Membranes in pulmonary vascular disease:
Gespeichert in:
| Weitere Verfasser: | , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Cambridge, MA ; San Diego, CA
Academic Press
2018
|
| Ausgabe: | First edition |
| Schriftenreihe: | Current topics in membranes
volume 82 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | xii, 279 Seiten Illustrationen 23 cm |
| ISBN: | 9780128158067 |
Internformat
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| 999 | |a oai:aleph.bib-bvb.de:BVB01-030719703 | ||
Datensatz im Suchindex
| _version_ | 1804179142508281856 |
|---|---|
| adam_text | CONTENTS
Contributors ix
Preface xi
1. Sphingolipids Signaling in Lamellipodia Formation and
Enhancement of Endothelial Barrier Function 1
Panfeng Fu, Mark Shaaya, Anantha Harijith, Jeffrey R. Jacobson,
Andrei Karginov, and Viswanathan Natarajan
1. Introduction 2
2. Dynamics of Lamellipodia 4
3. Modulation of Lung Endothelial Barrier Function by Inflammatory and
Protective Agents 8
4. Mechanisms of Lamellipodia Formation and Endothelial Barrier
Enhancement 9
5. Reactive Oxygen Species, Lamellipodia Formation, and Endothelial Barrier
Enhancement 17
6. Oxidized Phospholipids, Lamellipodia Formation, and Endothelial Barrier
Enhancement 19
7. Simvastatin Activation of S1P1 in Endothelial Barrier Enhancement 20
8. Conclusions and Future Directions 21
Acknowledgments 22
References 22
2. The Pulmonary Endothelial Glycocalyx in ARDS: A Critical Role
for Heparan Sulfate 33
Wells B. LaRiviere and Eric P. Schmidt
1. Emerging Understanding and Historical Underappreciation of Endothelial
Glycocalyx Structure and Function 34
2. Polysaccharide Structure of the Endothelial Glycocalyx: A Focus on
Eleparan Sulfate 37
3. Pulmonary Endothelial Glycocalyx Heparan Sulfate Is Essential for Lung
Homeostasis 39
4. Fate of Glycocalyx Heparan Sulfate During Sepsis-Induced ARDS Onset and
Resolution 41
5. Multisystemic Consequences of Glycocalyx Degradation 43
v
vi
Contents
6. Unanswered Questions: The Endothelial Gtycocalyx in Direct vs. Indirect
Lung Injury 45
7. Summary 47
References 47
3. Cholesterol Regulation of Pulmonary Endothelial Calcium
Homeostasis 53
Bojun Zhang, Michael L. Paffett, Jay S. Naik, Nikki L. Jernigan,
Benjimen R. Walker, and Thomas C. Resta
11. Introduction 55
2. Endothelial Ca2+ Channels in the Pulmonary Circulation 57
3. Hypoxic Regulation of Pulmonary Endothelial Ca2+ Entry 63
4. Role of Membrane Cholesterol in Regulating Endothelial Ca2+ Entry in
CH-Induced PH 67
5. Potential Mechanisms of Diminished Endothelial Membrane Cholesterol
by CH 76
6. Summary and Conclusions 78
References 79
4. Endothelial Protrusions in Junctional Integrity and Barrier Function 93
Natascha G. Alves, Zeinab Y. Motawe, Sarah Y. Yuan, and Jerome W. Breslin
1. Introduction 94
2. Determinants of Endothelial Barrier Function 95
3. Methods to Study Endothelial Barrier Function 98
4. Microvascular Hyperpermeability in Injury or Disease Conditions 106
5. Evidence of a Role for Local Lamellipodia in the Control of Endothelial Barrier
Function 118
6. Conclusions 126
Acknowledgments 126
References 126
5. Cortical Actin Dynamics in Endothelial Permeability 141
Patrick Belvitch, Yu Maw Htwe, Mary E. Brown, and Steven Dudek
1. The Pulmonary Endothelial Ceil Membrane and Physiology 142
2. Actin Structure and Force Generation 145
3. Endothelial Cell Membrane Morphology and Barrier Function 147
4. Membrane-Related Signaling and Barrier Function 150
5. Protein Regulation of Cortical Actin 155
Contents
vii
6. Junctional Complexes Link Membrane to Cytoskeleton 158
7. New Insights Into Cytoskeletal and Membrane Imaging 163
8. Conclusion 174
Acknowledgments 175
References 175
6. Endothelial Extracellular Vesicles in Pulmonary Function and
Disease 197
Eleftheria Letsiou and Natalie Bauer
1. Introduction 198
2. Overview of Endothelial Extracellular Vesicles (EVs) 199
3. Endothelial EVs and Lung Diseases 214
4. Conclusions and Future Directions 234
Acknowledgments 243
References 243
7. Caveolin and Endothelial NO Signaling 257
Suellen D.S. Oliveira and Richard D. Minshall
1. Endothelial Cell Caveolin-1 and Nitric Oxide Synthase: An Overview 258
2. Lung Endothelial Cell Cav-1 and eNOS-Mediated Signaling During Cell
Quiescence vs. Activation 261
3. Depletion of Endothelial Cell Cav-1 and eNOS Expression: Role in Acute and
Chronic Pulmonary Vascular Diseases 265
4. Endothelial Cell Phenotype Switching During Lung Inflammatory Response:
Role of Cav-1 Depletion and eNOS Uncoupling? 269
5. Conclusion and Future Directions 272
Acknowledgments 273
References 273
|
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| discipline | Biologie Medizin |
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| isbn | 9780128158067 |
| language | English |
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| spelling | Membranes in pulmonary vascular disease edited by Patrick Belvitch (Division of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine, The University of Illinois at Chicago, Chicago, IL, United States), Steven Dudek (Division of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine, The University of Illinois at Chicago, Chicago, IL, United States) First edition Cambridge, MA ; San Diego, CA Academic Press 2018 xii, 279 Seiten Illustrationen 23 cm txt rdacontent n rdamedia nc rdacarrier Current topics in membranes volume 82 Lungenkrankheit (DE-588)4036660-1 gnd rswk-swf Lungenfunktion (DE-588)4168318-3 gnd rswk-swf Membran (DE-588)4038571-1 gnd rswk-swf Lungs / Blood vessels / Diseases Membranes (Biology) (DE-588)4143413-4 Aufsatzsammlung gnd-content Lungenfunktion (DE-588)4168318-3 s Lungenkrankheit (DE-588)4036660-1 s Membran (DE-588)4038571-1 s b DE-604 Belvitch, Patrick edt Dudek, Steven edt Erscheint auch als Online-Ausgabe, EPUB 978-0-12-815807-4 Current topics in membranes volume 82 (DE-604)BV036839511 82 Digitalisierung UB Regensburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030719703&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Membranes in pulmonary vascular disease Current topics in membranes Lungenkrankheit (DE-588)4036660-1 gnd Lungenfunktion (DE-588)4168318-3 gnd Membran (DE-588)4038571-1 gnd |
| subject_GND | (DE-588)4036660-1 (DE-588)4168318-3 (DE-588)4038571-1 (DE-588)4143413-4 |
| title | Membranes in pulmonary vascular disease |
| title_auth | Membranes in pulmonary vascular disease |
| title_exact_search | Membranes in pulmonary vascular disease |
| title_full | Membranes in pulmonary vascular disease edited by Patrick Belvitch (Division of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine, The University of Illinois at Chicago, Chicago, IL, United States), Steven Dudek (Division of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine, The University of Illinois at Chicago, Chicago, IL, United States) |
| title_fullStr | Membranes in pulmonary vascular disease edited by Patrick Belvitch (Division of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine, The University of Illinois at Chicago, Chicago, IL, United States), Steven Dudek (Division of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine, The University of Illinois at Chicago, Chicago, IL, United States) |
| title_full_unstemmed | Membranes in pulmonary vascular disease edited by Patrick Belvitch (Division of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine, The University of Illinois at Chicago, Chicago, IL, United States), Steven Dudek (Division of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine, The University of Illinois at Chicago, Chicago, IL, United States) |
| title_short | Membranes in pulmonary vascular disease |
| title_sort | membranes in pulmonary vascular disease |
| topic | Lungenkrankheit (DE-588)4036660-1 gnd Lungenfunktion (DE-588)4168318-3 gnd Membran (DE-588)4038571-1 gnd |
| topic_facet | Lungenkrankheit Lungenfunktion Membran Aufsatzsammlung |
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