Die Funktion von Activin Receptor-Like Kinase 7 in braunen und weißen Adipozyten:
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| 1. Verfasser: | |
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| Format: | Abschlussarbeit Buch |
| Sprache: | German English |
| Veröffentlicht: |
Bonn
2017
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Inhaltsverzeichnis |
| Beschreibung: | 83 Seiten Illustrationen 21 cm |
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MARC
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| 245 | 1 | 0 | |a Die Funktion von Activin Receptor-Like Kinase 7 in braunen und weißen Adipozyten |c Johanna Jagow |
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Datensatz im Suchindex
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|---|---|
| adam_text | INHALTSVERZEICHNIS
1. DEUTSCHE ZUSAMMENFASSUNG 7
1.1 EINLEITUNG 7
1.2 MATERIAL UND METHODEN 9
1.3 ERGEBNISSE 11
1.4 DISKUSSION 14
1.5 LITERATURVERZEICHNIS DER DEUTSCHEN ZUSAMMENFASSUNG 16
2. VEROEFFENTLICHUNG 19
2.1 LIST OF ABBREVIATIONS 19
2.2 INTRODUCTION 22
2.2.1 ADIPOSE TISSUE 22
2 .2 .2 TYPES OF ADIPOSE TISSUE 22
2.2.3 THE CGMP-SIGNALING PATHWAY 24
2 .2 .4 TG FSS-SUPERFAM ILY 25
2.2.5 ACTIVIN RECEPTOR-LIKE KINASE 7 (ALK7), ITS LIGANDS AND SIGNALING
26
2 .2 .6 AIM OF THE MD THESIS 28
2.3 MATERIAL AND METHODS 29
2.3.1 G ENERAL 29
2.3.2 CELL CULTURE METHODS 29
2.3.3 BIOCHEMICAL METHODS 37
2.3.4 MOLECULAR BIOLOGICAL METHODS 45
2.3.5 STATISTICAL ANALYSIS 52
2.4 RESULTS 53
2.4.1 CGMP PROMOTES BROWN ADIPOCYTE DIFFERENTIATION 53
2.4.2 ALK7 MRNA EXPRESSION INCREASES WITH BROWN ADIPOCYTE
DIFFERENTIATION 54
2.4.3 CGMP INCREASES ALKJ MRNA EXPRESSION AND PROTEIN LEVELS 55
2.4.4 ROLE OF ALK7 IN LIPOLYSIS IN BROWN ADIPOCYTES 56
2.4.5 LIPOLYSIS IS NOT AFFECTED BY ACTIVIN B IN OVEREXPRESSION MODEL 56
2.4.6 EFFECT OF ALK7 RECEPTOR EXPRESSION ON PROLIFERATION OF BROWN
ADIPOCYTES AND CELL
MORPHOLOGY 57
2.4.7 ACTIVIN B TREATMENT FROM DAY -2 INHIBITS ADIPOGENESIS AND
THERMOGENESIS 60
2.4.3 ACTIVIN B TREATMENT FROM DAY 4 PROMOTES THERMOGENESIS 62
2.4.9 IN VITRO MODEL OF WHITE ADIPOCYTE DIFFERENTIATION 63
2.4.10 ALK7 MRNA EXPRESSION INCREASES WITH WHITE ADIPOCYTE
DIFFERENTIATION 63
2.4.11 OVEREXPRESSION OF CAALK? CHANGES MORPHOLOGY OF PRIMARY WHITE
ADIPOCYTES 64
2.4.12 ACTIVIN B TREATMENT REDUCES WHITE ADIPOCYTE DIFFERENTIATION 65
2.4.13 CAALK? CAUSES THE SHIFT FROM ADIPOGENIC TO MYOGENIC MARKERS IN
CELLS ISOLATED
FROM WHITE ADIPOSE TISSUE 66
2.4.14 ANALYSIS OF LIPOLYSIS IN WHITE ADIPOCYTES 67
2.5 DISCUSSION 69
2.5.1 EXPRESSION PATTERN OF ALK7 AND THE EFFECT OF CGMP 70
2.5.2 EFFECTS OF ALK7 LIGAND ACTIVIN B ON ADIPOCYTE DIFFERENTIATION 71
2.5.3 PROLIFERATION 72
2.5.4 LIPOLYSIS 73
2.5.5 MORPHOLOGY AND SHIFT TO MYOGENIC MARKERS 74
2.6 SUMMARY 75
3. LITERATURVERZEICHNIS 76
4. DANKSAGUNG
83
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| any_adam_object | 1 |
| author | Jagow, Johanna |
| author_facet | Jagow, Johanna |
| author_role | aut |
| author_sort | Jagow, Johanna |
| author_variant | j j jj |
| building | Verbundindex |
| bvnumber | BV045292122 |
| ctrlnum | (OCoLC)1135442887 (DE-599)DNB1148015655 |
| discipline | Biologie Medizin |
| format | Thesis Book |
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| indexdate | 2024-07-10T08:14:01Z |
| institution | BVB |
| language | German English |
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| physical | 83 Seiten Illustrationen 21 cm |
| publishDate | 2017 |
| publishDateSearch | 2017 |
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| spelling | Jagow, Johanna Verfasser aut Die Funktion von Activin Receptor-Like Kinase 7 in braunen und weißen Adipozyten Johanna Jagow Bonn 2017 83 Seiten Illustrationen 21 cm txt rdacontent n rdamedia nc rdacarrier Dissertation Rheinische Friedrich-Wilhelms-Universität Bonn 2017 (DE-588)4113937-9 Hochschulschrift gnd-content B:DE-101 application/pdf http://d-nb.info/1148015655/04 Inhaltsverzeichnis DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030679492&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Jagow, Johanna Die Funktion von Activin Receptor-Like Kinase 7 in braunen und weißen Adipozyten |
| subject_GND | (DE-588)4113937-9 |
| title | Die Funktion von Activin Receptor-Like Kinase 7 in braunen und weißen Adipozyten |
| title_auth | Die Funktion von Activin Receptor-Like Kinase 7 in braunen und weißen Adipozyten |
| title_exact_search | Die Funktion von Activin Receptor-Like Kinase 7 in braunen und weißen Adipozyten |
| title_full | Die Funktion von Activin Receptor-Like Kinase 7 in braunen und weißen Adipozyten Johanna Jagow |
| title_fullStr | Die Funktion von Activin Receptor-Like Kinase 7 in braunen und weißen Adipozyten Johanna Jagow |
| title_full_unstemmed | Die Funktion von Activin Receptor-Like Kinase 7 in braunen und weißen Adipozyten Johanna Jagow |
| title_short | Die Funktion von Activin Receptor-Like Kinase 7 in braunen und weißen Adipozyten |
| title_sort | die funktion von activin receptor like kinase 7 in braunen und weißen adipozyten |
| topic_facet | Hochschulschrift |
| url | http://d-nb.info/1148015655/04 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030679492&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT jagowjohanna diefunktionvonactivinreceptorlikekinase7inbraunenundweißenadipozyten |
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