Leukocyte Recruitment, Endothelial Cell Adhesion Molecules, and Transcriptional Control: Insights for Drug Discovery
The localized attachment of circulating leukocytes to endothelium has been recognized as the cellular hallmark of the inflammatory response. This adhesive interaction, a necessary antecedent to the emigration of leukocytes from the blood into the tissues, is mediated by vascular adhesion molecules....
Gespeichert in:
| Weitere Verfasser: | |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Boston, MA
Springer US
2001
|
| Schlagworte: | |
| Online-Zugang: | UBR01 Volltext |
| Zusammenfassung: | The localized attachment of circulating leukocytes to endothelium has been recognized as the cellular hallmark of the inflammatory response. This adhesive interaction, a necessary antecedent to the emigration of leukocytes from the blood into the tissues, is mediated by vascular adhesion molecules. Leukocyte Recruitment, Endothelial Cell Adhesion Molecules and Transcriptional Control: Insights for Drug Discovery outlines some of the cellular and molecular mechanisms of inflammation with contributions from top researchers. This volume provides an overview of three of these endothelial adhesion molecules, as examples of key mediators of leukocyte recruitment. It reviews the structure and regulation of these cell surface proteins and focus on the rapidly expanding field of transcriptional regulation of these inducible proteins, and closes with a discussion of drug discovery possibilities that target the regulation of leukocyte recruitment. This book will be of interest for any researchers, in academia or industry, looking for an overview of leukocyte recruitment or novel approaches to drug discovery |
| Beschreibung: | 1 Online-Ressource (XIII, 327 p) |
| ISBN: | 9781461515654 |
| DOI: | 10.1007/978-1-4615-1565-4 |
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| 520 | |a The localized attachment of circulating leukocytes to endothelium has been recognized as the cellular hallmark of the inflammatory response. This adhesive interaction, a necessary antecedent to the emigration of leukocytes from the blood into the tissues, is mediated by vascular adhesion molecules. Leukocyte Recruitment, Endothelial Cell Adhesion Molecules and Transcriptional Control: Insights for Drug Discovery outlines some of the cellular and molecular mechanisms of inflammation with contributions from top researchers. This volume provides an overview of three of these endothelial adhesion molecules, as examples of key mediators of leukocyte recruitment. It reviews the structure and regulation of these cell surface proteins and focus on the rapidly expanding field of transcriptional regulation of these inducible proteins, and closes with a discussion of drug discovery possibilities that target the regulation of leukocyte recruitment. This book will be of interest for any researchers, in academia or industry, looking for an overview of leukocyte recruitment or novel approaches to drug discovery | ||
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Datensatz im Suchindex
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| author2 | Collins, Tucker |
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| dewey-ones | 616 - Diseases |
| dewey-raw | 616.07 |
| dewey-search | 616.07 |
| dewey-sort | 3616.07 |
| dewey-tens | 610 - Medicine and health |
| discipline | Biologie Medizin |
| doi_str_mv | 10.1007/978-1-4615-1565-4 |
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| illustrated | Not Illustrated |
| indexdate | 2024-07-10T08:36:24Z |
| institution | BVB |
| isbn | 9781461515654 |
| language | English |
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| spelling | Leukocyte Recruitment, Endothelial Cell Adhesion Molecules, and Transcriptional Control Insights for Drug Discovery edited by Tucker Collins Boston, MA Springer US 2001 1 Online-Ressource (XIII, 327 p) txt rdacontent c rdamedia cr rdacarrier The localized attachment of circulating leukocytes to endothelium has been recognized as the cellular hallmark of the inflammatory response. This adhesive interaction, a necessary antecedent to the emigration of leukocytes from the blood into the tissues, is mediated by vascular adhesion molecules. Leukocyte Recruitment, Endothelial Cell Adhesion Molecules and Transcriptional Control: Insights for Drug Discovery outlines some of the cellular and molecular mechanisms of inflammation with contributions from top researchers. This volume provides an overview of three of these endothelial adhesion molecules, as examples of key mediators of leukocyte recruitment. It reviews the structure and regulation of these cell surface proteins and focus on the rapidly expanding field of transcriptional regulation of these inducible proteins, and closes with a discussion of drug discovery possibilities that target the regulation of leukocyte recruitment. This book will be of interest for any researchers, in academia or industry, looking for an overview of leukocyte recruitment or novel approaches to drug discovery Pathology Microbiology Veterinary Medicine/Veterinary Science Biochemistry, general Pneumology/Respiratory System Veterinary medicine Biochemistry Pneumology Transkription Genetik (DE-588)4185906-6 gnd rswk-swf Zelladhäsion (DE-588)4314136-5 gnd rswk-swf Leukozyt (DE-588)4074195-3 gnd rswk-swf Leukozyt (DE-588)4074195-3 s Zelladhäsion (DE-588)4314136-5 s Transkription Genetik (DE-588)4185906-6 s 1\p DE-604 Collins, Tucker edt Erscheint auch als Druck-Ausgabe 9780792372233 Erscheint auch als Druck-Ausgabe 9781461356172 Erscheint auch als Druck-Ausgabe 9781461515661 https://doi.org/10.1007/978-1-4615-1565-4 Verlag URL des Erstveröffentlichers Volltext 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Leukocyte Recruitment, Endothelial Cell Adhesion Molecules, and Transcriptional Control Insights for Drug Discovery Pathology Microbiology Veterinary Medicine/Veterinary Science Biochemistry, general Pneumology/Respiratory System Veterinary medicine Biochemistry Pneumology Transkription Genetik (DE-588)4185906-6 gnd Zelladhäsion (DE-588)4314136-5 gnd Leukozyt (DE-588)4074195-3 gnd |
| subject_GND | (DE-588)4185906-6 (DE-588)4314136-5 (DE-588)4074195-3 |
| title | Leukocyte Recruitment, Endothelial Cell Adhesion Molecules, and Transcriptional Control Insights for Drug Discovery |
| title_auth | Leukocyte Recruitment, Endothelial Cell Adhesion Molecules, and Transcriptional Control Insights for Drug Discovery |
| title_exact_search | Leukocyte Recruitment, Endothelial Cell Adhesion Molecules, and Transcriptional Control Insights for Drug Discovery |
| title_full | Leukocyte Recruitment, Endothelial Cell Adhesion Molecules, and Transcriptional Control Insights for Drug Discovery edited by Tucker Collins |
| title_fullStr | Leukocyte Recruitment, Endothelial Cell Adhesion Molecules, and Transcriptional Control Insights for Drug Discovery edited by Tucker Collins |
| title_full_unstemmed | Leukocyte Recruitment, Endothelial Cell Adhesion Molecules, and Transcriptional Control Insights for Drug Discovery edited by Tucker Collins |
| title_short | Leukocyte Recruitment, Endothelial Cell Adhesion Molecules, and Transcriptional Control |
| title_sort | leukocyte recruitment endothelial cell adhesion molecules and transcriptional control insights for drug discovery |
| title_sub | Insights for Drug Discovery |
| topic | Pathology Microbiology Veterinary Medicine/Veterinary Science Biochemistry, general Pneumology/Respiratory System Veterinary medicine Biochemistry Pneumology Transkription Genetik (DE-588)4185906-6 gnd Zelladhäsion (DE-588)4314136-5 gnd Leukozyt (DE-588)4074195-3 gnd |
| topic_facet | Pathology Microbiology Veterinary Medicine/Veterinary Science Biochemistry, general Pneumology/Respiratory System Veterinary medicine Biochemistry Pneumology Transkription Genetik Zelladhäsion Leukozyt |
| url | https://doi.org/10.1007/978-1-4615-1565-4 |
| work_keys_str_mv | AT collinstucker leukocyterecruitmentendothelialcelladhesionmoleculesandtranscriptionalcontrolinsightsfordrugdiscovery |