subsequent reproductive failure or early pregnancy loss. Given this relative lack of interest, acquisition of epidemiologic data and the development of a definitive model or mechanism for potential male-mediated effects has been hindered. However, recent laboratory and epidemiologic investigations have suggested that paternal exposures may be more important than previously suspected. This topic has been termed by some as "male-mediated developmental toxicity. " This is meant to refer to the effects of exposures and other factors relating to the male parent that result in toxicity to the conceptus and abnormal development. The developmental endpoints of interest can include fetal loss, congenital abnormalities, growth retardation, cancer, and neurobehavioral effects. These effects may operate through a variety of mechanisms including gene mutation, chromosomal aberrations, seminal fluid transfer of toxicants and epigenetic events | ||
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Datensatz im Suchindex
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any_adam_object | |
author2 | Olshan, Andrew F. Mattison, Donald R. |
author2_role | edt edt |
author2_variant | a f o af afo d r m dr drm |
author_facet | Olshan, Andrew F. Mattison, Donald R. |
building | Verbundindex |
bvnumber | BV046147092 |
collection | ZDB-2-SME |
ctrlnum | (ZDB-2-SME)978-1-4615-1877-8 (OCoLC)1119015701 (DE-599)BVBBV046147092 |
dewey-full | 615 |
dewey-hundreds | 600 - Technology (Applied sciences) |
dewey-ones | 615 - Pharmacology and therapeutics |
dewey-raw | 615 |
dewey-search | 615 |
dewey-sort | 3615 |
dewey-tens | 610 - Medicine and health |
discipline | Medizin |
doi_str_mv | 10.1007/978-1-4615-1877-8 |
format | Electronic eBook |
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isbn | 9781461518778 |
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spelling | Male-Mediated Developmental Toxicity edited by Andrew F. Olshan, Donald R. Mattison Proceedings of an international conference held in Pittsburgh, Pennsylvania, September 16-19, 1992 Boston, MA Springer US 1994 1 Online-Ressource (XII, 406 p) txt rdacontent c rdamedia cr rdacarrier Reproductive Biology The cause of many of the adverse reproductive outcomes and developmental diseases among offspring is not well understood. Most of the epidemiologic and experimental animal research has focused on the relationship between maternal exposures including medications, tobacco smoke, alcohol, infections, and occupation and the occurrence of spontaneous abortion, low birth weight, and birth defects. The potential role of paternal exposures has not been investigated as extensively despite long-standing animal research that demonstrates the induction of mutations in the male germ cell after exposure to certain agents and subsequent reproductive failure or early pregnancy loss. Given this relative lack of interest, acquisition of epidemiologic data and the development of a definitive model or mechanism for potential male-mediated effects has been hindered. However, recent laboratory and epidemiologic investigations have suggested that paternal exposures may be more important than previously suspected. This topic has been termed by some as "male-mediated developmental toxicity. " This is meant to refer to the effects of exposures and other factors relating to the male parent that result in toxicity to the conceptus and abnormal development. The developmental endpoints of interest can include fetal loss, congenital abnormalities, growth retardation, cancer, and neurobehavioral effects. These effects may operate through a variety of mechanisms including gene mutation, chromosomal aberrations, seminal fluid transfer of toxicants and epigenetic events Pharmacology/Toxicology Developmental Biology Environmental Management Toxicology Developmental biology Environmental management Zellschädigung (DE-588)4253444-6 gnd rswk-swf Teratogenese (DE-588)4184740-4 gnd rswk-swf Vater (DE-588)4062386-5 gnd rswk-swf Risikofaktor (DE-588)4050131-0 gnd rswk-swf Spermium (DE-588)4135383-3 gnd rswk-swf Angeborene Krankheit (DE-588)4331107-6 gnd rswk-swf 1\p (DE-588)1071861417 Konferenzschrift 1992 Pittsburgh Pa. gnd-content Angeborene Krankheit (DE-588)4331107-6 s Vater (DE-588)4062386-5 s Risikofaktor (DE-588)4050131-0 s 2\p DE-604 Spermium (DE-588)4135383-3 s Zellschädigung (DE-588)4253444-6 s Teratogenese (DE-588)4184740-4 s 3\p DE-604 Olshan, Andrew F. edt Mattison, Donald R. edt Erscheint auch als Druck-Ausgabe 9781461357643 Erscheint auch als Druck-Ausgabe 9780306448157 Erscheint auch als Druck-Ausgabe 9781461518785 https://doi.org/10.1007/978-1-4615-1877-8 Verlag URL des Erstveröffentlichers Volltext 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 2\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 3\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
spellingShingle | Male-Mediated Developmental Toxicity Pharmacology/Toxicology Developmental Biology Environmental Management Toxicology Developmental biology Environmental management Zellschädigung (DE-588)4253444-6 gnd Teratogenese (DE-588)4184740-4 gnd Vater (DE-588)4062386-5 gnd Risikofaktor (DE-588)4050131-0 gnd Spermium (DE-588)4135383-3 gnd Angeborene Krankheit (DE-588)4331107-6 gnd |
subject_GND | (DE-588)4253444-6 (DE-588)4184740-4 (DE-588)4062386-5 (DE-588)4050131-0 (DE-588)4135383-3 (DE-588)4331107-6 (DE-588)1071861417 |
title | Male-Mediated Developmental Toxicity |
title_alt | Proceedings of an international conference held in Pittsburgh, Pennsylvania, September 16-19, 1992 |
title_auth | Male-Mediated Developmental Toxicity |
title_exact_search | Male-Mediated Developmental Toxicity |
title_full | Male-Mediated Developmental Toxicity edited by Andrew F. Olshan, Donald R. Mattison |
title_fullStr | Male-Mediated Developmental Toxicity edited by Andrew F. Olshan, Donald R. Mattison |
title_full_unstemmed | Male-Mediated Developmental Toxicity edited by Andrew F. Olshan, Donald R. Mattison |
title_short | Male-Mediated Developmental Toxicity |
title_sort | male mediated developmental toxicity |
topic | Pharmacology/Toxicology Developmental Biology Environmental Management Toxicology Developmental biology Environmental management Zellschädigung (DE-588)4253444-6 gnd Teratogenese (DE-588)4184740-4 gnd Vater (DE-588)4062386-5 gnd Risikofaktor (DE-588)4050131-0 gnd Spermium (DE-588)4135383-3 gnd Angeborene Krankheit (DE-588)4331107-6 gnd |
topic_facet | Pharmacology/Toxicology Developmental Biology Environmental Management Toxicology Developmental biology Environmental management Zellschädigung Teratogenese Vater Risikofaktor Spermium Angeborene Krankheit Konferenzschrift 1992 Pittsburgh Pa. |
url | https://doi.org/10.1007/978-1-4615-1877-8 |
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