Antifolate Drugs in Cancer Therapy:
In Antifolate Drugs in Cancer Therapy, Ann Jackman and a panel of highly regarded researchers comprehensively review the current status of novel antifolates, an important class of anticancer drugs. The distinguished contributors discuss the preclinical and clinical pharmacology of methotrexate, othe...
Gespeichert in:
| Weitere Verfasser: | |
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| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Totowa, NJ
Humana Press
1999
|
| Schriftenreihe: | Cancer Drug Discovery and Development
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| Schlagworte: | |
| Online-Zugang: | UBR01 Volltext |
| Zusammenfassung: | In Antifolate Drugs in Cancer Therapy, Ann Jackman and a panel of highly regarded researchers comprehensively review the current status of novel antifolates, an important class of anticancer drugs. The distinguished contributors discuss the preclinical and clinical pharmacology of methotrexate, other dihydrofolate reductase inhibitors, 5-fluorouracil, and the new generation of antifolates-the thymidylate synthase and glycinamide ribonucleotide formyltransferase inhibitors. In addition, they review in depth the modulation of antifolate drugs, folate and antifolate transport mechanisms, polyglutamation, resistance, and drug combinations, as well as pharmacogenomics, pharmacodynamics, regulation of gene expression, and mechanisms of cell death. The wide and progressive scope of Antifolate Drugs in Cancer Therapy provides entré to exciting new avenues for future research, and constitutes a new standard reference for all basic scientists and clinicians engaged in cancer therapeutics |
| Beschreibung: | 1 Online-Ressource (X, 456 p. 13 illus) |
| ISBN: | 9781592597253 |
| DOI: | 10.1007/978-1-59259-725-3 |
Internformat
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| 520 | |a In Antifolate Drugs in Cancer Therapy, Ann Jackman and a panel of highly regarded researchers comprehensively review the current status of novel antifolates, an important class of anticancer drugs. The distinguished contributors discuss the preclinical and clinical pharmacology of methotrexate, other dihydrofolate reductase inhibitors, 5-fluorouracil, and the new generation of antifolates-the thymidylate synthase and glycinamide ribonucleotide formyltransferase inhibitors. In addition, they review in depth the modulation of antifolate drugs, folate and antifolate transport mechanisms, polyglutamation, resistance, and drug combinations, as well as pharmacogenomics, pharmacodynamics, regulation of gene expression, and mechanisms of cell death. The wide and progressive scope of Antifolate Drugs in Cancer Therapy provides entré to exciting new avenues for future research, and constitutes a new standard reference for all basic scientists and clinicians engaged in cancer therapeutics | ||
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Datensatz im Suchindex
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| dewey-ones | 615 - Pharmacology and therapeutics |
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| isbn | 9781592597253 |
| language | English |
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| spelling | Antifolate Drugs in Cancer Therapy edited by Ann L. Jackman Totowa, NJ Humana Press 1999 1 Online-Ressource (X, 456 p. 13 illus) txt rdacontent c rdamedia cr rdacarrier Cancer Drug Discovery and Development In Antifolate Drugs in Cancer Therapy, Ann Jackman and a panel of highly regarded researchers comprehensively review the current status of novel antifolates, an important class of anticancer drugs. The distinguished contributors discuss the preclinical and clinical pharmacology of methotrexate, other dihydrofolate reductase inhibitors, 5-fluorouracil, and the new generation of antifolates-the thymidylate synthase and glycinamide ribonucleotide formyltransferase inhibitors. In addition, they review in depth the modulation of antifolate drugs, folate and antifolate transport mechanisms, polyglutamation, resistance, and drug combinations, as well as pharmacogenomics, pharmacodynamics, regulation of gene expression, and mechanisms of cell death. The wide and progressive scope of Antifolate Drugs in Cancer Therapy provides entré to exciting new avenues for future research, and constitutes a new standard reference for all basic scientists and clinicians engaged in cancer therapeutics Pharmacy Folate (DE-588)4154952-1 gnd rswk-swf Therapie (DE-588)4059798-2 gnd rswk-swf Krebs Medizin (DE-588)4073781-0 gnd rswk-swf 1\p (DE-588)4143413-4 Aufsatzsammlung gnd-content Folate (DE-588)4154952-1 s Krebs Medizin (DE-588)4073781-0 s Therapie (DE-588)4059798-2 s 2\p DE-604 Jackman, Ann L. edt Erscheint auch als Druck-Ausgabe 9781475745214 Erscheint auch als Druck-Ausgabe 9780896035966 Erscheint auch als Druck-Ausgabe 9781475745207 https://doi.org/10.1007/978-1-59259-725-3 Verlag URL des Erstveröffentlichers Volltext 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 2\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Antifolate Drugs in Cancer Therapy Pharmacy Folate (DE-588)4154952-1 gnd Therapie (DE-588)4059798-2 gnd Krebs Medizin (DE-588)4073781-0 gnd |
| subject_GND | (DE-588)4154952-1 (DE-588)4059798-2 (DE-588)4073781-0 (DE-588)4143413-4 |
| title | Antifolate Drugs in Cancer Therapy |
| title_auth | Antifolate Drugs in Cancer Therapy |
| title_exact_search | Antifolate Drugs in Cancer Therapy |
| title_full | Antifolate Drugs in Cancer Therapy edited by Ann L. Jackman |
| title_fullStr | Antifolate Drugs in Cancer Therapy edited by Ann L. Jackman |
| title_full_unstemmed | Antifolate Drugs in Cancer Therapy edited by Ann L. Jackman |
| title_short | Antifolate Drugs in Cancer Therapy |
| title_sort | antifolate drugs in cancer therapy |
| topic | Pharmacy Folate (DE-588)4154952-1 gnd Therapie (DE-588)4059798-2 gnd Krebs Medizin (DE-588)4073781-0 gnd |
| topic_facet | Pharmacy Folate Therapie Krebs Medizin Aufsatzsammlung |
| url | https://doi.org/10.1007/978-1-59259-725-3 |
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