Risk Assessment of Prenatally-Induced Adverse Health Effects:
Since the thalidomide (Contergan) tragedy about 30 years ago the induction of prenatally-induced morphological or functional defects has been an area of extensive research. Risk assessment of prenatally-induced adverse health effects is still a difficult task from both experimental data as well asfr...
Gespeichert in:
| Weitere Verfasser: | , , , |
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| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Berlin, Heidelberg
Springer Berlin Heidelberg
1992
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| Schlagworte: | |
| Online-Zugang: | UBR01 Volltext |
| Zusammenfassung: | Since the thalidomide (Contergan) tragedy about 30 years ago the induction of prenatally-induced morphological or functional defects has been an area of extensive research. Risk assessment of prenatally-induced adverse health effects is still a difficult task from both experimental data as well asfrom observations in humans. In the contributions to this book three major aspects are dealt with: - Quantitative extrapolations of experimental data to the situation possibly relevant for man. - The significance for a risk assessment with respect to man of minor or rare structural abnormalities observed in experimental studies - The future need to assess congenital dysfunctions (e.g. of the hormone or the immune system) beside the present evaulation of structural defects. Limitations as well as gaps of the present knowledge in this area of basic and applied research are pointed out. Since the results of prenatally-induced lesions may manifest themselves not only pre- but often not before late postnatally, numerous aspects of structural and functional abnormaldevelopment must be studied in experimental and clinical investigations |
| Beschreibung: | 1 Online-Ressource (XIV, 565 p) |
| ISBN: | 9783642777530 |
| DOI: | 10.1007/978-3-642-77753-0 |
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| 245 | 1 | 0 | |a Risk Assessment of Prenatally-Induced Adverse Health Effects |c edited by Diether Neubert, Robert J. Kavlock, Hans-Joachim Merker, Jane Klein |
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| 520 | |a Since the thalidomide (Contergan) tragedy about 30 years ago the induction of prenatally-induced morphological or functional defects has been an area of extensive research. Risk assessment of prenatally-induced adverse health effects is still a difficult task from both experimental data as well asfrom observations in humans. In the contributions to this book three major aspects are dealt with: - Quantitative extrapolations of experimental data to the situation possibly relevant for man. - The significance for a risk assessment with respect to man of minor or rare structural abnormalities observed in experimental studies - The future need to assess congenital dysfunctions (e.g. of the hormone or the immune system) beside the present evaulation of structural defects. Limitations as well as gaps of the present knowledge in this area of basic and applied research are pointed out. Since the results of prenatally-induced lesions may manifest themselves not only pre- but often not before late postnatally, numerous aspects of structural and functional abnormaldevelopment must be studied in experimental and clinical investigations | ||
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| indexdate | 2024-07-10T08:36:25Z |
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| isbn | 9783642777530 |
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| spelling | Risk Assessment of Prenatally-Induced Adverse Health Effects edited by Diether Neubert, Robert J. Kavlock, Hans-Joachim Merker, Jane Klein Berlin, Heidelberg Springer Berlin Heidelberg 1992 1 Online-Ressource (XIV, 565 p) txt rdacontent c rdamedia cr rdacarrier Since the thalidomide (Contergan) tragedy about 30 years ago the induction of prenatally-induced morphological or functional defects has been an area of extensive research. Risk assessment of prenatally-induced adverse health effects is still a difficult task from both experimental data as well asfrom observations in humans. In the contributions to this book three major aspects are dealt with: - Quantitative extrapolations of experimental data to the situation possibly relevant for man. - The significance for a risk assessment with respect to man of minor or rare structural abnormalities observed in experimental studies - The future need to assess congenital dysfunctions (e.g. of the hormone or the immune system) beside the present evaulation of structural defects. Limitations as well as gaps of the present knowledge in this area of basic and applied research are pointed out. Since the results of prenatally-induced lesions may manifest themselves not only pre- but often not before late postnatally, numerous aspects of structural and functional abnormaldevelopment must be studied in experimental and clinical investigations Anatomy Pharmacology/Toxicology Statistics for Life Sciences, Medicine, Health Sciences Anthropology Human anatomy Toxicology Statistics Reproduktionstoxikologie (DE-588)4277009-9 gnd rswk-swf (DE-588)1071861417 Konferenzschrift 1991 Berlin gnd-content Reproduktionstoxikologie (DE-588)4277009-9 s DE-604 Neubert, Diether edt Kavlock, Robert J. edt Merker, Hans-Joachim edt Klein, Jane edt Erscheint auch als Druck-Ausgabe 9783642777554 Erscheint auch als Druck-Ausgabe 9783540558903 Erscheint auch als Druck-Ausgabe 9783642777547 https://doi.org/10.1007/978-3-642-77753-0 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Risk Assessment of Prenatally-Induced Adverse Health Effects Anatomy Pharmacology/Toxicology Statistics for Life Sciences, Medicine, Health Sciences Anthropology Human anatomy Toxicology Statistics Reproduktionstoxikologie (DE-588)4277009-9 gnd |
| subject_GND | (DE-588)4277009-9 (DE-588)1071861417 |
| title | Risk Assessment of Prenatally-Induced Adverse Health Effects |
| title_auth | Risk Assessment of Prenatally-Induced Adverse Health Effects |
| title_exact_search | Risk Assessment of Prenatally-Induced Adverse Health Effects |
| title_full | Risk Assessment of Prenatally-Induced Adverse Health Effects edited by Diether Neubert, Robert J. Kavlock, Hans-Joachim Merker, Jane Klein |
| title_fullStr | Risk Assessment of Prenatally-Induced Adverse Health Effects edited by Diether Neubert, Robert J. Kavlock, Hans-Joachim Merker, Jane Klein |
| title_full_unstemmed | Risk Assessment of Prenatally-Induced Adverse Health Effects edited by Diether Neubert, Robert J. Kavlock, Hans-Joachim Merker, Jane Klein |
| title_short | Risk Assessment of Prenatally-Induced Adverse Health Effects |
| title_sort | risk assessment of prenatally induced adverse health effects |
| topic | Anatomy Pharmacology/Toxicology Statistics for Life Sciences, Medicine, Health Sciences Anthropology Human anatomy Toxicology Statistics Reproduktionstoxikologie (DE-588)4277009-9 gnd |
| topic_facet | Anatomy Pharmacology/Toxicology Statistics for Life Sciences, Medicine, Health Sciences Anthropology Human anatomy Toxicology Statistics Reproduktionstoxikologie Konferenzschrift 1991 Berlin |
| url | https://doi.org/10.1007/978-3-642-77753-0 |
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