Oncogenes and Tumor Suppressor Genes in Human Malignancies:
The first edition of Oncogenes (1989) focused on several of the better known transforming mechanisms and surveyed a spectrum of solid tumors and hematologic malignancies. Several of the nearly 50 known oncogenes most relevant to human disease were examined. In contrast, this volume presents a very d...
Gespeichert in:
| Weitere Verfasser: | , |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Boston, MA
Springer US
1993
|
| Schriftenreihe: | Cancer Treatment and Research
63 |
| Schlagworte: | |
| Online-Zugang: | UBR01 Volltext |
| Zusammenfassung: | The first edition of Oncogenes (1989) focused on several of the better known transforming mechanisms and surveyed a spectrum of solid tumors and hematologic malignancies. Several of the nearly 50 known oncogenes most relevant to human disease were examined. In contrast, this volume presents a very different profile and balance of subject material that reflects the rapidly changing field of molecular oncology and its newly emerging concepts. Among the most important discoveries of the past 4 years are the identification of nearly a dozen different tumor suppressor genes and the finding of an entirely new class of cancer-causing gene (bcl-2) that acts by inhibiting cell death rather than stimulating cell proliferation. This edition begins by reviewing selected malignancies in which our earlier search for clinically relevant oncogenes has led to more focused studies on gain-of-function and loss-of-function genetic abnormalities, as well as autocrine and paracrine growth factor loops known to regulate tumor physiology and malignant cell behavior. Curiously, many of these genetic and functional abnormalities are shared by several different tumor types and are not uniformly present in all tumors of the same type. This observation brings up molecular questions about the tissue-specific determinants that underlie individual cancers and also gives added impetus to the suggestion that molecular abnormalities (referred to as tumor markers) be included among the histopathologic features used for clinical diagnosis and manage ment |
| Beschreibung: | 1 Online-Ressource (XVII, 382 p) |
| ISBN: | 9781461530886 |
| DOI: | 10.1007/978-1-4615-3088-6 |
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Datensatz im Suchindex
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| any_adam_object | |
| author2 | Benz, Christopher C. Liu, Edison T. |
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| dewey-full | 616.994 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
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| discipline | Medizin |
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| illustrated | Not Illustrated |
| indexdate | 2024-07-10T08:36:31Z |
| institution | BVB |
| isbn | 9781461530886 |
| language | English |
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| spelling | Oncogenes and Tumor Suppressor Genes in Human Malignancies edited by Christopher C. Benz, Edison T. Liu Boston, MA Springer US 1993 1 Online-Ressource (XVII, 382 p) txt rdacontent c rdamedia cr rdacarrier Cancer Treatment and Research 63 The first edition of Oncogenes (1989) focused on several of the better known transforming mechanisms and surveyed a spectrum of solid tumors and hematologic malignancies. Several of the nearly 50 known oncogenes most relevant to human disease were examined. In contrast, this volume presents a very different profile and balance of subject material that reflects the rapidly changing field of molecular oncology and its newly emerging concepts. Among the most important discoveries of the past 4 years are the identification of nearly a dozen different tumor suppressor genes and the finding of an entirely new class of cancer-causing gene (bcl-2) that acts by inhibiting cell death rather than stimulating cell proliferation. This edition begins by reviewing selected malignancies in which our earlier search for clinically relevant oncogenes has led to more focused studies on gain-of-function and loss-of-function genetic abnormalities, as well as autocrine and paracrine growth factor loops known to regulate tumor physiology and malignant cell behavior. Curiously, many of these genetic and functional abnormalities are shared by several different tumor types and are not uniformly present in all tumors of the same type. This observation brings up molecular questions about the tissue-specific determinants that underlie individual cancers and also gives added impetus to the suggestion that molecular abnormalities (referred to as tumor markers) be included among the histopathologic features used for clinical diagnosis and manage ment Oncology Cancer Research Oncology Suppressorgen (DE-588)4278851-1 gnd rswk-swf Onkogen (DE-588)4131118-8 gnd rswk-swf Carcinogenese (DE-588)4069853-1 gnd rswk-swf Maligne Transformation (DE-588)4168713-9 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Carcinogenese (DE-588)4069853-1 s Suppressorgen (DE-588)4278851-1 s DE-604 Onkogen (DE-588)4131118-8 s Maligne Transformation (DE-588)4168713-9 s Benz, Christopher C. edt Liu, Edison T. edt Erscheint auch als Druck-Ausgabe 9781461363491 Erscheint auch als Druck-Ausgabe 9780792319603 Erscheint auch als Druck-Ausgabe 9781461530893 https://doi.org/10.1007/978-1-4615-3088-6 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Oncogenes and Tumor Suppressor Genes in Human Malignancies Oncology Cancer Research Oncology Suppressorgen (DE-588)4278851-1 gnd Onkogen (DE-588)4131118-8 gnd Carcinogenese (DE-588)4069853-1 gnd Maligne Transformation (DE-588)4168713-9 gnd |
| subject_GND | (DE-588)4278851-1 (DE-588)4131118-8 (DE-588)4069853-1 (DE-588)4168713-9 (DE-588)4143413-4 |
| title | Oncogenes and Tumor Suppressor Genes in Human Malignancies |
| title_auth | Oncogenes and Tumor Suppressor Genes in Human Malignancies |
| title_exact_search | Oncogenes and Tumor Suppressor Genes in Human Malignancies |
| title_full | Oncogenes and Tumor Suppressor Genes in Human Malignancies edited by Christopher C. Benz, Edison T. Liu |
| title_fullStr | Oncogenes and Tumor Suppressor Genes in Human Malignancies edited by Christopher C. Benz, Edison T. Liu |
| title_full_unstemmed | Oncogenes and Tumor Suppressor Genes in Human Malignancies edited by Christopher C. Benz, Edison T. Liu |
| title_short | Oncogenes and Tumor Suppressor Genes in Human Malignancies |
| title_sort | oncogenes and tumor suppressor genes in human malignancies |
| topic | Oncology Cancer Research Oncology Suppressorgen (DE-588)4278851-1 gnd Onkogen (DE-588)4131118-8 gnd Carcinogenese (DE-588)4069853-1 gnd Maligne Transformation (DE-588)4168713-9 gnd |
| topic_facet | Oncology Cancer Research Oncology Suppressorgen Onkogen Carcinogenese Maligne Transformation Aufsatzsammlung |
| url | https://doi.org/10.1007/978-1-4615-3088-6 |
| work_keys_str_mv | AT benzchristopherc oncogenesandtumorsuppressorgenesinhumanmalignancies AT liuedisont oncogenesandtumorsuppressorgenesinhumanmalignancies |