New Paradigms of Coronary Artery Disease: Hibernation, Stunning, Ischemic Preconditioning
Detailed analyses of regional myocardial blood flow, function, metabolism and morphology in ischemic and reperfused myocardium have led to the identifi cation of important phenomena, i. e. , myocardial hibernation, myocardial stun ning and ischemic preconditioning. Both the hibernating and the stu...
Gespeichert in:
| Weitere Verfasser: | , |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Heidelberg
Steinkopff
1996
|
| Schlagworte: | |
| Online-Zugang: | UBR01 URL des Erstveröffentlichers |
| Zusammenfassung: | Detailed analyses of regional myocardial blood flow, function, metabolism and morphology in ischemic and reperfused myocardium have led to the identifi cation of important phenomena, i. e. , myocardial hibernation, myocardial stun ning and ischemic preconditioning. Both the hibernating and the stunned myocardium characterize viable though dysfunctional as distinguished from necrotic tissue. With the advent of reperfusion procedures, the distinction between reversibly injured, hypofunctional myocardium from irreversibly injured, hypofunctional myocardium is of utmost clinical importance. The pathophysiological distinction of hibernating and stunned myocardium is con troversial, but reperfusion is mandatory anyway. Ischemic preconditioning is the most powerful maneuver known so far to delay infarct development. Its clinical significance has been suggested from retrospective analyses of data from patients suffering a myocardial infarction as well as from controlled PTCA studies. Whether or not preconditioning can be achieved pharmacologically in the clinical setting remains to be established. The mechanisms and signal cascade underlying myocardial hibernation, myocardial stunning and ischemic preconditioning are not clear in detail. Over the last year, focussed issues on myocardial hibernation, myocardial stunning and ischemic preconditioning were published in Basic Research in Car diology; they have received great interest and a good response. Therefore, these focussed issues are now combined and published as a separate monograph. We express our gratitude once more to all our colleagues who contributed to this monograph, to Ms. Ibkendanz of Steinkopff, and to Ms. Philipp and Mr. Heinrichs from Bayer AG Germany, who supported this additional publication |
| Beschreibung: | 1 Online-Ressource (VIII, 182 p. 96 illus) |
| ISBN: | 9783642537936 |
| DOI: | 10.1007/978-3-642-53793-6 |
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| 520 | |a Detailed analyses of regional myocardial blood flow, function, metabolism and morphology in ischemic and reperfused myocardium have led to the identifi cation of important phenomena, i. e. , myocardial hibernation, myocardial stun ning and ischemic preconditioning. Both the hibernating and the stunned myocardium characterize viable though dysfunctional as distinguished from necrotic tissue. With the advent of reperfusion procedures, the distinction between reversibly injured, hypofunctional myocardium from irreversibly injured, hypofunctional myocardium is of utmost clinical importance. The pathophysiological distinction of hibernating and stunned myocardium is con troversial, but reperfusion is mandatory anyway. Ischemic preconditioning is the most powerful maneuver known so far to delay infarct development. Its clinical significance has been suggested from retrospective analyses of data from patients suffering a myocardial infarction as well as from controlled PTCA studies. Whether or not preconditioning can be achieved pharmacologically in the clinical setting remains to be established. The mechanisms and signal cascade underlying myocardial hibernation, myocardial stunning and ischemic preconditioning are not clear in detail. Over the last year, focussed issues on myocardial hibernation, myocardial stunning and ischemic preconditioning were published in Basic Research in Car diology; they have received great interest and a good response. Therefore, these focussed issues are now combined and published as a separate monograph. We express our gratitude once more to all our colleagues who contributed to this monograph, to Ms. Ibkendanz of Steinkopff, and to Ms. Philipp and Mr. Heinrichs from Bayer AG Germany, who supported this additional publication | ||
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| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| doi_str_mv | 10.1007/978-3-642-53793-6 |
| format | Electronic eBook |
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| id | DE-604.BV046145711 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-10T08:36:28Z |
| institution | BVB |
| isbn | 9783642537936 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-031525896 |
| oclc_num | 1119114698 |
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| physical | 1 Online-Ressource (VIII, 182 p. 96 illus) |
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| publishDate | 1996 |
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| publisher | Steinkopff |
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| spelling | New Paradigms of Coronary Artery Disease Hibernation, Stunning, Ischemic Preconditioning edited by Gerd Heusch, Rainer Schulz Heidelberg Steinkopff 1996 1 Online-Ressource (VIII, 182 p. 96 illus) txt rdacontent c rdamedia cr rdacarrier Detailed analyses of regional myocardial blood flow, function, metabolism and morphology in ischemic and reperfused myocardium have led to the identifi cation of important phenomena, i. e. , myocardial hibernation, myocardial stun ning and ischemic preconditioning. Both the hibernating and the stunned myocardium characterize viable though dysfunctional as distinguished from necrotic tissue. With the advent of reperfusion procedures, the distinction between reversibly injured, hypofunctional myocardium from irreversibly injured, hypofunctional myocardium is of utmost clinical importance. The pathophysiological distinction of hibernating and stunned myocardium is con troversial, but reperfusion is mandatory anyway. Ischemic preconditioning is the most powerful maneuver known so far to delay infarct development. Its clinical significance has been suggested from retrospective analyses of data from patients suffering a myocardial infarction as well as from controlled PTCA studies. Whether or not preconditioning can be achieved pharmacologically in the clinical setting remains to be established. The mechanisms and signal cascade underlying myocardial hibernation, myocardial stunning and ischemic preconditioning are not clear in detail. Over the last year, focussed issues on myocardial hibernation, myocardial stunning and ischemic preconditioning were published in Basic Research in Car diology; they have received great interest and a good response. Therefore, these focussed issues are now combined and published as a separate monograph. We express our gratitude once more to all our colleagues who contributed to this monograph, to Ms. Ibkendanz of Steinkopff, and to Ms. Philipp and Mr. Heinrichs from Bayer AG Germany, who supported this additional publication Cardiology Pathophysiologie (DE-588)4044898-8 gnd rswk-swf Koronare Herzkrankheit (DE-588)4073731-7 gnd rswk-swf Koronare Herzkrankheit (DE-588)4073731-7 s Pathophysiologie (DE-588)4044898-8 s DE-604 Heusch, Gerd edt Schulz, Rainer edt Erscheint auch als Druck-Ausgabe 9783798510593 Erscheint auch als Druck-Ausgabe 9783642537943 https://doi.org/10.1007/978-3-642-53793-6 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | New Paradigms of Coronary Artery Disease Hibernation, Stunning, Ischemic Preconditioning Cardiology Pathophysiologie (DE-588)4044898-8 gnd Koronare Herzkrankheit (DE-588)4073731-7 gnd |
| subject_GND | (DE-588)4044898-8 (DE-588)4073731-7 |
| title | New Paradigms of Coronary Artery Disease Hibernation, Stunning, Ischemic Preconditioning |
| title_auth | New Paradigms of Coronary Artery Disease Hibernation, Stunning, Ischemic Preconditioning |
| title_exact_search | New Paradigms of Coronary Artery Disease Hibernation, Stunning, Ischemic Preconditioning |
| title_full | New Paradigms of Coronary Artery Disease Hibernation, Stunning, Ischemic Preconditioning edited by Gerd Heusch, Rainer Schulz |
| title_fullStr | New Paradigms of Coronary Artery Disease Hibernation, Stunning, Ischemic Preconditioning edited by Gerd Heusch, Rainer Schulz |
| title_full_unstemmed | New Paradigms of Coronary Artery Disease Hibernation, Stunning, Ischemic Preconditioning edited by Gerd Heusch, Rainer Schulz |
| title_short | New Paradigms of Coronary Artery Disease |
| title_sort | new paradigms of coronary artery disease hibernation stunning ischemic preconditioning |
| title_sub | Hibernation, Stunning, Ischemic Preconditioning |
| topic | Cardiology Pathophysiologie (DE-588)4044898-8 gnd Koronare Herzkrankheit (DE-588)4073731-7 gnd |
| topic_facet | Cardiology Pathophysiologie Koronare Herzkrankheit |
| url | https://doi.org/10.1007/978-3-642-53793-6 |
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