Targeting Cell Survival Pathways to Enhance Response to Chemotherapy:
"Targeting Cell Survival Pathways to Enhance Response to Chemotherapy encompasses recently developed molecular targeting agents and approaches that suppress cell survival signaling. Cell survival signaling attenuates the effectiveness of conventional chemotherapy and numerous mechanisms have be...
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
London, United Kingdom
Academic Press, an imprint of Elsevier
[2018]
|
| Schriftenreihe: | Cancer sensitizing agents for chemotherapy
v. 3 |
| Schlagworte: | |
| Online-Zugang: | FAW01 Volltext |
| Zusammenfassung: | "Targeting Cell Survival Pathways to Enhance Response to Chemotherapy encompasses recently developed molecular targeting agents and approaches that suppress cell survival signaling. Cell survival signaling attenuates the effectiveness of conventional chemotherapy and numerous mechanisms have been described, and continue to be described, which contribute to cell survival in the face of chemotherapy treatment. Key pathways leading to chemoresistance emanate from growth factor receptors, PI3K, STAT3, anti-apoptotic Bcl-2 family members, autophagy, and the DNA damage response pathway. New advances have underscored the potential of targeting each of these cell survival mechanisms to improve responsiveness to chemotherapy. This book reviews these recent advances and provides a foundational background and hints of new opportunities for basic, translational, and clinical investigators focused on improving therapeutic responses to chemotherapy. Presents cutting-edge agents and approaches with proved success in different model systems that can be translated to a different type of cancerBrings updated information to be used to propose new clinical trials investigating innovative strategies for improving responses to chemotherapyProvides mechanistic details to help guide the design of laboratory studies associated with clinical trials"-- |
| Beschreibung: | Includes bibliographical references and index |
| Beschreibung: | 1 online resource |
| ISBN: | 9780128137543 0128137541 |
Internformat
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Datensatz im Suchindex
| _version_ | 1804179235687890945 |
|---|---|
| any_adam_object | |
| author | Johnson, Daniel E. |
| author_facet | Johnson, Daniel E. |
| author_role | aut |
| author_sort | Johnson, Daniel E. |
| author_variant | d e j de dej |
| building | Verbundindex |
| bvnumber | BV045383014 |
| classification_rvk | XH 3200 |
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| dewey-full | 615.58 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 615 - Pharmacology and therapeutics |
| dewey-raw | 615.58 |
| dewey-search | 615.58 |
| dewey-sort | 3615.58 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| format | Electronic eBook |
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| illustrated | Not Illustrated |
| indexdate | 2024-07-10T08:16:39Z |
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| isbn | 9780128137543 0128137541 |
| language | English |
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| series2 | Cancer sensitizing agents for chemotherapy |
| spelling | Johnson, Daniel E. Verfasser aut Targeting Cell Survival Pathways to Enhance Response to Chemotherapy Daniel E. Johnson London, United Kingdom Academic Press, an imprint of Elsevier [2018] © 2018 1 online resource txt rdacontent c rdamedia cr rdacarrier Cancer sensitizing agents for chemotherapy v. 3 Includes bibliographical references and index "Targeting Cell Survival Pathways to Enhance Response to Chemotherapy encompasses recently developed molecular targeting agents and approaches that suppress cell survival signaling. Cell survival signaling attenuates the effectiveness of conventional chemotherapy and numerous mechanisms have been described, and continue to be described, which contribute to cell survival in the face of chemotherapy treatment. Key pathways leading to chemoresistance emanate from growth factor receptors, PI3K, STAT3, anti-apoptotic Bcl-2 family members, autophagy, and the DNA damage response pathway. New advances have underscored the potential of targeting each of these cell survival mechanisms to improve responsiveness to chemotherapy. This book reviews these recent advances and provides a foundational background and hints of new opportunities for basic, translational, and clinical investigators focused on improving therapeutic responses to chemotherapy. Presents cutting-edge agents and approaches with proved success in different model systems that can be translated to a different type of cancerBrings updated information to be used to propose new clinical trials investigating innovative strategies for improving responses to chemotherapyProvides mechanistic details to help guide the design of laboratory studies associated with clinical trials"-- Molecular Targeted Therapy Neoplasms / drug therapy Antineoplastic Agents / therapeutic use MEDICAL / Pharmacology bisacsh Chemotherapy fast Drug targeting fast Chemotherapy Drug targeting Targeted drug delivery (DE-588)4302415-4 gnd rswk-swf Signaltransduktion (DE-588)4318717-1 gnd rswk-swf Chemotherapie (DE-588)4127083-6 gnd rswk-swf 1\p (DE-588)4143413-4 Aufsatzsammlung gnd-content Chemotherapie (DE-588)4127083-6 s Targeted drug delivery (DE-588)4302415-4 s Signaltransduktion (DE-588)4318717-1 s 2\p DE-604 Erscheint auch als Druck-Ausgabe 9780128164327 Erscheint auch als Druck-Ausgabe 0128164328 https://www.sciencedirect.com/science/book/9780128137536 Verlag URL des Erstveröffentlichers Volltext 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 2\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Johnson, Daniel E. Targeting Cell Survival Pathways to Enhance Response to Chemotherapy Molecular Targeted Therapy Neoplasms / drug therapy Antineoplastic Agents / therapeutic use MEDICAL / Pharmacology bisacsh Chemotherapy fast Drug targeting fast Chemotherapy Drug targeting Targeted drug delivery (DE-588)4302415-4 gnd Signaltransduktion (DE-588)4318717-1 gnd Chemotherapie (DE-588)4127083-6 gnd |
| subject_GND | (DE-588)4302415-4 (DE-588)4318717-1 (DE-588)4127083-6 (DE-588)4143413-4 |
| title | Targeting Cell Survival Pathways to Enhance Response to Chemotherapy |
| title_auth | Targeting Cell Survival Pathways to Enhance Response to Chemotherapy |
| title_exact_search | Targeting Cell Survival Pathways to Enhance Response to Chemotherapy |
| title_full | Targeting Cell Survival Pathways to Enhance Response to Chemotherapy Daniel E. Johnson |
| title_fullStr | Targeting Cell Survival Pathways to Enhance Response to Chemotherapy Daniel E. Johnson |
| title_full_unstemmed | Targeting Cell Survival Pathways to Enhance Response to Chemotherapy Daniel E. Johnson |
| title_short | Targeting Cell Survival Pathways to Enhance Response to Chemotherapy |
| title_sort | targeting cell survival pathways to enhance response to chemotherapy |
| topic | Molecular Targeted Therapy Neoplasms / drug therapy Antineoplastic Agents / therapeutic use MEDICAL / Pharmacology bisacsh Chemotherapy fast Drug targeting fast Chemotherapy Drug targeting Targeted drug delivery (DE-588)4302415-4 gnd Signaltransduktion (DE-588)4318717-1 gnd Chemotherapie (DE-588)4127083-6 gnd |
| topic_facet | Molecular Targeted Therapy Neoplasms / drug therapy Antineoplastic Agents / therapeutic use MEDICAL / Pharmacology Chemotherapy Drug targeting Targeted drug delivery Signaltransduktion Chemotherapie Aufsatzsammlung |
| url | https://www.sciencedirect.com/science/book/9780128137536 |
| work_keys_str_mv | AT johnsondaniele targetingcellsurvivalpathwaystoenhanceresponsetochemotherapy |