Blood Cell Biochemistry: Hematopoietic Cell Growth Factors and Their Receptors
Historically, the field of hematopoietic growth factor research began with the work of Carnot and Deflandre-in 1906 they suggested that the rate of erythropoiesis is regulated by a humoral factor found in the blood, namely, erythropoietin. From this comparatively early start, accelerating progress h...
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| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Boston, MA
Springer US
1996
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| Schriftenreihe: | Blood Cell Biochemistry
7 |
| Schlagworte: | |
| Online-Zugang: | UBR01 Volltext |
| Zusammenfassung: | Historically, the field of hematopoietic growth factor research began with the work of Carnot and Deflandre-in 1906 they suggested that the rate of erythropoiesis is regulated by a humoral factor found in the blood, namely, erythropoietin. From this comparatively early start, accelerating progress has been made in erythropoietin research, which demon strates the general trends in this field of study. Erythropoietin was purified to homogeneity by 1977 (from enormous quantities of urine from aplastic anemia patients). Subsequently, the gene for erythropoietin has been cloned (1985), and massive quantities of this growth factor have been produced for clinical trials (late 1980s onward). Erythropoietin has become established as a pharmaceutical product of great value in the treatment of a number of diseases, most notably chronic renal failure. Once the ligand had been cloned, interest turned to the erythropoietin receptor, which was cloned in 1989. Since then, structure/ function studies have been performed on receptor mutants, cellular signaling events down stream from the occupied receptor have been identified, and the specific producer cell types and molecular stimuli for erythropoietin production have been thoroughly investigated, as has the regulation of erythropoietin gene transcription. This schedule of events since the 1970s typifies that seen for a number of hematopoietic growth factors. Along the way, the hematopoietic growth factors have been recognized as members of the cytokine family of signaling molecules that are important in a number of different physiological and patholog ical situations (see below) |
| Beschreibung: | 1 Online-Ressource (XXIV, 420 p) |
| ISBN: | 9780585317281 |
| DOI: | 10.1007/978-0-585-31728-1 |
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| 520 | |a Historically, the field of hematopoietic growth factor research began with the work of Carnot and Deflandre-in 1906 they suggested that the rate of erythropoiesis is regulated by a humoral factor found in the blood, namely, erythropoietin. From this comparatively early start, accelerating progress has been made in erythropoietin research, which demon strates the general trends in this field of study. Erythropoietin was purified to homogeneity by 1977 (from enormous quantities of urine from aplastic anemia patients). Subsequently, the gene for erythropoietin has been cloned (1985), and massive quantities of this growth factor have been produced for clinical trials (late 1980s onward). Erythropoietin has become established as a pharmaceutical product of great value in the treatment of a number of diseases, most notably chronic renal failure. Once the ligand had been cloned, interest turned to the erythropoietin receptor, which was cloned in 1989. Since then, structure/ function studies have been performed on receptor mutants, cellular signaling events down stream from the occupied receptor have been identified, and the specific producer cell types and molecular stimuli for erythropoietin production have been thoroughly investigated, as has the regulation of erythropoietin gene transcription. This schedule of events since the 1970s typifies that seen for a number of hematopoietic growth factors. Along the way, the hematopoietic growth factors have been recognized as members of the cytokine family of signaling molecules that are important in a number of different physiological and patholog ical situations (see below) | ||
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Datensatz im Suchindex
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| spelling | Blood Cell Biochemistry Hematopoietic Cell Growth Factors and Their Receptors edited by Anthony D. Whetton, John Gordon Boston, MA Springer US 1996 1 Online-Ressource (XXIV, 420 p) txt rdacontent c rdamedia cr rdacarrier Blood Cell Biochemistry 7 Historically, the field of hematopoietic growth factor research began with the work of Carnot and Deflandre-in 1906 they suggested that the rate of erythropoiesis is regulated by a humoral factor found in the blood, namely, erythropoietin. From this comparatively early start, accelerating progress has been made in erythropoietin research, which demon strates the general trends in this field of study. Erythropoietin was purified to homogeneity by 1977 (from enormous quantities of urine from aplastic anemia patients). Subsequently, the gene for erythropoietin has been cloned (1985), and massive quantities of this growth factor have been produced for clinical trials (late 1980s onward). Erythropoietin has become established as a pharmaceutical product of great value in the treatment of a number of diseases, most notably chronic renal failure. Once the ligand had been cloned, interest turned to the erythropoietin receptor, which was cloned in 1989. Since then, structure/ function studies have been performed on receptor mutants, cellular signaling events down stream from the occupied receptor have been identified, and the specific producer cell types and molecular stimuli for erythropoietin production have been thoroughly investigated, as has the regulation of erythropoietin gene transcription. This schedule of events since the 1970s typifies that seen for a number of hematopoietic growth factors. Along the way, the hematopoietic growth factors have been recognized as members of the cytokine family of signaling molecules that are important in a number of different physiological and patholog ical situations (see below) Oncology Hematology Immunology Biochemistry, general Human Genetics Oncology Biochemistry Human genetics Rezeptor (DE-588)4049722-7 gnd rswk-swf Blutzelle (DE-588)4130604-1 gnd rswk-swf Wachstumsfaktor (DE-588)4188802-9 gnd rswk-swf Cytologie (DE-588)4070177-3 gnd rswk-swf Hämatopoese (DE-588)4113823-5 gnd rswk-swf Blutstammzelle (DE-588)4146093-5 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Blutstammzelle (DE-588)4146093-5 s Wachstumsfaktor (DE-588)4188802-9 s Rezeptor (DE-588)4049722-7 s DE-604 Blutzelle (DE-588)4130604-1 s Cytologie (DE-588)4070177-3 s Hämatopoese (DE-588)4113823-5 s Whetton, Anthony D. edt Gordon, John edt Erscheint auch als Druck-Ausgabe 9781475770520 Erscheint auch als Druck-Ausgabe 9780306452383 Erscheint auch als Druck-Ausgabe 9781475770513 https://doi.org/10.1007/978-0-585-31728-1 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Blood Cell Biochemistry Hematopoietic Cell Growth Factors and Their Receptors Oncology Hematology Immunology Biochemistry, general Human Genetics Oncology Biochemistry Human genetics Rezeptor (DE-588)4049722-7 gnd Blutzelle (DE-588)4130604-1 gnd Wachstumsfaktor (DE-588)4188802-9 gnd Cytologie (DE-588)4070177-3 gnd Hämatopoese (DE-588)4113823-5 gnd Blutstammzelle (DE-588)4146093-5 gnd |
| subject_GND | (DE-588)4049722-7 (DE-588)4130604-1 (DE-588)4188802-9 (DE-588)4070177-3 (DE-588)4113823-5 (DE-588)4146093-5 (DE-588)4143413-4 |
| title | Blood Cell Biochemistry Hematopoietic Cell Growth Factors and Their Receptors |
| title_auth | Blood Cell Biochemistry Hematopoietic Cell Growth Factors and Their Receptors |
| title_exact_search | Blood Cell Biochemistry Hematopoietic Cell Growth Factors and Their Receptors |
| title_full | Blood Cell Biochemistry Hematopoietic Cell Growth Factors and Their Receptors edited by Anthony D. Whetton, John Gordon |
| title_fullStr | Blood Cell Biochemistry Hematopoietic Cell Growth Factors and Their Receptors edited by Anthony D. Whetton, John Gordon |
| title_full_unstemmed | Blood Cell Biochemistry Hematopoietic Cell Growth Factors and Their Receptors edited by Anthony D. Whetton, John Gordon |
| title_short | Blood Cell Biochemistry |
| title_sort | blood cell biochemistry hematopoietic cell growth factors and their receptors |
| title_sub | Hematopoietic Cell Growth Factors and Their Receptors |
| topic | Oncology Hematology Immunology Biochemistry, general Human Genetics Oncology Biochemistry Human genetics Rezeptor (DE-588)4049722-7 gnd Blutzelle (DE-588)4130604-1 gnd Wachstumsfaktor (DE-588)4188802-9 gnd Cytologie (DE-588)4070177-3 gnd Hämatopoese (DE-588)4113823-5 gnd Blutstammzelle (DE-588)4146093-5 gnd |
| topic_facet | Oncology Hematology Immunology Biochemistry, general Human Genetics Oncology Biochemistry Human genetics Rezeptor Blutzelle Wachstumsfaktor Cytologie Hämatopoese Blutstammzelle Aufsatzsammlung |
| url | https://doi.org/10.1007/978-0-585-31728-1 |
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