Inheritance of Kidney and Urinary Tract Diseases:
Genetic disorders have emerged as a prominent cause of morbidity and mor tality among infants and adults. As many as 10% to 20% of hospital admis sions and at least 10% of the mortality in this age group are due to inherited diseases. There are at least two factors that have brought genetic disord...
Gespeichert in:
| Weitere Verfasser: | , |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Boston, MA
Springer US
1990
|
| Schriftenreihe: | Topics in Renal Medicine
9 |
| Schlagworte: | |
| Online-Zugang: | UBR01 Volltext |
| Zusammenfassung: | Genetic disorders have emerged as a prominent cause of morbidity and mor tality among infants and adults. As many as 10% to 20% of hospital admis sions and at least 10% of the mortality in this age group are due to inherited diseases. There are at least two factors that have brought genetic disorders into the forefront of pediatrics. One is a great reduction in childhood mortality due to infections and nutritional deficiency states, and the other is the rapid progress made in the identification of genetic defects. Amniocentesis, chorionic villus sampling, and recombinant DNA technology have already had a tremendous impact on the practice of medicine. This is why the first two chapters of this volume are dedicated to general principles of molecular genetics and to a description of the techniques used to diagnose genetic disorders at the DNA level. The relevance of this new area of science to the study of inherited renal diseases is reflected in the large body of knowledge that has been generated regarding the association between various glomerular nephritides and genetic markers such as the HLA system, and even more impressively in the direct or indirect identification of abnormal genes or gene products in Alport's syn drome, autosomal dominant polycystic kidney disease, and Lowe's syndrome. These discoveries figure prominently in the pages of this book. Yet, the progress we have made has barely scratched the surface of the problem |
| Beschreibung: | 1 Online-Ressource (XIV, 450 p) |
| ISBN: | 9781461316039 |
| DOI: | 10.1007/978-1-4613-1603-9 |
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| 520 | |a Genetic disorders have emerged as a prominent cause of morbidity and mor tality among infants and adults. As many as 10% to 20% of hospital admis sions and at least 10% of the mortality in this age group are due to inherited diseases. There are at least two factors that have brought genetic disorders into the forefront of pediatrics. One is a great reduction in childhood mortality due to infections and nutritional deficiency states, and the other is the rapid progress made in the identification of genetic defects. Amniocentesis, chorionic villus sampling, and recombinant DNA technology have already had a tremendous impact on the practice of medicine. This is why the first two chapters of this volume are dedicated to general principles of molecular genetics and to a description of the techniques used to diagnose genetic disorders at the DNA level. The relevance of this new area of science to the study of inherited renal diseases is reflected in the large body of knowledge that has been generated regarding the association between various glomerular nephritides and genetic markers such as the HLA system, and even more impressively in the direct or indirect identification of abnormal genes or gene products in Alport's syn drome, autosomal dominant polycystic kidney disease, and Lowe's syndrome. These discoveries figure prominently in the pages of this book. Yet, the progress we have made has barely scratched the surface of the problem | ||
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Datensatz im Suchindex
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| any_adam_object | |
| author2 | Spitzer, Adrian Avner, Ellis D. |
| author2_role | edt edt |
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| dewey-full | 616.61 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
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| dewey-sort | 3616.61 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
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| spelling | Inheritance of Kidney and Urinary Tract Diseases edited by Adrian Spitzer, Ellis D. Avner Boston, MA Springer US 1990 1 Online-Ressource (XIV, 450 p) txt rdacontent c rdamedia cr rdacarrier Topics in Renal Medicine 9 Genetic disorders have emerged as a prominent cause of morbidity and mor tality among infants and adults. As many as 10% to 20% of hospital admis sions and at least 10% of the mortality in this age group are due to inherited diseases. There are at least two factors that have brought genetic disorders into the forefront of pediatrics. One is a great reduction in childhood mortality due to infections and nutritional deficiency states, and the other is the rapid progress made in the identification of genetic defects. Amniocentesis, chorionic villus sampling, and recombinant DNA technology have already had a tremendous impact on the practice of medicine. This is why the first two chapters of this volume are dedicated to general principles of molecular genetics and to a description of the techniques used to diagnose genetic disorders at the DNA level. The relevance of this new area of science to the study of inherited renal diseases is reflected in the large body of knowledge that has been generated regarding the association between various glomerular nephritides and genetic markers such as the HLA system, and even more impressively in the direct or indirect identification of abnormal genes or gene products in Alport's syn drome, autosomal dominant polycystic kidney disease, and Lowe's syndrome. These discoveries figure prominently in the pages of this book. Yet, the progress we have made has barely scratched the surface of the problem Nephrology Urology Harnwegskrankheit (DE-588)4135486-2 gnd rswk-swf Nierenkrankheit (DE-588)4075399-2 gnd rswk-swf Erblichkeit (DE-588)4152594-2 gnd rswk-swf 1\p (DE-588)4143413-4 Aufsatzsammlung gnd-content Harnwegskrankheit (DE-588)4135486-2 s Erblichkeit (DE-588)4152594-2 s 2\p DE-604 Nierenkrankheit (DE-588)4075399-2 s 3\p DE-604 Spitzer, Adrian edt Avner, Ellis D. edt Erscheint auch als Druck-Ausgabe 9781461288879 Erscheint auch als Druck-Ausgabe 9780792302872 Erscheint auch als Druck-Ausgabe 9781461316046 https://doi.org/10.1007/978-1-4613-1603-9 Verlag URL des Erstveröffentlichers Volltext 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 2\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 3\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Inheritance of Kidney and Urinary Tract Diseases Nephrology Urology Harnwegskrankheit (DE-588)4135486-2 gnd Nierenkrankheit (DE-588)4075399-2 gnd Erblichkeit (DE-588)4152594-2 gnd |
| subject_GND | (DE-588)4135486-2 (DE-588)4075399-2 (DE-588)4152594-2 (DE-588)4143413-4 |
| title | Inheritance of Kidney and Urinary Tract Diseases |
| title_auth | Inheritance of Kidney and Urinary Tract Diseases |
| title_exact_search | Inheritance of Kidney and Urinary Tract Diseases |
| title_full | Inheritance of Kidney and Urinary Tract Diseases edited by Adrian Spitzer, Ellis D. Avner |
| title_fullStr | Inheritance of Kidney and Urinary Tract Diseases edited by Adrian Spitzer, Ellis D. Avner |
| title_full_unstemmed | Inheritance of Kidney and Urinary Tract Diseases edited by Adrian Spitzer, Ellis D. Avner |
| title_short | Inheritance of Kidney and Urinary Tract Diseases |
| title_sort | inheritance of kidney and urinary tract diseases |
| topic | Nephrology Urology Harnwegskrankheit (DE-588)4135486-2 gnd Nierenkrankheit (DE-588)4075399-2 gnd Erblichkeit (DE-588)4152594-2 gnd |
| topic_facet | Nephrology Urology Harnwegskrankheit Nierenkrankheit Erblichkeit Aufsatzsammlung |
| url | https://doi.org/10.1007/978-1-4613-1603-9 |
| work_keys_str_mv | AT spitzeradrian inheritanceofkidneyandurinarytractdiseases AT avnerellisd inheritanceofkidneyandurinarytractdiseases |