Liver and Environmental Xenobiotics:
The general populations are incidentally exposed to a wide variety of xenobiotics as a consequence of the pollution of the environment by industrial and agricultural chemicals. Xenobiotics entering the animal will undergo one or more of the following fate: (a) elimination unchanged, (b) metabolism b...
Gespeichert in:
| Weitere Verfasser: | , |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Berlin, Heidelberg
Springer Berlin Heidelberg
1997
|
| Schlagworte: | |
| Online-Zugang: | UBR01 Volltext |
| Zusammenfassung: | The general populations are incidentally exposed to a wide variety of xenobiotics as a consequence of the pollution of the environment by industrial and agricultural chemicals. Xenobiotics entering the animal will undergo one or more of the following fate: (a) elimination unchanged, (b) metabolism by enzymes, (c) spontaneous chemical transformation and (d) remain unchanged in the body. The actions of xenobiotics on the body exhibit certain specificity depending upon the compound's chemical structure and reactivity. Since the processes of metabolism change these chemical properties ofaxenobiotic, bewildering number of reactions continue to pose new challenges to toxicologists and pharmacologists. It necessitates periodic and precise revision of the subject. This book contains invited contributions from learned colleagues that offer an excellent survey of and profound insight into the disposition and metabolism of a few environmentally and industrially significant xenobiotics. The topics range from an assessment of drug metabolising enzymes in the liver, DNA damage by reactive oxygen species generated by pesticides, role of NO in liver injury, hepatotrophicgrowth factor in liver regeneration, extracellular matrix in the liver, oncogene expression in liver injury, the hepatocarcinogenesis to oxidative stress and undifferentiated gene expression. Detailed analysis of the validity of liver function tests has been included. Last Chapter addresses the problem of apoptosis, which plays a key role in the signal transduction system of xenobiotics-induced liver injury. The reader should appreciate that overall exposure to this field is expanding at a rapid pace and selections had to be made |
| Beschreibung: | 1 Online-Ressource (X, 235 p. 97 illus) |
| ISBN: | 9783662123850 |
| DOI: | 10.1007/978-3-662-12385-0 |
Internformat
MARC
| LEADER | 00000nmm a2200000zc 4500 | ||
|---|---|---|---|
| 001 | BV046144963 | ||
| 003 | DE-604 | ||
| 005 | 00000000000000.0 | ||
| 007 | cr|uuu---uuuuu | ||
| 008 | 190905s1997 |||| o||u| ||||||eng d | ||
| 020 | |a 9783662123850 |9 978-3-662-12385-0 | ||
| 024 | 7 | |a 10.1007/978-3-662-12385-0 |2 doi | |
| 035 | |a (ZDB-2-SME)978-3-662-12385-0 | ||
| 035 | |a (OCoLC)1118997404 | ||
| 035 | |a (DE-599)BVBBV046144963 | ||
| 040 | |a DE-604 |b ger |e aacr | ||
| 041 | 0 | |a eng | |
| 049 | |a DE-355 | ||
| 082 | 0 | |a 616.33 |2 23 | |
| 245 | 1 | 0 | |a Liver and Environmental Xenobiotics |c edited by S. V. S. Rana, K. Taketa |
| 264 | 1 | |a Berlin, Heidelberg |b Springer Berlin Heidelberg |c 1997 | |
| 300 | |a 1 Online-Ressource (X, 235 p. 97 illus) | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b c |2 rdamedia | ||
| 338 | |b cr |2 rdacarrier | ||
| 520 | |a The general populations are incidentally exposed to a wide variety of xenobiotics as a consequence of the pollution of the environment by industrial and agricultural chemicals. Xenobiotics entering the animal will undergo one or more of the following fate: (a) elimination unchanged, (b) metabolism by enzymes, (c) spontaneous chemical transformation and (d) remain unchanged in the body. The actions of xenobiotics on the body exhibit certain specificity depending upon the compound's chemical structure and reactivity. Since the processes of metabolism change these chemical properties ofaxenobiotic, bewildering number of reactions continue to pose new challenges to toxicologists and pharmacologists. It necessitates periodic and precise revision of the subject. This book contains invited contributions from learned colleagues that offer an excellent survey of and profound insight into the disposition and metabolism of a few environmentally and industrially significant xenobiotics. The topics range from an assessment of drug metabolising enzymes in the liver, DNA damage by reactive oxygen species generated by pesticides, role of NO in liver injury, hepatotrophicgrowth factor in liver regeneration, extracellular matrix in the liver, oncogene expression in liver injury, the hepatocarcinogenesis to oxidative stress and undifferentiated gene expression. Detailed analysis of the validity of liver function tests has been included. Last Chapter addresses the problem of apoptosis, which plays a key role in the signal transduction system of xenobiotics-induced liver injury. The reader should appreciate that overall exposure to this field is expanding at a rapid pace and selections had to be made | ||
| 650 | 4 | |a Gastroenterology | |
| 650 | 4 | |a Pathology | |
| 650 | 4 | |a Pharmacology/Toxicology | |
| 650 | 4 | |a Environmental Health | |
| 650 | 4 | |a Occupational Medicine/Industrial Medicine | |
| 650 | 4 | |a Gastroenterology | |
| 650 | 4 | |a Pathology | |
| 650 | 4 | |a Toxicology | |
| 650 | 4 | |a Environmental Medicine | |
| 650 | 4 | |a Medicine, Industrial | |
| 700 | 1 | |a Rana, S. V. S. |4 edt | |
| 700 | 1 | |a Taketa, K. |4 edt | |
| 776 | 0 | 8 | |i Erscheint auch als |n Druck-Ausgabe |z 9783662123874 |
| 776 | 0 | 8 | |i Erscheint auch als |n Druck-Ausgabe |z 9783662123867 |
| 776 | 0 | 8 | |i Erscheint auch als |n Druck-Ausgabe |z 9783540626909 |
| 856 | 4 | 0 | |u https://doi.org/10.1007/978-3-662-12385-0 |x Verlag |z URL des Erstveröffentlichers |3 Volltext |
| 912 | |a ZDB-2-SME | ||
| 940 | 1 | |q ZDB-2-SME_1990/2004 | |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-031525148 | ||
| 966 | e | |u https://doi.org/10.1007/978-3-662-12385-0 |l UBR01 |p ZDB-2-SME |q ZDB-2-SME_1990/2004 |x Verlag |3 Volltext | |
Datensatz im Suchindex
| _version_ | 1804180481032323072 |
|---|---|
| any_adam_object | |
| author2 | Rana, S. V. S. Taketa, K. |
| author2_role | edt edt |
| author2_variant | s v s r svs svsr k t kt |
| author_facet | Rana, S. V. S. Taketa, K. |
| building | Verbundindex |
| bvnumber | BV046144963 |
| collection | ZDB-2-SME |
| ctrlnum | (ZDB-2-SME)978-3-662-12385-0 (OCoLC)1118997404 (DE-599)BVBBV046144963 |
| dewey-full | 616.33 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
| dewey-raw | 616.33 |
| dewey-search | 616.33 |
| dewey-sort | 3616.33 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| doi_str_mv | 10.1007/978-3-662-12385-0 |
| format | Electronic eBook |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>03481nmm a2200517zc 4500</leader><controlfield tag="001">BV046144963</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">00000000000000.0</controlfield><controlfield tag="007">cr|uuu---uuuuu</controlfield><controlfield tag="008">190905s1997 |||| o||u| ||||||eng d</controlfield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9783662123850</subfield><subfield code="9">978-3-662-12385-0</subfield></datafield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/978-3-662-12385-0</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ZDB-2-SME)978-3-662-12385-0</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)1118997404</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV046144963</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">aacr</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-355</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">616.33</subfield><subfield code="2">23</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Liver and Environmental Xenobiotics</subfield><subfield code="c">edited by S. V. S. Rana, K. Taketa</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Berlin, Heidelberg</subfield><subfield code="b">Springer Berlin Heidelberg</subfield><subfield code="c">1997</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">1 Online-Ressource (X, 235 p. 97 illus)</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">The general populations are incidentally exposed to a wide variety of xenobiotics as a consequence of the pollution of the environment by industrial and agricultural chemicals. Xenobiotics entering the animal will undergo one or more of the following fate: (a) elimination unchanged, (b) metabolism by enzymes, (c) spontaneous chemical transformation and (d) remain unchanged in the body. The actions of xenobiotics on the body exhibit certain specificity depending upon the compound's chemical structure and reactivity. Since the processes of metabolism change these chemical properties ofaxenobiotic, bewildering number of reactions continue to pose new challenges to toxicologists and pharmacologists. It necessitates periodic and precise revision of the subject. This book contains invited contributions from learned colleagues that offer an excellent survey of and profound insight into the disposition and metabolism of a few environmentally and industrially significant xenobiotics. The topics range from an assessment of drug metabolising enzymes in the liver, DNA damage by reactive oxygen species generated by pesticides, role of NO in liver injury, hepatotrophicgrowth factor in liver regeneration, extracellular matrix in the liver, oncogene expression in liver injury, the hepatocarcinogenesis to oxidative stress and undifferentiated gene expression. Detailed analysis of the validity of liver function tests has been included. Last Chapter addresses the problem of apoptosis, which plays a key role in the signal transduction system of xenobiotics-induced liver injury. The reader should appreciate that overall exposure to this field is expanding at a rapid pace and selections had to be made</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Gastroenterology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Pathology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Pharmacology/Toxicology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Environmental Health</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Occupational Medicine/Industrial Medicine</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Gastroenterology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Pathology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Toxicology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Environmental Medicine</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Medicine, Industrial</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Rana, S. V. S.</subfield><subfield code="4">edt</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Taketa, K.</subfield><subfield code="4">edt</subfield></datafield><datafield tag="776" ind1="0" ind2="8"><subfield code="i">Erscheint auch als</subfield><subfield code="n">Druck-Ausgabe</subfield><subfield code="z">9783662123874</subfield></datafield><datafield tag="776" ind1="0" ind2="8"><subfield code="i">Erscheint auch als</subfield><subfield code="n">Druck-Ausgabe</subfield><subfield code="z">9783662123867</subfield></datafield><datafield tag="776" ind1="0" ind2="8"><subfield code="i">Erscheint auch als</subfield><subfield code="n">Druck-Ausgabe</subfield><subfield code="z">9783540626909</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1007/978-3-662-12385-0</subfield><subfield code="x">Verlag</subfield><subfield code="z">URL des Erstveröffentlichers</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-2-SME</subfield></datafield><datafield tag="940" ind1="1" ind2=" "><subfield code="q">ZDB-2-SME_1990/2004</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-031525148</subfield></datafield><datafield tag="966" ind1="e" ind2=" "><subfield code="u">https://doi.org/10.1007/978-3-662-12385-0</subfield><subfield code="l">UBR01</subfield><subfield code="p">ZDB-2-SME</subfield><subfield code="q">ZDB-2-SME_1990/2004</subfield><subfield code="x">Verlag</subfield><subfield code="3">Volltext</subfield></datafield></record></collection> |
| id | DE-604.BV046144963 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-10T08:36:26Z |
| institution | BVB |
| isbn | 9783662123850 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-031525148 |
| oclc_num | 1118997404 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR |
| owner_facet | DE-355 DE-BY-UBR |
| physical | 1 Online-Ressource (X, 235 p. 97 illus) |
| psigel | ZDB-2-SME ZDB-2-SME_1990/2004 ZDB-2-SME ZDB-2-SME_1990/2004 |
| publishDate | 1997 |
| publishDateSearch | 1997 |
| publishDateSort | 1997 |
| publisher | Springer Berlin Heidelberg |
| record_format | marc |
| spelling | Liver and Environmental Xenobiotics edited by S. V. S. Rana, K. Taketa Berlin, Heidelberg Springer Berlin Heidelberg 1997 1 Online-Ressource (X, 235 p. 97 illus) txt rdacontent c rdamedia cr rdacarrier The general populations are incidentally exposed to a wide variety of xenobiotics as a consequence of the pollution of the environment by industrial and agricultural chemicals. Xenobiotics entering the animal will undergo one or more of the following fate: (a) elimination unchanged, (b) metabolism by enzymes, (c) spontaneous chemical transformation and (d) remain unchanged in the body. The actions of xenobiotics on the body exhibit certain specificity depending upon the compound's chemical structure and reactivity. Since the processes of metabolism change these chemical properties ofaxenobiotic, bewildering number of reactions continue to pose new challenges to toxicologists and pharmacologists. It necessitates periodic and precise revision of the subject. This book contains invited contributions from learned colleagues that offer an excellent survey of and profound insight into the disposition and metabolism of a few environmentally and industrially significant xenobiotics. The topics range from an assessment of drug metabolising enzymes in the liver, DNA damage by reactive oxygen species generated by pesticides, role of NO in liver injury, hepatotrophicgrowth factor in liver regeneration, extracellular matrix in the liver, oncogene expression in liver injury, the hepatocarcinogenesis to oxidative stress and undifferentiated gene expression. Detailed analysis of the validity of liver function tests has been included. Last Chapter addresses the problem of apoptosis, which plays a key role in the signal transduction system of xenobiotics-induced liver injury. The reader should appreciate that overall exposure to this field is expanding at a rapid pace and selections had to be made Gastroenterology Pathology Pharmacology/Toxicology Environmental Health Occupational Medicine/Industrial Medicine Toxicology Environmental Medicine Medicine, Industrial Rana, S. V. S. edt Taketa, K. edt Erscheint auch als Druck-Ausgabe 9783662123874 Erscheint auch als Druck-Ausgabe 9783662123867 Erscheint auch als Druck-Ausgabe 9783540626909 https://doi.org/10.1007/978-3-662-12385-0 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Liver and Environmental Xenobiotics Gastroenterology Pathology Pharmacology/Toxicology Environmental Health Occupational Medicine/Industrial Medicine Toxicology Environmental Medicine Medicine, Industrial |
| title | Liver and Environmental Xenobiotics |
| title_auth | Liver and Environmental Xenobiotics |
| title_exact_search | Liver and Environmental Xenobiotics |
| title_full | Liver and Environmental Xenobiotics edited by S. V. S. Rana, K. Taketa |
| title_fullStr | Liver and Environmental Xenobiotics edited by S. V. S. Rana, K. Taketa |
| title_full_unstemmed | Liver and Environmental Xenobiotics edited by S. V. S. Rana, K. Taketa |
| title_short | Liver and Environmental Xenobiotics |
| title_sort | liver and environmental xenobiotics |
| topic | Gastroenterology Pathology Pharmacology/Toxicology Environmental Health Occupational Medicine/Industrial Medicine Toxicology Environmental Medicine Medicine, Industrial |
| topic_facet | Gastroenterology Pathology Pharmacology/Toxicology Environmental Health Occupational Medicine/Industrial Medicine Toxicology Environmental Medicine Medicine, Industrial |
| url | https://doi.org/10.1007/978-3-662-12385-0 |
| work_keys_str_mv | AT ranasvs liverandenvironmentalxenobiotics AT taketak liverandenvironmentalxenobiotics |