Advances in nanomedicine for the delivery of therapeutic nucleic acids:
Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids addresses several issues related to safe and effective delivery of nucleic acids (NAs)ïÅưusing nanoparticles. A further emphasis would be laid on the mechanism of delivery of NAs, the barriers encountered and the strategies adapt...
Gespeichert in:
| Weitere Verfasser: | , , |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Duxford
Woodhead Publishing
[2017]
|
| Schriftenreihe: | Woodhead Publishing series in biomedicine
|
| Schlagworte: | |
| Online-Zugang: | FAW01 URL des Erstveröffentlichers |
| Zusammenfassung: | Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids addresses several issues related to safe and effective delivery of nucleic acids (NAs)ïÅưusing nanoparticles. A further emphasis would be laid on the mechanism of delivery of NAs, the barriers encountered and the strategies adapted to combat them. An exhaustive account of the advantages as well shortcomings of all the delivery vectors being employed in delivery of various NAs will be provided. On final note the regulatory aspects of nanoparticles mediated NA would be discussed, with focus on their clinical relevance.ïÅư The design and development of nucleic acid-based therapeutics for the treatment of diseases arising from genetic abnormalities has made significant progress over the past few years. NAs have been widely explored for the treatment of cancer and infectious diseases or to block cell proliferation and thereby caused diseases. Advances in synthetic oligonucleotide chemistry resulted in synthesis of NAs that are relatively stable in in vivo environments. However, cellular targeting and intracellular delivery of NAs still remains a challenge. Further development of NA-based therapeutics depends on the progress of safe and effective carriers for systemic administration. Nanomedicine has facilitated availability of vectors with diminished cytotoxicity and enhanced efficacy which are rapidly emerging as systems of choice. These vectors protect NAs from enzymatic degradation by forming condensed complexes along with targeted tissue and cellular delivery. During the past few years, a myriad reports have appeared reporting delivery of NAs mediated by nanoparticles. This book will provide an overview of nanoparticles being employed in the in vitro and in vivo delivery of therapeutically relevant NAs likeïÅưDNA, siRNA, LNA, PNA, etc |
| Beschreibung: | Includes bibliographical references and index |
| Beschreibung: | 1 online resource |
| ISBN: | 9780081005637 0081005636 |
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| 520 | |a Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids addresses several issues related to safe and effective delivery of nucleic acids (NAs)ïÅưusing nanoparticles. A further emphasis would be laid on the mechanism of delivery of NAs, the barriers encountered and the strategies adapted to combat them. An exhaustive account of the advantages as well shortcomings of all the delivery vectors being employed in delivery of various NAs will be provided. On final note the regulatory aspects of nanoparticles mediated NA would be discussed, with focus on their clinical relevance.ïÅư The design and development of nucleic acid-based therapeutics for the treatment of diseases arising from genetic abnormalities has made significant progress over the past few years. NAs have been widely explored for the treatment of cancer and infectious diseases or to block cell proliferation and thereby caused diseases. Advances in synthetic oligonucleotide chemistry resulted in synthesis of NAs that are relatively stable in in vivo environments. However, cellular targeting and intracellular delivery of NAs still remains a challenge. Further development of NA-based therapeutics depends on the progress of safe and effective carriers for systemic administration. Nanomedicine has facilitated availability of vectors with diminished cytotoxicity and enhanced efficacy which are rapidly emerging as systems of choice. These vectors protect NAs from enzymatic degradation by forming condensed complexes along with targeted tissue and cellular delivery. During the past few years, a myriad reports have appeared reporting delivery of NAs mediated by nanoparticles. This book will provide an overview of nanoparticles being employed in the in vitro and in vivo delivery of therapeutically relevant NAs likeïÅưDNA, siRNA, LNA, PNA, etc | ||
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| discipline | Medizin |
| format | Electronic eBook |
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| indexdate | 2024-07-10T08:16:37Z |
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| isbn | 9780081005637 0081005636 |
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| spelling | Advances in nanomedicine for the delivery of therapeutic nucleic acids edited by Surendra Nimesh, Ramesh Chandra, Nidhi Gupta Duxford Woodhead Publishing [2017] © 2017 1 online resource txt rdacontent c rdamedia cr rdacarrier Woodhead Publishing series in biomedicine Includes bibliographical references and index Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids addresses several issues related to safe and effective delivery of nucleic acids (NAs)ïÅưusing nanoparticles. A further emphasis would be laid on the mechanism of delivery of NAs, the barriers encountered and the strategies adapted to combat them. An exhaustive account of the advantages as well shortcomings of all the delivery vectors being employed in delivery of various NAs will be provided. On final note the regulatory aspects of nanoparticles mediated NA would be discussed, with focus on their clinical relevance.ïÅư The design and development of nucleic acid-based therapeutics for the treatment of diseases arising from genetic abnormalities has made significant progress over the past few years. NAs have been widely explored for the treatment of cancer and infectious diseases or to block cell proliferation and thereby caused diseases. Advances in synthetic oligonucleotide chemistry resulted in synthesis of NAs that are relatively stable in in vivo environments. However, cellular targeting and intracellular delivery of NAs still remains a challenge. Further development of NA-based therapeutics depends on the progress of safe and effective carriers for systemic administration. Nanomedicine has facilitated availability of vectors with diminished cytotoxicity and enhanced efficacy which are rapidly emerging as systems of choice. These vectors protect NAs from enzymatic degradation by forming condensed complexes along with targeted tissue and cellular delivery. During the past few years, a myriad reports have appeared reporting delivery of NAs mediated by nanoparticles. This book will provide an overview of nanoparticles being employed in the in vitro and in vivo delivery of therapeutically relevant NAs likeïÅưDNA, siRNA, LNA, PNA, etc HEALTH & FITNESS / Holism bisacsh HEALTH & FITNESS / Reference bisacsh MEDICAL / Alternative Medicine bisacsh MEDICAL / Atlases bisacsh MEDICAL / Essays bisacsh MEDICAL / Family & General Practice bisacsh MEDICAL / Holistic Medicine bisacsh MEDICAL / Osteopathy bisacsh Nanomedicine fast Nucleic Acids / therapeutic use Nanoparticles / therapeutic use Nanomedicine Nucleic acids Treatment Nimesh, Surendra edt Chan, Ramesh edt Gupta, Nidhi edt Erscheint auch als Druck-Ausgabe 9780081005576 Erscheint auch als Druck-Ausgabe 0081005571 http://www.sciencedirect.com/science/book/9780081005576 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Advances in nanomedicine for the delivery of therapeutic nucleic acids HEALTH & FITNESS / Holism bisacsh HEALTH & FITNESS / Reference bisacsh MEDICAL / Alternative Medicine bisacsh MEDICAL / Atlases bisacsh MEDICAL / Essays bisacsh MEDICAL / Family & General Practice bisacsh MEDICAL / Holistic Medicine bisacsh MEDICAL / Osteopathy bisacsh Nanomedicine fast Nucleic Acids / therapeutic use Nanoparticles / therapeutic use Nanomedicine Nucleic acids Treatment |
| title | Advances in nanomedicine for the delivery of therapeutic nucleic acids |
| title_auth | Advances in nanomedicine for the delivery of therapeutic nucleic acids |
| title_exact_search | Advances in nanomedicine for the delivery of therapeutic nucleic acids |
| title_full | Advances in nanomedicine for the delivery of therapeutic nucleic acids edited by Surendra Nimesh, Ramesh Chandra, Nidhi Gupta |
| title_fullStr | Advances in nanomedicine for the delivery of therapeutic nucleic acids edited by Surendra Nimesh, Ramesh Chandra, Nidhi Gupta |
| title_full_unstemmed | Advances in nanomedicine for the delivery of therapeutic nucleic acids edited by Surendra Nimesh, Ramesh Chandra, Nidhi Gupta |
| title_short | Advances in nanomedicine for the delivery of therapeutic nucleic acids |
| title_sort | advances in nanomedicine for the delivery of therapeutic nucleic acids |
| topic | HEALTH & FITNESS / Holism bisacsh HEALTH & FITNESS / Reference bisacsh MEDICAL / Alternative Medicine bisacsh MEDICAL / Atlases bisacsh MEDICAL / Essays bisacsh MEDICAL / Family & General Practice bisacsh MEDICAL / Holistic Medicine bisacsh MEDICAL / Osteopathy bisacsh Nanomedicine fast Nucleic Acids / therapeutic use Nanoparticles / therapeutic use Nanomedicine Nucleic acids Treatment |
| topic_facet | HEALTH & FITNESS / Holism HEALTH & FITNESS / Reference MEDICAL / Alternative Medicine MEDICAL / Atlases MEDICAL / Essays MEDICAL / Family & General Practice MEDICAL / Holistic Medicine MEDICAL / Osteopathy Nanomedicine Nucleic Acids / therapeutic use Nanoparticles / therapeutic use Nucleic acids Treatment |
| url | http://www.sciencedirect.com/science/book/9780081005576 |
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