Verfügbarkeit: Extracellular mechanisms of neutrophil granulocytes against Aspergillus fumigatus

Extracellular mechanisms of neutrophil granulocytes against Aspergillus fumigatus:

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Bibliographische Detailangaben
1. Verfasser:	Shopova, Iordana Atanasova 1984- (VerfasserIn)
Format:	Abschlussarbeit Buch
Sprache:	English
Veröffentlicht:	Jena 2018
Schlagworte:	Hochschulschrift
Online-Zugang:	Inhaltsverzeichnis Inhaltsverzeichnis
Beschreibung:	iii, 293 Seiten Illustrationen 30 cm 1 CD

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MARC


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Datensatz im Suchindex

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adam_text	TABLE OF CONTENTS 1. INTRODUCTION.....................................................................................................1 1.1 ASPERGILLUS FUMIGATUS: FROM THE ENVIRONMENT TO THE HOST ................................. 1 1.2 NEUTROPHILS - ON IMMUNE PATROL FOR FUNGI IN THE MURINE AND HUMAN HOST ........... 5 1.3 THE COMPLEMENT SYSTEM IS ENGAGED IN ANTIFUNGAL DEFENSE..............................10 1.4 EXTRACELLULAR VESICLES ARE UNIQUE CELLULAR MESSENGERS WITH DIVERSE REGULATORY FUNCTIONS AND PATHWAYS OF FORMATION .................................................... 11 1.5 POLYMORPHONUCLEAR-GRANULOCYTE DERIVED EXTRACELLULAR VESICLES AS IMMUNOMODULATORS.............................................................................................. 14 2. RESEARCH AIMS.................................................................................................16 3. MANUSCRIPTS.....................................................................................................20 3.1 MANUSCRIPT A: EXTRINSIC EXTRACELLULAR DNA LEADS TO BIOFILM FORMATION AND COLOCALIZES WITH MATRIX POLYSACCHARIDES IN THE HUMAN PATHOGENIC FUNGUS ASPERGILLUS FUMIGATUS ............................................................................................ 20 3.2 MANUSCRIPT B: INTERFERENCE OF ASPERGILLUS FUMIGATUS WITH THE IMMUNE RESPONSE................................................................................................................33 3.3 MANUSCRIPT C: CHALLENGES AND STRATEGIES FOR PROTEOME ANALYSIS OF THE INTERACTION OF HUMAN PATHOGENIC FUNGI WITH HOST IMMUNE CELLS..............................46 3.4 MANUSCRIPT D: CRISS-CROSS TALK BETWEEN EXTRACELLULAR VESICLES FROM HUMAN NEUTROPHILS AND A COSMOPOLITAN PATHOGENIC FUNGUS .............................................. 76 3.5 MANUSCRIPT E: ASPERGILLUS FUMIGATUS USES THE SURFACE PROTEIN ASPF2 TO ACQUIRE HUMAN IMMUNE REGULATORS FOR IMMUNE EVASION .................................... 118 3.6 MANUSCRIPT F: SIMULTANEOUS DUAL PROTEOME ANALYSIS TOWARDS UNDERSTANDING NEUTROPHIL INTERACTION WITH THE HUMAN-PATHOGENIC FUNGUS ASPERGILLUS FUMIGATUS..........................................................................................169 4. SUPPLEMENTARY MATERIAL AND METHODS 240 4.1 OPSONIZATION OF FUNGI AND C3B DETECTION....................................................... 240 4.2 CONFOCAL IMAGING OF INFECTED NEUTROPHILS AND 3D RECONSTRUCTIONS ................ 240 5. ADDITIONAL RESULTS ..................................................................................... 242 5.1 DHN-MELANIN MODULATES C3B COMPLEMENT DEPOSITION..................................242 5.2 CD177 IS EXPRESSED ON ANTIFUNGAL NEUTROPHIL DERIVED EXTRACELLULAR VESICLES. 243 6. DISCUSSION.......................................................................................................246 6.1 POLYMORPHONUCLEAR-GRANULOCYTE DERIVED EXTRACELLULAR VESICLES ARE NOVEL ANTIMICROBIAL AGENTS..............................................................................................246 6.2 NEUTROPHIL VESICLE BIOGENESIS AND RELEASE ARE LINKED TO AN ACTIVATED NEUTROPHIL PHENOTYPE............................................................................................249 6.3 CD177 - A POTENTIAL PLAYER IN ANTIFUNGAL DEFENSE?.........................................253 6.4 TERRA INCOGNITA - PMNDEVS* INTERNALIZATION IN FUNGAL CELLS AND THEIR FUNGISTATIC EFFECTS..................................................................................................254 6.5 MOONLIGHTING PROTEINS SURFACE OUT TO PERFORM UNCONVENTIONAL ROLES IN THE CELL........................................................................................................................ 257 6.6. SIMULTANEOUS DUAL PROTEOME: A CHALLENGING TECHNIQUE THAT REVEALS NOVEL BIOLOGY OF NEUTROPHILS............................................................................................258 7. SUMMARY...........................................................................................................260 ZUSAMMENFASSUNG............................................................................................263 LIST OF ABBREVIATIONS...............................................................................................267 LIST OF FIGURES AND TABLES.......................................................................................268 LIST OF SCIENTIFIC PUBLICATIONS AND CONFERENCE CONTRIBUTIONS 269 PUBLICATIONS 269 CONFERENCE CONTRIBUTIONS.................................................................................... 270 ACKNOWLEDGEMENTS.............................................................................................. 272 CURRICULUM VITAE.................................................................................................... 274 EIGENSTAENDIGKEITSERKLAERUNG................................................................................. 277 REFERENCES..............................................................................................................278
any_adam_object	1
author	Shopova, Iordana Atanasova 1984-
author_GND	(DE-588)1164095625
author_facet	Shopova, Iordana Atanasova 1984-
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bvnumber	BV045354339
ctrlnum	(OCoLC)1048394803 (DE-599)DNB1163760544
discipline	Biologie
format	Thesis Book
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spelling	Shopova, Iordana Atanasova 1984- Verfasser (DE-588)1164095625 aut Extracellular mechanisms of neutrophil granulocytes against Aspergillus fumigatus by Iordana Atanasova Shopova Jena 2018 iii, 293 Seiten Illustrationen 30 cm 1 CD txt rdacontent n rdamedia nc rdacarrier Dissertation Friedrich-Schiller-Universität Jena 2018 (DE-588)4113937-9 Hochschulschrift gnd-content B:DE-101 application/pdf http://d-nb.info/1163760544/04 Inhaltsverzeichnis DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030740954&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis
spellingShingle	Shopova, Iordana Atanasova 1984- Extracellular mechanisms of neutrophil granulocytes against Aspergillus fumigatus
subject_GND	(DE-588)4113937-9
title	Extracellular mechanisms of neutrophil granulocytes against Aspergillus fumigatus
title_auth	Extracellular mechanisms of neutrophil granulocytes against Aspergillus fumigatus
title_exact_search	Extracellular mechanisms of neutrophil granulocytes against Aspergillus fumigatus
title_full	Extracellular mechanisms of neutrophil granulocytes against Aspergillus fumigatus by Iordana Atanasova Shopova
title_fullStr	Extracellular mechanisms of neutrophil granulocytes against Aspergillus fumigatus by Iordana Atanasova Shopova
title_full_unstemmed	Extracellular mechanisms of neutrophil granulocytes against Aspergillus fumigatus by Iordana Atanasova Shopova
title_short	Extracellular mechanisms of neutrophil granulocytes against Aspergillus fumigatus
title_sort	extracellular mechanisms of neutrophil granulocytes against aspergillus fumigatus
topic_facet	Hochschulschrift
url	http://d-nb.info/1163760544/04 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030740954&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
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