Hereditary Colorectal Cancer: Proceedings of the Fourth International Symposium on Colorectal Cancer (ISCC-4) November 9–11, 1989, Kobe Japan
Since the success in chemical induction of cancer in rabbit's ear skin by K. Yamagiwa in 1915, oncologists of the world have come to believe that they can only solve their problems by means of animal experimen tation. The importance of environmental factors became moreevident in 1935 when T. Y...
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| Weitere Verfasser: | , |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Tokyo
Springer Japan
1990
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| Schlagworte: | |
| Online-Zugang: | UBR01 Volltext |
| Zusammenfassung: | Since the success in chemical induction of cancer in rabbit's ear skin by K. Yamagiwa in 1915, oncologists of the world have come to believe that they can only solve their problems by means of animal experimen tation. The importance of environmental factors became moreevident in 1935 when T. Yoshida and T. Sasaki introduced azodye hepatocarcino genesis in rats. In the domain of the gastrointestinal tract, T. Sugimura has more recently accumulated enough evidence to indicate that locally active chemical mutagens are carcinogenic. In contrast, principal approaches to colorectal tumors have been quite different: emphasis has been placed on gene identification. Long before cancer of the large bowel was recognized, importance of the roles of adenomatosis coli and its familial occurrence attracted the attention of epidemiologists and geneticists. Morphological characteri zation and analysis of hereditary trends of human material have already bad a long history, and recently detailed analysis of genetic material has become feasible in the wake of rapid development in our knowledge of the oncoviruses, oncogenes, suppressor genes, chromosomal and DNA mapping, molecular mutation and so on. lt is true that in colorectal pathology, and in no other field, these areas of research have been explored more extensively and decisively. The identification of previ ously ill-defined lesions such as precancers and benign neoplasms have been improved because sequential changes can be observed in multiple samples spread over a wide area and followed up in due course |
| Beschreibung: | 1 Online-Ressource (XXIV, 575 p. 51 illus) |
| ISBN: | 9784431683377 |
| DOI: | 10.1007/978-4-431-68337-7 |
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| 520 | |a Since the success in chemical induction of cancer in rabbit's ear skin by K. Yamagiwa in 1915, oncologists of the world have come to believe that they can only solve their problems by means of animal experimen tation. The importance of environmental factors became moreevident in 1935 when T. Yoshida and T. Sasaki introduced azodye hepatocarcino genesis in rats. In the domain of the gastrointestinal tract, T. Sugimura has more recently accumulated enough evidence to indicate that locally active chemical mutagens are carcinogenic. In contrast, principal approaches to colorectal tumors have been quite different: emphasis has been placed on gene identification. Long before cancer of the large bowel was recognized, importance of the roles of adenomatosis coli and its familial occurrence attracted the attention of epidemiologists and geneticists. Morphological characteri zation and analysis of hereditary trends of human material have already bad a long history, and recently detailed analysis of genetic material has become feasible in the wake of rapid development in our knowledge of the oncoviruses, oncogenes, suppressor genes, chromosomal and DNA mapping, molecular mutation and so on. lt is true that in colorectal pathology, and in no other field, these areas of research have been explored more extensively and decisively. The identification of previ ously ill-defined lesions such as precancers and benign neoplasms have been improved because sequential changes can be observed in multiple samples spread over a wide area and followed up in due course | ||
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Datensatz im Suchindex
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| author2 | Utsunomiya, Joji Lynch, Henry T. |
| author2_role | edt edt |
| author2_variant | j u ju h t l ht htl |
| author_facet | Utsunomiya, Joji Lynch, Henry T. |
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| dewey-full | 617 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 617 - Surgery & related medical specialties |
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| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| doi_str_mv | 10.1007/978-4-431-68337-7 |
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| isbn | 9784431683377 |
| language | English |
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| spelling | Hereditary Colorectal Cancer Proceedings of the Fourth International Symposium on Colorectal Cancer (ISCC-4) November 9–11, 1989, Kobe Japan edited by Joji Utsunomiya, Henry T. Lynch Tokyo Springer Japan 1990 1 Online-Ressource (XXIV, 575 p. 51 illus) txt rdacontent c rdamedia cr rdacarrier Since the success in chemical induction of cancer in rabbit's ear skin by K. Yamagiwa in 1915, oncologists of the world have come to believe that they can only solve their problems by means of animal experimen tation. The importance of environmental factors became moreevident in 1935 when T. Yoshida and T. Sasaki introduced azodye hepatocarcino genesis in rats. In the domain of the gastrointestinal tract, T. Sugimura has more recently accumulated enough evidence to indicate that locally active chemical mutagens are carcinogenic. In contrast, principal approaches to colorectal tumors have been quite different: emphasis has been placed on gene identification. Long before cancer of the large bowel was recognized, importance of the roles of adenomatosis coli and its familial occurrence attracted the attention of epidemiologists and geneticists. Morphological characteri zation and analysis of hereditary trends of human material have already bad a long history, and recently detailed analysis of genetic material has become feasible in the wake of rapid development in our knowledge of the oncoviruses, oncogenes, suppressor genes, chromosomal and DNA mapping, molecular mutation and so on. lt is true that in colorectal pathology, and in no other field, these areas of research have been explored more extensively and decisively. The identification of previ ously ill-defined lesions such as precancers and benign neoplasms have been improved because sequential changes can be observed in multiple samples spread over a wide area and followed up in due course General Surgery Oncology Hepatology Gastroenterology Surgery Oncology Clinical medicine Erbkrankheit (DE-588)4015106-2 gnd rswk-swf Vererbung (DE-588)4187668-4 gnd rswk-swf Dickdarmkrebs (DE-588)4012122-7 gnd rswk-swf (DE-588)1071861417 Konferenzschrift 1989 Kobe gnd-content Dickdarmkrebs (DE-588)4012122-7 s Erbkrankheit (DE-588)4015106-2 s DE-604 Vererbung (DE-588)4187668-4 s Utsunomiya, Joji edt Lynch, Henry T. edt Erscheint auch als Druck-Ausgabe 9784431683391 Erscheint auch als Druck-Ausgabe 9784431683384 Erscheint auch als Druck-Ausgabe 9784431700524 https://doi.org/10.1007/978-4-431-68337-7 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Hereditary Colorectal Cancer Proceedings of the Fourth International Symposium on Colorectal Cancer (ISCC-4) November 9–11, 1989, Kobe Japan General Surgery Oncology Hepatology Gastroenterology Surgery Oncology Clinical medicine Erbkrankheit (DE-588)4015106-2 gnd Vererbung (DE-588)4187668-4 gnd Dickdarmkrebs (DE-588)4012122-7 gnd |
| subject_GND | (DE-588)4015106-2 (DE-588)4187668-4 (DE-588)4012122-7 (DE-588)1071861417 |
| title | Hereditary Colorectal Cancer Proceedings of the Fourth International Symposium on Colorectal Cancer (ISCC-4) November 9–11, 1989, Kobe Japan |
| title_auth | Hereditary Colorectal Cancer Proceedings of the Fourth International Symposium on Colorectal Cancer (ISCC-4) November 9–11, 1989, Kobe Japan |
| title_exact_search | Hereditary Colorectal Cancer Proceedings of the Fourth International Symposium on Colorectal Cancer (ISCC-4) November 9–11, 1989, Kobe Japan |
| title_full | Hereditary Colorectal Cancer Proceedings of the Fourth International Symposium on Colorectal Cancer (ISCC-4) November 9–11, 1989, Kobe Japan edited by Joji Utsunomiya, Henry T. Lynch |
| title_fullStr | Hereditary Colorectal Cancer Proceedings of the Fourth International Symposium on Colorectal Cancer (ISCC-4) November 9–11, 1989, Kobe Japan edited by Joji Utsunomiya, Henry T. Lynch |
| title_full_unstemmed | Hereditary Colorectal Cancer Proceedings of the Fourth International Symposium on Colorectal Cancer (ISCC-4) November 9–11, 1989, Kobe Japan edited by Joji Utsunomiya, Henry T. Lynch |
| title_short | Hereditary Colorectal Cancer |
| title_sort | hereditary colorectal cancer proceedings of the fourth international symposium on colorectal cancer iscc 4 november 9 11 1989 kobe japan |
| title_sub | Proceedings of the Fourth International Symposium on Colorectal Cancer (ISCC-4) November 9–11, 1989, Kobe Japan |
| topic | General Surgery Oncology Hepatology Gastroenterology Surgery Oncology Clinical medicine Erbkrankheit (DE-588)4015106-2 gnd Vererbung (DE-588)4187668-4 gnd Dickdarmkrebs (DE-588)4012122-7 gnd |
| topic_facet | General Surgery Oncology Hepatology Gastroenterology Surgery Oncology Clinical medicine Erbkrankheit Vererbung Dickdarmkrebs Konferenzschrift 1989 Kobe |
| url | https://doi.org/10.1007/978-4-431-68337-7 |
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