The contribution of transposable elements to meiotic sex chromosome inactivation (MSCI) and their detection in whole exome sequencing data:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
Erlangen ; Nürnberg
2018
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Inhaltsverzeichnis |
| Beschreibung: | VI, 107, xlii Seiten Illustrationen, Diagramme 21 cm |
Internformat
MARC
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| 245 | 1 | 0 | |a The contribution of transposable elements to meiotic sex chromosome inactivation (MSCI) and their detection in whole exome sequencing data |c vorgelegt von Sören Lukassen |
| 264 | 1 | |a Erlangen ; Nürnberg |c 2018 | |
| 300 | |a VI, 107, xlii Seiten |b Illustrationen, Diagramme |c 21 cm | ||
| 336 | |b txt |2 rdacontent | ||
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| 650 | 0 | 7 | |a Geschlechtschromosom |0 (DE-588)4157012-1 |2 gnd |9 rswk-swf |
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Datensatz im Suchindex
| _version_ | 1804179219986513920 |
|---|---|
| adam_text | 3 INTRODUCTION
1
3.1
SPERMATOGENESIS................................................................................................
1
3.2 EPIGENETICS
......................................................................................................
4
3.3 RETROTRANSPOSONS
............................................................................................
8
3.4 SPO C
1...............................................................................................................
11
3.5 MEIOTIC SEX CHROMOSOME IN A CTIV ATIO N
........................................................... 13
4 RESULTS 16
4.1 CHIP-SEQ FOR SPOC1 IN MOUSE TE S T E S
..........................................................
17
4.2 TRANSCRIPTOME ANALYSIS OF SPOCL+/ +AND SPOOL / MOUSE T E S T E S
..................
30
4.3 METHYLATION ANALYSES OF LINE ELEM ENTS
.......................................................
40
4.4 SEQUENCING OF FULL-LENGTH LINE LI INSERTION SITE
S........................................ 46
4.5 BIOINFORMATIC DETECTION OF TRANSPOSON INSERTION S ITE S
.................................. 48
5 DISCUSSION 69
5.1 SPOC1 IN MSCI
............................................................................................
69
5.2 SPOC1 AND M 6 A
............................................................................................
74
5.3 TRANSPOSON REPRESSION
...................................................................................
77
5.4 SEQUENCING OF LI INSERTIONS IN THE MOUSE GENOME
..................................... 80
5.5 DETECTION OF TE-ASSOCIATED VARIANTS IN HUMAN EXOM ES
................................
81
5.6 TE VULNERABILITY PREDICTION
..........................................................................
82
6 OUTLOOK 85
6.1 SPOC1, LINES, AND M S C
I.............................................................................
85
6.2 TE IDENTIFICATION FROM WES D A T A
................................................................
86
6.3 PREDICTION OF TE INSERTION LIKELIHOOD
86
7 MATERIAL AND METHODS 87
7.1 M A TE RIA
L............................................................................................................
88
7.2 M
ETHODS............................................................................................................
96
8 APPENDIX
8.1 SCRIPTS AND CODE
9 ABBREVIATIONS
LIST OF FIGURES
LIST OF TABLES
10 ACKNOWLEDGMENTS
XII
XIV
XVI
XVIII
11 BIBLIOGRAPHY XIX
|
| any_adam_object | 1 |
| author | Lukassen, Sören |
| author_GND | (DE-588)1177420376 |
| author_facet | Lukassen, Sören |
| author_role | aut |
| author_sort | Lukassen, Sören |
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| building | Verbundindex |
| bvnumber | BV045374179 |
| ctrlnum | (OCoLC)1090110679 (DE-599)DNB1171495757 |
| discipline | Biologie |
| format | Thesis Book |
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| indexdate | 2024-07-10T08:16:24Z |
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| spelling | Lukassen, Sören Verfasser (DE-588)1177420376 aut The contribution of transposable elements to meiotic sex chromosome inactivation (MSCI) and their detection in whole exome sequencing data vorgelegt von Sören Lukassen Erlangen ; Nürnberg 2018 VI, 107, xlii Seiten Illustrationen, Diagramme 21 cm txt rdacontent n rdamedia nc rdacarrier Dissertation Friedrich-Alexander-Universität Erlangen-Nürnberg 2018 Transponierbares Element (DE-588)4319836-3 gnd rswk-swf Nachweis (DE-588)4115334-0 gnd rswk-swf Geschlechtschromosom (DE-588)4157012-1 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Transponierbares Element (DE-588)4319836-3 s Geschlechtschromosom (DE-588)4157012-1 s Nachweis (DE-588)4115334-0 s DE-604 B:DE-101 application/pdf http://d-nb.info/1171495757/04 Inhaltsverzeichnis DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030760604&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Lukassen, Sören The contribution of transposable elements to meiotic sex chromosome inactivation (MSCI) and their detection in whole exome sequencing data Transponierbares Element (DE-588)4319836-3 gnd Nachweis (DE-588)4115334-0 gnd Geschlechtschromosom (DE-588)4157012-1 gnd |
| subject_GND | (DE-588)4319836-3 (DE-588)4115334-0 (DE-588)4157012-1 (DE-588)4113937-9 |
| title | The contribution of transposable elements to meiotic sex chromosome inactivation (MSCI) and their detection in whole exome sequencing data |
| title_auth | The contribution of transposable elements to meiotic sex chromosome inactivation (MSCI) and their detection in whole exome sequencing data |
| title_exact_search | The contribution of transposable elements to meiotic sex chromosome inactivation (MSCI) and their detection in whole exome sequencing data |
| title_full | The contribution of transposable elements to meiotic sex chromosome inactivation (MSCI) and their detection in whole exome sequencing data vorgelegt von Sören Lukassen |
| title_fullStr | The contribution of transposable elements to meiotic sex chromosome inactivation (MSCI) and their detection in whole exome sequencing data vorgelegt von Sören Lukassen |
| title_full_unstemmed | The contribution of transposable elements to meiotic sex chromosome inactivation (MSCI) and their detection in whole exome sequencing data vorgelegt von Sören Lukassen |
| title_short | The contribution of transposable elements to meiotic sex chromosome inactivation (MSCI) and their detection in whole exome sequencing data |
| title_sort | the contribution of transposable elements to meiotic sex chromosome inactivation msci and their detection in whole exome sequencing data |
| topic | Transponierbares Element (DE-588)4319836-3 gnd Nachweis (DE-588)4115334-0 gnd Geschlechtschromosom (DE-588)4157012-1 gnd |
| topic_facet | Transponierbares Element Nachweis Geschlechtschromosom Hochschulschrift |
| url | http://d-nb.info/1171495757/04 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030760604&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT lukassensoren thecontributionoftransposableelementstomeioticsexchromosomeinactivationmsciandtheirdetectioninwholeexomesequencingdata |
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