Recent Progress in the Genetic Epidemiology of Cancer:
The discipline of genetic epidemiology pertains to the vertical transmission of the susceptibility (predisposition) to a complex disease in a structured population. This statement meets halfway 1 the broad definitiongiven by N. E. Morton and S. c. Chung in 1978 2 and the concise one given by M. -C....
Gespeichert in:
| Weitere Verfasser: | , |
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| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Berlin, Heidelberg
Springer Berlin Heidelberg
1991
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| Schlagworte: | |
| Online-Zugang: | UBR01 Volltext |
| Zusammenfassung: | The discipline of genetic epidemiology pertains to the vertical transmission of the susceptibility (predisposition) to a complex disease in a structured population. This statement meets halfway 1 the broad definitiongiven by N. E. Morton and S. c. Chung in 1978 2 and the concise one given by M. -C. King et al. in 1984. 1t pinpoints the fundamental genetic hypothesis, namely, the existence of an inherited condition that predisposes an individual to a specific disease, and the corresponding subject ofinvestigation, the family. Thus, the genetic epidemiological situation consists of three basic elements: (l) the genealogical structure, (2) the mode of inherit ance (i. e. , the "genetic model") for the trait of interest, and (3) the observable phenotypes of susceptibility. It is clear that genetic epidemiology is a research field posi tioned at the intersection of molecular genetics, population gen etics, and clinical genetics. Perhaps the genealogical tree should be its central element: it evidences something forgotten in mole cular genetics, namely the relationships, and associations with probabilistic and statistical concepts from population genetics. It offers a structure and a "history" for those clinicians studying familial diseases who are searching for genetic determinants of susceptibility. The genetic epidemiologist begins his analysis with a point on this genealogical tree, namely the proband, and attempts to carry out (nonrandom) "ascertainment sampling" by using a strategy that depends on the form and dimension (extended pedigrees versus nuclear families) of the tree |
| Beschreibung: | 1 Online-Ressource (XI, 162 p. 7 illus) |
| ISBN: | 9783642759932 |
| DOI: | 10.1007/978-3-642-75993-2 |
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| 520 | |a The discipline of genetic epidemiology pertains to the vertical transmission of the susceptibility (predisposition) to a complex disease in a structured population. This statement meets halfway 1 the broad definitiongiven by N. E. Morton and S. c. Chung in 1978 2 and the concise one given by M. -C. King et al. in 1984. 1t pinpoints the fundamental genetic hypothesis, namely, the existence of an inherited condition that predisposes an individual to a specific disease, and the corresponding subject ofinvestigation, the family. Thus, the genetic epidemiological situation consists of three basic elements: (l) the genealogical structure, (2) the mode of inherit ance (i. e. , the "genetic model") for the trait of interest, and (3) the observable phenotypes of susceptibility. It is clear that genetic epidemiology is a research field posi tioned at the intersection of molecular genetics, population gen etics, and clinical genetics. Perhaps the genealogical tree should be its central element: it evidences something forgotten in mole cular genetics, namely the relationships, and associations with probabilistic and statistical concepts from population genetics. It offers a structure and a "history" for those clinicians studying familial diseases who are searching for genetic determinants of susceptibility. The genetic epidemiologist begins his analysis with a point on this genealogical tree, namely the proband, and attempts to carry out (nonrandom) "ascertainment sampling" by using a strategy that depends on the form and dimension (extended pedigrees versus nuclear families) of the tree | ||
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Datensatz im Suchindex
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| any_adam_object | |
| author2 | Lynch, Henry T. Tautu, Petre |
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| dewey-full | 616.994 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
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| indexdate | 2024-07-10T08:36:26Z |
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| isbn | 9783642759932 |
| language | English |
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| spelling | Recent Progress in the Genetic Epidemiology of Cancer edited by Henry T. Lynch, Petre Tautu Berlin, Heidelberg Springer Berlin Heidelberg 1991 1 Online-Ressource (XI, 162 p. 7 illus) txt rdacontent c rdamedia cr rdacarrier The discipline of genetic epidemiology pertains to the vertical transmission of the susceptibility (predisposition) to a complex disease in a structured population. This statement meets halfway 1 the broad definitiongiven by N. E. Morton and S. c. Chung in 1978 2 and the concise one given by M. -C. King et al. in 1984. 1t pinpoints the fundamental genetic hypothesis, namely, the existence of an inherited condition that predisposes an individual to a specific disease, and the corresponding subject ofinvestigation, the family. Thus, the genetic epidemiological situation consists of three basic elements: (l) the genealogical structure, (2) the mode of inherit ance (i. e. , the "genetic model") for the trait of interest, and (3) the observable phenotypes of susceptibility. It is clear that genetic epidemiology is a research field posi tioned at the intersection of molecular genetics, population gen etics, and clinical genetics. Perhaps the genealogical tree should be its central element: it evidences something forgotten in mole cular genetics, namely the relationships, and associations with probabilistic and statistical concepts from population genetics. It offers a structure and a "history" for those clinicians studying familial diseases who are searching for genetic determinants of susceptibility. The genetic epidemiologist begins his analysis with a point on this genealogical tree, namely the proband, and attempts to carry out (nonrandom) "ascertainment sampling" by using a strategy that depends on the form and dimension (extended pedigrees versus nuclear families) of the tree Oncology Biomedicine general Statistics for Life Sciences, Medicine, Health Sciences Human Genetics Health Informatics Oncology Medicine Statistics Human genetics Medical records / Data processing Krebs Medizin (DE-588)4073781-0 gnd rswk-swf Genetik (DE-588)4071711-2 gnd rswk-swf Epidemiologie (DE-588)4015016-1 gnd rswk-swf Erbkrankheit (DE-588)4015106-2 gnd rswk-swf (DE-588)1071861417 Konferenzschrift gnd-content Krebs Medizin (DE-588)4073781-0 s Erbkrankheit (DE-588)4015106-2 s Epidemiologie (DE-588)4015016-1 s DE-604 Genetik (DE-588)4071711-2 s Lynch, Henry T. edt Tautu, Petre edt Erscheint auch als Druck-Ausgabe 9783540530220 Erscheint auch als Druck-Ausgabe 9783642759949 https://doi.org/10.1007/978-3-642-75993-2 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Recent Progress in the Genetic Epidemiology of Cancer Oncology Biomedicine general Statistics for Life Sciences, Medicine, Health Sciences Human Genetics Health Informatics Oncology Medicine Statistics Human genetics Medical records / Data processing Krebs Medizin (DE-588)4073781-0 gnd Genetik (DE-588)4071711-2 gnd Epidemiologie (DE-588)4015016-1 gnd Erbkrankheit (DE-588)4015106-2 gnd |
| subject_GND | (DE-588)4073781-0 (DE-588)4071711-2 (DE-588)4015016-1 (DE-588)4015106-2 (DE-588)1071861417 |
| title | Recent Progress in the Genetic Epidemiology of Cancer |
| title_auth | Recent Progress in the Genetic Epidemiology of Cancer |
| title_exact_search | Recent Progress in the Genetic Epidemiology of Cancer |
| title_full | Recent Progress in the Genetic Epidemiology of Cancer edited by Henry T. Lynch, Petre Tautu |
| title_fullStr | Recent Progress in the Genetic Epidemiology of Cancer edited by Henry T. Lynch, Petre Tautu |
| title_full_unstemmed | Recent Progress in the Genetic Epidemiology of Cancer edited by Henry T. Lynch, Petre Tautu |
| title_short | Recent Progress in the Genetic Epidemiology of Cancer |
| title_sort | recent progress in the genetic epidemiology of cancer |
| topic | Oncology Biomedicine general Statistics for Life Sciences, Medicine, Health Sciences Human Genetics Health Informatics Oncology Medicine Statistics Human genetics Medical records / Data processing Krebs Medizin (DE-588)4073781-0 gnd Genetik (DE-588)4071711-2 gnd Epidemiologie (DE-588)4015016-1 gnd Erbkrankheit (DE-588)4015106-2 gnd |
| topic_facet | Oncology Biomedicine general Statistics for Life Sciences, Medicine, Health Sciences Human Genetics Health Informatics Oncology Medicine Statistics Human genetics Medical records / Data processing Krebs Medizin Genetik Epidemiologie Erbkrankheit Konferenzschrift |
| url | https://doi.org/10.1007/978-3-642-75993-2 |
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