The Polymerase Chain Reaction:
James D. Watson When, in late March of 1953, Francis Crick and I came to write the first Nature paper describing the double helical structure of the DNA molecule, Francis had wanted to include a lengthy discussion of the genetic implications of a molecule whose struc ture we had divined from a mini...
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| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Boston, MA
Birkhäuser Boston
1994
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| Online-Zugang: | UBR01 URL des Erstveröffentlichers |
| Zusammenfassung: | James D. Watson When, in late March of 1953, Francis Crick and I came to write the first Nature paper describing the double helical structure of the DNA molecule, Francis had wanted to include a lengthy discussion of the genetic implications of a molecule whose struc ture we had divined from a minimum of experimental data and on theoretical argu ments based on physical principles. But I felt that this might be tempting fate, given that we had not yet seen the detailed evidence from King's College. Nevertheless, we reached a compromise and decided to include a sentence that pointed to the biological significance of the molecule's key feature-the complementary pairing of the bases. "It has not escaped our notice," Francis wrote, "that the specific pairing that we have postulated immediately suggests a possible copying mechanism for the genetic material." By May, when we were writing the second Nature paper, I was more confident that the proposed structure was at the very least substantially correct, so that this second paper contains a discussion of molecular self-duplication using templates or molds. We pointed out that, as a consequence of base pairing, a DNA molecule has two chains that are complementary to each other. Each chain could then act ". . . as a template for the formation on itself of a new companion chain, so that eventually we shall have two pairs of chains, where we only had one before" and, moreover, " .. |
| Beschreibung: | 1 Online-Ressource (XXII, 458 p. 85 illus) |
| ISBN: | 9781461202578 |
| DOI: | 10.1007/978-1-4612-0257-8 |
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| 520 | |a James D. Watson When, in late March of 1953, Francis Crick and I came to write the first Nature paper describing the double helical structure of the DNA molecule, Francis had wanted to include a lengthy discussion of the genetic implications of a molecule whose struc ture we had divined from a minimum of experimental data and on theoretical argu ments based on physical principles. But I felt that this might be tempting fate, given that we had not yet seen the detailed evidence from King's College. Nevertheless, we reached a compromise and decided to include a sentence that pointed to the biological significance of the molecule's key feature-the complementary pairing of the bases. "It has not escaped our notice," Francis wrote, "that the specific pairing that we have postulated immediately suggests a possible copying mechanism for the genetic material." By May, when we were writing the second Nature paper, I was more confident that the proposed structure was at the very least substantially correct, so that this second paper contains a discussion of molecular self-duplication using templates or molds. We pointed out that, as a consequence of base pairing, a DNA molecule has two chains that are complementary to each other. Each chain could then act ". . . as a template for the formation on itself of a new companion chain, so that eventually we shall have two pairs of chains, where we only had one before" and, moreover, " .. | ||
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| spelling | The Polymerase Chain Reaction edited by Kary B. Mullis, François Ferré, Richard A. Gibbs Boston, MA Birkhäuser Boston 1994 1 Online-Ressource (XXII, 458 p. 85 illus) txt rdacontent c rdamedia cr rdacarrier James D. Watson When, in late March of 1953, Francis Crick and I came to write the first Nature paper describing the double helical structure of the DNA molecule, Francis had wanted to include a lengthy discussion of the genetic implications of a molecule whose struc ture we had divined from a minimum of experimental data and on theoretical argu ments based on physical principles. But I felt that this might be tempting fate, given that we had not yet seen the detailed evidence from King's College. Nevertheless, we reached a compromise and decided to include a sentence that pointed to the biological significance of the molecule's key feature-the complementary pairing of the bases. "It has not escaped our notice," Francis wrote, "that the specific pairing that we have postulated immediately suggests a possible copying mechanism for the genetic material." By May, when we were writing the second Nature paper, I was more confident that the proposed structure was at the very least substantially correct, so that this second paper contains a discussion of molecular self-duplication using templates or molds. We pointed out that, as a consequence of base pairing, a DNA molecule has two chains that are complementary to each other. Each chain could then act ". . . as a template for the formation on itself of a new companion chain, so that eventually we shall have two pairs of chains, where we only had one before" and, moreover, " .. Pharmacy Polymerase-Kettenreaktion (DE-588)4256726-9 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Polymerase-Kettenreaktion (DE-588)4256726-9 s DE-604 Mullis, Kary B. edt Ferré, François edt Gibbs, Richard A. edt Erscheint auch als Druck-Ausgabe 9780817636074 Erscheint auch als Druck-Ausgabe 9780817637507 Erscheint auch als Druck-Ausgabe 9781461202585 https://doi.org/10.1007/978-1-4612-0257-8 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | The Polymerase Chain Reaction Pharmacy Polymerase-Kettenreaktion (DE-588)4256726-9 gnd |
| subject_GND | (DE-588)4256726-9 (DE-588)4143413-4 |
| title | The Polymerase Chain Reaction |
| title_auth | The Polymerase Chain Reaction |
| title_exact_search | The Polymerase Chain Reaction |
| title_full | The Polymerase Chain Reaction edited by Kary B. Mullis, François Ferré, Richard A. Gibbs |
| title_fullStr | The Polymerase Chain Reaction edited by Kary B. Mullis, François Ferré, Richard A. Gibbs |
| title_full_unstemmed | The Polymerase Chain Reaction edited by Kary B. Mullis, François Ferré, Richard A. Gibbs |
| title_short | The Polymerase Chain Reaction |
| title_sort | the polymerase chain reaction |
| topic | Pharmacy Polymerase-Kettenreaktion (DE-588)4256726-9 gnd |
| topic_facet | Pharmacy Polymerase-Kettenreaktion Aufsatzsammlung |
| url | https://doi.org/10.1007/978-1-4612-0257-8 |
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