The habenula as an evolutionary conserved link between basal ganglia, limbic and sensory systems: from anuran amphibians to mammals
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
Köln
2019
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Inhaltsverzeichnis |
| Beschreibung: | IX, 106 Seiten Illustrationen, Diagramme 21 cm |
Internformat
MARC
| LEADER | 00000nam a2200000 c 4500 | ||
|---|---|---|---|
| 001 | BV046114740 | ||
| 003 | DE-604 | ||
| 005 | 00000000000000.0 | ||
| 007 | t | ||
| 008 | 190823s2019 gw a||| m||| 00||| eng d | ||
| 015 | |a 19,H06 |2 dnb | ||
| 016 | 7 | |a 1184816867 |2 DE-101 | |
| 020 | |c Broschur | ||
| 035 | |a (OCoLC)1119068208 | ||
| 035 | |a (DE-599)DNB1184816867 | ||
| 040 | |a DE-604 |b ger |e rda | ||
| 041 | 0 | |a eng | |
| 044 | |a gw |c XA-DE | ||
| 049 | |a DE-355 |a DE-83 | ||
| 084 | |a 570 |2 sdnb | ||
| 100 | 1 | |a Freudenmacher, Lars |e Verfasser |0 (DE-588)1180303903 |4 aut | |
| 245 | 1 | 0 | |a The habenula as an evolutionary conserved link between basal ganglia, limbic and sensory systems |b from anuran amphibians to mammals |c vorgelegt von Lars Freudenmacher |
| 264 | 1 | |a Köln |c 2019 | |
| 300 | |a IX, 106 Seiten |b Illustrationen, Diagramme |c 21 cm | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 502 | |b Dissertation |c Universität zu Köln |d 2018 | ||
| 655 | 7 | |0 (DE-588)4113937-9 |a Hochschulschrift |2 gnd-content | |
| 856 | 4 | 2 | |m B:DE-101 |q application/pdf |u http://d-nb.info/1184816867/04 |3 Inhaltsverzeichnis |
| 856 | 4 | 2 | |m DNB Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=031495263&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-031495263 | ||
Datensatz im Suchindex
| _version_ | 1804180432087941121 |
|---|---|
| adam_text | INDEX
I
I
NDEX
I
NDEX
............................................................................................................................................................
I
ABSTRACT
........................................................................................................................................................
V
ZUSAMMENFASSUNG
......................................................................................................................................
VI
LIST
OF
ABBREVIATIONS
................................................................................................................................
VIII
1
INTRODUCTION
..........................................................................................................................................
1
1.1
THE
BASAL
GANGLIA
.........................................................................................................................
2
1.1.1
THE
BASAL
GANGLIA
OF
ANURAN
AMPHIBIANS
............................................................................
6
CAUDATE-PUTAMEN
AND
DORSAL
PALLIDUM
...........................................................................................
6
SUBSTANTIA
NIGRA
PARS
COMPACTA
AND
VENTRAL
TEGMENTAL
AREA
...........................................................
7
CORTICAL/PALLIAL
LOOP
.........................................................................................................................
8
1.2
THE
HABENULA
................................................................................................................................
9
1.3
AIM
OF
THE
STUDY
..........................................................................................................................
12
2
EXPERIMENTAL
PREPARATION
...................................................................................................................
14
2.1
ISOLATED
BRAIN
PREPARATIONS
....................................................................................................
14
2.2
ANATOMICAL
TRACINGS
....................................................................................................................
14
2.2.1
IMMUNOHISTOCHEMICAL
PROCEDURES
....................................................................................
15
2.2.2
ANALYSIS
OF
HISTOLOGICAL
STAININGS
......................................................................................
16
2.3
INTRA-
AND EXTRACELLULAR
SHARP
ELECTRODE
RECORDINGS
.................................................................
17
2.3.1
DATA
ANALYSIS
OF
INTRA-
AND
EXTRACELLULAR
RECORDINGS
.........................................................
19
2.4
EXTRACELLULAR
RECORDINGS
OF
LOCAL FIELD
POTENTIALS
.....................................................................
20
2.4.1
DATA
ANALYSIS
OF
LOCAL
FIELD
POTENTIALS
...............................................................................
21
3
RESULTS
................................................................................................................................................
22
3.1
CONNECTIVITY
OF
THE
HABENULA
......................................................................................................
22
3.1.1
AFFERENTS
OF
THE
HABENULAR
NUCLEI
.....................................................................................
22
INPUT
FROM
BED
NUCLEUS
OF
THE
STRIA
TERMINALIS
AND
VENTRAL
PALLIDUM
...........................................
24
INPUT
FROM
PREOPTIC
AREA
AND
SUPRACHIASMATIC
NUCLEUS
...............................................................
24
INPUT
FROM SEPTUM
AND
NUCLEUS
OF
THE
DIAGONAL
BAND
OF
BROCA
..................................................
24
INPUT
FROM
NUCLEUS
ACCUMBENS
AND
ROSTRAL
PALLIUM
.....................................................................
24
LABELED
CELLS
IN
THE
OLFACTORY
BULBS
...............................................................................................
27
LABELED
CELLS
IN
THE
MEDIAL
PALLIUM
..............................................................................................
27
LABELED
CELLS
IN
THE
THALAMUS
........................................................................................................27
LABELED
CELLS
IN
STRIATUM
AND
STRIATOPALLIDUM
...............................................................................
27
INPUT
FROM
BED NUCLEUS
OF
THE
PALLIAL
COMMISSURE
AND
THALAMIC
EMINENCE
................................
28
INNERVATION
OF
THE
VENTRAL
HABENULA
BY
CELL
POPULATIONS
IN
THE
VENTRAL
THALAMUS
.......................
28
INPUT
FROM
OPTIC TECTUM
AND
TORUS
SEMICIRCULARIS
.........................................................................
28
II
INDEX
INPUT
FROM
HYPOTHALAMUS
AND
POSTERIOR
TUBERCLE
.........................................................................
29
INPUT
FROM
INTERFASCICULAR
AND
INTERPEDUNCULAR
NUCLEUS
.............................................................
29
INPUT
FROM
RAPHE
NUCLEI
..................................................................................................................29
3.2
EFFERENTS
OF
THE
HABENULAR
NUCLEI
..............................................................................................
30
THE
FASCICULUS
RETROFLEXUS
.............................................................................................................
30
VENTRAL
HABENULA
EFFERENTS
TO
THE
THALAMUS
..................................................................................
30
VENTRAL
HABENULA
EFFERENTS
TO
THE
VENTRAL
HYPOTHALAMUS,
PREOPTIC
AREA,
SEPTUM,
AND
NUCLEUS
OF
THE
DIAGONAL
BAND
OF
BROCA
............................................................................................................
30
VENTRAL
HABENULA EFFERENTS
TO
THE
SUPERFICIAL
MAMMILLAR
AREA
AND
POSTERIOR
TUBERCLE
...............
31
VENTRAL
HABENULA EFFERENTS
TO
THE
TORUS
SEMICIRCULARIS
AND OPTIC
TECTUM
...................................
31
DORSAL
HABENULA EFFERENTS
TO
THE
INTERPEDUNCULAR
AND
INTERFASCICULAR
NUCLEUS
..........................
31
VENTRAL
HABENULA
EFFERENTS
TO
THE
RAPHD
NUCLEI
............................................................................
31
3.2.1
TOPOGRAPHIC
ORGANIZATION
OF
THE
HABENULAR
NUCLEI
.........................................................
32
*
SUPERFICIAL
MAMMILLAR
*
RMTG
PROJECTING
VENTRAL
HABENULA
NEURONS
.....................................
33
DORSOMEDIAL
AND
DORSOLATERAL
POSTERIOR
TUBERCLE
PROJECTING
VENTRAL
HABENULA
NEURONS
............
33
INTERFASCICULAR
NUCLEUS
PROJECTING DORSAL
HABENULA
NEURONS
.......................................................
33
INTERPEDUNCULAR
NUCLEUS
PROJECTING
DORSAL
HABENULA
NEURONS
.....................................................
33
RAPHE
NUCLEI
PROJECTING
VENTRAL
HABENULA
NEURONS
.......................................................................
34
3.2.2
HABENULA
EFFERENTS
TO
DOPAMINERGIC
NEURONS
...................................................................
35
HABENULA
EFFERENTS
TO
THE
RETROMAMMILLAR
AREA
...........................................................................
35
VENTRAL
HABENULA
EFFERENTS
TO
THE
DORSOMEDIAL
POSTERIOR
TUBERCLE
...............................................
35
VENTRAL
HABENULA EFFERENTS
TO
THE
DORSOLATERAL
POSTERIOR
TUBERCLE
................................................
35
DORSAL
HABENULA
EFFERENTS
TO
THE
INTERFASCICULAR
NUCLEUS
............................................................
37
3.2.3
VENTRAL
HABENULA EFFERENTS
TO
GABAERGIC,
SEROTONERGIC,
AND
HISTAMINERGIC
NEURONS...
37
3.2.4
CONNECTIONS
OF
THE
*SUPERFICIAL
MAMMILLAR
*
RMTG
......................................................
38
3.3
DOPAMINERGIC
PROJECTIONS
OF
THE
POSTERIOR
TUBERCLE
AND
INTERFASCICULAR
NUCLEUS
TO
THE
STRIATUM,
NUCLEUS
ACCUMBENS,
ROSTRAL
PALLIUM,
AND
MEDULLA
OBLONGATA
.................................
39
3.4
INTRA-
AND
EXTRACELLULAR
RECORDINGS
OF
HABENULA
NEURONS
........................................................
40
3.4.1
BASIC
FIRING
PROPERTIES
........................................................................................................40
3.4.2
CHANGING
FIRING PATTERNS
IN
VENTRAL
HABENULA
NEURONS
.....................................................
42
3.4.3
CHARACTERIZATION
OF
SENSORY
INPUT
IN
VENTRAL
HABENULA
NEURONS
......................................
43
3.4.4
CHARACTERIZATION
OF
AUDITORY
INPUT
IN
VENTRAL
HABENULA
NEURONS
..................................... 44
3.4.5
CHARACTERIZATION
OF
OPTIC
INPUT
IN
VENTRAL
HABENULA
NEURONS
...........................................46
3.4.6
CHARACTERIZATION
OF
ROSTRO-PALLIAL
INPUT
IN
VENTRAL
HABENULA
NEURONS
.............................47
3.4.7
BASAL
GANGLIA,
LIMBIC,
AND
SENSORY
INPUT
IN
VENTRAL
HABENULA
NEURONS
...........................
49
INDEX
III
3.5
INTRA-
AND
EXTRACELLULAR
RECORDINGS
OF
POSTERIOR
TUBERCLE
NEURONS
51
3.5.1
BASIC
FIRING
PROPERTIES
51
3.5.2
CHARACTERIZATION
OF
AUDITORY
INPUT
IN
POSTERIOR
TUBERCLE
NEURONS
52
3.5.3
CHARACTERIZATION
OF
HABENULA
INPUT
IN
POSTERIOR
TUBERCLE
NEURONS
54
3.6
LOCAL
FIELD
POTENTIALS
IN
AMYGDALA
AND
STRIATOPALLIDAL
SYSTEM
FOLLOWING
OPTIC
NERVE
STIMULATION
55
4
DISCUSSION
58
4.1
CONNECTIVITY
OF
THE
HABENULA
58
4.1.1
AFFERENT
CONNECTIONS
OF
THE
HABENULA
60
BED
NUCLEUS
OF
THE
STRIA
TERMINALIS
AND
VENTRAL
PALLIDUM
INPUT
TO
THE
HABENULA
60
POSSIBLE
STRIATAL
INPUT
TO
THE
HABENULA
60
NUCLEUS
ACCUMBENS
INPUT
TO
THE
HABENULA
61
PALLIUM/CORTEX
INPUT
TO
THE
VENTRAL
HABENULA
62
BED
NUCLEUS
OF
THE
PALLIAL
COMMISSURE
AND
THALAMIC
EMINENCE
INPUT
TO
THE
HABENULA
63
VENTRAL
HABENULA
INPUT
FROM
THE
VENTRAL
PRETHALAMUS,
THE
HOMOLOG
OF
THE
INTERNAL
GLOBUS
PALLIDUS?
64
LABELED CELLS
IN
THE
VENTRAL
NUCLEUS
OF
THE
LATERAL
GENICULATE
65
4.1.2
RECIPROCAL
CONNECTIONS
OF
THE
HABENULA
65
RECIPROCAL
CONNECTION
OF
THE
HABENULA
WITH THE
SEPTUM
AND
NUCLEUS
OF
THE
DIAGONAL
BAND
OF
BROCA
65
RECIPROCAL
CONNECTION
OF
THE
HABENULA
WITH
THE
PREOPTIC
AREA
66
RECIPROCAL
CONNECTION
OF
THE
HABENULA WITH
THE
HYPOTHALAMUS
AND
INPUT
FROM
POSTERIOR
TUBERCLE
67
RECIPROCAL
CONNECTION
OF
THE HABENULA
WITH
THE
TORUS
SEMICIRCULARIS
AND
OPTIC
TECTUM
68
4.1.3
FIBERS
BY-PASSING
THE
HABENULA
69
OLFACTORY
FIBERS
BY-PASSING
THE
HABENULA
AND
HABENULA
PROJECTION
TO
THE
OLFACTORY
BULBS
69
AMYGDALA
FIBERS
BY-PASSING
THE
HABENULA
70
MEDIAL
PALLIUM
FIBERS
BY-PASSING
THE
HABENULA
70
THALAMIC
FIBERS
BY-PASSING
THE
HABENULA
71
4.1.4
CONSERVED
HABENULAR
EFFERENTS
71
HABENULA
EFFERENTS
TO
THE
ANURAN
VTA
AND
SNC
72
VENTRAL
HABENULA
EFFERENTS
TO
THE
*
SUPERFICIAL
MAMMILLAR
*
RMTG
74
VENTRAL
HABENULA
EFFERENTS
TO
THE
SEROTONERGIC RAPHE
NUCLEI
75
4.2
CONSERVED
CHEMOARCHITECTURE
76
4.3
FUNCTION
OF
THE
HABENULA
76
4.3.1
BASIC
CELL
PROPERTIES
OF
THE
VENTRAL
HABENULA
76
4.3.2
CURRENT
THEORY
OF
HABENULA
FUNCTION
78
IV
INDEX
4.3.3
INTEGRATION
OF
SENSORY
AND
INTERNAL
STATE
INFORMATION
INTO
THE
VENTRAL
HABENULA
.............
79
4.3.4
INTEGRATION
OF
ASSOCIATIVE
AND
LIMBIC
INFORMATION
INTO
THE
VENTRAL
HABENULA
.................
80
4.3.5
INTEGRATION
OF
BASAL
GANGLIA
INFORMATION
INTO
THE
VENTRAL
HABENULA
................................
81
4.3.6
THE
HABENULA
AND
THE DOPAMINERGIC
SYSTEM
.....................................................................
81
4.4
TOWARDS
A
UNIFIED
THEORY
OF
HABENULA
FUNCTION
........................................................................
83
5
OUTLOOK
................................................................................................................................................
86
SUPPLEMENTARY
.............................................................................................................................................
87
LIST
OF
FIGURES
..............................................................................................................................................
88
LIST
OF
TABLES
................................................................................................................................................
89
REFERENCES
...................................................................................................................................................
90
ACKNOWLEDGEMENTS
..................................................................................................................................
105
EIDESSTATTLICHE
ERKLSRUNG
..........................................................................................................................
106
|
| any_adam_object | 1 |
| author | Freudenmacher, Lars |
| author_GND | (DE-588)1180303903 |
| author_facet | Freudenmacher, Lars |
| author_role | aut |
| author_sort | Freudenmacher, Lars |
| author_variant | l f lf |
| building | Verbundindex |
| bvnumber | BV046114740 |
| ctrlnum | (OCoLC)1119068208 (DE-599)DNB1184816867 |
| discipline | Biologie |
| format | Thesis Book |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01417nam a2200349 c 4500</leader><controlfield tag="001">BV046114740</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">00000000000000.0</controlfield><controlfield tag="007">t</controlfield><controlfield tag="008">190823s2019 gw a||| m||| 00||| eng d</controlfield><datafield tag="015" ind1=" " ind2=" "><subfield code="a">19,H06</subfield><subfield code="2">dnb</subfield></datafield><datafield tag="016" ind1="7" ind2=" "><subfield code="a">1184816867</subfield><subfield code="2">DE-101</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="c">Broschur</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)1119068208</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DNB1184816867</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rda</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="044" ind1=" " ind2=" "><subfield code="a">gw</subfield><subfield code="c">XA-DE</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-355</subfield><subfield code="a">DE-83</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">570</subfield><subfield code="2">sdnb</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Freudenmacher, Lars</subfield><subfield code="e">Verfasser</subfield><subfield code="0">(DE-588)1180303903</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">The habenula as an evolutionary conserved link between basal ganglia, limbic and sensory systems</subfield><subfield code="b">from anuran amphibians to mammals</subfield><subfield code="c">vorgelegt von Lars Freudenmacher</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Köln</subfield><subfield code="c">2019</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">IX, 106 Seiten</subfield><subfield code="b">Illustrationen, Diagramme</subfield><subfield code="c">21 cm</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="502" ind1=" " ind2=" "><subfield code="b">Dissertation</subfield><subfield code="c">Universität zu Köln</subfield><subfield code="d">2018</subfield></datafield><datafield tag="655" ind1=" " ind2="7"><subfield code="0">(DE-588)4113937-9</subfield><subfield code="a">Hochschulschrift</subfield><subfield code="2">gnd-content</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">B:DE-101</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://d-nb.info/1184816867/04</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">DNB Datenaustausch</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=031495263&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-031495263</subfield></datafield></record></collection> |
| genre | (DE-588)4113937-9 Hochschulschrift gnd-content |
| genre_facet | Hochschulschrift |
| id | DE-604.BV046114740 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T08:35:40Z |
| institution | BVB |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-031495263 |
| oclc_num | 1119068208 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR DE-83 |
| owner_facet | DE-355 DE-BY-UBR DE-83 |
| physical | IX, 106 Seiten Illustrationen, Diagramme 21 cm |
| publishDate | 2019 |
| publishDateSearch | 2019 |
| publishDateSort | 2019 |
| record_format | marc |
| spelling | Freudenmacher, Lars Verfasser (DE-588)1180303903 aut The habenula as an evolutionary conserved link between basal ganglia, limbic and sensory systems from anuran amphibians to mammals vorgelegt von Lars Freudenmacher Köln 2019 IX, 106 Seiten Illustrationen, Diagramme 21 cm txt rdacontent n rdamedia nc rdacarrier Dissertation Universität zu Köln 2018 (DE-588)4113937-9 Hochschulschrift gnd-content B:DE-101 application/pdf http://d-nb.info/1184816867/04 Inhaltsverzeichnis DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=031495263&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Freudenmacher, Lars The habenula as an evolutionary conserved link between basal ganglia, limbic and sensory systems from anuran amphibians to mammals |
| subject_GND | (DE-588)4113937-9 |
| title | The habenula as an evolutionary conserved link between basal ganglia, limbic and sensory systems from anuran amphibians to mammals |
| title_auth | The habenula as an evolutionary conserved link between basal ganglia, limbic and sensory systems from anuran amphibians to mammals |
| title_exact_search | The habenula as an evolutionary conserved link between basal ganglia, limbic and sensory systems from anuran amphibians to mammals |
| title_full | The habenula as an evolutionary conserved link between basal ganglia, limbic and sensory systems from anuran amphibians to mammals vorgelegt von Lars Freudenmacher |
| title_fullStr | The habenula as an evolutionary conserved link between basal ganglia, limbic and sensory systems from anuran amphibians to mammals vorgelegt von Lars Freudenmacher |
| title_full_unstemmed | The habenula as an evolutionary conserved link between basal ganglia, limbic and sensory systems from anuran amphibians to mammals vorgelegt von Lars Freudenmacher |
| title_short | The habenula as an evolutionary conserved link between basal ganglia, limbic and sensory systems |
| title_sort | the habenula as an evolutionary conserved link between basal ganglia limbic and sensory systems from anuran amphibians to mammals |
| title_sub | from anuran amphibians to mammals |
| topic_facet | Hochschulschrift |
| url | http://d-nb.info/1184816867/04 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=031495263&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT freudenmacherlars thehabenulaasanevolutionaryconservedlinkbetweenbasalganglialimbicandsensorysystemsfromanuranamphibianstomammals |
Es ist kein Print-Exemplar vorhanden.
Inhaltsverzeichnis