The Human Yolk Sac and Yolk Sac Tumors:
I am honored to have been invited to write a foreword for this book, because tumors of the yolk sac have been a preoccupation of mine since the days of my residency, now more than 3 decades ago. At that time, a 3-year-old boy died of a testicular cancer of unknown histo genesis. It was bad enough t...
Gespeichert in:
| Weitere Verfasser: | |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Berlin, Heidelberg
Springer Berlin Heidelberg
1993
|
| Schlagworte: | |
| Online-Zugang: | UBR01 URL des Erstveröffentlichers |
| Zusammenfassung: | I am honored to have been invited to write a foreword for this book, because tumors of the yolk sac have been a preoccupation of mine since the days of my residency, now more than 3 decades ago. At that time, a 3-year-old boy died of a testicular cancer of unknown histo genesis. It was bad enough that the child died, but it bothered me even more that medical science did not know the histogenesis of the tumor that destroyed him, and I decided to study testicular cancer. For re search training I sought out F. J. Dixon, who had written the Armed Forces Fascicle on testicular tumors. Dr. Dixon and I showed that embryonal carcinoma was a multipoten tial malignant stem cell that differentiated into the three embryonic germ layers of murine teratocarcinoma. This led to the idea that the normal counterpart of embryonal carcinoma must also be multi potent, and we focused on the preimplantation embryo for the histo genesis of the tumor. This idea was strengthened by the discovery that embryonal carcinoma cells made embryoid bodies in the ascites and it was possible to observe the development of these bodies in vitro. These observations led to the idea that embryonal carcinoma was a caricature (gross misrepresentation) of early development, and car cinomas in general were a caricature of the process of renewal of their normal counterpart |
| Beschreibung: | 1 Online-Ressource (XVI, 367 p) |
| ISBN: | 9783642778520 |
| DOI: | 10.1007/978-3-642-77852-0 |
Internformat
MARC
| LEADER | 00000nmm a2200000zc 4500 | ||
|---|---|---|---|
| 001 | BV046144371 | ||
| 003 | DE-604 | ||
| 005 | 00000000000000.0 | ||
| 007 | cr|uuu---uuuuu | ||
| 008 | 190905s1993 |||| o||u| ||||||eng d | ||
| 020 | |a 9783642778520 |9 978-3-642-77852-0 | ||
| 024 | 7 | |a 10.1007/978-3-642-77852-0 |2 doi | |
| 035 | |a (ZDB-2-SME)978-3-642-77852-0 | ||
| 035 | |a (OCoLC)1119008497 | ||
| 035 | |a (DE-599)BVBBV046144371 | ||
| 040 | |a DE-604 |b ger |e aacr | ||
| 041 | 0 | |a eng | |
| 049 | |a DE-355 | ||
| 082 | 0 | |a 618.2 |2 23 | |
| 084 | |a XH 8325 |0 (DE-625)152955:13154 |2 rvk | ||
| 245 | 1 | 0 | |a The Human Yolk Sac and Yolk Sac Tumors |c edited by Francisco F. Nogales |
| 264 | 1 | |a Berlin, Heidelberg |b Springer Berlin Heidelberg |c 1993 | |
| 300 | |a 1 Online-Ressource (XVI, 367 p) | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b c |2 rdamedia | ||
| 338 | |b cr |2 rdacarrier | ||
| 520 | |a I am honored to have been invited to write a foreword for this book, because tumors of the yolk sac have been a preoccupation of mine since the days of my residency, now more than 3 decades ago. At that time, a 3-year-old boy died of a testicular cancer of unknown histo genesis. It was bad enough that the child died, but it bothered me even more that medical science did not know the histogenesis of the tumor that destroyed him, and I decided to study testicular cancer. For re search training I sought out F. J. Dixon, who had written the Armed Forces Fascicle on testicular tumors. Dr. Dixon and I showed that embryonal carcinoma was a multipoten tial malignant stem cell that differentiated into the three embryonic germ layers of murine teratocarcinoma. This led to the idea that the normal counterpart of embryonal carcinoma must also be multi potent, and we focused on the preimplantation embryo for the histo genesis of the tumor. This idea was strengthened by the discovery that embryonal carcinoma cells made embryoid bodies in the ascites and it was possible to observe the development of these bodies in vitro. These observations led to the idea that embryonal carcinoma was a caricature (gross misrepresentation) of early development, and car cinomas in general were a caricature of the process of renewal of their normal counterpart | ||
| 650 | 4 | |a Obstetrics/Perinatology/Midwifery | |
| 650 | 4 | |a Pathology | |
| 650 | 4 | |a Oncology | |
| 650 | 4 | |a Biochemistry, general | |
| 650 | 4 | |a Obstetrics | |
| 650 | 4 | |a Pathology | |
| 650 | 4 | |a Oncology | |
| 650 | 4 | |a Biochemistry | |
| 650 | 0 | 7 | |a Dottersack |0 (DE-588)4321805-2 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Endodermaler Sinustumor |0 (DE-588)4152379-9 |2 gnd |9 rswk-swf |
| 655 | 7 | |0 (DE-588)4143413-4 |a Aufsatzsammlung |2 gnd-content | |
| 689 | 0 | 0 | |a Endodermaler Sinustumor |0 (DE-588)4152379-9 |D s |
| 689 | 0 | |5 DE-604 | |
| 689 | 1 | 0 | |a Dottersack |0 (DE-588)4321805-2 |D s |
| 689 | 1 | |5 DE-604 | |
| 700 | 1 | |a Nogales, Francisco F. |4 edt | |
| 776 | 0 | 8 | |i Erscheint auch als |n Druck-Ausgabe |z 9783642778544 |
| 776 | 0 | 8 | |i Erscheint auch als |n Druck-Ausgabe |z 9783540560319 |
| 776 | 0 | 8 | |i Erscheint auch als |n Druck-Ausgabe |z 9783642778537 |
| 856 | 4 | 0 | |u https://doi.org/10.1007/978-3-642-77852-0 |x Verlag |z URL des Erstveröffentlichers |3 Volltext |
| 912 | |a ZDB-2-SME | ||
| 940 | 1 | |q ZDB-2-SME_1990/2004 | |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-031524556 | ||
| 966 | e | |u https://doi.org/10.1007/978-3-642-77852-0 |l UBR01 |p ZDB-2-SME |q ZDB-2-SME_1990/2004 |x Verlag |3 Volltext | |
Datensatz im Suchindex
| _version_ | 1804180479683854336 |
|---|---|
| any_adam_object | |
| author2 | Nogales, Francisco F. |
| author2_role | edt |
| author2_variant | f f n ff ffn |
| author_facet | Nogales, Francisco F. |
| building | Verbundindex |
| bvnumber | BV046144371 |
| classification_rvk | XH 8325 |
| collection | ZDB-2-SME |
| ctrlnum | (ZDB-2-SME)978-3-642-77852-0 (OCoLC)1119008497 (DE-599)BVBBV046144371 |
| dewey-full | 618.2 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 618 - Gynecology, obstetrics, pediatrics, geriatrics |
| dewey-raw | 618.2 |
| dewey-search | 618.2 |
| dewey-sort | 3618.2 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| doi_str_mv | 10.1007/978-3-642-77852-0 |
| format | Electronic eBook |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>03403nmm a2200577zc 4500</leader><controlfield tag="001">BV046144371</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">00000000000000.0</controlfield><controlfield tag="007">cr|uuu---uuuuu</controlfield><controlfield tag="008">190905s1993 |||| o||u| ||||||eng d</controlfield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9783642778520</subfield><subfield code="9">978-3-642-77852-0</subfield></datafield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/978-3-642-77852-0</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ZDB-2-SME)978-3-642-77852-0</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)1119008497</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV046144371</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">aacr</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-355</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">618.2</subfield><subfield code="2">23</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">XH 8325</subfield><subfield code="0">(DE-625)152955:13154</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">The Human Yolk Sac and Yolk Sac Tumors</subfield><subfield code="c">edited by Francisco F. Nogales</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Berlin, Heidelberg</subfield><subfield code="b">Springer Berlin Heidelberg</subfield><subfield code="c">1993</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">1 Online-Ressource (XVI, 367 p)</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">I am honored to have been invited to write a foreword for this book, because tumors of the yolk sac have been a preoccupation of mine since the days of my residency, now more than 3 decades ago. At that time, a 3-year-old boy died of a testicular cancer of unknown histo genesis. It was bad enough that the child died, but it bothered me even more that medical science did not know the histogenesis of the tumor that destroyed him, and I decided to study testicular cancer. For re search training I sought out F. J. Dixon, who had written the Armed Forces Fascicle on testicular tumors. Dr. Dixon and I showed that embryonal carcinoma was a multipoten tial malignant stem cell that differentiated into the three embryonic germ layers of murine teratocarcinoma. This led to the idea that the normal counterpart of embryonal carcinoma must also be multi potent, and we focused on the preimplantation embryo for the histo genesis of the tumor. This idea was strengthened by the discovery that embryonal carcinoma cells made embryoid bodies in the ascites and it was possible to observe the development of these bodies in vitro. These observations led to the idea that embryonal carcinoma was a caricature (gross misrepresentation) of early development, and car cinomas in general were a caricature of the process of renewal of their normal counterpart</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Obstetrics/Perinatology/Midwifery</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Pathology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Oncology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Biochemistry, general</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Obstetrics</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Pathology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Oncology </subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Biochemistry</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Dottersack</subfield><subfield code="0">(DE-588)4321805-2</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Endodermaler Sinustumor</subfield><subfield code="0">(DE-588)4152379-9</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="655" ind1=" " ind2="7"><subfield code="0">(DE-588)4143413-4</subfield><subfield code="a">Aufsatzsammlung</subfield><subfield code="2">gnd-content</subfield></datafield><datafield tag="689" ind1="0" ind2="0"><subfield code="a">Endodermaler Sinustumor</subfield><subfield code="0">(DE-588)4152379-9</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="689" ind1="1" ind2="0"><subfield code="a">Dottersack</subfield><subfield code="0">(DE-588)4321805-2</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="1" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Nogales, Francisco F.</subfield><subfield code="4">edt</subfield></datafield><datafield tag="776" ind1="0" ind2="8"><subfield code="i">Erscheint auch als</subfield><subfield code="n">Druck-Ausgabe</subfield><subfield code="z">9783642778544</subfield></datafield><datafield tag="776" ind1="0" ind2="8"><subfield code="i">Erscheint auch als</subfield><subfield code="n">Druck-Ausgabe</subfield><subfield code="z">9783540560319</subfield></datafield><datafield tag="776" ind1="0" ind2="8"><subfield code="i">Erscheint auch als</subfield><subfield code="n">Druck-Ausgabe</subfield><subfield code="z">9783642778537</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1007/978-3-642-77852-0</subfield><subfield code="x">Verlag</subfield><subfield code="z">URL des Erstveröffentlichers</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-2-SME</subfield></datafield><datafield tag="940" ind1="1" ind2=" "><subfield code="q">ZDB-2-SME_1990/2004</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-031524556</subfield></datafield><datafield tag="966" ind1="e" ind2=" "><subfield code="u">https://doi.org/10.1007/978-3-642-77852-0</subfield><subfield code="l">UBR01</subfield><subfield code="p">ZDB-2-SME</subfield><subfield code="q">ZDB-2-SME_1990/2004</subfield><subfield code="x">Verlag</subfield><subfield code="3">Volltext</subfield></datafield></record></collection> |
| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV046144371 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-10T08:36:25Z |
| institution | BVB |
| isbn | 9783642778520 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-031524556 |
| oclc_num | 1119008497 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR |
| owner_facet | DE-355 DE-BY-UBR |
| physical | 1 Online-Ressource (XVI, 367 p) |
| psigel | ZDB-2-SME ZDB-2-SME_1990/2004 ZDB-2-SME ZDB-2-SME_1990/2004 |
| publishDate | 1993 |
| publishDateSearch | 1993 |
| publishDateSort | 1993 |
| publisher | Springer Berlin Heidelberg |
| record_format | marc |
| spelling | The Human Yolk Sac and Yolk Sac Tumors edited by Francisco F. Nogales Berlin, Heidelberg Springer Berlin Heidelberg 1993 1 Online-Ressource (XVI, 367 p) txt rdacontent c rdamedia cr rdacarrier I am honored to have been invited to write a foreword for this book, because tumors of the yolk sac have been a preoccupation of mine since the days of my residency, now more than 3 decades ago. At that time, a 3-year-old boy died of a testicular cancer of unknown histo genesis. It was bad enough that the child died, but it bothered me even more that medical science did not know the histogenesis of the tumor that destroyed him, and I decided to study testicular cancer. For re search training I sought out F. J. Dixon, who had written the Armed Forces Fascicle on testicular tumors. Dr. Dixon and I showed that embryonal carcinoma was a multipoten tial malignant stem cell that differentiated into the three embryonic germ layers of murine teratocarcinoma. This led to the idea that the normal counterpart of embryonal carcinoma must also be multi potent, and we focused on the preimplantation embryo for the histo genesis of the tumor. This idea was strengthened by the discovery that embryonal carcinoma cells made embryoid bodies in the ascites and it was possible to observe the development of these bodies in vitro. These observations led to the idea that embryonal carcinoma was a caricature (gross misrepresentation) of early development, and car cinomas in general were a caricature of the process of renewal of their normal counterpart Obstetrics/Perinatology/Midwifery Pathology Oncology Biochemistry, general Obstetrics Oncology Biochemistry Dottersack (DE-588)4321805-2 gnd rswk-swf Endodermaler Sinustumor (DE-588)4152379-9 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Endodermaler Sinustumor (DE-588)4152379-9 s DE-604 Dottersack (DE-588)4321805-2 s Nogales, Francisco F. edt Erscheint auch als Druck-Ausgabe 9783642778544 Erscheint auch als Druck-Ausgabe 9783540560319 Erscheint auch als Druck-Ausgabe 9783642778537 https://doi.org/10.1007/978-3-642-77852-0 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | The Human Yolk Sac and Yolk Sac Tumors Obstetrics/Perinatology/Midwifery Pathology Oncology Biochemistry, general Obstetrics Oncology Biochemistry Dottersack (DE-588)4321805-2 gnd Endodermaler Sinustumor (DE-588)4152379-9 gnd |
| subject_GND | (DE-588)4321805-2 (DE-588)4152379-9 (DE-588)4143413-4 |
| title | The Human Yolk Sac and Yolk Sac Tumors |
| title_auth | The Human Yolk Sac and Yolk Sac Tumors |
| title_exact_search | The Human Yolk Sac and Yolk Sac Tumors |
| title_full | The Human Yolk Sac and Yolk Sac Tumors edited by Francisco F. Nogales |
| title_fullStr | The Human Yolk Sac and Yolk Sac Tumors edited by Francisco F. Nogales |
| title_full_unstemmed | The Human Yolk Sac and Yolk Sac Tumors edited by Francisco F. Nogales |
| title_short | The Human Yolk Sac and Yolk Sac Tumors |
| title_sort | the human yolk sac and yolk sac tumors |
| topic | Obstetrics/Perinatology/Midwifery Pathology Oncology Biochemistry, general Obstetrics Oncology Biochemistry Dottersack (DE-588)4321805-2 gnd Endodermaler Sinustumor (DE-588)4152379-9 gnd |
| topic_facet | Obstetrics/Perinatology/Midwifery Pathology Oncology Biochemistry, general Obstetrics Oncology Biochemistry Dottersack Endodermaler Sinustumor Aufsatzsammlung |
| url | https://doi.org/10.1007/978-3-642-77852-0 |
| work_keys_str_mv | AT nogalesfranciscof thehumanyolksacandyolksactumors |