Il castello di Solfagnano: la natura del bel paesaggio
Gespeichert in:
| Weitere Verfasser: | , , |
|---|---|
| Format: | Buch |
| Sprache: | Italian English |
| Veröffentlicht: |
Perugia
ABA Press
[2017]
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | 269 Seiten Illustrationen, Karten, Pläne |
| ISBN: | 9788889298671 |
Internformat
MARC
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| 245 | 1 | 0 | |a Il castello di Solfagnano |b la natura del bel paesaggio |c a cura di Paolo Belardi, Sonia Merli, Manuel Vaquero Piñeiro |
| 264 | 1 | |a Perugia |b ABA Press |c [2017] | |
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| 653 | |a Castello di Solfagnano <Perugia> | ||
| 653 | |a Storia | ||
| 653 | |a Paesaggio agrario | ||
| 653 | |a Solfagnano <Perugia> | ||
| 653 | |a Storia | ||
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Datensatz im Suchindex
| _version_ | 1806055337048932352 |
|---|---|
| adam_text |
KLEIP DEFICIENT MICE:
A NEW MODEL SYSTEM TO ANALYZE
CORNEA DYSTROPHY AND
NEONATAL RESPIRATORY FAILURE
GUTACHTER:
PROF. DR. ANDREAS TRUMPP
PROF. DR. JENS KROLL
HTTP://D-NB.INFO/1065827644
CONTENTS
ZUSAMMENFASSUNG VII
SUMMARY IX
1 INTRODUCTION 1
1.1 ASPECTS OF CORNEAL
TRANSPARENCY 1
1.1.1 CORNEAL ANATOMY 1
1.1.2 CORNEAL EPITHELIAL REGENERATION 3
1.1.3 CORNEAL VASCULAR PRIVILEGE 4
1.2 CORNEAL DISEASES AND
DYSTROPHIC LESIONS 5
1.2.1 DYSTROPHIC LESIONS 6
1.2.2 INFLAMMATORY AND VASCULAR LESIONS - KERATITIS 7
1.2.3 FINAL CLINICAL STATEMENT 8
1.3 THE PULMONARY-VASCULAR INTERPLAY AT
BIRTH 8
1.3.1 LUNG DEVELOPMENT 9
1.3.2 VASCULAR DEVELOPMENT AND THE VASCULAR ENDOTHELIAL GROWTH FACTOR 11
1.3.3 INTERDEPENDENCY OF AIRWAY AND VASCULAR BRANCHING 13
1.3.4 THE SACCULAR STAGE - PREPARING FOR BIRTH 14
1.4 ANGIOCRINE SIGNALING IN ORGAN
DEVELOPMENT AND REGENERATION 16
1.5 OXYGEN SENSORS OF
THE RESPIRATORY SYSTEM 18
1.5.1 PHYSIOLOGICAL RELEVANCE OF HYPOXIA INDUCIBLE FACTORS 20
1.5.2 HYPOXIA INDUCIBLE FACTORS IN ANGIOGENESIS 21
1.5.3 HYPOXIA INDUCIBLE FACTORS IN LUNG DEVELOPMENT 21
1.6 THE
HYPOXIA INDUCIBLE
BTB-KELCH
PROTEIN KLEIP 23
1.6.1 THE ROLE OF KLEIP IN ANGIOGENESIS 24
1.6.2 THE ROLE OF KLEIP IN CELL-CELL CONTACT FORMATION 25
1.7 AIMS OF THE
THESIS 27
2 RESULTS 28
2.1 LOSS OF KLEIP
RESULTS IN CORNEA
EPITHELIAL DYSTROPHY 28
2.1.1 PROGREDIENT CORNEAL OPACITY IN KLEIP^ MICE 28
2.1.2 CORNEAL OPACITY IS NOT DUE TO EMBRYONIC MALFORMATIONS AND DEVELOPS
INDEPENDENT OF THE LACRIMAL FUNCTIONAL UNIT 30
2.1.3 LOSS OF KLEIP RESULTS IN CORNEAL EPITHELIAL DYSTROPHY 33
2.1.4 EPITHELIAL DYSTROPHY INVOLVES EPITHELIAL - EPIDERMAL TRANSITION 35
I
2.1.5 EPITHELIAL DYSTROPHY IS ACCOMPANIED BY STRONG NEOVASCULARIZATION
37
2.1.6 EPITHELIAL FRAGILITY CAUSES CORNEAL DYSTROPHY IN KLEIF
A
MICE 38
2.1.7 DYSTROPHY DEVELOPMENT IS TRIGGERED BY MECHANICAL INJURY 39
2.2 LOSS OF KLEIP CAUSES PULMONARY
ENDOTHELIAL FAILURE AND NEONATAL DEATH
42
2.2.1 KLEIP DEFICIENCY INCREASES NEONATAL LETHALITY 42
2.2.2 KLEIP^' NEWBORNS SUFFER FROM RESPIRATORY DISTRESS 45
2.2.3 PNEUMOCYTE IMMATURITY CAUSES REDUCED SURFACTANT IN KLEIP* EMBRYOS
4 7
2.2.4 ENDOTHELIAL APOPTOSIS MEDIATES VASCULAR REGRESSION IN KLEIP^
NEONATES 50
2.2.5 KLEIP SHOWS VASCULAR EXPRESSION PATTERN IN THE LUNG 52
2.2.6 REDUCED HIF-2A AND VEGF IN KLEIP* ENDOTHELIUM CAUSES CAPILLARY
REGRESSION AND THEREBY PNEUMOCYTE IMMATURITY AND NEONATAL DEATH 53
2.2.7 ANTENATAL BETAMETHASONE RESCUES RESPIRATORY DISTRESS IN KLEIP
R/
~ MICE 55
2.2.8 BETAMETHASONE RESCUES LOSS OF KLEIP INCREASING ENDOTHELIAL HIF-2A
57
3 DISCUSSION 59
3.1 KLEIP REGULATES CORNEAL EPITHELIAL INTEGRITY 59
3.1.1 EPITHELIAL NEOVASCULAR DYSTROPHY IS CAUSED BY KLEIP ABSENCE 59
3.1.2 CORNEAL EPITHELIAL INTEGRITY AND WOUND CLOSURE IS REGULATED BY
KLEIP AND
E-CADHERIN 61
3.1.3 KLEIP-DYSTROPHY RESULTS IN CONTINUOUS REGENERATION AND SCARING 63
3.2 KLEIP REGULATES
LATE
PULMONARY
MATURATION VIA HIF-2A 65
3.2.1 KLEIP REGULATES PULMONARY EPITHELIAL MATURATION AND SURFACTANT
PRODUCTION 65
3.2.2 KLEIP MEDIATES PULMONARY ENDOTHELIAL VIABILITY AND ANGIOCRINE
SIGNALING 68
3.2.3 HIF-2A UPREGULATION COMPENSATES FOR KLEIP DEFICIENCY 72
3.2.4 BETAMETHASONE ACTS ON THE KLEIP/HIF-2AA/EGFPATHWAY 72
4 MATERIAL AND
METHODS 75
4.1 MATERIAL 75
4.1.1 CONSUMABLES AND CHEMICALS 75
4.1.2 PCR REAGENTS AND PRIMERS 75
4.1.3 ANTIBODIES AND KITS 76
4.1.4 ANIMAL STRAINS AND SURGERY EQUIPMENT 78
4.1.5 CELL CULTURE 79
4.1.6 SOLUTIONS AND BUFFERS 80
4.1.7 EQUIPMENT 81
4.1.8 ANALYTICAL SOFTWARE 82
II
4.2 METHODS 83
4.2.1 ANIMALS 83
4.2.2 ANIMAL STUDIES 84
4.2.3 CELL ISOLATION AND CULTURE 86
4.2.4 CYTO- AND HISTOCHEMISTRY 87
4.2.5 LACZ STAINING OF TRANSGENIC TISSUE 90
4.2.6 RNA AND DNA ISOLATION, RT-,TRIPLE-, HOT START AND QPCR 90
4.2.7 PROTEIN ISOLATION, DETECTION AND QUANTIFICATION 91
ABBREVIATIONS XI
REFERENCES XV
III |
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| geographic_facet | Solfagnano |
| id | DE-604.BV045277597 |
| illustrated | Illustrated |
| indexdate | 2024-07-31T01:16:28Z |
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| isbn | 9788889298671 |
| language | Italian English |
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| physical | 269 Seiten Illustrationen, Karten, Pläne |
| publishDate | 2017 |
| publishDateSearch | 2017 |
| publishDateSort | 2017 |
| publisher | ABA Press |
| record_format | marc |
| spelling | Il castello di Solfagnano la natura del bel paesaggio a cura di Paolo Belardi, Sonia Merli, Manuel Vaquero Piñeiro Perugia ABA Press [2017] 269 Seiten Illustrationen, Karten, Pläne txt rdacontent sti rdacontent n rdamedia nc rdacarrier Text italienisch, Zusammenfassung englisch Antinori Familie : 13. Jh.- (DE-588)133309290 gnd rswk-swf Kastell (DE-588)4136071-0 gnd rswk-swf Solfagnano (DE-588)1173193847 gnd rswk-swf Castello di Solfagnano <Perugia> Storia Paesaggio agrario Solfagnano <Perugia> (DE-588)4145395-5 Bildband gnd-content Solfagnano (DE-588)1173193847 g Kastell (DE-588)4136071-0 s DE-604 Antinori Familie : 13. Jh.- (DE-588)133309290 p Belardi, Paolo 1958- (DE-588)123566797 edt Merli, Sonia edt Vaquero Piñeiro, Manuel (DE-588)135933439 edt DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030665242&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Il castello di Solfagnano la natura del bel paesaggio Antinori Familie : 13. Jh.- (DE-588)133309290 gnd Kastell (DE-588)4136071-0 gnd |
| subject_GND | (DE-588)133309290 (DE-588)4136071-0 (DE-588)1173193847 (DE-588)4145395-5 |
| title | Il castello di Solfagnano la natura del bel paesaggio |
| title_auth | Il castello di Solfagnano la natura del bel paesaggio |
| title_exact_search | Il castello di Solfagnano la natura del bel paesaggio |
| title_full | Il castello di Solfagnano la natura del bel paesaggio a cura di Paolo Belardi, Sonia Merli, Manuel Vaquero Piñeiro |
| title_fullStr | Il castello di Solfagnano la natura del bel paesaggio a cura di Paolo Belardi, Sonia Merli, Manuel Vaquero Piñeiro |
| title_full_unstemmed | Il castello di Solfagnano la natura del bel paesaggio a cura di Paolo Belardi, Sonia Merli, Manuel Vaquero Piñeiro |
| title_short | Il castello di Solfagnano |
| title_sort | il castello di solfagnano la natura del bel paesaggio |
| title_sub | la natura del bel paesaggio |
| topic | Antinori Familie : 13. Jh.- (DE-588)133309290 gnd Kastell (DE-588)4136071-0 gnd |
| topic_facet | Antinori Familie : 13. Jh.- Kastell Solfagnano Bildband |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030665242&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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