The Complement System: Novel Roles in Health and Disease
As a phylogenetically old system complement is now regarded as a part of innate immunity. But it is much more than that. It bridges innate and adapted immunity, participates not only in host defense but also in many essential physiological processes, old and new diseases and adverse conditions. Inde...
Gespeichert in:
| Weitere Verfasser: | |
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| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Boston, MA
Springer US
2004
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| Schlagworte: | |
| Online-Zugang: | UBR01 Volltext |
| Zusammenfassung: | As a phylogenetically old system complement is now regarded as a part of innate immunity. But it is much more than that. It bridges innate and adapted immunity, participates not only in host defense but also in many essential physiological processes, old and new diseases and adverse conditions. Indeed, complement became a term that almost defies categorization. What was for a long time a subject for a limited number of specialists has now moved into the mainstream of experimental and clinical immunology. In 1973 I visited the Basel Institute of Immunology and met its director, the eminent scientist and Nobel laureate Nils Jerne. When I entered his office he greeted me with the following words: "Complement, does that really exist?" I was never certain whether he wanted only to tease me or whether he sincerely believed that the complement system was an unimportant biological curiosity, a misstep of evolution. But, of course, missteps do not survive the evolutionary process. Little did I foresee the dramatic developments of recent years when Hans J. Müller-Eberhard and I started to unravel the specifics of the action of the cobra venom factor on the complement system in 1968 and defined a new pathway to its activation. An elucidation of the role of the system in diseases and its control for therapeutic reasons is now getting closer to actual realization in the clinic although many problems, in particular those of highly specificinhibition free of side effects, have still to be resolved |
| Beschreibung: | 1 Online-Ressource (XXI, 565 p) |
| ISBN: | 9781402080562 |
| DOI: | 10.1007/b110959 |
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| 520 | |a As a phylogenetically old system complement is now regarded as a part of innate immunity. But it is much more than that. It bridges innate and adapted immunity, participates not only in host defense but also in many essential physiological processes, old and new diseases and adverse conditions. Indeed, complement became a term that almost defies categorization. What was for a long time a subject for a limited number of specialists has now moved into the mainstream of experimental and clinical immunology. In 1973 I visited the Basel Institute of Immunology and met its director, the eminent scientist and Nobel laureate Nils Jerne. When I entered his office he greeted me with the following words: "Complement, does that really exist?" I was never certain whether he wanted only to tease me or whether he sincerely believed that the complement system was an unimportant biological curiosity, a misstep of evolution. But, of course, missteps do not survive the evolutionary process. Little did I foresee the dramatic developments of recent years when Hans J. Müller-Eberhard and I started to unravel the specifics of the action of the cobra venom factor on the complement system in 1968 and defined a new pathway to its activation. An elucidation of the role of the system in diseases and its control for therapeutic reasons is now getting closer to actual realization in the clinic although many problems, in particular those of highly specificinhibition free of side effects, have still to be resolved | ||
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| spelling | The Complement System Novel Roles in Health and Disease edited by Janos Szebeni Boston, MA Springer US 2004 1 Online-Ressource (XXI, 565 p) txt rdacontent c rdamedia cr rdacarrier As a phylogenetically old system complement is now regarded as a part of innate immunity. But it is much more than that. It bridges innate and adapted immunity, participates not only in host defense but also in many essential physiological processes, old and new diseases and adverse conditions. Indeed, complement became a term that almost defies categorization. What was for a long time a subject for a limited number of specialists has now moved into the mainstream of experimental and clinical immunology. In 1973 I visited the Basel Institute of Immunology and met its director, the eminent scientist and Nobel laureate Nils Jerne. When I entered his office he greeted me with the following words: "Complement, does that really exist?" I was never certain whether he wanted only to tease me or whether he sincerely believed that the complement system was an unimportant biological curiosity, a misstep of evolution. But, of course, missteps do not survive the evolutionary process. Little did I foresee the dramatic developments of recent years when Hans J. Müller-Eberhard and I started to unravel the specifics of the action of the cobra venom factor on the complement system in 1968 and defined a new pathway to its activation. An elucidation of the role of the system in diseases and its control for therapeutic reasons is now getting closer to actual realization in the clinic although many problems, in particular those of highly specificinhibition free of side effects, have still to be resolved Internal Medicine Immunology Allergology Infectious Diseases Rheumatology Internal medicine Allergy Emerging infectious diseases Komplement Immunologie (DE-588)4120589-3 gnd rswk-swf Komplement Immunologie (DE-588)4120589-3 s 1\p DE-604 Szebeni, Janos edt Erscheint auch als Druck-Ausgabe 9781475779288 Erscheint auch als Druck-Ausgabe 9781402080555 Erscheint auch als Druck-Ausgabe 9781475779271 https://doi.org/10.1007/b110959 Verlag URL des Erstveröffentlichers Volltext 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | The Complement System Novel Roles in Health and Disease Internal Medicine Immunology Allergology Infectious Diseases Rheumatology Internal medicine Allergy Emerging infectious diseases Komplement Immunologie (DE-588)4120589-3 gnd |
| subject_GND | (DE-588)4120589-3 |
| title | The Complement System Novel Roles in Health and Disease |
| title_auth | The Complement System Novel Roles in Health and Disease |
| title_exact_search | The Complement System Novel Roles in Health and Disease |
| title_full | The Complement System Novel Roles in Health and Disease edited by Janos Szebeni |
| title_fullStr | The Complement System Novel Roles in Health and Disease edited by Janos Szebeni |
| title_full_unstemmed | The Complement System Novel Roles in Health and Disease edited by Janos Szebeni |
| title_short | The Complement System |
| title_sort | the complement system novel roles in health and disease |
| title_sub | Novel Roles in Health and Disease |
| topic | Internal Medicine Immunology Allergology Infectious Diseases Rheumatology Internal medicine Allergy Emerging infectious diseases Komplement Immunologie (DE-588)4120589-3 gnd |
| topic_facet | Internal Medicine Immunology Allergology Infectious Diseases Rheumatology Internal medicine Allergy Emerging infectious diseases Komplement Immunologie |
| url | https://doi.org/10.1007/b110959 |
| work_keys_str_mv | AT szebenijanos thecomplementsystemnovelrolesinhealthanddisease |