Protein Tyrosine Phosphatases: Structure, Signaling and Drug Discovery
Protein tyrosine phosphatases remove phosphates from the phosphotyrosine residues of target proteins and reverse the action of various protein tyrosine kinases. This essential interplay between the opposing actions of protein tyrosine phosphatases and protein tyrosine kinases forms the basis of sign...
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| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Berlin ; Boston
De Gruyter
[2018]
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| Schlagworte: | |
| Online-Zugang: | FHA01 FKE01 FLA01 UPA01 FAW01 FAB01 FCO01 Volltext |
| Zusammenfassung: | Protein tyrosine phosphatases remove phosphates from the phosphotyrosine residues of target proteins and reverse the action of various protein tyrosine kinases. This essential interplay between the opposing actions of protein tyrosine phosphatases and protein tyrosine kinases forms the basis of signaling networks that underlie the cellular workings of human physiology. Initially passed-off as housekeeping genes; these proteins were only acknowledged to maintain a steady background of phosphotyrosine levels in the cell. However, recent progress in studying their role in embryonic development and human disease has established their importance as regulators of signal regulation. Convincing evidence shows the role of mutations in these proteins to cause and/or intensify the severity of various diseases including metabolic and neurological disorders and also cancer. Protein tyrosine phosphatases have slowly, yet convincingly become crucial targets for therapeutic intervention of various human pathophysiologies. This book describes these signaling enzymes using the molecular details of their structure and mechanistic function. Various subtypes of cysteine-based Class I, II, III and the Haloacid dehalogenase related Class IV protein tyrosine phosphatases have been illustrated and explained. The superfamily of proteins is also described vis-a-vis its complimentary protein phosphoserine/phosphoserine phosphatases. Membrane bound receptor forms and the cytosolic non-receptor protein tyrosine phosphatases have been described for their biological function. This book serves as a reference for any reader looking to understand the sequence features, structural elements, molecular mechanism and cellular function of this superfamily of signaling enzymes |
| Beschreibung: | Description based on online resource; title from PDF title page (publisher's Web site, viewed 23. Okt 2018) |
| Beschreibung: | 1 online resource (296 pages) |
| ISBN: | 9783110421774 |
| DOI: | 10.1515/9783110421774 |
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Datensatz im Suchindex
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|---|---|
| any_adam_object | |
| author | Ahuja, Lalima G. |
| author_facet | Ahuja, Lalima G. |
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| discipline | Biologie |
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| indexdate | 2024-07-10T08:29:10Z |
| institution | BVB |
| isbn | 9783110421774 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-031260879 |
| oclc_num | 1101914767 |
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| spelling | Ahuja, Lalima G. Verfasser aut Protein Tyrosine Phosphatases Structure, Signaling and Drug Discovery Lalima G. Ahuja Berlin ; Boston De Gruyter [2018] © 2018 1 online resource (296 pages) txt rdacontent c rdamedia cr rdacarrier Description based on online resource; title from PDF title page (publisher's Web site, viewed 23. Okt 2018) Protein tyrosine phosphatases remove phosphates from the phosphotyrosine residues of target proteins and reverse the action of various protein tyrosine kinases. This essential interplay between the opposing actions of protein tyrosine phosphatases and protein tyrosine kinases forms the basis of signaling networks that underlie the cellular workings of human physiology. Initially passed-off as housekeeping genes; these proteins were only acknowledged to maintain a steady background of phosphotyrosine levels in the cell. However, recent progress in studying their role in embryonic development and human disease has established their importance as regulators of signal regulation. Convincing evidence shows the role of mutations in these proteins to cause and/or intensify the severity of various diseases including metabolic and neurological disorders and also cancer. Protein tyrosine phosphatases have slowly, yet convincingly become crucial targets for therapeutic intervention of various human pathophysiologies. This book describes these signaling enzymes using the molecular details of their structure and mechanistic function. Various subtypes of cysteine-based Class I, II, III and the Haloacid dehalogenase related Class IV protein tyrosine phosphatases have been illustrated and explained. The superfamily of proteins is also described vis-a-vis its complimentary protein phosphoserine/phosphoserine phosphatases. Membrane bound receptor forms and the cytosolic non-receptor protein tyrosine phosphatases have been described for their biological function. This book serves as a reference for any reader looking to understand the sequence features, structural elements, molecular mechanism and cellular function of this superfamily of signaling enzymes In English Biochemie Medizinische Chemie Proteintyrosinphosphatase Signalproteine Wirkstoffdesign Proteintyrosinphosphatase (DE-588)4311372-2 gnd rswk-swf Proteintyrosinphosphatase (DE-588)4311372-2 s 1\p DE-604 Erscheint auch als Druck-Ausgabe 9783110426434 https://doi.org/10.1515/9783110421774 Verlag URL des Erstveröffentlichers Volltext 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Ahuja, Lalima G. Protein Tyrosine Phosphatases Structure, Signaling and Drug Discovery Biochemie Medizinische Chemie Proteintyrosinphosphatase Signalproteine Wirkstoffdesign Proteintyrosinphosphatase (DE-588)4311372-2 gnd |
| subject_GND | (DE-588)4311372-2 |
| title | Protein Tyrosine Phosphatases Structure, Signaling and Drug Discovery |
| title_auth | Protein Tyrosine Phosphatases Structure, Signaling and Drug Discovery |
| title_exact_search | Protein Tyrosine Phosphatases Structure, Signaling and Drug Discovery |
| title_full | Protein Tyrosine Phosphatases Structure, Signaling and Drug Discovery Lalima G. Ahuja |
| title_fullStr | Protein Tyrosine Phosphatases Structure, Signaling and Drug Discovery Lalima G. Ahuja |
| title_full_unstemmed | Protein Tyrosine Phosphatases Structure, Signaling and Drug Discovery Lalima G. Ahuja |
| title_short | Protein Tyrosine Phosphatases |
| title_sort | protein tyrosine phosphatases structure signaling and drug discovery |
| title_sub | Structure, Signaling and Drug Discovery |
| topic | Biochemie Medizinische Chemie Proteintyrosinphosphatase Signalproteine Wirkstoffdesign Proteintyrosinphosphatase (DE-588)4311372-2 gnd |
| topic_facet | Biochemie Medizinische Chemie Proteintyrosinphosphatase Signalproteine Wirkstoffdesign |
| url | https://doi.org/10.1515/9783110421774 |
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