Alterations of Excitation-Contraction Coupling in the Failing Human Heart:
Alteration of excitation-contraction coupling in the failing human heart was deemed an interesting subject for a dialogue between basic scientists and clinical researchers in continuation of previous Gargellen Conferences concerned with the function of the normal and failing human myocardium. In 198...
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| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Heidelberg
Steinkopff
1998
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| Schlagworte: | |
| Online-Zugang: | UBR01 Volltext |
| Zusammenfassung: | Alteration of excitation-contraction coupling in the failing human heart was deemed an interesting subject for a dialogue between basic scientists and clinical researchers in continuation of previous Gargellen Conferences concerned with the function of the normal and failing human myocardium. In 1987 basic mechanisms and clinical implications of then new insights into cardiac energetics was followed by a comprehensive review of inotropic stimulation and myocardial energetics in 1989. Here, we undertook a re-evaluation of the principles of inotropic stimulation and of its potential therapeutic value, based on new observa tions from experiments with human myocardium. In 1992 the risk due to myocardial phenotype change as a consequence of adaptation in heart failure was published. Here, alterations of subcellular structures and functions as a consequence of chronic heart failure, summarized as phenotype change, could be described as an essential characteristic of the failing human myocardium. This topic was discussed in greater depth in the volume "Cellular and Molecular Alterations in the Failing Human Heart", considering both the sarcolemma and the phosphodiesterases, as well as excitation-contraction coupling and contractile proteins, extracellular matrix, and mitrochondrial function |
| Beschreibung: | 1 Online-Ressource (X, 108 p. 129 illus) |
| ISBN: | 9783642486708 |
| DOI: | 10.1007/978-3-642-48670-8 |
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| 520 | |a Alteration of excitation-contraction coupling in the failing human heart was deemed an interesting subject for a dialogue between basic scientists and clinical researchers in continuation of previous Gargellen Conferences concerned with the function of the normal and failing human myocardium. In 1987 basic mechanisms and clinical implications of then new insights into cardiac energetics was followed by a comprehensive review of inotropic stimulation and myocardial energetics in 1989. Here, we undertook a re-evaluation of the principles of inotropic stimulation and of its potential therapeutic value, based on new observa tions from experiments with human myocardium. In 1992 the risk due to myocardial phenotype change as a consequence of adaptation in heart failure was published. Here, alterations of subcellular structures and functions as a consequence of chronic heart failure, summarized as phenotype change, could be described as an essential characteristic of the failing human myocardium. This topic was discussed in greater depth in the volume "Cellular and Molecular Alterations in the Failing Human Heart", considering both the sarcolemma and the phosphodiesterases, as well as excitation-contraction coupling and contractile proteins, extracellular matrix, and mitrochondrial function | ||
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Datensatz im Suchindex
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| discipline | Medizin |
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| genre_facet | Konferenzschrift 1995 Freiburg im Breisgau |
| id | DE-604.BV046144792 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-10T08:36:26Z |
| institution | BVB |
| isbn | 9783642486708 |
| language | English |
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| spelling | Alterations of Excitation-Contraction Coupling in the Failing Human Heart edited by G. Hasenfuss, H. Just Heidelberg Steinkopff 1998 1 Online-Ressource (X, 108 p. 129 illus) txt rdacontent c rdamedia cr rdacarrier Alteration of excitation-contraction coupling in the failing human heart was deemed an interesting subject for a dialogue between basic scientists and clinical researchers in continuation of previous Gargellen Conferences concerned with the function of the normal and failing human myocardium. In 1987 basic mechanisms and clinical implications of then new insights into cardiac energetics was followed by a comprehensive review of inotropic stimulation and myocardial energetics in 1989. Here, we undertook a re-evaluation of the principles of inotropic stimulation and of its potential therapeutic value, based on new observa tions from experiments with human myocardium. In 1992 the risk due to myocardial phenotype change as a consequence of adaptation in heart failure was published. Here, alterations of subcellular structures and functions as a consequence of chronic heart failure, summarized as phenotype change, could be described as an essential characteristic of the failing human myocardium. This topic was discussed in greater depth in the volume "Cellular and Molecular Alterations in the Failing Human Heart", considering both the sarcolemma and the phosphodiesterases, as well as excitation-contraction coupling and contractile proteins, extracellular matrix, and mitrochondrial function Cardiology Pathophysiologie (DE-588)4044898-8 gnd rswk-swf Herzmuskel (DE-588)4024675-9 gnd rswk-swf Muskelkontraktion (DE-588)4170858-1 gnd rswk-swf Molekularpathologie (DE-588)4170396-0 gnd rswk-swf Herzinsuffizienz (DE-588)4024655-3 gnd rswk-swf (DE-588)1071861417 Konferenzschrift 1995 Freiburg im Breisgau gnd-content Herzinsuffizienz (DE-588)4024655-3 s Herzmuskel (DE-588)4024675-9 s Muskelkontraktion (DE-588)4170858-1 s Pathophysiologie (DE-588)4044898-8 s DE-604 Molekularpathologie (DE-588)4170396-0 s Hasenfuss, G. edt Just, H. edt Erscheint auch als Druck-Ausgabe 9783642486722 Erscheint auch als Druck-Ausgabe 9783798510470 Erscheint auch als Druck-Ausgabe 9783642486715 https://doi.org/10.1007/978-3-642-48670-8 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Alterations of Excitation-Contraction Coupling in the Failing Human Heart Cardiology Pathophysiologie (DE-588)4044898-8 gnd Herzmuskel (DE-588)4024675-9 gnd Muskelkontraktion (DE-588)4170858-1 gnd Molekularpathologie (DE-588)4170396-0 gnd Herzinsuffizienz (DE-588)4024655-3 gnd |
| subject_GND | (DE-588)4044898-8 (DE-588)4024675-9 (DE-588)4170858-1 (DE-588)4170396-0 (DE-588)4024655-3 (DE-588)1071861417 |
| title | Alterations of Excitation-Contraction Coupling in the Failing Human Heart |
| title_auth | Alterations of Excitation-Contraction Coupling in the Failing Human Heart |
| title_exact_search | Alterations of Excitation-Contraction Coupling in the Failing Human Heart |
| title_full | Alterations of Excitation-Contraction Coupling in the Failing Human Heart edited by G. Hasenfuss, H. Just |
| title_fullStr | Alterations of Excitation-Contraction Coupling in the Failing Human Heart edited by G. Hasenfuss, H. Just |
| title_full_unstemmed | Alterations of Excitation-Contraction Coupling in the Failing Human Heart edited by G. Hasenfuss, H. Just |
| title_short | Alterations of Excitation-Contraction Coupling in the Failing Human Heart |
| title_sort | alterations of excitation contraction coupling in the failing human heart |
| topic | Cardiology Pathophysiologie (DE-588)4044898-8 gnd Herzmuskel (DE-588)4024675-9 gnd Muskelkontraktion (DE-588)4170858-1 gnd Molekularpathologie (DE-588)4170396-0 gnd Herzinsuffizienz (DE-588)4024655-3 gnd |
| topic_facet | Cardiology Pathophysiologie Herzmuskel Muskelkontraktion Molekularpathologie Herzinsuffizienz Konferenzschrift 1995 Freiburg im Breisgau |
| url | https://doi.org/10.1007/978-3-642-48670-8 |
| work_keys_str_mv | AT hasenfussg alterationsofexcitationcontractioncouplinginthefailinghumanheart AT justh alterationsofexcitationcontractioncouplinginthefailinghumanheart |