Blood—Brain Barrier: Drug Delivery and Brain Pathology
The vasculature of the central nervous system (eNS) is characterized by the existence of the blood-brain barrier (BBB), which can be regarded as both an anatomical and physiological phenomenon. The BBB is formed by a complex cellular system of endothelial cells, astroglia, pericytes, perivascular ma...
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| Format: | Elektronisch E-Book |
| Sprache: | English |
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Boston, MA
Springer US
2001
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| Schlagworte: | |
| Online-Zugang: | UBR01 Volltext |
| Zusammenfassung: | The vasculature of the central nervous system (eNS) is characterized by the existence of the blood-brain barrier (BBB), which can be regarded as both an anatomical and physiological phenomenon. The BBB is formed by a complex cellular system of endothelial cells, astroglia, pericytes, perivascular macrophages and a basal membrane, although the anatomic substrate of the BBB is the interendothelial tight junctions that form a continuous sealing. The BBB serves as an exquisitely controlled, functional gate to the eNS. It not only protects the brain from agents in the blood that could impair neurological function, but also controls the influx and efflux of numerous substances to maintain proper homeostasis and provide the brain with necessary nutrients. The structural and functional integrity of the BBB was shown to be dramatically altered during various diseases of the eNS, including neoplasia, ischemia, trauma, hypertension, inflammation and epilepsy. Recent years research has partially elucidated the mechanisms underlying the development of some of these brain disorders as well as the pathways used by different pathogens, like bacteria and viruses, to initiate eNS infections. The development of in vitro models of the BBB had instrumental role in the understanding of the involvement of the BBB in the pathogenesis of several eNS diseases. The intimate, functional association between the function of the brain and the activity of the BBB makes the later a target for pharmacological modulation that will expand the therapeutic possibilities for a range of neurological diseases |
| Beschreibung: | 1 Online-Ressource (XII, 434 p) |
| ISBN: | 9781461505792 |
| DOI: | 10.1007/978-1-4615-0579-2 |
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| author2 | Kobiler, David Lustig, Shlomo Shapira, Shlomo |
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| discipline | Biologie Medizin |
| doi_str_mv | 10.1007/978-1-4615-0579-2 |
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| spelling | Blood—Brain Barrier Drug Delivery and Brain Pathology edited by David Kobiler, Shlomo Lustig, Shlomo Shapira Proceedings of the 44th OHOLO Conference on Blood-Brain Barrier: Drug Delivery and Brain Pathology, held September 10-14, 2000, Dead Sea, Israel Boston, MA Springer US 2001 1 Online-Ressource (XII, 434 p) txt rdacontent c rdamedia cr rdacarrier The vasculature of the central nervous system (eNS) is characterized by the existence of the blood-brain barrier (BBB), which can be regarded as both an anatomical and physiological phenomenon. The BBB is formed by a complex cellular system of endothelial cells, astroglia, pericytes, perivascular macrophages and a basal membrane, although the anatomic substrate of the BBB is the interendothelial tight junctions that form a continuous sealing. The BBB serves as an exquisitely controlled, functional gate to the eNS. It not only protects the brain from agents in the blood that could impair neurological function, but also controls the influx and efflux of numerous substances to maintain proper homeostasis and provide the brain with necessary nutrients. The structural and functional integrity of the BBB was shown to be dramatically altered during various diseases of the eNS, including neoplasia, ischemia, trauma, hypertension, inflammation and epilepsy. Recent years research has partially elucidated the mechanisms underlying the development of some of these brain disorders as well as the pathways used by different pathogens, like bacteria and viruses, to initiate eNS infections. The development of in vitro models of the BBB had instrumental role in the understanding of the involvement of the BBB in the pathogenesis of several eNS diseases. The intimate, functional association between the function of the brain and the activity of the BBB makes the later a target for pharmacological modulation that will expand the therapeutic possibilities for a range of neurological diseases Neurology Neurosciences Veterinary Medicine/Veterinary Science Pathology Veterinary medicine Arzneimittel (DE-588)4003115-9 gnd rswk-swf Hirnkrankheit (DE-588)4025013-1 gnd rswk-swf Wirkstofffreisetzung (DE-588)4190018-2 gnd rswk-swf Blut-Hirn-Schranke (DE-588)4007279-4 gnd rswk-swf Stofftransport Biologie (DE-588)4443397-9 gnd rswk-swf 1\p (DE-588)1071861417 Konferenzschrift gnd-content Blut-Hirn-Schranke (DE-588)4007279-4 s Arzneimittel (DE-588)4003115-9 s Stofftransport Biologie (DE-588)4443397-9 s 2\p DE-604 Wirkstofffreisetzung (DE-588)4190018-2 s 3\p DE-604 Hirnkrankheit (DE-588)4025013-1 s 4\p DE-604 Kobiler, David edt Lustig, Shlomo edt Shapira, Shlomo edt Erscheint auch als Druck-Ausgabe 9780306467080 Erscheint auch als Druck-Ausgabe 9781461351412 Erscheint auch als Druck-Ausgabe 9781461505808 https://doi.org/10.1007/978-1-4615-0579-2 Verlag URL des Erstveröffentlichers Volltext 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 2\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 3\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 4\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Blood—Brain Barrier Drug Delivery and Brain Pathology Neurology Neurosciences Veterinary Medicine/Veterinary Science Pathology Veterinary medicine Arzneimittel (DE-588)4003115-9 gnd Hirnkrankheit (DE-588)4025013-1 gnd Wirkstofffreisetzung (DE-588)4190018-2 gnd Blut-Hirn-Schranke (DE-588)4007279-4 gnd Stofftransport Biologie (DE-588)4443397-9 gnd |
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| title | Blood—Brain Barrier Drug Delivery and Brain Pathology |
| title_alt | Proceedings of the 44th OHOLO Conference on Blood-Brain Barrier: Drug Delivery and Brain Pathology, held September 10-14, 2000, Dead Sea, Israel |
| title_auth | Blood—Brain Barrier Drug Delivery and Brain Pathology |
| title_exact_search | Blood—Brain Barrier Drug Delivery and Brain Pathology |
| title_full | Blood—Brain Barrier Drug Delivery and Brain Pathology edited by David Kobiler, Shlomo Lustig, Shlomo Shapira |
| title_fullStr | Blood—Brain Barrier Drug Delivery and Brain Pathology edited by David Kobiler, Shlomo Lustig, Shlomo Shapira |
| title_full_unstemmed | Blood—Brain Barrier Drug Delivery and Brain Pathology edited by David Kobiler, Shlomo Lustig, Shlomo Shapira |
| title_short | Blood—Brain Barrier |
| title_sort | blood brain barrier drug delivery and brain pathology |
| title_sub | Drug Delivery and Brain Pathology |
| topic | Neurology Neurosciences Veterinary Medicine/Veterinary Science Pathology Veterinary medicine Arzneimittel (DE-588)4003115-9 gnd Hirnkrankheit (DE-588)4025013-1 gnd Wirkstofffreisetzung (DE-588)4190018-2 gnd Blut-Hirn-Schranke (DE-588)4007279-4 gnd Stofftransport Biologie (DE-588)4443397-9 gnd |
| topic_facet | Neurology Neurosciences Veterinary Medicine/Veterinary Science Pathology Veterinary medicine Arzneimittel Hirnkrankheit Wirkstofffreisetzung Blut-Hirn-Schranke Stofftransport Biologie Konferenzschrift |
| url | https://doi.org/10.1007/978-1-4615-0579-2 |
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