Microfluidics for multicellular systems:
Gespeichert in:
| Weitere Verfasser: | , , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Cambridge, MA ; San Diego, CA ; Oxford ; London
Academic Press
2018
|
| Ausgabe: | First edition |
| Schriftenreihe: | Methods in cell biology
Volume 146 Microfluidics in cell biology Part A |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | xiii, 259 Seiten Illustrationen |
| ISBN: | 9780128142806 |
Internformat
MARC
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| 250 | |a First edition | ||
| 264 | 1 | |a Cambridge, MA ; San Diego, CA ; Oxford ; London |b Academic Press |c 2018 | |
| 300 | |a xiii, 259 Seiten |b Illustrationen | ||
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| 490 | 1 | |a Methods in cell biology |v Volume 146 | |
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Datensatz im Suchindex
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|---|---|
| adam_text | Contents
Contributors............................................................ix
Preface............................................................. xiii
SECTION 1 MICROFLUIDICS FOR CELL MONOLAYERS/
_______________SPHEROIDS___________________________________________
CHAPTER t Tubular microscaffolds for studying collective
cell migration............................................3
Wang Xi, Surabhi Sonam, Chwee Teck Lim, Benoit Ladoux
1. Introduction..............................................4
2. Microfabrication of Microtubular Architectures
for Epithelial Collective Migration Study.................6
3. Functionalization of the Tubular Microscaffolds
With Extracellular Matrix Protein and Cell Seeding.......10
4. 3D Imaging and Image Analysis...........................14
5. Discussion and Perspectives.............................18
Acknowledgments.............................................19
References..................................................19
CHAPTER 2 Endothelial cell monolayer-based microfluidic
systems mimicking complex in vivo
microenvironments for the study of leukocyte
dynamics in inflamed blood vessels.......................23
Jaehyun Lee, Hyung Kyu Huh, Sung Ho Park,
Sang ioon Lee, Junsang Doh
1. Introduction............................................25
2. Assembly and Characterization of a Parallel-Plate Flow
Chamber..................................................26
3. Alignment of Endothelial Monolayers Using Nanogrooved
Surfaces.................................................31
4. Fabrication of Stenotic Structures and Characterization
of Complex Flow Patterns in Post-stenotic Regions........33
5. Extension to 3D Blood Vessel/Inflamed Tissue Structures.37
6. Summary and Outlook.....................................39
Acknowledgments.............................................40
References..................................................40
vi Contents
CHAPTER 3 Constrained spheroids/organoids in perfusion
culture.............................................. 43
Fan Lee, Ciprian lliescu, Fang Yu, Hanry Yu
1. Introduction.............................................44
2. Tethered Spheroids/Organoids.............................47
3. Physically-Constrained Spheroids/Organoids...............50
4. Perfusion Culture in Microfluidic Channels...............57
5. Applications............................................60
6. Conclusions..............................................61
Acknowledgments.............................................61
References..................................................62
SECTION 2 ORGANS ON CHIPS_________________________________________________
CHAPTER 4 Generation of functional cardiac microtissues
in a beating heart-on-a-chip.............................69
Giovanni Stefano Ugolini, Roberta Visone,
Daniela Cruz-Moreira, Andrea Mainardi, Marco Rasponi
1. Introduction.............................................70
2. Materials and Equipment..................................72
3. Methods..................................................74
References.............................................. 83
CHAPTER 5 Kidney on chips............................................ .85
Jeonghwan Lee, Kipyo Kim, Sejoong Kim
1. Basic Functions of the Kidney............................86
2. Kidney Tubule-on-a-Chip..................................88
3. Glomerulus-on-a-Chip.....................................94
4. Kidney Chamber in Multi-organs-on-a-Chip.................99
5. Future Perspective......................................101
Acknowledgment.............................................102
References............................................... 102
CHAPTER 6 Liver sinusoid on a chip..................................105
Yu Du, Ning Li, Mian Long
1. Introduction of Cell-Cell Interactions in Liver
Sinusoidal Microenvironments............................106
2. Construction of the Liver Sinusoid Chip.................114
3. Mechanical Microenvironment Analysis....................121
4. Liver-Specific Functions of the Sinusoidal Chip.........124
5. Hepatic Immune Response.................................127
6. Conclusive Remarks and Future Perspectives..............129
Contents
vn
Acknowledgments..........................................130
References...............................................131
Further Reading..........................................133
CHAPTER 7 Pathomimetic modeling of human intestinal
diseases and underlying host-gut microbiome
interactions in a gut-on-a-chip.......................135
Woojung Shin, Hyun Jung Kim
1. Introduction.........................................136
2. Microfabrication of a Gut-on-a-Chip Device............137
3. Recreation of Intestinal Microenvironment and Physiology.... 140
4. Recapitulation of Host-Gut Microbiome Intercellular
Interactions..........................................141
5. Pathomimetic Modeling I: Intestinal Inflammation......144
6. Pathomimetic Modeling II: Intestinal Bacterial
Overgrowth............................................146
7. Outlook...............................................146
Acknowledgments..........................................147
References...............................................147
CHAPTER 8 3D in vitro microvascular model-based
lymphoma model........................................149
Robert G. Mannino, Pallab Pradhan, Krishnendu Roy,
Wilbur A. Lam
1. Introduction..........................................150
2. Materials and Equipment........................... 154
3. Methods...............................................154
4. Closing Remarks.......................................157
References...............................................157
CHAPTER 9 Blood-brain barrier on a chip.....................159
Eunice Chin, Eyleen Goh
1. Introduction.................................. 160
2. The Endogenous BBB....................................161
3. Current BBB Models....................................164
4. BBB-on-Chip Models....................................165
5. Considerations for Modeling the BBB on a Chip.........172
6. Conclusion............................................176
References...............................................177
Contents
CHAPTER 10 Pharmacokinetic-based multi-organ chip for
recapitulating organ interactions.................. 183
Jong Hwan Sung
1. Introduction.........................................184
2. Materials and Equipment..............................186
3. Methods..............................................187
4. Exemplary MATLAB Code for Liver-Tumor-Blood Chip.....194
5. Final Remarks........................................195
Acknowledgment..........................................195
References..............................................195
CHAPTER 11 Studying TCR T cell anti-tumor activity in a
microfluidic intrahepatic tumor model................199
Giulia Adrian!» Andrea Pavesi, Roger D. Kamm
1. Introduction to Microfluidic Technology..............200
2. Materials and Equipment..............................204
3. Methods..............................................205
4. Sample Results.......................................210
5. Future Directions....................................211
Acknowledgments.........................................212
Financial Disclosure....................................212
References............................................ 212
SECTION 3 MICROFLUIDICS FOR MODEL ORGANISMS
CHAPTER 12 Microfluidics for mechanobiology of model
organisms...................................... 217
Anna A. Kim, Adam L Nekimken, Sylvia Fechner,
Lucy E. O’Brien, Beth L. Pruitt
1. Introduction.........................................218
2. Mechanobiology...................................... 218
3. Multicellular Model Organisms........................221
4. Design Considerations for Microfluidics..............224
5. Microfluidics for Mechanobiology of Model Organisms..230
6. Conclusion...........................................243
Acknowledgments.........................................243
References..............................................243
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| indexdate | 2024-07-10T08:13:13Z |
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| isbn | 9780128142806 |
| language | English |
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| series | Methods in cell biology Microfluidics in cell biology |
| series2 | Methods in cell biology Microfluidics in cell biology |
| spelling | Microfluidics for multicellular systems edited by Junsang Doh, Daniel Fletcher, Matthieu Piel First edition Cambridge, MA ; San Diego, CA ; Oxford ; London Academic Press 2018 xiii, 259 Seiten Illustrationen txt rdacontent n rdamedia nc rdacarrier Methods in cell biology Volume 146 Microfluidics in cell biology Part A Mikrofluidik (DE-588)4803438-1 gnd rswk-swf Cytologie (DE-588)4070177-3 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Mikrofluidik (DE-588)4803438-1 s Cytologie (DE-588)4070177-3 s b DE-604 Doh, Junsang (DE-588)1165711648 edt Fletcher, Daniel (DE-588)116571180X edt Piel, Matthieu 1973- (DE-588)116571213X edt Methods in cell biology Volume 146 (DE-604)BV002534878 146 Microfluidics in cell biology Part A (DE-604)BV045262771 A Digitalisierung UB Regensburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030650721&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Microfluidics for multicellular systems Methods in cell biology Microfluidics in cell biology Mikrofluidik (DE-588)4803438-1 gnd Cytologie (DE-588)4070177-3 gnd |
| subject_GND | (DE-588)4803438-1 (DE-588)4070177-3 (DE-588)4143413-4 |
| title | Microfluidics for multicellular systems |
| title_auth | Microfluidics for multicellular systems |
| title_exact_search | Microfluidics for multicellular systems |
| title_full | Microfluidics for multicellular systems edited by Junsang Doh, Daniel Fletcher, Matthieu Piel |
| title_fullStr | Microfluidics for multicellular systems edited by Junsang Doh, Daniel Fletcher, Matthieu Piel |
| title_full_unstemmed | Microfluidics for multicellular systems edited by Junsang Doh, Daniel Fletcher, Matthieu Piel |
| title_short | Microfluidics for multicellular systems |
| title_sort | microfluidics for multicellular systems |
| topic | Mikrofluidik (DE-588)4803438-1 gnd Cytologie (DE-588)4070177-3 gnd |
| topic_facet | Mikrofluidik Cytologie Aufsatzsammlung |
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