Diagnostik des von Willebrand-Syndroms Typ 2B:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | German |
| Veröffentlicht: |
Hamburg
[2018]
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Inhaltsverzeichnis |
| Beschreibung: | 69 Blätter Illustrationen, Diagramme 30 cm |
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MARC
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Datensatz im Suchindex
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| adam_text | 1
EINLEITUNG.............................................................................................................1
1.1 GESCHICHTE DES VON
WILLEBRAND-SYNDROMS....................................................1
1.2 DER VON WILLEBRAND-FAKTOR
...........................................................................
2
1.2.1
BIOSYNTHESE..............................................................................................
2
1.2.2 SPEICHERUNG UND
SEKRETION......................................................................
3
1.2.3
FUNKTION...................................................................................................
4
1.2.4
ABBAU........................................................................................................
6
1.3 DAS VON
WILLEBRAND-SYNDROM.........................................................................6
1.3.1
KLASSIFIKATION...........................................................................................
6
1.3.2 VWS TYP
2B............................................................................................
7
1.3.3 PLATELET-TYPE VON WILLEBRAND-SYNDROM VS. VWS TYP 2B
......................
8
1.3.4
THERAPIE....................................................................................................
8
1.4
DIAGNOSTIK.....................................................................................................
9
1.4.1 VWF:
AG.................................................................................................
10
1.4.2 FUNKTIONELLE
ANALYSE..............................................................................
11
1.4.3
RATIO.......................................................................................................
12
1.4.4
MULTIMERANALYSE.....................................................................................
12
1.4.5 SPEZIELLE DIAGNOSTIK DES VWS TYP 2B
...................................................13
1.4.6
GENDIAGNOSTIK........................................................................................
14
1.5 F
RAGESTELLUNG...............................................................................................
15
2 MATERIAL UND METHODEN
...................................................................................
16
2.1
PATIENTEN......................................................................................................
16
2.2
MATERIALIEN..................................................................................................
16
2.3 VWF
ELISA...............................................................................................
16
2.4
MULTIMERANALYSE..........................................................................................
18
2.5 DNA
EXTRAKTION..........................................................................................
18
2.6
PCR.............................................................................................................
18
2.7
GELELEKTROPHORESE.......................................................................................
19
2.8
AGAROSEGELELEKTROPHORESE.............................................................................19
2.9
SEQUENZIERUNG.............................................................................................
20
2.10
ZELLKULTUR.....................................................................................................20
2.11
MUTAGENESE.................................................................................................21
2.12
TRANSFORMATION............................................................................................
22
2.13 MINIPRAEPARATION DER PLASMIDE
.....................................................................
22
2.14 SEQUENZANALYSE DER PLASMIDE
.....................................................................
22
2.15
MAXIPRAEPARATION..........................................................................................
23
2.16 BESTIMMUNG DER
PLASMIDKONZENTRATION......................................................23
2.17 ZELLKULTUR FUER DIE TRANSIENTE
TRANSFEKTION...................................................23
2.18 T
RANSFEKTION................................................................................................
24
3
ERGEBNISSE.........................................................................................................
25
3.1
PATIENTENDATEN...............................................................................................25
3.2
MUTATIONSCREENING.......................................................................................
26
3.3
GPIBA-BINDUNGSASSAY.................................................................................
26
3.3.1 BINDUNGSKURVEN DER PATIENTENPROBEN
....................................................
26
3.3.2 BINDUNGSKURVEN DER REKOMBINANTEN VWF-MUTANTEN
............................
30
3.4 V
WF-MULTIMERANALYSE...............................................................................
32
4
DISKUSSION..........................................................................................................
35
4.1 MUTATIONSSCREENING
......................................................................................
35
4.2
GPIBA-BINDUNGSASSAY.................................................................................
36
4.3 GPIBA-BINDUNGSKURVEN
..............................................................................
38
4.3.1 GPIBA-BINDUNGSKURVEN DES PATIENTEN-VWF
.........................................
38
4.3.2 BINDUNGSKURVEN BEI GLEICHER MUTATION
..................................................
38
4.4
EXPRESSIONSSTUDIE........................................................................................
39
5
ZUSAMMENFASSUNG............................................................................................
41
5.1 S UMMARY
..................................................
42
6
ABKUERZUNGSVERZEICHNIS....................................................................................
43
7
LITERATURVERZEICHNIS.........................................................................................
45
8
ANHANG..............................................................................................................
55
8.1 ABBILDUNGS- UND T ABELLENVERZEICHNIS
..........................................................
55
8.2 LISTE DER GERAETE UND MATERIALIEN
.................................................................
56
8.3 SOFTWARE
PROGRAMME....................................................................................
60
8.4 LISTE DER
OLIGONUKLEOTIDE............................................................................
60
8.5 ANSATZ UND
PROTOKOLLE.................................................................................
62
8.6 WERTE FUER DIE BINDUNGSKURVEN
....................................................................
65
9
DANKSAGUNG.......................................................................................................
67
10
LEBENSLAUF.........................................................................................................
68
11 EIDESSTATTLICHE
ERKLAERUNG.................................................................................
69
|
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| bvnumber | BV045361407 |
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| discipline | Medizin |
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| indexdate | 2024-07-10T08:16:00Z |
| institution | BVB |
| language | German |
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| physical | 69 Blätter Illustrationen, Diagramme 30 cm |
| publishDate | 2018 |
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| spelling | Yildiz, Yesim Verfasser aut Diagnostik des von Willebrand-Syndroms Typ 2B vorgelegt von: Yesim Yildiz Hamburg [2018] 69 Blätter Illustrationen, Diagramme 30 cm txt rdacontent n rdamedia nc rdacarrier Dissertation Universität Hamburg 2018 (DE-588)4113937-9 Hochschulschrift gnd-content B:DE-101 application/pdf http://d-nb.info/1165355698/04 Inhaltsverzeichnis DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030747988&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Yildiz, Yesim Diagnostik des von Willebrand-Syndroms Typ 2B |
| subject_GND | (DE-588)4113937-9 |
| title | Diagnostik des von Willebrand-Syndroms Typ 2B |
| title_auth | Diagnostik des von Willebrand-Syndroms Typ 2B |
| title_exact_search | Diagnostik des von Willebrand-Syndroms Typ 2B |
| title_full | Diagnostik des von Willebrand-Syndroms Typ 2B vorgelegt von: Yesim Yildiz |
| title_fullStr | Diagnostik des von Willebrand-Syndroms Typ 2B vorgelegt von: Yesim Yildiz |
| title_full_unstemmed | Diagnostik des von Willebrand-Syndroms Typ 2B vorgelegt von: Yesim Yildiz |
| title_short | Diagnostik des von Willebrand-Syndroms Typ 2B |
| title_sort | diagnostik des von willebrand syndroms typ 2b |
| topic_facet | Hochschulschrift |
| url | http://d-nb.info/1165355698/04 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030747988&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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