Therapeutic Angiogenesis:
Over the past decade, rapid progress had been made in elucidating the cellular and molecular mechanisms of new blood vessel formation in both health and disease. Lack of sufficient angiogenesis (new capillary development) and collateral formation (remodeling of existing blood vessels) in adult tissu...
Gespeichert in:
| Weitere Verfasser: | , , |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Berlin, Heidelberg
Springer Berlin Heidelberg
1999
|
| Schriftenreihe: | Ernst Schering Foundation Symposium Proceedings
28 |
| Schlagworte: | |
| Online-Zugang: | UBR01 URL des Erstveröffentlichers |
| Zusammenfassung: | Over the past decade, rapid progress had been made in elucidating the cellular and molecular mechanisms of new blood vessel formation in both health and disease. Lack of sufficient angiogenesis (new capillary development) and collateral formation (remodeling of existing blood vessels) in adult tissues (e. g. , heart, brain, skeletal muscle) during criti cal ischemia has prompted novel therapeutic strategies to stimulate/fa cilitate angiogenesis and collateral formation in ischemic conditions ("therapeutic angiogenesis"). Therapeutic angiogenesis describes a strategy of inducing new col lateral vessels that can bypass vascular obstructions caused by atherosclerotic disease and stimulating new capillaries that can en hance tissue oxygen exchange. Naturally occurring growth factors (e. g. , FGFs, VEGFs) have been identified and demonstrated to induce new blood vessel formation in the adult organism. The therapeutic ap plication of these growth factors has been demonstrated to enhance these natural processes and have been shown in a number of animal models to increase blood flow and oxygen exchange to ischemic tis sues. Therapeutic angiogenesis therefore represents a new medical principle that is anticipated to be used as an adjunct or alternative to angioplasty and/or bypass surgery. A number of strategies have been proposed and tested to deliver growth factors. One strategy is the direct administration of the growth factor protein by intramuscular, intraarte rial or intravenous delivery |
| Beschreibung: | 1 Online-Ressource (XI, 186 p. 21 illus) |
| ISBN: | 9783662037768 |
| DOI: | 10.1007/978-3-662-03776-8 |
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| 520 | |a Over the past decade, rapid progress had been made in elucidating the cellular and molecular mechanisms of new blood vessel formation in both health and disease. Lack of sufficient angiogenesis (new capillary development) and collateral formation (remodeling of existing blood vessels) in adult tissues (e. g. , heart, brain, skeletal muscle) during criti cal ischemia has prompted novel therapeutic strategies to stimulate/fa cilitate angiogenesis and collateral formation in ischemic conditions ("therapeutic angiogenesis"). Therapeutic angiogenesis describes a strategy of inducing new col lateral vessels that can bypass vascular obstructions caused by atherosclerotic disease and stimulating new capillaries that can en hance tissue oxygen exchange. Naturally occurring growth factors (e. g. , FGFs, VEGFs) have been identified and demonstrated to induce new blood vessel formation in the adult organism. The therapeutic ap plication of these growth factors has been demonstrated to enhance these natural processes and have been shown in a number of animal models to increase blood flow and oxygen exchange to ischemic tis sues. Therapeutic angiogenesis therefore represents a new medical principle that is anticipated to be used as an adjunct or alternative to angioplasty and/or bypass surgery. A number of strategies have been proposed and tested to deliver growth factors. One strategy is the direct administration of the growth factor protein by intramuscular, intraarte rial or intravenous delivery | ||
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Datensatz im Suchindex
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| any_adam_object | |
| author2 | Dormandy, J. A. Dole, W. P. Rubanyi, G. M. |
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| author_facet | Dormandy, J. A. Dole, W. P. Rubanyi, G. M. |
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| bvnumber | BV046144842 |
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| ctrlnum | (ZDB-2-SME)978-3-662-03776-8 (OCoLC)1119096733 (DE-599)BVBBV046144842 |
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| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
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| dewey-search | 616.12 |
| dewey-sort | 3616.12 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| doi_str_mv | 10.1007/978-3-662-03776-8 |
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| genre_facet | Konferenzschrift 1998 San Francisco, Calif. Konferenzschrift 1998 San Francisco Calif. |
| id | DE-604.BV046144842 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-10T08:36:26Z |
| institution | BVB |
| isbn | 9783662037768 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-031525027 |
| oclc_num | 1119096733 |
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| physical | 1 Online-Ressource (XI, 186 p. 21 illus) |
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| publishDate | 1999 |
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| spelling | Therapeutic Angiogenesis edited by J. A. Dormandy, W. P. Dole, G. M. Rubanyi Berlin, Heidelberg Springer Berlin Heidelberg 1999 1 Online-Ressource (XI, 186 p. 21 illus) txt rdacontent c rdamedia cr rdacarrier Ernst Schering Foundation Symposium Proceedings 28 Over the past decade, rapid progress had been made in elucidating the cellular and molecular mechanisms of new blood vessel formation in both health and disease. Lack of sufficient angiogenesis (new capillary development) and collateral formation (remodeling of existing blood vessels) in adult tissues (e. g. , heart, brain, skeletal muscle) during criti cal ischemia has prompted novel therapeutic strategies to stimulate/fa cilitate angiogenesis and collateral formation in ischemic conditions ("therapeutic angiogenesis"). Therapeutic angiogenesis describes a strategy of inducing new col lateral vessels that can bypass vascular obstructions caused by atherosclerotic disease and stimulating new capillaries that can en hance tissue oxygen exchange. Naturally occurring growth factors (e. g. , FGFs, VEGFs) have been identified and demonstrated to induce new blood vessel formation in the adult organism. The therapeutic ap plication of these growth factors has been demonstrated to enhance these natural processes and have been shown in a number of animal models to increase blood flow and oxygen exchange to ischemic tis sues. Therapeutic angiogenesis therefore represents a new medical principle that is anticipated to be used as an adjunct or alternative to angioplasty and/or bypass surgery. A number of strategies have been proposed and tested to deliver growth factors. One strategy is the direct administration of the growth factor protein by intramuscular, intraarte rial or intravenous delivery Cardiology Angiology Angiography Ischämie (DE-588)4162456-7 gnd rswk-swf Angiogenese (DE-588)4142449-9 gnd rswk-swf Therapie (DE-588)4059798-2 gnd rswk-swf Wachstumsfaktor (DE-588)4188802-9 gnd rswk-swf Pharmakotherapie (DE-588)4076066-2 gnd rswk-swf (DE-588)1071861417 Konferenzschrift 1998 San Francisco, Calif. gnd-content (DE-588)1071861417 Konferenzschrift 1998 San Francisco Calif. gnd-content Ischämie (DE-588)4162456-7 s Angiogenese (DE-588)4142449-9 s Wachstumsfaktor (DE-588)4188802-9 s Pharmakotherapie (DE-588)4076066-2 s DE-604 Therapie (DE-588)4059798-2 s Dormandy, J. A. edt Dole, W. P. edt Rubanyi, G. M. edt Erscheint auch als Druck-Ausgabe 9783662037782 Erscheint auch als Druck-Ausgabe 9783662037775 Erscheint auch als Druck-Ausgabe 9783540656937 https://doi.org/10.1007/978-3-662-03776-8 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Therapeutic Angiogenesis Cardiology Angiology Angiography Ischämie (DE-588)4162456-7 gnd Angiogenese (DE-588)4142449-9 gnd Therapie (DE-588)4059798-2 gnd Wachstumsfaktor (DE-588)4188802-9 gnd Pharmakotherapie (DE-588)4076066-2 gnd |
| subject_GND | (DE-588)4162456-7 (DE-588)4142449-9 (DE-588)4059798-2 (DE-588)4188802-9 (DE-588)4076066-2 (DE-588)1071861417 |
| title | Therapeutic Angiogenesis |
| title_auth | Therapeutic Angiogenesis |
| title_exact_search | Therapeutic Angiogenesis |
| title_full | Therapeutic Angiogenesis edited by J. A. Dormandy, W. P. Dole, G. M. Rubanyi |
| title_fullStr | Therapeutic Angiogenesis edited by J. A. Dormandy, W. P. Dole, G. M. Rubanyi |
| title_full_unstemmed | Therapeutic Angiogenesis edited by J. A. Dormandy, W. P. Dole, G. M. Rubanyi |
| title_short | Therapeutic Angiogenesis |
| title_sort | therapeutic angiogenesis |
| topic | Cardiology Angiology Angiography Ischämie (DE-588)4162456-7 gnd Angiogenese (DE-588)4142449-9 gnd Therapie (DE-588)4059798-2 gnd Wachstumsfaktor (DE-588)4188802-9 gnd Pharmakotherapie (DE-588)4076066-2 gnd |
| topic_facet | Cardiology Angiology Angiography Ischämie Angiogenese Therapie Wachstumsfaktor Pharmakotherapie Konferenzschrift 1998 San Francisco, Calif. Konferenzschrift 1998 San Francisco Calif. |
| url | https://doi.org/10.1007/978-3-662-03776-8 |
| work_keys_str_mv | AT dormandyja therapeuticangiogenesis AT dolewp therapeuticangiogenesis AT rubanyigm therapeuticangiogenesis |