Mimicking paracrine cell communication in vitro in 3D scaffolds:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Elektronisch Software E-Book |
| Sprache: | English |
| Veröffentlicht: |
Leipzig
2018
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Inhaltsverzeichnis |
| Beschreibung: | 1 CD-ROM (82 Seiten) Illustrationen 12 cm |
Internformat
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| 245 | 1 | 0 | |a Mimicking paracrine cell communication in vitro in 3D scaffolds |c vorgelegt von Michael Ansorge |
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Datensatz im Suchindex
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|---|---|
| adam_text | CONTENTS
1 INTR O D U C TIO N
.......................................................................................................................................................................................
1
2
STATE-OF-THE-ART.................................................................................................................................................................................3
2 .1 P
ARACRINE
C
ELL
C
O M M U N IC A T IO N
...................................................................................................................................................3
2.2 I
N
VITRO
M
ODELS
OF
P
ARACRINE
C
ELL
C
O M M U N IC A T IO N
............................................................................................................6
2.2.1 TRANSFERRING THE IN VIVO SITUATION TO IN VITRO SETUPS
...............................................................................................
6
2.2.2 ENGINEERING PARACRINE COMMUNICATION IN VITRO
........................................................................................................
7
2 .3 R
OAD
TO
L
OCALIZED
R
ELEASE
..........................................................................................................................................................
10
2.3.1 AFFINITY-BASED RELEASE
......................................................................................................................................................
10
2.3.2 MICROPARTICLES AS CYTOKINE POINT SOURCES
..................................................................................................................
13
2 .4 G
RADIENT
F
OR M ATIO N
FROM
L
OCALIZED
R
ELEASE
S
YS T E M S
....................................................................................................
14
2.4.1 ANALYSIS O F GRADIENT FORMATION
.....................................................................................................................................
14
2.4.2 THEORY OF GRADIENT FORMATION
........................................................................................................................................
18
2.5 A
PPLICATION
A N D
V
ERIFICATION
OF
B
IO M IM E T IC
P
ARACRINE
S
YSTEMS
IN
C
ELL
C
ULTURE
.....................................................
21
2.5.1 LOCALIZED SINGLE CELL ANALYSIS IN 3D SYSTEMS
.............................................................................................................
21
2.5.2 CELL CULTURE STUDIES ON PARACRINE CELL SIGNALS IN VITRO
............................................................................................
22
3
PUBLICATIONS.......................................................................................................................................................................................
27
3.1 M
O T IV A T IO N
.....................................................................................................................................................................................
27
3.2 O
BJECTIVES
........................................................................................................................................................................................27
3.3 O
VERVIEW
OF
P
U BLICATIO NS
..........................................................................................................................................................29
3 .4 P
UBLISHED
A
RTICLES
.........................................................................................................................................................................30
SHORT-RANGE CYTOKINE GRADIENTS TO MIMIC PARACRINE CELL INTERACTIONS IN
VITRO
...........................................................
31
MIMICKING PARACRINE TGF61 SIGNALS DURING MYOFIBROBLAST DIFFERENTIATION
IN 3D COLLAGEN NETWORKS
.............
43
4
CONCLUSIONS.......................................................................................................................................................................................
53
5
REFERENCES...........................................................................................................................................................................................
57
APPENDIX...................................................................................................................................................................................................69
Z
U SA M M ENFA SSUN G
...............................................................................................................................................................................
69
L
IST
OF
A
BBREVIATIONS
..........................................................................................................................................................................
73
D
ECLARATION
OF
AU TH O R SHIP
...............................................................................................................................................................
74
A
UTHOR
C
ONTRIBUTIONS
TO
C
HAPTER
2 S
TATE
-
OF
-
THE
-A
RT
.......................................................................................................
75
A
UTHOR
C
ONTRIBUTIONS
TO
P
UBLISHED
A
RTICLE
1
............................................................................................................................
76
A
UTHOR
C
ONTRIBUTIONS
TO
P
UBLISHED
A
RTICLE
2
............................................................................................................................
78
C
URRICULUM
V
ITAE
..................................................................................................................................................................................79
L
IST
OF
P
UBLICATIONS
AN D
C
ONFERENCE
C
ONTRIBUTIONS
.................................................................................................................
80
A
CKNOWLEDGEMENTS
82
|
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| spelling | Ansorge, Michael 1987- Verfasser (DE-588)115531218X aut Mimicking paracrine cell communication in vitro in 3D scaffolds vorgelegt von Michael Ansorge Leipzig 2018 1 CD-ROM (82 Seiten) Illustrationen 12 cm txt rdacontent c rdamedia cd rdacarrier Dissertation Universität Leipzig 2018 (DE-588)4113937-9 Hochschulschrift gnd-content (DE-588)4139307-7 CD-ROM gnd-carrier B:DE-101 application/pdf http://d-nb.info/1154704882/04 Inhaltsverzeichnis DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=031522573&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Textdatei PDF |
| spellingShingle | Ansorge, Michael 1987- Mimicking paracrine cell communication in vitro in 3D scaffolds |
| subject_GND | (DE-588)4113937-9 (DE-588)4139307-7 |
| title | Mimicking paracrine cell communication in vitro in 3D scaffolds |
| title_auth | Mimicking paracrine cell communication in vitro in 3D scaffolds |
| title_exact_search | Mimicking paracrine cell communication in vitro in 3D scaffolds |
| title_full | Mimicking paracrine cell communication in vitro in 3D scaffolds vorgelegt von Michael Ansorge |
| title_fullStr | Mimicking paracrine cell communication in vitro in 3D scaffolds vorgelegt von Michael Ansorge |
| title_full_unstemmed | Mimicking paracrine cell communication in vitro in 3D scaffolds vorgelegt von Michael Ansorge |
| title_short | Mimicking paracrine cell communication in vitro in 3D scaffolds |
| title_sort | mimicking paracrine cell communication in vitro in 3d scaffolds |
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