Freeze drying from organic co-solvent systems: thermal analysis and process design = Gefriertrocknung von organischen Co-Solvent Systemen : thermische Analyse und Prozessdesign
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| Main Author: | |
|---|---|
| Format: | Thesis Book |
| Language: | English |
| Published: |
Erlangen ; Nürnberg
[2019]
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis Inhaltsverzeichnis |
| Item Description: | Enthält Sonderabdrucke |
| Physical Description: | 39 Seiten, 48 verschieden gezählte Seiten Illustrationen, Diagramme 21 cm |
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MARC
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| 100 | 1 | |a Kunz, Claudia |d 1986- |e Verfasser |0 (DE-588)1182467822 |4 aut | |
| 245 | 1 | 0 | |a Freeze drying from organic co-solvent systems |b thermal analysis and process design = Gefriertrocknung von organischen Co-Solvent Systemen : thermische Analyse und Prozessdesign |c vorgelegt von Claudia Kunz |
| 246 | 1 | 3 | |a Gefriertrocknung von organischen Co-Solvent Systemen |
| 246 | 1 | 1 | |a Gefriertrocknung von organischen Co-Solvent Systemen : thermische Analyse und Prozessdesign |
| 264 | 1 | |a Erlangen ; Nürnberg |c [2019] | |
| 300 | |a 39 Seiten, 48 verschieden gezählte Seiten |b Illustrationen, Diagramme |c 21 cm | ||
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| 502 | |b Dissertation |c Friedrich-Alexander-Universität Erlangen-Nürnberg |d 2019 | ||
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Record in the Search Index
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|---|---|
| adam_text | TABLE
OF
CONTENTS
1.
FOCUS
OF
THE
THESIS
.............................................................................................................
1
2.
INTRODUCTION
........................................................................................................................
2
2.1
FREEZE-DRYING
....................................................................................................................
2
2.1.1
FREEZING
.....................................................................................................................
2
2.1.2
PRIMARY
DRYING
............................................................................................................
2
2.1.3 SECONDARY
DRYING
......................................................................................................
3
2.2
THE
USE
OF
CO-SOLVENT
SYSTEMS
IN
FREEZE-DRYING
...............................................................
4
2.2.1
POTENTIAL
BENEFITS
OF
USING
CO-SOLVENT
SYSTEMS
.........................................................
4
2.2.2
CURRENT
CHALLENGES
ASSOCIATED
WITH
THE
USE
OF
CO-SOLVENT
SYSTEMS
..........................
5
2.3
MATERIAL
CHARACTERIZATION
USING
DVS
.................................................................................
7
3.
THERMAL
ANALYSIS
OF
CO-SOLVENT-BASED
FORMULATIONS
[APPENDIX
A1]
...........................
9
3.1
PRESELECTION
OF
CO-SOLVENTS,
EXCIPIENTS
AND
APIS
.............................................................
9
3.2
DSC
STUDIES
....................................................................................................................
10
3.3
FDM
STUDIES
....................................................................................................................
11
4.
PROCESS
MODIFICATIONS
FOR
FREEZE-DRYING
FROM
CO-SOLVENT
SYSTEMS
[APPENDIX
A2]
14
4.1
THERMAL
TREATMENT
...........................................................................................................
15
4.2
INCORPORATION
OF
AN
EVAPORATION
STEP
..............................................................................
16
4.3
POST-DRYING
STABILITY
OF
ACTIVE
INGREDIENTS
.......................................................................
17
5.
DVS
OF
FREEZE-DRIED
PRODUCTS
[APPENDIX
A3]
...............................................................
18
5.1
IMPACT
OF
SAMPLE
HANDLING
AND
PRODUCT
PARAMETERS
......................................................
18
5.2
QUANTIFICATION
OF
THE
DEGREE
OF
CRYSTALLINITY
....................................................................
19
5.3
DETERMINATION
OF
THE
SSA
...............................................................................................
20
6.
CONTROL
OF
RESIDUAL
SOLVENT
LEVELS
[APPENDIX
A4]
..........................................................
22
6.1
POSTULATED
MECHANISMS
OF
THE
RETENTION
OF
CO-SOLVENTS
................................................
22
6.2
OPTIONS
TO
REDUCE
RESIDUAL
CO-SOLVENT
LEVELS
IN
LYOPHILISATES
.........................................
23
6.3
DVS
STUDIES
....................................................................................................................
24
7.
CONCLUSION
.......................................................................................................................
26
8.
REFERENCES
.........................................................................................................................
27
9.
CURRICULUM
VITAE
...............................................................................................................
36
10.
APPENDIX
..........................................................................................................................
37
|
| any_adam_object | 1 |
| author | Kunz, Claudia 1986- |
| author_GND | (DE-588)1182467822 |
| author_facet | Kunz, Claudia 1986- |
| author_role | aut |
| author_sort | Kunz, Claudia 1986- |
| author_variant | c k ck |
| building | Verbundindex |
| bvnumber | BV045864102 |
| ctrlnum | (OCoLC)1104925395 (DE-599)DNB1182467415 |
| discipline | Chemie / Pharmazie Medizin |
| format | Thesis Book |
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| genre_facet | Hochschulschrift |
| id | DE-604.BV045864102 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T08:28:51Z |
| institution | BVB |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-031247536 |
| oclc_num | 1104925395 |
| open_access_boolean | |
| owner | DE-29T DE-29 |
| owner_facet | DE-29T DE-29 |
| physical | 39 Seiten, 48 verschieden gezählte Seiten Illustrationen, Diagramme 21 cm |
| publishDate | 2019 |
| publishDateSearch | 2019 |
| publishDateSort | 2019 |
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| spelling | Kunz, Claudia 1986- Verfasser (DE-588)1182467822 aut Freeze drying from organic co-solvent systems thermal analysis and process design = Gefriertrocknung von organischen Co-Solvent Systemen : thermische Analyse und Prozessdesign vorgelegt von Claudia Kunz Gefriertrocknung von organischen Co-Solvent Systemen Gefriertrocknung von organischen Co-Solvent Systemen : thermische Analyse und Prozessdesign Erlangen ; Nürnberg [2019] 39 Seiten, 48 verschieden gezählte Seiten Illustrationen, Diagramme 21 cm txt rdacontent n rdamedia nc rdacarrier Enthält Sonderabdrucke Dissertation Friedrich-Alexander-Universität Erlangen-Nürnberg 2019 Organischer Stoff (DE-588)4203832-7 gnd rswk-swf Gefriertrocknung (DE-588)4156264-1 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Gefriertrocknung (DE-588)4156264-1 s Organischer Stoff (DE-588)4203832-7 s DE-604 B:DE-101 application/pdf http://d-nb.info/1182467415/04 Inhaltsverzeichnis DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=031247536&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Kunz, Claudia 1986- Freeze drying from organic co-solvent systems thermal analysis and process design = Gefriertrocknung von organischen Co-Solvent Systemen : thermische Analyse und Prozessdesign Organischer Stoff (DE-588)4203832-7 gnd Gefriertrocknung (DE-588)4156264-1 gnd |
| subject_GND | (DE-588)4203832-7 (DE-588)4156264-1 (DE-588)4113937-9 |
| title | Freeze drying from organic co-solvent systems thermal analysis and process design = Gefriertrocknung von organischen Co-Solvent Systemen : thermische Analyse und Prozessdesign |
| title_alt | Gefriertrocknung von organischen Co-Solvent Systemen Gefriertrocknung von organischen Co-Solvent Systemen : thermische Analyse und Prozessdesign |
| title_auth | Freeze drying from organic co-solvent systems thermal analysis and process design = Gefriertrocknung von organischen Co-Solvent Systemen : thermische Analyse und Prozessdesign |
| title_exact_search | Freeze drying from organic co-solvent systems thermal analysis and process design = Gefriertrocknung von organischen Co-Solvent Systemen : thermische Analyse und Prozessdesign |
| title_full | Freeze drying from organic co-solvent systems thermal analysis and process design = Gefriertrocknung von organischen Co-Solvent Systemen : thermische Analyse und Prozessdesign vorgelegt von Claudia Kunz |
| title_fullStr | Freeze drying from organic co-solvent systems thermal analysis and process design = Gefriertrocknung von organischen Co-Solvent Systemen : thermische Analyse und Prozessdesign vorgelegt von Claudia Kunz |
| title_full_unstemmed | Freeze drying from organic co-solvent systems thermal analysis and process design = Gefriertrocknung von organischen Co-Solvent Systemen : thermische Analyse und Prozessdesign vorgelegt von Claudia Kunz |
| title_short | Freeze drying from organic co-solvent systems |
| title_sort | freeze drying from organic co solvent systems thermal analysis and process design gefriertrocknung von organischen co solvent systemen thermische analyse und prozessdesign |
| title_sub | thermal analysis and process design = Gefriertrocknung von organischen Co-Solvent Systemen : thermische Analyse und Prozessdesign |
| topic | Organischer Stoff (DE-588)4203832-7 gnd Gefriertrocknung (DE-588)4156264-1 gnd |
| topic_facet | Organischer Stoff Gefriertrocknung Hochschulschrift |
| url | http://d-nb.info/1182467415/04 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=031247536&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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