Covering a key topic due to growing research into the role of signaling mechanisms in toxicology, this book focuses on practical approaches for informatics, big data, and complex data sets.* Combines fundamentals / basics with experimental applications that can help those involved in preclinical dru...

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Format:	Buch
Sprache:	English
Veröffentlicht:	Hoboken, NJ Wiley 2019
Schlagworte:	Signaltransduktion Molekularpharmakologie Toxikologie Chemie
Zusammenfassung:	Covering a key topic due to growing research into the role of signaling mechanisms in toxicology, this book focuses on practical approaches for informatics, big data, and complex data sets.* Combines fundamentals / basics with experimental applications that can help those involved in preclinical drug studies and translational research* Includes detailed presentations of study methodology and data collection, analysis, and interpretation* Discusses tools like experimental design, sample handling, analytical measurement techniques
Beschreibung:	Provides practical approaches for informatics, big data, and complex data sets of cellular signal transduction in toxicology and pharmacologyThis book offers a thorough discussion of signal transduction mechanisms and approaches that can help toxicologists and pharmacologists guide future study design and data interpretation. It gives readers a solid background in signal transduction networks, while supplying the tools necessary for further research in this expanding area. These tools include a discussion of experimental design, sample handling, analytical measurement techniques, and data analysis and interpretation (including novel modeling approaches).Cellular Signal Transduction in Toxicology and Pharmacology: Data Collection, Analysis, and Interpretation is organized hierarchically. The first four chapters describe the architecture of signaling networks-from a physical basis of understanding signaling through mechanisms, physiological response, and human disease. . - The last half of the book is a how-to for incorporating signal transduction research into your portfolio-from designing signal transduction studies, to measuring and monitoring signaling responses, interpreting and transforming data into useable information, and finally outlining critical future needs in signal transduction research.* Covers a topic of key interest to toxicologists as there is a growing body of research into the role of signaling mechanisms in toxicology* Features a practical focus on modern approaches like the use of informatics, big data, and complex data sets* Combines fundamentals/basics with experimental applications that can help those involved in preclinical drug studies and translational research* Includes detailed presentations of study methodology and data collection, analysis, and interpretation* Discusses tools like experimental design, sample handling, . - analytical measurement techniquesWritten for an audience with a background in biochemistry or cell biology, List of Contributors; About the Editors; Preface; Chapter 1: Introduction to cellular signal transduction: The connection between a biological system and its surroundings; Jonathan Boyd, Richard Neubig, Alice Han, Maren Prediger; Chapter 2: Mechanisms of cellular signal transduction; Richard Neubig, Jonathan Boyd, Julia Mouch, Nicole Prince; Chapter 3: From cellular mechanisms to physiological responses: Functional signal integration across multiple biological levels; Robert Newman; Chapter 4: Signal transduction in disease: Relating cell signaling to morbidity and mortality; Patricia E. Ganey, Sean E. Misek; Chapter 5: Experimental design in signal transduction; Weimin Gao, Meghan Cromie, Qian Wang, Zhongwei Liu, Song Tang, Julie Miller; Chapter 6: Techniques for measuring cellular signal transduction; Julie Miller, Weimin Gao, Meghan Cromie; Chapter 7: Computational methods for signal transduction: A network approach; Giovanni Scardoni, Gabriele Tosadori, John Morris, A. Pegoraro, Sakshi Pratap, Carlo Laudanna, Alice Han; Chapter 8: A toxicological application of signal transduction: Early cellular changes can be indicative of toxicity; Julie Miller, Nicole Prince, Julia Mouch, Jonathan Boyd; Chapter 9: Future research in signaling; Jonathan Boyd, Nicole Prince; Index
Beschreibung:	xx, 310 pages illustrations
ISBN:	9781119060260