Protease Inhibitors as Cancer Chemopreventive Agents:
Protease inhibitors (PIs) are widely distributed in plants and animals, and have a variety of functions, which include preventing digestion of seeds by insects and modifying blood clotting in animals. After it was noted that synthetic and natural inhibitors suppress two-stage carcinogenesis and brea...
Gespeichert in:
| Weitere Verfasser: | , |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Boston, MA
Springer US
1993
|
| Schlagworte: | |
| Online-Zugang: | UBR01 Volltext |
| Zusammenfassung: | Protease inhibitors (PIs) are widely distributed in plants and animals, and have a variety of functions, which include preventing digestion of seeds by insects and modifying blood clotting in animals. After it was noted that synthetic and natural inhibitors suppress two-stage carcinogenesis and breast cancer, extensive work investigating PIs as chemopreventive agents was started. PIs are unique in that they interfere with cancer development in a variety of ways, including suppression of oxygen radicals, oncogenes, and metastases. Epidemiologic evidence supports their prevention of major human cancers in populations that consume foods containing them. Their supervised use in humans is on the threshold of development. The epidemiologic discovery of the importance of lentils and other seeds rich in PIs in preventing many human cancers allowed us to look at the action of PIs as chemopreventive agents, as reviewed in Chapter I (Fontham and Correa). Chapter 2 (Kennedy) discusses the role of natural PIs (e. g. , the Bowman-Birk inhibitor) as anticarcinogens and the possible limitations of their use. In Chapter 3 (Kennedy), the transformation of C3HI lOTlh cells caused by carcinogens and promoters is shown to be suppressed by PIs. Bowman (Chapter 4) relates the discovery of inhibitors in soybeans that are distinct from the Kunitz inhibitor, and the occurrence of a similar inhibitor in peanuts and other legumes. Chapter 5 (Birk) is an overview of PIs of plant origin and their role in human nutrition |
| Beschreibung: | 1 Online-Ressource (XVIII, 315 p) |
| ISBN: | 9781461528821 |
| DOI: | 10.1007/978-1-4615-2882-1 |
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| 520 | |a Protease inhibitors (PIs) are widely distributed in plants and animals, and have a variety of functions, which include preventing digestion of seeds by insects and modifying blood clotting in animals. After it was noted that synthetic and natural inhibitors suppress two-stage carcinogenesis and breast cancer, extensive work investigating PIs as chemopreventive agents was started. PIs are unique in that they interfere with cancer development in a variety of ways, including suppression of oxygen radicals, oncogenes, and metastases. Epidemiologic evidence supports their prevention of major human cancers in populations that consume foods containing them. Their supervised use in humans is on the threshold of development. The epidemiologic discovery of the importance of lentils and other seeds rich in PIs in preventing many human cancers allowed us to look at the action of PIs as chemopreventive agents, as reviewed in Chapter I (Fontham and Correa). Chapter 2 (Kennedy) discusses the role of natural PIs (e. g. , the Bowman-Birk inhibitor) as anticarcinogens and the possible limitations of their use. In Chapter 3 (Kennedy), the transformation of C3HI lOTlh cells caused by carcinogens and promoters is shown to be suppressed by PIs. Bowman (Chapter 4) relates the discovery of inhibitors in soybeans that are distinct from the Kunitz inhibitor, and the occurrence of a similar inhibitor in peanuts and other legumes. Chapter 5 (Birk) is an overview of PIs of plant origin and their role in human nutrition | ||
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| illustrated | Not Illustrated |
| indexdate | 2024-07-10T08:36:30Z |
| institution | BVB |
| isbn | 9781461528821 |
| language | English |
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| spelling | Protease Inhibitors as Cancer Chemopreventive Agents edited by Walter Troll, Ann R. Kennedy Boston, MA Springer US 1993 1 Online-Ressource (XVIII, 315 p) txt rdacontent c rdamedia cr rdacarrier Protease inhibitors (PIs) are widely distributed in plants and animals, and have a variety of functions, which include preventing digestion of seeds by insects and modifying blood clotting in animals. After it was noted that synthetic and natural inhibitors suppress two-stage carcinogenesis and breast cancer, extensive work investigating PIs as chemopreventive agents was started. PIs are unique in that they interfere with cancer development in a variety of ways, including suppression of oxygen radicals, oncogenes, and metastases. Epidemiologic evidence supports their prevention of major human cancers in populations that consume foods containing them. Their supervised use in humans is on the threshold of development. The epidemiologic discovery of the importance of lentils and other seeds rich in PIs in preventing many human cancers allowed us to look at the action of PIs as chemopreventive agents, as reviewed in Chapter I (Fontham and Correa). Chapter 2 (Kennedy) discusses the role of natural PIs (e. g. , the Bowman-Birk inhibitor) as anticarcinogens and the possible limitations of their use. In Chapter 3 (Kennedy), the transformation of C3HI lOTlh cells caused by carcinogens and promoters is shown to be suppressed by PIs. Bowman (Chapter 4) relates the discovery of inhibitors in soybeans that are distinct from the Kunitz inhibitor, and the occurrence of a similar inhibitor in peanuts and other legumes. Chapter 5 (Birk) is an overview of PIs of plant origin and their role in human nutrition Oncology Biochemistry, general Oncology Biochemistry Chemotherapie (DE-588)4127083-6 gnd rswk-swf Krebs Medizin (DE-588)4073781-0 gnd rswk-swf Proteaseinhibitor (DE-588)4130450-0 gnd rswk-swf Krebs Medizin (DE-588)4073781-0 s Chemotherapie (DE-588)4127083-6 s Proteaseinhibitor (DE-588)4130450-0 s DE-604 Troll, Walter edt Kennedy, Ann R. edt Erscheint auch als Druck-Ausgabe 9780306443909 Erscheint auch als Druck-Ausgabe 9781461362494 Erscheint auch als Druck-Ausgabe 9781461528838 https://doi.org/10.1007/978-1-4615-2882-1 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Protease Inhibitors as Cancer Chemopreventive Agents Oncology Biochemistry, general Oncology Biochemistry Chemotherapie (DE-588)4127083-6 gnd Krebs Medizin (DE-588)4073781-0 gnd Proteaseinhibitor (DE-588)4130450-0 gnd |
| subject_GND | (DE-588)4127083-6 (DE-588)4073781-0 (DE-588)4130450-0 |
| title | Protease Inhibitors as Cancer Chemopreventive Agents |
| title_auth | Protease Inhibitors as Cancer Chemopreventive Agents |
| title_exact_search | Protease Inhibitors as Cancer Chemopreventive Agents |
| title_full | Protease Inhibitors as Cancer Chemopreventive Agents edited by Walter Troll, Ann R. Kennedy |
| title_fullStr | Protease Inhibitors as Cancer Chemopreventive Agents edited by Walter Troll, Ann R. Kennedy |
| title_full_unstemmed | Protease Inhibitors as Cancer Chemopreventive Agents edited by Walter Troll, Ann R. Kennedy |
| title_short | Protease Inhibitors as Cancer Chemopreventive Agents |
| title_sort | protease inhibitors as cancer chemopreventive agents |
| topic | Oncology Biochemistry, general Oncology Biochemistry Chemotherapie (DE-588)4127083-6 gnd Krebs Medizin (DE-588)4073781-0 gnd Proteaseinhibitor (DE-588)4130450-0 gnd |
| topic_facet | Oncology Biochemistry, general Oncology Biochemistry Chemotherapie Krebs Medizin Proteaseinhibitor |
| url | https://doi.org/10.1007/978-1-4615-2882-1 |
| work_keys_str_mv | AT trollwalter proteaseinhibitorsascancerchemopreventiveagents AT kennedyannr proteaseinhibitorsascancerchemopreventiveagents |