Verfügbarkeit: New insights into autophagosome-vacuole fusion

New insights into autophagosome-vacuole fusion:

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Bibliographische Detailangaben
1. Verfasser:	Gao, Jieqiong (VerfasserIn)
Format:	Abschlussarbeit Buch
Sprache:	English
Veröffentlicht:	Osnabrück May 2018
Schlagworte:	Hochschulschrift
Online-Zugang:	Inhaltsverzeichnis Inhaltsverzeichnis
Beschreibung:	Enthält Sonderabdrucke
Beschreibung:	138 Blätter Illustrationen, Diagramme 30 cm

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Datensatz im Suchindex

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adam_text	CONTENTS L IS T O F P U B LIC A TIO N S AND M A N U S C RIP TS ..................................................................7 S U M M A RY.....................................................................................................................8 Z U SA M M E N FA SSU N G .................................................................................................. 9 1 IN TRO D U C TIO N ........................................................................................................... 11 1.1 OVERVIEW OF AUTOPHAGY....................................................................................... 11 1.1.1 CROSSTALK OF AUTOPHAGY AND ENDOCYTOSIS..................................................14 1.2 MATURATION OF AUTOPHAGOSOMES..........................................................................15 1.2.1 ATG8/LC3 CONJUGATION SYSTEM ................................................................... 16 1.2.2 PHOSPHATIDYLINOSITOL-3-PHOSPHATE (PI3P)..................................................17 1.3 FUSION OF AUTOPHAGOSOMES WITH LYSOSOMES.......................................................18 1.3.1 RAB GTPASES ......................... 19 1.3.2 PHOSPHOINOSITIDES..................................................................................... 21 1.3.3 TETHERING FACTORS.......................................................................................23 1.3.4 SNARES.................................................................................................... 27 1.4 ESCRT MACHINERY IN AUTOPHAGY.......................... 29 2 R ATIO N A LE .................................................................................................................32 2.1 MOLECULAR MECHANISM TO TARGET THE ENDOSOMAL MON1-CCZ1 GEF COMPLEX TO THE PRE-AUTOPHAGOSOMAL STRUCTURE...................................................32 2.2 A NOVEL IN VITRO ASSAY UNCOVERS SNARE TOPOLOGY DURING AUTOPHAGOSOME FUSION WITH VACUOLES ................................................................ 32 2.3 VACUOLAR MEMBRANE PROTEINS DEGRADATION REQUIRES UBIQUITINATION AND ESCRT MACHINERY DIRECTLY ON THE VACUOLAR SURFACE...................................33 2.4 MULTIVALENT RAB INTERACTIONS DETERMINE TETHER-MEDIATED MEMBRANE FUSION ...... 33 3 RESULTS...............................................................................................................34 3.1 FACTORS REQUIRED FOR THE FUSION OF AUTOPHAGOSOMES WITH LYSOSOMES ............... 35 3.1.1 MOLECULAR MECHANISM TO TARGET THE ENDOSOMAL MON1-CCZ1 GEF COMPLEX TO THE PRE-AUTOPHAGOSOMAL STRUCTURE ......................................... 35 3.1.2 A NOVEL IN VITRO ASSAY UNCOVERS SNARE TOPOLOGY DURING AUTOPHAGOSOME FUSION WITH VACUOLES....................................................... 60 3.2 REGULATION OF LYSOSOMAL MEMBRANE PROTEINS .................................................... 87 3.2.1 VACUOLAR MEMBRANE PROTEINS DEGRADATION REQUIRES UBIQUITINATION AND ESCRT MACHINERY DIRECTLY ON THE VACUOLAR SURFACE...87 3.3 MECHANISM OF MEMBRANE TETHERING AND FUSION...............................................104 3.3.1 MULTIVALENT RAB INTERACTIONS DETERMINE TETHER-MEDIATED MEMBRANE FUSION ..................................................................................... 104 4 DISCUSSION....................................................................................................... 120 4.1 FACTORS REQUIRED FOR THE FUSION OF AUTOPHAGOSOMES WITH LYSOSOMES .............. 120 4.2 REGULATION OF LYSOSOMAL MEMBRANE PROTEINS....................................................121 4.3 MECHANISM OF MEMBRANE TETHERING AND FUSION................................................122 4.4 CONCLUDING REMARKS...........................................................................................123 REFERENCES..........................................................................................................124 ABBREVIATIONS .......................................... 135 ACKNOWLEDGMENTS............................................................................................137 ERKLAERUNG UEBER DIE EIGENSTAENDIGKEIT DER ERBRACHTEN LEISTUNG ............... 138
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author	Gao, Jieqiong
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spelling	Gao, Jieqiong Verfasser aut New insights into autophagosome-vacuole fusion Jieqiong Gao Osnabrück May 2018 138 Blätter Illustrationen, Diagramme 30 cm txt rdacontent n rdamedia nc rdacarrier Enthält Sonderabdrucke Dissertation University of Osnabrück 2018 (DE-588)4113937-9 Hochschulschrift gnd-content B:DE-101 application/pdf http://d-nb.info/1172234558/04 Inhaltsverzeichnis DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=031426990&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis
spellingShingle	Gao, Jieqiong New insights into autophagosome-vacuole fusion
subject_GND	(DE-588)4113937-9
title	New insights into autophagosome-vacuole fusion
title_auth	New insights into autophagosome-vacuole fusion
title_exact_search	New insights into autophagosome-vacuole fusion
title_full	New insights into autophagosome-vacuole fusion Jieqiong Gao
title_fullStr	New insights into autophagosome-vacuole fusion Jieqiong Gao
title_full_unstemmed	New insights into autophagosome-vacuole fusion Jieqiong Gao
title_short	New insights into autophagosome-vacuole fusion
title_sort	new insights into autophagosome vacuole fusion
topic_facet	Hochschulschrift
url	http://d-nb.info/1172234558/04 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=031426990&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
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