Sequence-based classification of select agents: a brighter line
Gespeichert in:
| Körperschaft: | |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Washington, D.C.
National Academies Press
[2010], 2010
|
| Schlagworte: | |
| Beschreibung: | Print version record |
| Beschreibung: | 1 online resource (xv, 220 pages) illustrations |
| ISBN: | 9780309159050 0309159059 1282885723 9781282885721 |
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| 110 | 2 | |a National Research Council (U.S.) |b Committee on Scientific Milestones for the Development of a Gene Sequence-Based Classification System for the Oversight of Select Agents |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Sequence-based classification of select agents |b a brighter line |c Committee on Scientific Milestones for the Development of a Gene Sequence-Based Classification System for the Oversight of Select Agents, Board on Life Sciences, Division on Earth and Life Studies, National Research Council of the National Academies |
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| 505 | 8 | |a "Select Agents are defined in regulations through a list of names of particularly dangerous known bacteria, viruses, toxins, and fungi. However, natural variation and intentional genetic modification blur the boundaries of any discrete Select Agent list based on names. Access to technologies that can generate or 'synthesize' any DNA sequence is expanding, making it easier and less expensive for researchers, industry scientists, and amateur users to create organisms without needing to obtain samples of existing stocks or cultures. This has led to growing concerns that these DNA synthesis technologies might be used to synthesize Select Agents, modify such agents by introducing small changes to the genetic sequence, or create entirely new pathogens. | |
| 505 | 8 | |a Amid these concerns, the National Institutes of Health requested that the Research Council investigate the science and technology needed to replace the current Select Agent list with an oversight system that predicts if a DNA sequence could be used to produce an organism that should be regulated as a Select Agent. A DNA sequence-based system to better define when a pathogen or toxin is subject to Select Agent regulations could be developed. This could be coupled with a 'yellow flag' system that would recognize requests to synthesize suspicious sequences and serve as a reference to anyone with relevant questions, allowing for appropriate follow-up. Sequence-Based Classification of Select Agents finds that replacing the current list of Select Agents with a system that could predict if fragments of DNA sequences could be used to produce novel pathogens with Select Agent characteristics is not feasible. | |
| 505 | 8 | |a However, it emphasized that for the foreseeable future, any threat from synthetic biology and synthetic genomics is far more likely to come from assembling known Select Agents, or modifications of them, rather than construction of previously unknown agents. Therefore, the book recommends modernizing the regulations to define Select Agents in terms of their gene sequences, not by their names, and called this 'sequence-based classification.'"--Publisher's description | |
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Datensatz im Suchindex
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|---|---|
| any_adam_object | |
| author_corporate | National Research Council (U.S.) Committee on Scientific Milestones for the Development of a Gene Sequence-Based Classification System for the Oversight of Select Agents |
| author_corporate_role | aut |
| author_facet | National Research Council (U.S.) Committee on Scientific Milestones for the Development of a Gene Sequence-Based Classification System for the Oversight of Select Agents |
| author_sort | National Research Council (U.S.) Committee on Scientific Milestones for the Development of a Gene Sequence-Based Classification System for the Oversight of Select Agents |
| building | Verbundindex |
| bvnumber | BV045344135 |
| collection | ZDB-4-ENC |
| contents | "Select Agents are defined in regulations through a list of names of particularly dangerous known bacteria, viruses, toxins, and fungi. However, natural variation and intentional genetic modification blur the boundaries of any discrete Select Agent list based on names. Access to technologies that can generate or 'synthesize' any DNA sequence is expanding, making it easier and less expensive for researchers, industry scientists, and amateur users to create organisms without needing to obtain samples of existing stocks or cultures. This has led to growing concerns that these DNA synthesis technologies might be used to synthesize Select Agents, modify such agents by introducing small changes to the genetic sequence, or create entirely new pathogens. Amid these concerns, the National Institutes of Health requested that the Research Council investigate the science and technology needed to replace the current Select Agent list with an oversight system that predicts if a DNA sequence could be used to produce an organism that should be regulated as a Select Agent. A DNA sequence-based system to better define when a pathogen or toxin is subject to Select Agent regulations could be developed. This could be coupled with a 'yellow flag' system that would recognize requests to synthesize suspicious sequences and serve as a reference to anyone with relevant questions, allowing for appropriate follow-up. Sequence-Based Classification of Select Agents finds that replacing the current list of Select Agents with a system that could predict if fragments of DNA sequences could be used to produce novel pathogens with Select Agent characteristics is not feasible. However, it emphasized that for the foreseeable future, any threat from synthetic biology and synthetic genomics is far more likely to come from assembling known Select Agents, or modifications of them, rather than construction of previously unknown agents. Therefore, the book recommends modernizing the regulations to define Select Agents in terms of their gene sequences, not by their names, and called this 'sequence-based classification.'"--Publisher's description |
| ctrlnum | (ZDB-4-ENC)ocn681623253 (OCoLC)681623253 (DE-599)BVBBV045344135 |
| dewey-full | 660.6 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 660 - Chemical engineering |
| dewey-raw | 660.6 |
| dewey-search | 660.6 |
| dewey-sort | 3660.6 |
| dewey-tens | 660 - Chemical engineering |
| discipline | Chemie / Pharmazie |
| format | Electronic eBook |
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| spelling | National Research Council (U.S.) Committee on Scientific Milestones for the Development of a Gene Sequence-Based Classification System for the Oversight of Select Agents Verfasser aut Sequence-based classification of select agents a brighter line Committee on Scientific Milestones for the Development of a Gene Sequence-Based Classification System for the Oversight of Select Agents, Board on Life Sciences, Division on Earth and Life Studies, National Research Council of the National Academies Washington, D.C. National Academies Press [2010], 2010 1 online resource (xv, 220 pages) illustrations txt rdacontent c rdamedia cr rdacarrier Print version record "Select Agents are defined in regulations through a list of names of particularly dangerous known bacteria, viruses, toxins, and fungi. However, natural variation and intentional genetic modification blur the boundaries of any discrete Select Agent list based on names. Access to technologies that can generate or 'synthesize' any DNA sequence is expanding, making it easier and less expensive for researchers, industry scientists, and amateur users to create organisms without needing to obtain samples of existing stocks or cultures. This has led to growing concerns that these DNA synthesis technologies might be used to synthesize Select Agents, modify such agents by introducing small changes to the genetic sequence, or create entirely new pathogens. Amid these concerns, the National Institutes of Health requested that the Research Council investigate the science and technology needed to replace the current Select Agent list with an oversight system that predicts if a DNA sequence could be used to produce an organism that should be regulated as a Select Agent. A DNA sequence-based system to better define when a pathogen or toxin is subject to Select Agent regulations could be developed. This could be coupled with a 'yellow flag' system that would recognize requests to synthesize suspicious sequences and serve as a reference to anyone with relevant questions, allowing for appropriate follow-up. Sequence-Based Classification of Select Agents finds that replacing the current list of Select Agents with a system that could predict if fragments of DNA sequences could be used to produce novel pathogens with Select Agent characteristics is not feasible. However, it emphasized that for the foreseeable future, any threat from synthetic biology and synthetic genomics is far more likely to come from assembling known Select Agents, or modifications of them, rather than construction of previously unknown agents. Therefore, the book recommends modernizing the regulations to define Select Agents in terms of their gene sequences, not by their names, and called this 'sequence-based classification.'"--Publisher's description SCIENCE / Biotechnology bisacsh Genetic engineering fast Microbiological laboratories / Safety measures fast Molecular biology fast Pathogenic microorganisms fast Clinical Laboratory Techniques / standards / United States / Congresses Clinical Laboratory Techniques Microbiological Techniques Genetic Engineering Safety Management Microbiological Techniques / standards / United States / Congresses Genetic Engineering / United States / Congresses Safety Management / methods / United States / Congresses Laboratory Techniques and Procedures / standards / United States / Congresses Pathogenic microorganisms Microbiological laboratories United States Safety measures Genetic engineering Molecular biology 1\p (DE-588)1071861417 Konferenzschrift gnd-content National Research Council (U.S.) Sonstige oth Erscheint auch als Druck-Ausgabe National Research Council (U.S.). Committee on Scientific Milestones for the Development of a Gene Sequence-Based Classification System for the Oversight of Select Agents Sequence-based classification of select agents Washington, D.C. : National Academies Press, 2010 0309159040 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Sequence-based classification of select agents a brighter line "Select Agents are defined in regulations through a list of names of particularly dangerous known bacteria, viruses, toxins, and fungi. However, natural variation and intentional genetic modification blur the boundaries of any discrete Select Agent list based on names. Access to technologies that can generate or 'synthesize' any DNA sequence is expanding, making it easier and less expensive for researchers, industry scientists, and amateur users to create organisms without needing to obtain samples of existing stocks or cultures. This has led to growing concerns that these DNA synthesis technologies might be used to synthesize Select Agents, modify such agents by introducing small changes to the genetic sequence, or create entirely new pathogens. Amid these concerns, the National Institutes of Health requested that the Research Council investigate the science and technology needed to replace the current Select Agent list with an oversight system that predicts if a DNA sequence could be used to produce an organism that should be regulated as a Select Agent. A DNA sequence-based system to better define when a pathogen or toxin is subject to Select Agent regulations could be developed. This could be coupled with a 'yellow flag' system that would recognize requests to synthesize suspicious sequences and serve as a reference to anyone with relevant questions, allowing for appropriate follow-up. Sequence-Based Classification of Select Agents finds that replacing the current list of Select Agents with a system that could predict if fragments of DNA sequences could be used to produce novel pathogens with Select Agent characteristics is not feasible. However, it emphasized that for the foreseeable future, any threat from synthetic biology and synthetic genomics is far more likely to come from assembling known Select Agents, or modifications of them, rather than construction of previously unknown agents. Therefore, the book recommends modernizing the regulations to define Select Agents in terms of their gene sequences, not by their names, and called this 'sequence-based classification.'"--Publisher's description SCIENCE / Biotechnology bisacsh Genetic engineering fast Microbiological laboratories / Safety measures fast Molecular biology fast Pathogenic microorganisms fast Clinical Laboratory Techniques / standards / United States / Congresses Clinical Laboratory Techniques Microbiological Techniques Genetic Engineering Safety Management Microbiological Techniques / standards / United States / Congresses Genetic Engineering / United States / Congresses Safety Management / methods / United States / Congresses Laboratory Techniques and Procedures / standards / United States / Congresses Pathogenic microorganisms Microbiological laboratories United States Safety measures Genetic engineering Molecular biology |
| subject_GND | (DE-588)1071861417 |
| title | Sequence-based classification of select agents a brighter line |
| title_auth | Sequence-based classification of select agents a brighter line |
| title_exact_search | Sequence-based classification of select agents a brighter line |
| title_full | Sequence-based classification of select agents a brighter line Committee on Scientific Milestones for the Development of a Gene Sequence-Based Classification System for the Oversight of Select Agents, Board on Life Sciences, Division on Earth and Life Studies, National Research Council of the National Academies |
| title_fullStr | Sequence-based classification of select agents a brighter line Committee on Scientific Milestones for the Development of a Gene Sequence-Based Classification System for the Oversight of Select Agents, Board on Life Sciences, Division on Earth and Life Studies, National Research Council of the National Academies |
| title_full_unstemmed | Sequence-based classification of select agents a brighter line Committee on Scientific Milestones for the Development of a Gene Sequence-Based Classification System for the Oversight of Select Agents, Board on Life Sciences, Division on Earth and Life Studies, National Research Council of the National Academies |
| title_short | Sequence-based classification of select agents |
| title_sort | sequence based classification of select agents a brighter line |
| title_sub | a brighter line |
| topic | SCIENCE / Biotechnology bisacsh Genetic engineering fast Microbiological laboratories / Safety measures fast Molecular biology fast Pathogenic microorganisms fast Clinical Laboratory Techniques / standards / United States / Congresses Clinical Laboratory Techniques Microbiological Techniques Genetic Engineering Safety Management Microbiological Techniques / standards / United States / Congresses Genetic Engineering / United States / Congresses Safety Management / methods / United States / Congresses Laboratory Techniques and Procedures / standards / United States / Congresses Pathogenic microorganisms Microbiological laboratories United States Safety measures Genetic engineering Molecular biology |
| topic_facet | SCIENCE / Biotechnology Genetic engineering Microbiological laboratories / Safety measures Molecular biology Pathogenic microorganisms Clinical Laboratory Techniques / standards / United States / Congresses Clinical Laboratory Techniques Microbiological Techniques Genetic Engineering Safety Management Microbiological Techniques / standards / United States / Congresses Genetic Engineering / United States / Congresses Safety Management / methods / United States / Congresses Laboratory Techniques and Procedures / standards / United States / Congresses Pathogenic microorganisms Microbiological laboratories United States Safety measures Genetic engineering Molecular biology Konferenzschrift |
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