Trace amines and neurological disorders: potential mechanisms and risk factors
Trace Amines and Neurological Disorders: Potential Mechanisms and Risk Factors explores trace amines which, under normal conditions, are present in the mammalian brain and peripheral nervous tissues at very low (nanomolar) concentrations. However, in a diverse array of human pathologies ranging from...
Gespeichert in:
| Weitere Verfasser: | , |
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| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
London, United Kingdom
Academic Press is an imprint of Elsevier
2016
|
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Zusammenfassung: | Trace Amines and Neurological Disorders: Potential Mechanisms and Risk Factors explores trace amines which, under normal conditions, are present in the mammalian brain and peripheral nervous tissues at very low (nanomolar) concentrations. However, in a diverse array of human pathologies ranging from substance abuse, depression, attention deficit hyperactivity disorder, eating disorders, schizophrenia, and other neurological and neuropsychiatric diseases, the levels of trace amines are unusually high with an imbalance in their functions. Furthermore, the rapid turnover of trace amines is evidenced by their dramatic increases following treatment with monoamine oxidase inhibitors (MAOI) or deletion of the MAO genes. This suggests that the concentration of trace amines may be considerably higher at neuronal synapses than predicted by steady-state measures, implicating some pathophysiological role. Therefore, understanding molecular mechanisms and developing selective agonists and antagonists for trace amine-associated receptors (TAARs) has become a good approach for treating these diseases. Although the effects of trace amines at low physiological concentrations in mammalian species have been difficult to demonstrate, they may serve to maintain the neuronal activity of other monoamine neurotransmitters by possessing postsynaptic modulatory effects, particularly dopamine and serotonin, within defined physiological limits. Such an effect of trace amines makes them ideal candidates for the development of novel therapeutics for a wide range of human disorders. This book presents up-to-date, cutting-edge, and comprehensive information on the link between trace amines and neurological disorders |
| Beschreibung: | Includes index |
| Beschreibung: | 1 online resource |
| ISBN: | 9780128036167 0128036168 |
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| dewey-search | 572/.548 |
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| discipline | Biologie |
| format | Electronic eBook |
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| id | DE-604.BV045381959 |
| illustrated | Not Illustrated |
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| isbn | 9780128036167 0128036168 |
| language | English |
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| spelling | Trace amines and neurological disorders potential mechanisms and risk factors edited by Tahira Farooqui, Akhlaq A. Farooqui London, United Kingdom Academic Press is an imprint of Elsevier 2016 1 online resource txt rdacontent c rdamedia cr rdacarrier Includes index Trace Amines and Neurological Disorders: Potential Mechanisms and Risk Factors explores trace amines which, under normal conditions, are present in the mammalian brain and peripheral nervous tissues at very low (nanomolar) concentrations. However, in a diverse array of human pathologies ranging from substance abuse, depression, attention deficit hyperactivity disorder, eating disorders, schizophrenia, and other neurological and neuropsychiatric diseases, the levels of trace amines are unusually high with an imbalance in their functions. Furthermore, the rapid turnover of trace amines is evidenced by their dramatic increases following treatment with monoamine oxidase inhibitors (MAOI) or deletion of the MAO genes. This suggests that the concentration of trace amines may be considerably higher at neuronal synapses than predicted by steady-state measures, implicating some pathophysiological role. Therefore, understanding molecular mechanisms and developing selective agonists and antagonists for trace amine-associated receptors (TAARs) has become a good approach for treating these diseases. Although the effects of trace amines at low physiological concentrations in mammalian species have been difficult to demonstrate, they may serve to maintain the neuronal activity of other monoamine neurotransmitters by possessing postsynaptic modulatory effects, particularly dopamine and serotonin, within defined physiological limits. Such an effect of trace amines makes them ideal candidates for the development of novel therapeutics for a wide range of human disorders. This book presents up-to-date, cutting-edge, and comprehensive information on the link between trace amines and neurological disorders Amines SCIENCE / Life Sciences / Biochemistry bisacsh Amines in the body fast Nervous system / Diseases / Molecular aspects fast Amines in the body Nervous system Diseases Molecular aspects Farooqui, Tahira edt Farooqui, Akhlaq A. edt Erscheint auch als Druck-Ausgabe 9780128036037 Erscheint auch als Druck-Ausgabe 0128036036 http://www.sciencedirect.com/science/book/9780128036037 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Trace amines and neurological disorders potential mechanisms and risk factors Amines SCIENCE / Life Sciences / Biochemistry bisacsh Amines in the body fast Nervous system / Diseases / Molecular aspects fast Amines in the body Nervous system Diseases Molecular aspects |
| title | Trace amines and neurological disorders potential mechanisms and risk factors |
| title_auth | Trace amines and neurological disorders potential mechanisms and risk factors |
| title_exact_search | Trace amines and neurological disorders potential mechanisms and risk factors |
| title_full | Trace amines and neurological disorders potential mechanisms and risk factors edited by Tahira Farooqui, Akhlaq A. Farooqui |
| title_fullStr | Trace amines and neurological disorders potential mechanisms and risk factors edited by Tahira Farooqui, Akhlaq A. Farooqui |
| title_full_unstemmed | Trace amines and neurological disorders potential mechanisms and risk factors edited by Tahira Farooqui, Akhlaq A. Farooqui |
| title_short | Trace amines and neurological disorders |
| title_sort | trace amines and neurological disorders potential mechanisms and risk factors |
| title_sub | potential mechanisms and risk factors |
| topic | Amines SCIENCE / Life Sciences / Biochemistry bisacsh Amines in the body fast Nervous system / Diseases / Molecular aspects fast Amines in the body Nervous system Diseases Molecular aspects |
| topic_facet | Amines SCIENCE / Life Sciences / Biochemistry Amines in the body Nervous system / Diseases / Molecular aspects Nervous system Diseases Molecular aspects |
| url | http://www.sciencedirect.com/science/book/9780128036037 |
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