The IGF System: Molecular Biology, Physiology, and Clinical Applications
It has been over 40 years since the original report by Salmon and Daughaday demon strating that the ability of GH to stimulate sulfation of cartilage was mediated by a "sulfation factor. " In the ensuing decades, it has become apparent that this "sulfation factor activity" encom...
Gespeichert in:
| Weitere Verfasser: | , |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Totowa, NJ
Humana Press
1999
|
| Schriftenreihe: | Contemporary Endocrinology
17 |
| Schlagworte: | |
| Online-Zugang: | UBR01 Volltext |
| Zusammenfassung: | It has been over 40 years since the original report by Salmon and Daughaday demon strating that the ability of GH to stimulate sulfation of cartilage was mediated by a "sulfation factor. " In the ensuing decades, it has become apparent that this "sulfation factor activity" encompasses a complex system ofligands (IGFs), receptors, and carrier proteins that are, in tum, responsible for a wide array of cellular actions. The IGF system has been demonstrated to be critically involved in both intrauterine and postnatal growth, and to have important implications in cancer biology as well, owing to the ability of the IGFs to function in endocrine, paracrine, and autocrine modes and given the wide distri bution of IGFs in virtually every organ system. The contributions to The /GF System reflect the wide span of interest in the IGF system and its implications for normal and abnormal growth and metabolism. The chapters have been divided into four broad sections: I. Molecular biology of the IGF system; II. Bio logical actions of the IGFs; III. IGF physiology; and IV. Clinical aspects of the IGFs. We have made every effort to highlight the major contemporary themes in IGF biology, but as is inevitable in such a fast-moving field, perspectives will continue to change as new information is accumulated |
| Beschreibung: | 1 Online-Ressource (XII, 788 p) |
| ISBN: | 9781592597123 |
| DOI: | 10.1007/978-1-59259-712-3 |
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| 520 | |a It has been over 40 years since the original report by Salmon and Daughaday demon strating that the ability of GH to stimulate sulfation of cartilage was mediated by a "sulfation factor. " In the ensuing decades, it has become apparent that this "sulfation factor activity" encompasses a complex system ofligands (IGFs), receptors, and carrier proteins that are, in tum, responsible for a wide array of cellular actions. The IGF system has been demonstrated to be critically involved in both intrauterine and postnatal growth, and to have important implications in cancer biology as well, owing to the ability of the IGFs to function in endocrine, paracrine, and autocrine modes and given the wide distri bution of IGFs in virtually every organ system. The contributions to The /GF System reflect the wide span of interest in the IGF system and its implications for normal and abnormal growth and metabolism. The chapters have been divided into four broad sections: I. Molecular biology of the IGF system; II. Bio logical actions of the IGFs; III. IGF physiology; and IV. Clinical aspects of the IGFs. We have made every effort to highlight the major contemporary themes in IGF biology, but as is inevitable in such a fast-moving field, perspectives will continue to change as new information is accumulated | ||
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| dewey-hundreds | 600 - Technology (Applied sciences) |
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| discipline | Medizin |
| doi_str_mv | 10.1007/978-1-59259-712-3 |
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| indexdate | 2024-07-10T08:36:24Z |
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| isbn | 9781592597123 |
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| spelling | The IGF System Molecular Biology, Physiology, and Clinical Applications edited by Ron G. Rosenfeld, Charles T. Roberts Totowa, NJ Humana Press 1999 1 Online-Ressource (XII, 788 p) txt rdacontent c rdamedia cr rdacarrier Contemporary Endocrinology 17 It has been over 40 years since the original report by Salmon and Daughaday demon strating that the ability of GH to stimulate sulfation of cartilage was mediated by a "sulfation factor. " In the ensuing decades, it has become apparent that this "sulfation factor activity" encompasses a complex system ofligands (IGFs), receptors, and carrier proteins that are, in tum, responsible for a wide array of cellular actions. The IGF system has been demonstrated to be critically involved in both intrauterine and postnatal growth, and to have important implications in cancer biology as well, owing to the ability of the IGFs to function in endocrine, paracrine, and autocrine modes and given the wide distri bution of IGFs in virtually every organ system. The contributions to The /GF System reflect the wide span of interest in the IGF system and its implications for normal and abnormal growth and metabolism. The chapters have been divided into four broad sections: I. Molecular biology of the IGF system; II. Bio logical actions of the IGFs; III. IGF physiology; and IV. Clinical aspects of the IGFs. We have made every effort to highlight the major contemporary themes in IGF biology, but as is inevitable in such a fast-moving field, perspectives will continue to change as new information is accumulated Human Physiology Endocrinology Reproductive Medicine Human physiology Rosenfeld, Ron G. edt Roberts, Charles T. edt Erscheint auch als Druck-Ausgabe 9781617371387 Erscheint auch als Druck-Ausgabe 9780896036925 Erscheint auch als Druck-Ausgabe 9781475767438 https://doi.org/10.1007/978-1-59259-712-3 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | The IGF System Molecular Biology, Physiology, and Clinical Applications Human Physiology Endocrinology Reproductive Medicine Human physiology |
| title | The IGF System Molecular Biology, Physiology, and Clinical Applications |
| title_auth | The IGF System Molecular Biology, Physiology, and Clinical Applications |
| title_exact_search | The IGF System Molecular Biology, Physiology, and Clinical Applications |
| title_full | The IGF System Molecular Biology, Physiology, and Clinical Applications edited by Ron G. Rosenfeld, Charles T. Roberts |
| title_fullStr | The IGF System Molecular Biology, Physiology, and Clinical Applications edited by Ron G. Rosenfeld, Charles T. Roberts |
| title_full_unstemmed | The IGF System Molecular Biology, Physiology, and Clinical Applications edited by Ron G. Rosenfeld, Charles T. Roberts |
| title_short | The IGF System |
| title_sort | the igf system molecular biology physiology and clinical applications |
| title_sub | Molecular Biology, Physiology, and Clinical Applications |
| topic | Human Physiology Endocrinology Reproductive Medicine Human physiology |
| topic_facet | Human Physiology Endocrinology Reproductive Medicine Human physiology |
| url | https://doi.org/10.1007/978-1-59259-712-3 |
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